| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shahram Aarabi, Kirit A Bhatt, Yubin Shi, Josemaria Paterno, Edward I Chang, Shang A Loh, Jeffrey W Holmes, Michael T Longaker, Herman Yee, Geoffrey C Gurtne. Mechanical load initiates hypertrophic scar formation through decreased cellular apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 21. issue 12. 2008-01-07. PMID:17504973. |
the increased cellularity is accompanied by a four-fold decrease in cellular apoptosis and increased activation of the prosurvival marker akt. |
2008-01-07 |
2023-08-12 |
mouse |
| Xiaomeng Zhang, Ming-Tat Ling, Qi Wang, Chi-Keung Lau, Steve C L Leung, Terence K Lee, Annie L M Cheung, Yong-Chuan Wong, Xianghong Wan. Identification of a novel inhibitor of differentiation-1 (ID-1) binding partner, caveolin-1, and its role in epithelial-mesenchymal transition and resistance to apoptosis in prostate cancer cells. The Journal of biological chemistry. vol 282. issue 46. 2008-01-03. PMID:17855368. |
our study demonstrates a novel id-1 binding partner and suggests a molecular mechanism that mediates the function of id-1 in promoting prostate cancer progression through activation of the akt pathway leading to cancer cell invasion and resistance to anticancer drug-induced apoptosis. |
2008-01-03 |
2023-08-12 |
human |
| Ozlen Saglam, Christopher R Garrett, David Boulware, Zena Sayegh, David Shibata, Mokenge Malafa, Timothy Yeatman, Jin Q Cheng, Said Sebti, Domenico Coppol. Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia. Clinical colorectal cancer. vol 6. issue 9. 2008-01-03. PMID:17945038. |
akt has been identified as a major regulator of cell proliferation, tumorigenesis, and apoptosis. |
2008-01-03 |
2023-08-12 |
Not clear |
| Hiraku Ono, Hideyuki Sakoda, Midori Fujishiro, Motonobu Anai, Akifumi Kushiyama, Yasushi Fukushima, Hideki Katagiri, Takehide Ogihara, Yoshitomo Oka, Hideaki Kamata, Nanao Horike, Yasunobu Uchijima, Hiroki Kurihara, Tomoichiro Asan. Carboxy-terminal modulator protein induces Akt phosphorylation and activation, thereby enhancing antiapoptotic, glycogen synthetic, and glucose uptake pathways. American journal of physiology. Cell physiology. vol 293. issue 5. 2007-12-27. PMID:17615157. |
uv-b-induced apoptosis of hela cells was significantly reversed not only by overexpression of the active mutant of akt (myr-akt) but also by that of ctmp. |
2007-12-27 |
2023-08-12 |
Not clear |
| Norifumi Sawamukai, Kazuyoshi Saito, Kunihiro Yamaoka, Shingo Nakayamada, Chisei Ra, Yoshiya Tanak. Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 10. 2007-12-27. PMID:17982036. |
a77 1726 dramatically induced apoptosis of human mast cells and inhibited the phosphorylation of akt, an important survival signal of mast cells, in a concentration-dependent manner. |
2007-12-27 |
2023-08-12 |
mouse |
| Hoon Han, Sung-Won Shin, Chi-Yeon Seo, Hyuk-Chan Kwon, Jin-Yeong Han, In-Hoo Kim, Jong-Young Kwak, Joo-In Par. 15-Deoxy-delta 12,14-prostaglandin J2 (15d-PGJ 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation. Apoptosis : an international journal on programmed cell death. vol 12. issue 11. 2007-12-21. PMID:17786557. |
15-deoxy-delta 12,14-prostaglandin j2 (15d-pgj 2) sensitizes human leukemic hl-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (trail)-induced apoptosis through akt downregulation. |
2007-12-21 |
2023-08-12 |
human |
| Hoon Han, Sung-Won Shin, Chi-Yeon Seo, Hyuk-Chan Kwon, Jin-Yeong Han, In-Hoo Kim, Jong-Young Kwak, Joo-In Par. 15-Deoxy-delta 12,14-prostaglandin J2 (15d-PGJ 2) sensitizes human leukemic HL-60 cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis through Akt downregulation. Apoptosis : an international journal on programmed cell death. vol 12. issue 11. 2007-12-21. PMID:17786557. |
taken together, these findings indicate that 15d-pgj2 may augment trail-induced apoptosis in human leukemia cells by down-regulating the expression and phosphorylation of akt. |
2007-12-21 |
2023-08-12 |
human |
| Gretchen A Repasky, Yixing Zhou, Staeci Morita, Channing J De. Ras-mediated intestinal epithelial cell transformation requires cyclooxygenase-2-induced prostaglandin E2 signaling. Molecular carcinogenesis. vol 46. issue 12. 2007-12-20. PMID:17477350. |
finally, we found that pge2 stimulated the activation of ras and erk, but not akt, and reduced matrix deprivation-induced apoptosis, in untransformed epithelial cells. |
2007-12-20 |
2023-08-12 |
Not clear |
| Jing Fang, Min Ding, Lily Yang, Ling-Zhi Liu, Bing-Hua Jian. PI3K/PTEN/AKT signaling regulates prostate tumor angiogenesis. Cellular signalling. vol 19. issue 12. 2007-12-20. PMID:17826033. |
pi3k pathway exerts its function through its downstream molecule akt in regulating various cell functions including cell proliferation, cell transformation, cell apoptosis, tumor growth and angiogenesis. |
2007-12-20 |
2023-08-12 |
mouse |
| Dan Li, Qiao Cui, Shen-geng Chen, Li-jun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Inactivation of ras and changes of mitochondrial membrane potential contribute to oridonin-induced autophagy in a431 cells. Journal of pharmacological sciences. vol 105. issue 1. 2007-12-20. PMID:17895587. |
preincubation with the pi3-k inhibitor wortmannin and akt inhibitor kp372-1 enhanced oridonin-induced apoptosis, whereas it inhibited oridonin-induced autophagy. |
2007-12-20 |
2023-08-12 |
Not clear |
| Bayan T Takizawa, Edward M Uchio, Justin J Cohen, Marcia A Wheeler, Robert M Weis. Downregulation of survivin is associated with reductions in TNF receptors' mRNA and protein and alterations in nuclear factor kappa B signaling in urothelial cancer cells. Cancer investigation. vol 25. issue 8. 2007-12-20. PMID:18058462. |
microarray analysis of apoptosis genes showed that levels of 14/114 gene products were decreased after 72 hours treatment with survivin sirna, including survivin, three tnf receptors, akt, c-abl, caspases and their related genes and bcl-2 and nf-kappab signaling related genes. |
2007-12-20 |
2023-08-12 |
Not clear |
| Rivka Steinberg, Olivier A Harari, Elaine A Lidington, Joseph J Boyle, Mahrokh Nohadani, Allen M Samarel, Motoi Ohba, Dorian O Haskard, Justin C Maso. A protein kinase Cepsilon-anti-apoptotic kinase signaling complex protects human vascular endothelial cells against apoptosis through induction of Bcl-2. The Journal of biological chemistry. vol 282. issue 44. 2007-12-13. PMID:17785460. |
we demonstrate that pkcepsilon forms a signaling complex and acts co-operatively with akt to protect human vascular endothelial cells against apoptosis through induction of the anti-apoptotic protein bcl-2 and inhibition of caspase-3 cleavage. |
2007-12-13 |
2023-08-12 |
human |
| David Vauzour, Katerina Vafeiadou, Catherine Rice-Evans, Robert J Williams, Jeremy P E Spence. Activation of pro-survival Akt and ERK1/2 signalling pathways underlie the anti-apoptotic effects of flavanones in cortical neurons. Journal of neurochemistry. vol 103. issue 4. 2007-12-13. PMID:17961201. |
the activation of erk1/2 and akt by flavanones led to the inhibition of the pro-apoptotic proteins, apoptosis signal-regulating kinase 1, by phosphorylation at ser83 and bad, by phosphorylation at both ser136 and ser112 and to the inhibition of peroxide-induced caspase 9 and caspase 3 activation. |
2007-12-13 |
2023-08-12 |
Not clear |
| Maria A Theodoraki, Mary Kunjappu, David W Sternberg, Avrom J Capla. Akt shows variable sensitivity to an Hsp90 inhibitor depending on cell context. Experimental cell research. vol 313. issue 18. 2007-12-12. PMID:17643429. |
our results showed that npm-alk expression makes akt and cdk4 more resistant to degradation in the presence of geldanamycin, and there was a slightly reduced amount of apoptosis. |
2007-12-12 |
2023-08-12 |
Not clear |
| P Y Chuang, Q Yu, W Fang, J Uribarri, J C H. Advanced glycation endproducts induce podocyte apoptosis by activation of the FOXO4 transcription factor. Kidney international. vol 72. issue 8. 2007-12-12. PMID:17667983. |
exposure to age-bsa was associated with akt dephosphorylation and foxo4 transcriptional activation leading to an increase in the expression of an effector protein of apoptosis, bim. |
2007-12-12 |
2023-08-12 |
cattle |
| Mousumi Bose, Xingpei Hao, Jihyeung Ju, Ali Husain, Sunny Park, Joshua D Lambert, Chung S Yan. Inhibition of tumorigenesis in ApcMin/+ mice by a combination of (-)-epigallocatechin-3-gallate and fish oil. Journal of agricultural and food chemistry. vol 55. issue 19. 2007-12-12. PMID:17696481. |
akt phosphorylation in adenomas was significantly reduced in all treatment groups, which may have contributed to the observed increase in apoptosis. |
2007-12-12 |
2023-08-12 |
mouse |
| Jitesh P Jani, Richard S Finn, Mary Campbell, Kevin G Coleman, Richard D Connell, Nicolas Currier, Erling O Emerson, Eugenia Floyd, Shawn Harriman, John C Kath, Joel Morris, James D Moyer, Leslie R Pustilnik, Kristina Rafidi, Sherry Ralston, Ann Marie K Rossi, Stefanus J Steyn, Larry Wagner, Steven M Winter, Samit K Bhattachary. Discovery and pharmacologic characterization of CP-724,714, a selective ErbB2 tyrosine kinase inhibitor. Cancer research. vol 67. issue 20. 2007-12-12. PMID:17942920. |
it induces a marked reduction of extracellular signal-regulated kinase and akt phosphorylation, tumor cell apoptosis, and release of caspase-3. |
2007-12-12 |
2023-08-12 |
mouse |
| Oxana Selivanova, Jürgen Brieger, Ulf-Rüdiger Heinrich, Wolf Man. Akt and c-Jun N-terminal kinase are regulated in response to moderate noise exposure in the cochlea of guinea pigs. ORL; journal for oto-rhino-laryngology and its related specialties. vol 69. issue 5. 2007-12-10. PMID:17565230. |
akt and c-jun n-terminal kinase (jnk) are key factors of signaling pathways balancing cellular survival and apoptosis. |
2007-12-10 |
2023-08-12 |
Not clear |
| Chun Gui, Jian An Wang, Ai Na He, Tie Long Chen, Rong Hua Luo, Jun Jiang, Xin Yang Hu, Xiao Jie Xi. Heregulin protects mesenchymal stem cells from serum deprivation and hypoxia-induced apoptosis. Molecular and cellular biochemistry. vol 305. issue 1-2. 2007-12-07. PMID:17619951. |
these results suggested hrg could decrease the apoptosis of mscs induced by sd and hypoxia through the activation of akt and erk, the increase of bcl-2/bax ratio and the inhibition of caspase3 activation. |
2007-12-07 |
2023-08-12 |
rat |
| Y K Jeon, C H Park, K-Y Kim, Y C Li, J Kim, Y A Kim, J-H Paik, B-K Park, C-W Kim, Y-N Ki. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation. The Journal of pathology. vol 213. issue 2. 2007-12-07. PMID:17768706. |
ebv-positive nktl cell lines, hank-1 and nk-ys, and an ebv-negative nk leukaemia cell line, nk-l, were treated with pi3k and akt inhibitors, ga, and 17-aag, and were subjected to apoptosis and cell viability assays, and immunoblot analysis. |
2007-12-07 |
2023-08-12 |
Not clear |