| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Y K Jeon, C H Park, K-Y Kim, Y C Li, J Kim, Y A Kim, J-H Paik, B-K Park, C-W Kim, Y-N Ki. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation. The Journal of pathology. vol 213. issue 2. 2007-12-07. PMID:17768706. |
hank-1 and nk-ys cell viability was compromised and apoptosis was induced by ly294002 (pi3k inhibitor) or akt inhibitor ii. |
2007-12-07 |
2023-08-12 |
Not clear |
| Y K Jeon, C H Park, K-Y Kim, Y C Li, J Kim, Y A Kim, J-H Paik, B-K Park, C-W Kim, Y-N Ki. The heat-shock protein 90 inhibitor, geldanamycin, induces apoptotic cell death in Epstein-Barr virus-positive NK/T-cell lymphoma by Akt down-regulation. The Journal of pathology. vol 213. issue 2. 2007-12-07. PMID:17768706. |
ga or 17-aag administration resulted in the apoptosis of nktl cells, accompanied by akt and pakt down-regulation, caspase 3 activation, and mitochondrial membrane potential disruption. |
2007-12-07 |
2023-08-12 |
Not clear |
| S Bhattacharya, R M Ray, L R Johnso. Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-kappaB activation but not GSK3beta activity. Apoptosis : an international journal on programmed cell death. vol 10. issue 4. 2007-12-06. PMID:16133867. |
increased akt activation in polyamine depleted intestinal epithelial cells correlated well with the decrease in tnf-alpha-induced apoptosis. |
2007-12-06 |
2023-08-12 |
Not clear |
| S Bhattacharya, R M Ray, L R Johnso. Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-kappaB activation but not GSK3beta activity. Apoptosis : an international journal on programmed cell death. vol 10. issue 4. 2007-12-06. PMID:16133867. |
inhibition of pi3-kinase and over-expression of dominant negative akt (dn-akt), significantly increased apoptosis in polyamine depleted cells. |
2007-12-06 |
2023-08-12 |
Not clear |
| S Bhattacharya, R M Ray, L R Johnso. Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-kappaB activation but not GSK3beta activity. Apoptosis : an international journal on programmed cell death. vol 10. issue 4. 2007-12-06. PMID:16133867. |
constitutively active akt (ca-akt) expression increased resistance to tnf-alpha-induced apoptosis. |
2007-12-06 |
2023-08-12 |
Not clear |
| C-B Chan, X Liu, X Tang, H Fu, K Y. Akt phosphorylation of zyxin mediates its interaction with acinus-S and prevents acinus-triggered chromatin condensation. Cell death and differentiation. vol 14. issue 9. 2007-12-06. PMID:17572661. |
thus, akt regulates zyxin/acinus complex formation in the nucleus, contributing to suppression of apoptosis. |
2007-12-06 |
2023-08-12 |
Not clear |
| Rochelle P Coelho, Shawn G Payne, Robert Bittman, Sarah Spiegel, Carmen Sato-Bigbe. The immunomodulator FTY720 has a direct cytoprotective effect in oligodendrocyte progenitors. The Journal of pharmacology and experimental therapeutics. vol 323. issue 2. 2007-12-06. PMID:17726159. |
treatment of these cells with fty720 causes activation of extracellular signal-regulated kinase 1/2 and akt, accompanied by protection from apoptosis. |
2007-12-06 |
2023-08-12 |
Not clear |
| Daniel E Voth, Jimmy D Ballar. Critical intermediate steps in Clostridium sordellii lethal toxin-induced apoptosis. Biochemical and biophysical research communications. vol 363. issue 4. 2007-12-06. PMID:17910886. |
the decrease in phosphorylated akt was followed by caspase-dependent processing of bcl-x(l) and bid, revealing the connection between gtpase inactivation and mitochondrial-mediated apoptosis observed in tcsl-intoxicated cells. |
2007-12-06 |
2023-08-12 |
Not clear |
| Haitao Meng, Chunmei Yang, Wanmao Ni, Wei Ding, Xiudi Yang, Wenbin Qia. Antitumor activity of fludarabine against human multiple myeloma in vitro and in vivo. European journal of haematology. vol 79. issue 6. 2007-12-06. PMID:17976186. |
we demonstrated that myeloma cell line rpmi8226 was efficiently inhibited by fludarabine, concomitantly with decreased phosphorylation of akt, down-regulation of the inhibitor of apoptosis proteins (iap) family, including xiap and survivin, and induction of apoptosis related to activation of caspase cascade. |
2007-12-06 |
2023-08-12 |
mouse |
| Yen-Shen Lu, Yoko Kashida, Samuel K Kulp, Yu-Chieh Wang, Dasheng Wang, Jui-Hsiang Hung, Monica Tang, Zhong-Zhe Lin, Te-Jung Chen, Ann-Lii Cheng, Ching-Shih Che. Efficacy of a novel histone deacetylase inhibitor in murine models of hepatocellular carcinoma. Hepatology (Baltimore, Md.). vol 46. issue 4. 2007-11-30. PMID:17654699. |
with respect to saha, osu-hdac42 exhibited greater apoptogenic potency, which was associated with reduced levels of the apoptotic regulators phosphorylated akt b-cell lymphoma-xl, survivin, cellular inhibitor of apoptosis protein 1, and cellular inhibitor of apoptosis protein 2. |
2007-11-30 |
2023-08-12 |
mouse |
| Hang Yin, Julie Chao, Michael Bader, Lee Cha. Differential role of kinin B1 and B2 receptors in ischemia-induced apoptosis and ventricular remodeling. Peptides. vol 28. issue 7. 2007-11-28. PMID:17644219. |
bradykinin, but not des-arg(9)-bk, reduced cardiomyocyte apoptosis and increased akt and gsk-3beta phosphorylation. |
2007-11-28 |
2023-08-12 |
mouse |
| Min Ho Han, Sung Ok Kim, Gi Young Kim, Taeg Kyu Kwon, Byung Tae Choi, Won Ho Lee, Yung Hyun Cho. Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt. Anti-cancer drugs. vol 18. issue 8. 2007-11-28. PMID:17667597. |
induction of apoptosis by sanguinarine in c6 rat glioblastoma cells is associated with the modulation of the bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and akt. |
2007-11-28 |
2023-08-12 |
rat |
| Min Ho Han, Sung Ok Kim, Gi Young Kim, Taeg Kyu Kwon, Byung Tae Choi, Won Ho Lee, Yung Hyun Cho. Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt. Anti-cancer drugs. vol 18. issue 8. 2007-11-28. PMID:17667597. |
moreover, the activity of extracellular signal-regulated kinase and akt was downregulated in sanguinarine-treated cells, and pd98059, a specific extracellular signal-regulated kinase inhibitor, and phosphatidylinositol 3'-kinase/akt inhibitors, ly294002 and wortmanin, sensitized the cells to sanguinarine-induced apoptosis, indicating that the downregulation of the extracellular signal-regulated kinase and akt signaling pathway may play a key role in sanguinarine-induced apoptosis in c6 cells. |
2007-11-28 |
2023-08-12 |
rat |
| Hitoshi Ikeda, Yukio Kume, Kazuaki Tejima, Tomoaki Tomiya, Takako Nishikawa, Naoko Watanabe, Natsuko Ohtomo, Masahiro Arai, Chihiro Arai, Masao Omata, Kenji Fujiwara, Yutaka Yatom. Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats. American journal of physiology. Gastrointestinal and liver physiology. vol 293. issue 4. 2007-11-28. PMID:17761835. |
ha-1077 stimulated phosphorylation of akt, and wortmannin, an inhibitor of phosphatidylinositol 3-kinase (pi3-kinase)/akt pathway, abrogated the reduction of hepatocyte apoptosis by ha-1077 in vitro. |
2007-11-28 |
2023-08-12 |
rat |
| Arthur Edwards, Jiannong Li, Peter Atadja, Kapil Bhalla, Eric B Haur. Effect of the histone deacetylase inhibitor LBH589 against epidermal growth factor receptor-dependent human lung cancer cells. Molecular cancer therapeutics. vol 6. issue 9. 2007-11-27. PMID:17876048. |
lbh589 selectively depleted proteins important in signaling cascades in cell lines harboring egfr kinase mutations, such as egfr, stat3, and akt, and these cells underwent apoptosis following exposure to lbh589. |
2007-11-27 |
2023-08-12 |
human |
| Li-Hua Chen, Jing Fang, Huaixing Li, Wendy Demark-Wahnefried, Xu Li. Enterolactone induces apoptosis in human prostate carcinoma LNCaP cells via a mitochondrial-mediated, caspase-dependent pathway. Molecular cancer therapeutics. vol 6. issue 9. 2007-11-27. PMID:17876055. |
mechanistic studies suggested roles for akt, gsk-3beta, mdm2, and p53 in enterolactone-dependent apoptosis. |
2007-11-27 |
2023-08-12 |
human |
| Dorrah Deeb, Xiaohua Gao, Scott A Dulchavsky, Subhash C Gauta. CDDO-me induces apoptosis and inhibits Akt, mTOR and NF-kappaB signaling proteins in prostate cancer cells. Anticancer research. vol 27. issue 5A. 2007-11-27. PMID:17970042. |
cddo-me induces apoptosis and inhibits akt, mtor and nf-kappab signaling proteins in prostate cancer cells. |
2007-11-27 |
2023-08-12 |
Not clear |
| Tomohiro Okunaga, Yoshishige Urata, Shinji Goto, Takayuki Matsuo, Shingo Mizota, Keisuke Tsutsumi, Izumi Nagata, Takahito Kondo, Yoshito Ihar. Calreticulin, a molecular chaperone in the endoplasmic reticulum, modulates radiosensitivity of human glioblastoma U251MG cells. Cancer research. vol 66. issue 17. 2007-11-26. PMID:16951181. |
thus, overexpression of crt modulates radiation-induced apoptosis by suppressing akt signaling through the up-regulation of pp2ac alpha expression via altered ca(2+) homeostasis. |
2007-11-26 |
2023-08-12 |
human |
| Feng Xue, Yoshitaka Isaka, Terumi Takahara, Ryoichi Imamura, Chigure Suzuki, Naotsugu Ichimaru, Paolo Michieli, Shiro Takahar. HGF-MSP chimera protects kidneys from ischemia-reperfusion injury. Biochemical and biophysical research communications. vol 363. issue 2. 2007-11-26. PMID:17888399. |
in contrast, mf-1 treatment up-regulated akt phosphorylation, and inhibited caspase 3 activation and tubular apoptosis, thereby ameliorating renal dysfunction. |
2007-11-26 |
2023-08-12 |
rat |
| Dayna J Groskreutz, Martha M Monick, Timur O Yarovinsky, Linda S Powers, Dawn E Quelle, Steven M Varga, Dwight C Look, Gary W Hunninghak. Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells. Journal of immunology (Baltimore, Md. : 1950). vol 179. issue 5. 2007-11-20. PMID:17709487. |
mdm2 is activated by phospho-akt, and we previously showed that rsv activates akt and delays apoptosis in primary human airway epithelial cells. |
2007-11-20 |
2023-08-12 |
human |