| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ping Wu, Baoju Qi, Hua Zhu, Yamin Zheng, Fei Li, Jianwen Che. Suppression of staurosporine-mediated apoptosis in Hs578T breast cells through inhibition of neutral-sphingomyelinase by caveolin-1. Cancer letters. vol 256. issue 1. 2007-11-06. PMID:17618736. |
our findings indicate for the first time in hs578t cells that caveolin-1 might play a pivotal role in regulating apoptosis as a suppressor rather than a facilitator through inhibition of neutral-sphingomyelinase, decrease of ceramide, furthermore, activation of akt signaling pathway. |
2007-11-06 |
2023-08-12 |
Not clear |
| Richa Arya, Moushami Mallik, Subhash C Lakhoti. Heat shock genes - integrating cell survival and death. Journal of biosciences. vol 32. issue 3. 2007-11-05. PMID:17536179. |
hsp90, which acts as a chaperone for unstable signal transducers to keep them poised for activation, interacts with rip and akt and promotes nf-kappa b mediated inhibition of apoptosis; in addition it also blocks some steps in the apoptotic pathways. |
2007-11-05 |
2023-08-12 |
drosophila_melanogaster |
| I Daniels, A M Abulayha, B J Thomson, A P Hayne. Caspase-independent killing of Burkitt lymphoma cell lines by rituximab. Apoptosis : an international journal on programmed cell death. vol 11. issue 6. 2007-11-01. PMID:16544097. |
rituximab-treated cells show leakage of adenylate kinase, surface expression of phosphatidylserine, upregulation of the cellular stress protein hsp70, phosphorylation of the survival protein akt, and depolarisation of the mitochondrial membrane but no loss of cytochrome c or apoptosis inducing factor. |
2007-11-01 |
2023-08-12 |
human |
| D Duguay, D deBloi. Differential regulation of Akt, caspases and MAP kinases underlies smooth muscle cell apoptosis during aortic remodelling in SHR treated with amlodipine. British journal of pharmacology. vol 151. issue 8. 2007-10-31. PMID:17592516. |
differential regulation of akt, caspases and map kinases underlies smooth muscle cell apoptosis during aortic remodelling in shr treated with amlodipine. |
2007-10-31 |
2023-08-12 |
rat |
| Beat C Bornhauser, Laura Bonapace, Dan Lindholm, Rodrigo Martinez, Gunnar Cario, Martin Schrappe, Felix K Niggli, Beat W Schäfer, Jean-Pierre Bourqui. Low-dose arsenic trioxide sensitizes glucocorticoid-resistant acute lymphoblastic leukemia cells to dexamethasone via an Akt-dependent pathway. Blood. vol 110. issue 6. 2007-10-30. PMID:17537996. |
in gc-resistant cell lines, this effect was mediated, at least in part, by inhibition of akt and affecting downstream akt targets such as bad, a proapoptotic bcl-2 family member, and the x-linked inhibitor of apoptosis protein (xiap). |
2007-10-30 |
2023-08-12 |
Not clear |
| Nan-Hyung Kim, Songhee Jeon, Hyun-Joo Lee, Ai-Young Le. Impaired PI3K/Akt activation-mediated NF-kappaB inactivation under elevated TNF-alpha is more vulnerable to apoptosis in vitiliginous keratinocytes. The Journal of investigative dermatology. vol 127. issue 11. 2007-10-29. PMID:17522703. |
moreover, pten, which could inhibit the phosphatidylinositol 3-kinase/protein kinase b (pi3k/akt) signaling pathway, was significantly higher in depigmented epidermis, implying that vitiliginous keratinocytes may be more susceptible to tnf-alpha-mediated apoptosis through impaired akt and nf-kappab activation. |
2007-10-29 |
2023-08-12 |
human |
| Nan-Hyung Kim, Songhee Jeon, Hyun-Joo Lee, Ai-Young Le. Impaired PI3K/Akt activation-mediated NF-kappaB inactivation under elevated TNF-alpha is more vulnerable to apoptosis in vitiliginous keratinocytes. The Journal of investigative dermatology. vol 127. issue 11. 2007-10-29. PMID:17522703. |
keratinocytes showing impaired akt activation demonstrated increased apoptosis with less activation of nf-kappab. |
2007-10-29 |
2023-08-12 |
human |
| Jon M Oatley, Mary R Avarbock, Ralph L Brinste. Glial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase signaling. The Journal of biological chemistry. vol 282. issue 35. 2007-10-29. PMID:17597063. |
apoptosis analysis revealed a significant increase in the percentage of apoptotic cells when akt, but not sfk, signaling was impaired, indicating that multiple signaling pathways are responsible for ssc self-renewal and survival. |
2007-10-29 |
2023-08-12 |
mouse |
| Yunxiu Dai, Zelan Wei, Chantelle F Sephton, Di Zhang, Deborah H Anderson, Darrell D Moussea. Haloperidol induces the nuclear translocation of phosphatidylinositol 3'-kinase to disrupt Akt phosphorylation in PC12 cells. Journal of psychiatry & neuroscience : JPN. vol 32. issue 5. 2007-10-29. PMID:17823648. |
the antipsychotic drug haloperidol (hal) has been linked to apoptosis and to inhibition of prosurvival akt signalling in pheochromocytoma (pc12) and neuronal cell cultures. |
2007-10-29 |
2023-08-12 |
Not clear |
| Sue-Jane Lin, Chungming Chang, Ah-Kau Ng, Shu-Han Wang, Jia-Je Li, Cheng-po H. Prevention of TGF-beta-induced apoptosis by interlukin-4 through Akt activation and p70S6K survival signaling pathways. Apoptosis : an international journal on programmed cell death. vol 12. issue 9. 2007-10-26. PMID:17624592. |
prevention of tgf-beta-induced apoptosis by interlukin-4 through akt activation and p70s6k survival signaling pathways. |
2007-10-26 |
2023-08-12 |
human |
| Sue-Jane Lin, Chungming Chang, Ah-Kau Ng, Shu-Han Wang, Jia-Je Li, Cheng-po H. Prevention of TGF-beta-induced apoptosis by interlukin-4 through Akt activation and p70S6K survival signaling pathways. Apoptosis : an international journal on programmed cell death. vol 12. issue 9. 2007-10-26. PMID:17624592. |
however, in the presence of both rapamycin and dominant negative akt with or without gö6976, il-4 almost completely lost the anti-apoptotic effect, suggesting that both akt and p70s6k pathways were required for the protective effect of il-4 against tgf-beta-induced apoptosis. |
2007-10-26 |
2023-08-12 |
human |
| E Suzuki, K Umezawa, B Bonavid. Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis. Oncogene. vol 26. issue 42. 2007-10-24. PMID:17420722. |
treatment of tumor cells with ly294002 or with akt sirna, but not control sirna, resulted in inhibition of bcl-(xl) expression and sensitization to drug-induced apoptosis. |
2007-10-24 |
2023-08-12 |
Not clear |
| E Suzuki, K Umezawa, B Bonavid. Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis. Oncogene. vol 26. issue 42. 2007-10-24. PMID:17420722. |
although rituximab did not inhibit the akt pathway nor sensitized the rituximab-resistant ramos rr1 clone, treatment with ly294002 or akt sirna sensitized the clone to drug-induced apoptosis. |
2007-10-24 |
2023-08-12 |
Not clear |
| E Suzuki, K Umezawa, B Bonavid. Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis. Oncogene. vol 26. issue 42. 2007-10-24. PMID:17420722. |
the present findings demonstrate for the first time that rituximab inhibits the constitutively activated akt pathway in b-nhl cell lines, and this inhibition contributes to sensitization of drug-resistant cells to apoptosis by chemotherapeutic drugs. |
2007-10-24 |
2023-08-12 |
Not clear |
| Hui Su, Xin Sun, Heng Ma, Hai-Feng Zhang, Qiu-Jun Yu, Chen Huang, Xiao-Ming Wang, Rong-Hua Luan, Guo-Liang Jia, Hai-Chang Wang, Feng Ga. Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17519283. |
hyperglycemia during ischemia not only significantly increased myocardial apoptosis (23.6 +/- 1.7% vs. 18.8 +/- 1.4%, p < 0.05 vs. vehicle), increased infarct size (is) (45.6 +/- 3.0% vs. 37.6 +/- 2.0%, p < 0.05 vs. vehicle), decreased akt and gsk-3beta phosphorylations (0.5 +/- 0.2 and 0.6 +/- 0.1% fold of vehicle, respectively, p < 0.05 vs. vehicle) following mi/r, but almost completely blocked the cardioprotective effect afforded by gik, as evidenced by significantly increased apoptotic index (19.1 +/- 2.0 vs. 10.3 +/- 1.2%, p < 0.01 vs. gik), increased myocardial is (39.2 +/- 2.8 vs. 27.2 +/- 2.1%, p < 0.01 vs. gik), decreased akt phosphorylation (1.1 +/- 0.1 vs. 1.7 +/- 0.2%, p < 0.01 vs. gik) and gsk-3beta phosphorylation (1.4 +/- 0.2 vs. 2.3 +/- 0.2%, p < 0.05 vs. gik). |
2007-10-24 |
2023-08-12 |
rat |
| Michaela Artwohl, Kathrin Muth, Karin Kosulin, Rainer de Martin, Thomas Hölzenbein, Georg Rainer, Angelika Freudenthaler, Nicole Huttary, Leopold Schmetterer, Werner K Waldhäusl, Sabina M Baumgartner-Parze. R-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of Akt and retinoblastoma protein/E2F-1. American journal of physiology. Endocrinology and metabolism. vol 293. issue 3. 2007-10-24. PMID:17566113. |
r-(+)-alpha-lipoic acid inhibits endothelial cell apoptosis and proliferation: involvement of akt and retinoblastoma protein/e2f-1. |
2007-10-24 |
2023-08-12 |
human |
| Venkateswaran Subramaniam, Isabella R Vincent, Helena Gardner, Emily Chan, Helena Dhamko, Serge Joth. CD44 regulates cell migration in human colon cancer cells via Lyn kinase and AKT phosphorylation. Experimental and molecular pathology. vol 83. issue 2. 2007-10-24. PMID:17599831. |
given the well-defined roles of cd44, phosphorylated akt in apoptosis and cancer, these results indicate that cd44-induced cell migration is dependent on its complex formation with lyn and its consequent regulation of akt phosphorylation and cofilin expression. |
2007-10-24 |
2023-08-12 |
mouse |
| Lisa M Ballou, Elzbieta S Selinger, Jun Yong Choi, Dale G Drueckhammer, Richard Z Li. Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. The Journal of biological chemistry. vol 282. issue 33. 2007-10-19. PMID:17562705. |
because increased akt activity promotes survival, this may explain why the level of apoptosis was increased in the presence of 401 but not rapamycin. |
2007-10-19 |
2023-08-12 |
human |
| Jinjin Guo, Tongbo Zhu, Zhi-Xiong J Xiao, Chang-Yan Che. Modulation of intracellular signaling pathways to induce apoptosis in prostate cancer cells. The Journal of biological chemistry. vol 282. issue 33. 2007-10-19. PMID:17573344. |
however, the concurrent activation of jnk1 and akt, under the condition of pkc abrogation, dramatically augment the magnitude of apoptosis in the cells. |
2007-10-19 |
2023-08-12 |
Not clear |
| Jinjin Guo, Tongbo Zhu, Zhi-Xiong J Xiao, Chang-Yan Che. Modulation of intracellular signaling pathways to induce apoptosis in prostate cancer cells. The Journal of biological chemistry. vol 282. issue 33. 2007-10-19. PMID:17573344. |
thus, our study suggests that akt, jnk1, and pkc act in concert to signal the intracellular apoptotic machinery for a full execution of apoptosis in prostate cancer cells. |
2007-10-19 |
2023-08-12 |
Not clear |