| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Song Jin, Jing-Nan Shen, Jin Wang, Gang Huang, Jia-Guo Zho. Oridonin induced apoptosis through Akt and MAPKs signaling pathways in human osteosarcoma cells. Cancer biology & therapy. vol 6. issue 2. 2007-08-31. PMID:17218775. |
all together, our results suggested that oridonin is able to inactivate akt and erk and activate p38 mapk and jnk signalling pathways in osteosarcoma cells causing the suppression of proliferation and induction of mitochondria- and caspase-dependent apoptosis. |
2007-08-31 |
2023-08-12 |
human |
| Nathan M Weir, Karuppaiyah Selvendiran, Vijay Kumar Kutala, Liyue Tong, Shilpa Vishwanath, Murugesan Rajaram, Susheela Tridandapani, Shrikant Anant, Periannan Kuppusam. Curcumin induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating Akt and p38 MAPK. Cancer biology & therapy. vol 6. issue 2. 2007-08-31. PMID:17218783. |
curcumin induces g2/m arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by modulating akt and p38 mapk. |
2007-08-31 |
2023-08-12 |
human |
| Jack L Arbiser, Tweeny Kau, Martha Konar, Krishna Narra, Ramani Ramchandran, Scott A Summers, Chris J Vlahos, Keqiang Ye, Betsy N Perry, William Matter, Anthony Fischl, James Cook, Pamela A Silver, Jenny Bain, Philip Cohen, David Whitmire, Scott Furness, Baskaran Govindarajan, J Phillip Bowe. Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis. Blood. vol 109. issue 2. 2007-08-30. PMID:16990598. |
phosphatidylinositol-3-kinase (pi3k), and its downstream effector akt, or protein kinase balpha (pkbalpha), play a major regulatory role in control of apoptosis, proliferation, and angiogenesis. |
2007-08-30 |
2023-08-12 |
Not clear |
| Xiang Gu, Yibai Feng, Chunzhi Shi, Ming Li, Zuolin Fu, Xinping Zhan. Antiapoptotic mechanism of insulin in reoxygenation-induced injury in cultured cardiomyocytes of neonatal rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 25. issue 6. 2007-08-28. PMID:16696310. |
at the end of reoxygenation of 4 h, activity of lactate dehydrogenase (ldh) and content of malondialdehyde (mda) were spectrophotometrically determined, apoptosis of cardiomyocytes were detected by using tunel and dna ladder, and western blotting was employed to examine the expression of phosphorylated akt in all groups. |
2007-08-28 |
2023-08-12 |
rat |
| Xiang Gu, Yibai Feng, Chunzhi Shi, Ming Li, Zuolin Fu, Xinping Zhan. Antiapoptotic mechanism of insulin in reoxygenation-induced injury in cultured cardiomyocytes of neonatal rats. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 25. issue 6. 2007-08-28. PMID:16696310. |
our results showed that compared with vehicle-treated group, activities of ldh, contents of mda, apoptosis index (ai) were significantly decreased, and expression of phosphorylated akt was increased significantly in insulin-treated group. |
2007-08-28 |
2023-08-12 |
rat |
| L-H Meng, K W Kohn, Y Pommie. Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288). Oncogene. vol 26. issue 33. 2007-08-23. PMID:17297446. |
suppression of akt by small interfering rna was associated with downregulation of mdm2 and p21(cip1/waf1) and with enhanced apoptosis. |
2007-08-23 |
2023-08-12 |
Not clear |
| L-H Meng, K W Kohn, Y Pommie. Dose-response transition from cell cycle arrest to apoptosis with selective degradation of Mdm2 and p21WAF1/CIP1 in response to the novel anticancer agent, aminoflavone (NSC 686,288). Oncogene. vol 26. issue 33. 2007-08-23. PMID:17297446. |
these results suggest that the cellular responses to af are determined at least in part by mdm2 and p21(cip1/waf1) protein levels, as well as by akt activity, leading either to cell cycle arrest when mdm2 and p21(cip1/waf1) are elevated, or to apoptosis when mdm2 and p21(cip1/waf1) are degraded by the proteasome and akt insufficiently activated to protect against apoptosis. |
2007-08-23 |
2023-08-12 |
Not clear |
| Xiaofang Wang, Chun Wang, Shi-Ke Yan, Yan-Rong Ga. XIAP is upregulated in HL-60 cells cocultured with stromal cells by direct cell contact. Leukemia research. vol 31. issue 8. 2007-08-22. PMID:17049600. |
phosphatidylinositol 3-kinase (pi3k) and akt were activated and ly294002 downregulated xiap and increased apoptosis in hl-60 cells co-cultured with bmscs. |
2007-08-22 |
2023-08-12 |
Not clear |
| K J Schmitz, J Wohlschlaeger, H Alakus, J Bohr, M A Stauder, K Worm, G Winde, K W Schmid, H A Bab. Activation of extracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations. Virchows Archiv : an international journal of pathology. vol 450. issue 2. 2007-08-21. PMID:17149612. |
the aim of this study was to determine the prognostic relevance of two kinases important in the regulation of cell proliferation and apoptosis in 135 colorectal cancer cases: akt and extracellular regulated kinases (erk1/2). |
2007-08-21 |
2023-08-12 |
Not clear |
| Mathilde Dromard, Guillaume Bompard, Murielle Glondu-Lassis, Carole Puech, Dany Chalbos, Gilles Freis. The putative tumor suppressor gene PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation. Cancer research. vol 67. issue 14. 2007-08-21. PMID:17638892. |
we showed previously that its expression was necessary for inhibition of akt activation and induction of apoptosis by antiestrogens in breast cancer cells. |
2007-08-21 |
2023-08-12 |
Not clear |
| Marie P Piechocki, George H Yoo, Susan K Dibbley, Fulvio Lonard. Breast cancer expressing the activated HER2/neu is sensitive to gefitinib in vitro and in vivo and acquires resistance through a novel point mutation in the HER2/neu. Cancer research. vol 67. issue 14. 2007-08-21. PMID:17638894. |
diminished survival signaling through akt, induction of bim, loss of connexin43, and decreased production of vascular endothelial growth factor-d preceded caspase-3 and poly(adp)ribose polymerase (parp) cleavage and apoptosis (>50% 2 micromol/l, 48 h). |
2007-08-21 |
2023-08-12 |
Not clear |
| Shogo Ishiuchi, Yukari Yoshida, Kenichi Sugawara, Masanori Aihara, Toshiyuki Ohtani, Takashi Watanabe, Nobuhito Saito, Keisuke Tsuzuki, Haruo Okado, Akiko Miwa, Yoichi Nakazato, Seiji Ozaw. Ca2+-permeable AMPA receptors regulate growth of human glioblastoma via Akt activation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 27. issue 30. 2007-08-20. PMID:17652589. |
in contrast, introduction of a constitutively active form of akt rescued tumor cells from apoptosis induced by the conversion of ca2+-permeable ampa receptor to ca2+-impermeable receptors by the delivery of glur2 cdna. |
2007-08-20 |
2023-08-12 |
human |
| Wanda Mäuser, Nina Perwitz, Britta Meier, Mathias Fasshauer, Johannes Klei. Direct adipotropic actions of atorvastatin: differentiation state-dependent induction of apoptosis, modulation of endocrine function, and inhibition of glucose uptake. European journal of pharmacology. vol 564. issue 1-3. 2007-08-17. PMID:17376428. |
moreover, atorvastatin induced apoptosis and inhibited protein kinase b (akt) phosphorylation in proliferating and differentiating preadipocytes, but not in differentiated adipocytes. |
2007-08-17 |
2023-08-12 |
Not clear |
| Yong Zhang, Xun She. Heat shock protein 27 protects L929 cells from cisplatin-induced apoptosis by enhancing Akt activation and abating suppression of thioredoxin reductase activity. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 13. issue 10. 2007-08-13. PMID:17504983. |
heat shock protein 27 protects l929 cells from cisplatin-induced apoptosis by enhancing akt activation and abating suppression of thioredoxin reductase activity. |
2007-08-13 |
2023-08-12 |
Not clear |
| Sheng-Huei Yang, Ching-Ming Chien, Long-Sen Chang, Shinne-Ren Li. Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by cardiotoxin III (Naja naja atra) in K562 leukemia cells. Toxicon : official journal of the International Society on Toxinology. vol 49. issue 7. 2007-08-09. PMID:17368702. |
taken together, our data show for the first time that jnk, but not erk, p38mapk or akt signaling, plays an important role in ctx iii-mediated g2/m arrest and apoptosis in k562 cancer cells. |
2007-08-09 |
2023-08-12 |
Not clear |
| Carolyn J Mullonkal, Luis H Toledo-Pereyr. Akt in ischemia and reperfusion. Journal of investigative surgery : the official journal of the Academy of Surgical Research. vol 20. issue 3. 2007-08-09. PMID:17613695. |
over the last few years, the akt pathway has become such a target due to its role as a signaling pathway where modulation of substrates prevents apoptosis. |
2007-08-09 |
2023-08-12 |
Not clear |
| Qiao Cui, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Augmentation of oridonin-induced apoptosis observed with reduced autophagy. Journal of pharmacological sciences. vol 101. issue 3. 2007-08-08. PMID:16861822. |
akt, down-stream factor of pi3k, was activated in autophagic process but suppressed in apoptosis in this study. |
2007-08-08 |
2023-08-12 |
Not clear |
| Hiroyuki Moriyama, Shin Yonehar. Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes. Immunology letters. vol 109. issue 1. 2007-08-07. PMID:17275920. |
the bcr-induced rapid expression of c-flip was not affected by inactivation of nf-kappab, but was inhibited by either treatment with a pi3k inhibitor, ly294002, or expression of a dominant negative pi3k p85 subunit, both of which suppressed phosphorylation of akt and sensitized bcr-stimulated a20 cells to fas-mediated apoptosis. |
2007-08-07 |
2023-08-12 |
mouse |
| Hiroyuki Moriyama, Shin Yonehar. Rapid up-regulation of c-FLIP expression by BCR signaling through the PI3K/Akt pathway inhibits simultaneously induced Fas-mediated apoptosis in murine B lymphocytes. Immunology letters. vol 109. issue 1. 2007-08-07. PMID:17275920. |
overexpression of constitutively active akt was shown not only to up-regulate c-flip expression but also to render a20 cells resistant to fas-mediated apoptosis. |
2007-08-07 |
2023-08-12 |
mouse |
| Ting-Fang Lee, Yun-Lian Lin, Yi-Tsau Huan. Studies on antiproliferative effects of phthalides from Ligusticum chuanxiong in hepatic stellate cells. Planta medica. vol 73. issue 6. 2007-08-07. PMID:17520522. |
in hsc-t6, the two compounds induced apoptosis through the activation of caspases 9 and 3, increase in cytosolic cytochrome c release, and downregulation of bcl-2 and akt phosphorylation. |
2007-08-07 |
2023-08-12 |
human |