| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mouad Edderkaoui, Peggy Hong, Jong K Lee, Stephen J Pandol, Anna S Gukovskay. Insulin-like growth factor-I receptor mediates the prosurvival effect of fibronectin. The Journal of biological chemistry. vol 282. issue 37. 2007-10-19. PMID:17627944. |
this process of complex formation, in turn, prevents shp-2 from dephosphorylating igf-ir resulting in sustained phosphorylation of igf-ir and leading to the downstream activation of akt kinase, up-regulation of antiapoptotic bcl(xl), and inhibition of apoptosis. |
2007-10-19 |
2023-08-12 |
Not clear |
| Joell J Gills, S Sianna Castillo, Chunyu Zhang, Pavel A Petukhov, Regan M Memmott, Melinda Hollingshead, Noel Warfel, Jiahuai Han, Alan P Kozikowski, Phillip A Denni. Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms. The Journal of biological chemistry. vol 282. issue 37. 2007-10-19. PMID:17631503. |
previously, we identified five active phosphatidylinositol ether lipid analogues (pias) that target the pleckstrin homology domain of akt and selectively induce apoptosis in cancer cells with high levels of akt activity. |
2007-10-19 |
2023-08-12 |
Not clear |
| Jin-Wen Xu, Katsumi Ikeda, Yukio Yamor. Inhibitory effect of polyphenol cyanidin on TNF-alpha-induced apoptosis through multiple signaling pathways in endothelial cells. Atherosclerosis. vol 193. issue 2. 2007-10-16. PMID:17045269. |
our data show that inhibitory effect of cyanidin on tnf-alpha-induced apoptosis involves multiple pathways, such as akt activation, enos and thioredoxin expression in endothelial cells. |
2007-10-16 |
2023-08-12 |
Not clear |
| Xiaohua Gao, Dorrah Deeb, Hao Jiang, Yongbo Liu, Scott A Dulchavsky, Subhash C Gauta. Synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival Akt, NF-kappaB and Notch1 signaling. Journal of neuro-oncology. vol 84. issue 2. 2007-10-12. PMID:17361329. |
synthetic triterpenoids inhibit growth and induce apoptosis in human glioblastoma and neuroblastoma cells through inhibition of prosurvival akt, nf-kappab and notch1 signaling. |
2007-10-12 |
2023-08-12 |
human |
| Danilo Fliser, Ferdinand H Bahlmann, Hermann Halle. EPO: renoprotection beyond anemia correction. Pediatric nephrology (Berlin, Germany). vol 21. issue 12. 2007-10-11. PMID:16957890. |
as a result, akt phosphorylates the proapoptotic factor bad, which in turn causes inhibition of programmed cell death (apoptosis). |
2007-10-11 |
2023-08-12 |
human |
| Hiroshige Hori, Tetsuo Ajiki, Yoshiyasu Mita, Hideki Horiuchi, Kenro Hirata, Taku Matsumoto, Haruki Morimoto, Tsunenori Fujita, Yonson Ku, Yoshikazu Kurod. Frequent activation of mitogen-activated protein kinase relative to Akt in extrahepatic biliary tract cancer. Journal of gastroenterology. vol 42. issue 7. 2007-10-11. PMID:17653653. |
the mitogen-activated protein kinase (mapk) and akt signaling pathways, which activate cell proliferation and suppress apoptosis, respectively, may function as important targets for such therapies. |
2007-10-11 |
2023-08-12 |
Not clear |
| Carmen Cañibano, Noela L Rodriguez, Carmen Saez, Sulay Tovar, Montse Garcia-Lavandeira, Maria Grazia Borrello, Anxo Vidal, Frank Costantini, Miguel Japon, Carlos Dieguez, Clara V Alvare. The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth. The EMBO journal. vol 26. issue 8. 2007-10-04. PMID:17380130. |
in the presence of gdnf, akt is activated, and the pit-1 overexpression and resulting apoptosis are blocked. |
2007-10-04 |
2023-08-12 |
mouse |
| Manchao Zhang, Xueliang Fang, Hongpeng Liu, Ribo Guo, Xiaojin Wu, Bihua Li, Feng Zhu, Yan Ling, Brian N Griffith, Shaomeng Wang, Dajun Yan. Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells. Cancer letters. vol 252. issue 2. 2007-10-01. PMID:17293030. |
the possible effects of potent compound on pi3k/akt, pdk1, and mapk, its antiproliferative and apoptosis-inducing effects on breast cancer cells which have high-levels of akt activation were assessed by western blot analysis, cell viability assay, and apoptosis assay. |
2007-10-01 |
2023-08-12 |
human |
| Manchao Zhang, Xueliang Fang, Hongpeng Liu, Ribo Guo, Xiaojin Wu, Bihua Li, Feng Zhu, Yan Ling, Brian N Griffith, Shaomeng Wang, Dajun Yan. Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells. Cancer letters. vol 252. issue 2. 2007-10-01. PMID:17293030. |
cmep inhibits growth and induces apoptosis in breast cancer cells which have high-levels of akt activation and lack functional pten; however, cmep only shows a minimal activity in nih3t3 cells which do not have akt activation. |
2007-10-01 |
2023-08-12 |
human |
| Manchao Zhang, Xueliang Fang, Hongpeng Liu, Ribo Guo, Xiaojin Wu, Bihua Li, Feng Zhu, Yan Ling, Brian N Griffith, Shaomeng Wang, Dajun Yan. Bioinformatics-based discovery and characterization of an AKT-selective inhibitor 9-chloro-2-methylellipticinium acetate (CMEP) in breast cancer cells. Cancer letters. vol 252. issue 2. 2007-10-01. PMID:17293030. |
cmep inhibits growth and induces apoptosis in cancer cells which have high-levels of akt activation and lack pten or harbor pten mutation. |
2007-10-01 |
2023-08-12 |
human |
| Sheng-jun Wang, Shu-hua Wang, Zhao-feng Song, Xue-wu Liu, Rong Wang, Zhao-fu Ch. Poly(ADP-ribose) polymerase inhibitor is neuroprotective in epileptic rat via apoptosis-inducing factor and Akt signaling. Neuroreport. vol 18. issue 12. 2007-09-27. PMID:17632284. |
altogether, our data suggested that 3-ab might have a therapeutic value in seizure-induced hippocampal neuron damage, probably due to the inhibition of apoptosis and activation of akt cell survival signaling. |
2007-09-27 |
2023-08-12 |
rat |
| J Lin, L Chen, Z Lin, M Zha. Inhibitory effect of triptolide on glioblastoma multiforme in vitro. The Journal of international medical research. vol 35. issue 4. 2007-09-27. PMID:17697526. |
cell apoptosis was determined using annexin v. levels of the oncogenic transformation-related proteins ras-guanosine triphosphate (ras-gtp), extracellular signal-regulated kinase (erk) and akt were determined by western blotting. |
2007-09-27 |
2023-08-12 |
human |
| Junyang Gong, JuneGoo Lee, Horiguchi Akio, Peter N Schlegel, Ruoqian She. Attenuation of apoptosis by chromogranin A-induced Akt and survivin pathways in prostate cancer cells. Endocrinology. vol 148. issue 9. 2007-09-26. PMID:17584963. |
attenuation of apoptosis by chromogranin a-induced akt and survivin pathways in prostate cancer cells. |
2007-09-26 |
2023-08-12 |
Not clear |
| Anat Achiron, Anna Feldman, Mathilda Mandel, Michael Gurevic. Impaired expression of peripheral blood apoptotic-related gene transcripts in acute multiple sclerosis relapse. Annals of the New York Academy of Sciences. vol 1107. 2007-09-26. PMID:17804543. |
an additional group of antiapoptotic genes related to t cell receptor-mediated apoptosis was also found to be overexpressed in acute relapse and included tcr-binding cd3e antigen, antiapoptotic serine threonin kinase (akt), and nf kappa b-associated genes like reticuloendotheliosis viral oncogene homolog a (rela) and human t cell leukemia virus type i-binding protein (tax1bp) known to inhibit tumor necrosis factor (tnf)-induced apoptosis. |
2007-09-26 |
2023-08-12 |
human |
| H Lue, M Thiele, J Franz, E Dahl, S Speckgens, L Leng, G Fingerle-Rowson, R Bucala, B Lüscher, J Bernhage. Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity. Oncogene. vol 26. issue 35. 2007-09-24. PMID:17310986. |
here, we show that mif prevents apoptosis and promotes tumor cell survival by directly activating the akt pathway. |
2007-09-24 |
2023-08-12 |
Not clear |
| H Lue, M Thiele, J Franz, E Dahl, S Speckgens, L Leng, G Fingerle-Rowson, R Bucala, B Lüscher, J Bernhage. Macrophage migration inhibitory factor (MIF) promotes cell survival by activation of the Akt pathway and role for CSN5/JAB1 in the control of autocrine MIF activity. Oncogene. vol 26. issue 35. 2007-09-24. PMID:17310986. |
apoptosis inhibition by mif was functionally associated with akt activation as it was abolished by overexpression of the akt pathway inhibitor pten and occurred independently of p53. |
2007-09-24 |
2023-08-12 |
Not clear |
| Cheng-Yun Jin, Dong-Oh Moon, Yung Hyun Choi, Jae-Dong Lee, Gi-Young Ki. Bcl-2 and caspase-3 are major regulators in Agaricus blazei-induced human leukemic U937 cell apoptosis through dephoshorylation of Akt. Biological & pharmaceutical bulletin. vol 30. issue 8. 2007-09-21. PMID:17666799. |
bcl-2 and caspase-3 are major regulators in agaricus blazei-induced human leukemic u937 cell apoptosis through dephoshorylation of akt. |
2007-09-21 |
2023-08-12 |
human |
| Cheng-Yun Jin, Dong-Oh Moon, Yung Hyun Choi, Jae-Dong Lee, Gi-Young Ki. Bcl-2 and caspase-3 are major regulators in Agaricus blazei-induced human leukemic U937 cell apoptosis through dephoshorylation of Akt. Biological & pharmaceutical bulletin. vol 30. issue 8. 2007-09-21. PMID:17666799. |
the results indicated that major regulators of abe-induced apoptosis in human leukemic u937 cells are bcl-2 and caspase-3, which are associated with dephosphorylation of the akt signal pathway. |
2007-09-21 |
2023-08-12 |
human |
| Rui Wu, Hina Kausar, Paul Johnson, Diego E Montoya-Durango, Michael Merchant, Madhavi J Ran. Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex. The Journal of biological chemistry. vol 282. issue 30. 2007-09-20. PMID:17510053. |
hsp27 regulates akt activation and polymorphonuclear leukocyte apoptosis by scaffolding mk2 to akt signal complex. |
2007-09-20 |
2023-08-12 |
Not clear |
| Rui Wu, Hina Kausar, Paul Johnson, Diego E Montoya-Durango, Michael Merchant, Madhavi J Ran. Hsp27 regulates Akt activation and polymorphonuclear leukocyte apoptosis by scaffolding MK2 to Akt signal complex. The Journal of biological chemistry. vol 282. issue 30. 2007-09-20. PMID:17510053. |
additionally, dissociation of hsp27 from akt, prior to akt activation, induced polymorphonuclear leukocyte (pmn) apoptosis. |
2007-09-20 |
2023-08-12 |
Not clear |