| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zuoyan Wang, Ming Cui, Lijie Sun, Zhuqing Jia, Yun Bai, Kangtao Ma, Fengrong Chen, Chunyan Zho. Angiopoietin-1 protects H9c2 cells from H2O2-induced apoptosis through AKT signaling. Biochemical and biophysical research communications. vol 359. issue 3. 2007-08-07. PMID:17559808. |
angiopoietin-1 protects h9c2 cells from h2o2-induced apoptosis through akt signaling. |
2007-08-07 |
2023-08-12 |
Not clear |
| Zuoyan Wang, Ming Cui, Lijie Sun, Zhuqing Jia, Yun Bai, Kangtao Ma, Fengrong Chen, Chunyan Zho. Angiopoietin-1 protects H9c2 cells from H2O2-induced apoptosis through AKT signaling. Biochemical and biophysical research communications. vol 359. issue 3. 2007-08-07. PMID:17559808. |
transfection of recombinant adenovirus expressing ang1 resulted in a sustained phosphorylation of akt and inhibition of h(2)o(2)-induced apoptosis in h9c2 cells. |
2007-08-07 |
2023-08-12 |
Not clear |
| Zuoyan Wang, Ming Cui, Lijie Sun, Zhuqing Jia, Yun Bai, Kangtao Ma, Fengrong Chen, Chunyan Zho. Angiopoietin-1 protects H9c2 cells from H2O2-induced apoptosis through AKT signaling. Biochemical and biophysical research communications. vol 359. issue 3. 2007-08-07. PMID:17559808. |
these results suggest that ang1 protects cardiomyocytes from oxidative stress-induced apoptosis by regulating the activity of akt. |
2007-08-07 |
2023-08-12 |
Not clear |
| Kento Tateishi, Eishi Ashihara, Naofumi Takehara, Tetsuya Nomura, Shoken Honsho, Takuo Nakagami, Shigehiro Morikawa, Tomosaburo Takahashi, Tomomi Ueyama, Hiroaki Matsubara, Hidemasa O. Clonally amplified cardiac stem cells are regulated by Sca-1 signaling for efficient cardiovascular regeneration. Journal of cell science. vol 120. issue Pt 10. 2007-08-06. PMID:17502484. |
knockdown of sca-1 transcripts in cscs led to retarded ex vivo expansion and apoptosis through akt inactivation. |
2007-08-06 |
2023-08-12 |
Not clear |
| Z-M Liu, G G Chen, A C Vlantis, G M Tse, C K Y Shum, C A van Hassel. Calcium-mediated activation of PI3K and p53 leads to apoptosis in thyroid carcinoma cells. Cellular and molecular life sciences : CMLS. vol 64. issue 11. 2007-08-06. PMID:17514353. |
buffering of the calcium response attenuated mitochondrial impairment, recovered the cadmium-activated akt, p53, jnk, erk and p38, and subsequently blocked the apoptosis. |
2007-08-06 |
2023-08-12 |
Not clear |
| Ruth Gomel, Cunli Xiang, Susan Finniss, Hae Kyung Lee, Wei Lu, Hana Okhrimenko, Chaya Brodi. The localization of protein kinase Cdelta in different subcellular sites affects its proapoptotic and antiapoptotic functions and the activation of distinct downstream signaling pathways. Molecular cancer research : MCR. vol 5. issue 6. 2007-08-06. PMID:17579121. |
pkcdelta-cyto increased the phosphorylation of p38 and decreased the phosphorylation of akt and the expression of x-linked inhibitor of apoptosis protein, whereas pkcdelta-nuc increased c-jun nh(2)-terminal kinase phosphorylation. |
2007-08-06 |
2023-08-12 |
Not clear |
| Cheryl H Baker, Jose G Trevino, Justin M Summy, Fahao Zhang, Alexis Caron, Mark Nesbit, Gary E Gallick, Isaiah J Fidle. Inhibition of PDGFR phosphorylation and Src and Akt activity by GN963 leads to therapy of human pancreatic cancer growing orthotopically in nude mice. International journal of oncology. vol 29. issue 1. 2007-08-03. PMID:16773192. |
administration of gn963 inhibited pdgfr phosphorylation in both tumor and tumor-associated endothelial cells, decreased src and akt kinase activity in tumor cells, decreased microvessel density, and decreased tumor cell proliferation, while increasing apoptosis of tumor and tumor-associated endothelial cells. |
2007-08-03 |
2023-08-12 |
mouse |
| Yen-Chuan Ou, Chi-Rei Yang, Chen-Li Cheng, Shue-Ling Raung, Yu-Yeh Hung, Chun-Jung Che. Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT. European journal of pharmacology. vol 563. issue 1-3. 2007-08-03. PMID:17341418. |
indomethacin induces apoptosis in 786-o renal cell carcinoma cells by activating mitogen-activated protein kinases and akt. |
2007-08-03 |
2023-08-12 |
human |
| Tetsuo Sugahara, Yzumi Yamashita, Masahito Shinomi, Yumiko Isobe, Banri Yamanoha, Hiroyoshi Iseki, Akihiko Takeda, Yasushi Okazaki, Kenji Kawai, Hiroshi Suemizu, Toshiwo Ando. von Willebrand factor type D domain mutant of SVS-1/SUSD2, vWD(m), induces apoptosis in HeLa cells. Cancer science. vol 98. issue 6. 2007-08-01. PMID:17428257. |
together these data suggest that vwd(m) induces apoptosis by inactivation of survival signaling component akt and activation of caspase cascade (mitochondrial pathway) in hela cells. |
2007-08-01 |
2023-08-12 |
Not clear |
| Elizabeth Cannings, Tove Kirkegaard, Sian M Tovey, Barbara Dunne, T G Cooke, John M S Bartlet. Bad expression predicts outcome in patients treated with tamoxifen. Breast cancer research and treatment. vol 102. issue 2. 2007-07-31. PMID:17004114. |
the present study was carried out to test the hypothesis that disruption of apoptosis in breast cancer, via akt activation, is linked with hormone resistance. |
2007-07-31 |
2023-08-12 |
Not clear |
| Yi Luo, C Jane Dixon, John F Hall, Pamela J White, Michael R Boarde. A role for Akt in epidermal growth factor-stimulated cell cycle progression in cultured hepatocytes: generation of a hyperproliferative window after adenoviral expression of constitutively active Akt. The Journal of pharmacology and experimental therapeutics. vol 321. issue 3. 2007-07-30. PMID:17371807. |
infection of cells with an adenoviral vector expressing a constitutively active form of akt but not a kinase-dead form increased hepatocyte proliferation probably through enhanced cell cycle progression and reduced apoptosis. |
2007-07-30 |
2023-08-12 |
rat |
| Hiroshi Aoki, Yasunari Takada, Seiji Kondo, Raymond Sawaya, Bharat B Aggarwal, Yasuko Kond. Evidence that curcumin suppresses the growth of malignant gliomas in vitro and in vivo through induction of autophagy: role of Akt and extracellular signal-regulated kinase signaling pathways. Molecular pharmacology. vol 72. issue 1. 2007-07-30. PMID:17395690. |
it is interesting that activation of the akt pathway inhibited curcumin-induced autophagy and cytotoxicity, whereas inhibition of the erk1/2 pathway inhibited curcumin-induced autophagy and induced apoptosis, thus resulting in enhanced cytotoxicity. |
2007-07-30 |
2023-08-12 |
Not clear |
| Kuan-Chou Chen, Chiung-Chi Peng, Robert Y Peng, Ching-Hua Su, Han-Sun Chiang, Jr-Hung Yan, Hsiu Mei Hsieh-L. Unique formosan mushroom Antrodia camphorata differentially inhibits androgen-responsive LNCaP and -independent PC-3 prostate cancer cells. Nutrition and cancer. vol 57. issue 1. 2007-07-30. PMID:17516868. |
such dose-dependent behavior of lncap cells in response to acce was confirmed to proceed as akt-->p53-->p21-->cdk4/cyclin d1-->g1/s-phase arrest-->apoptosis, which involved inhibiting cyclin d1 activity and preventing prb phosphorylation. |
2007-07-30 |
2023-08-12 |
Not clear |
| Yue Y Shi, George W Small, Robert Z Orlowsk. Proteasome inhibitors induce a p38 mitogen-activated protein kinase (MAPK)-dependent anti-apoptotic program involving MAPK phosphatase-1 and Akt in models of breast cancer. Breast cancer research and treatment. vol 100. issue 1. 2007-07-27. PMID:16807678. |
finally, inhibition of akt with phosphatidylinositol-3-kinase inhibitors increased apoptosis, as did over-expression of dn-akt. |
2007-07-27 |
2023-08-12 |
human |
| Todd D McCall, Carolyn A Pedone, Daniel W Fult. Apoptosis suppression by somatic cell transfer of Bcl-2 promotes Sonic hedgehog-dependent medulloblastoma formation in mice. Cancer research. vol 67. issue 11. 2007-07-26. PMID:17545597. |
instead, elevated levels of phosphorylated akt were found, suggesting that activated phosphatidylinositol 3-kinase signaling is one intrinsic mechanism for suppressing apoptosis in shh-dependent medulloblastomas. |
2007-07-26 |
2023-08-12 |
mouse |
| Irene Mamali, Marianthi N Tatari, Ilina Micheva, Maria Lampropoulou, Vassilis J Marmara. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling. Journal of cellular biochemistry. vol 101. issue 2. 2007-07-24. PMID:17177294. |
apoptosis in medfly hemocytes is regulated during pupariation through fak, src, erk, pi-3k p85a, and akt survival signaling. |
2007-07-24 |
2023-08-12 |
Not clear |
| Irene Mamali, Marianthi N Tatari, Ilina Micheva, Maria Lampropoulou, Vassilis J Marmara. Apoptosis in medfly hemocytes is regulated during pupariation through FAK, Src, ERK, PI-3K p85a, and Akt survival signaling. Journal of cellular biochemistry. vol 101. issue 2. 2007-07-24. PMID:17177294. |
the novel aspect of this report is based on the fact that hemocytes attempt to suppress apoptosis, by increasing the expression/phosphorylation of fak and, hence its downstream targets signaling molecules src, erk, pi-3k p85a, and akt. |
2007-07-24 |
2023-08-12 |
Not clear |
| Shishir Shishodia, Gautam Sethi, Kwang Seok Ahn, Bharat B Aggarwa. Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Biochemical pharmacology. vol 74. issue 1. 2007-07-19. PMID:17475222. |
guggulsterone inhibits tumor cell proliferation, induces s-phase arrest, and promotes apoptosis through activation of c-jun n-terminal kinase, suppression of akt pathway, and downregulation of antiapoptotic gene products. |
2007-07-19 |
2023-08-12 |
human |
| Shishir Shishodia, Gautam Sethi, Kwang Seok Ahn, Bharat B Aggarwa. Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products. Biochemical pharmacology. vol 74. issue 1. 2007-07-19. PMID:17475222. |
overall, our results indicate that guggulsterone can inhibit cell proliferation and induce apoptosis through the activation of jnk, suppression of akt, and downregulation of antiapoptotic protein expression. |
2007-07-19 |
2023-08-12 |
human |
| Ken C Walls, Barbara J Klocke, Paul Saftig, Masahiro Shibata, Yasuo Uchiyama, Kevin A Roth, John J Shack. Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain. Autophagy. vol 3. issue 3. 2007-07-18. PMID:17297299. |
this p25-26-specific decrease in phosphorylation of akt and gsk-3beta in cd-/- brain coincided temporally with markers of apoptosis but followed the induction of autophagic stress observed at both p14 and p25-26. |
2007-07-18 |
2023-08-12 |
mouse |