| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Karin Görner, Eve Holtorf, Jens Waak, Thu-Trang Pham, Daniela M Vogt-Weisenhorn, Wolfgang Wurst, Christian Haass, Philipp J Kahl. Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1. The Journal of biological chemistry. vol 282. issue 18. 2007-06-14. PMID:17331951. |
we found that wild-type, but not mutant dj-1 facilitated the akt pathway and simultaneously blocked the apoptosis signal-regulating kinase 1, with which dj-1 interacted in a redox-dependent manner. |
2007-06-14 |
2023-08-12 |
mouse |
| Shuhua Xia, Lora W Forman, Douglas V Falle. Protein kinase C delta is required for survival of cells expressing activated p21RAS. The Journal of biological chemistry. vol 282. issue 18. 2007-06-14. PMID:17350960. |
conversely, constitutively activated akt rescued cells from apoptosis induced by pkcdelta inhibition. |
2007-06-14 |
2023-08-12 |
Not clear |
| Jing Wang, Shi Pan, Bradford C Ber. Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner. Arteriosclerosis, thrombosis, and vascular biology. vol 27. issue 6. 2007-06-14. PMID:17431186. |
this system has been shown to protect cells from hydrogen peroxide-induced apoptosis by regulating the redox state of akt. |
2007-06-14 |
2023-08-12 |
Not clear |
| Xiaojian Wang, Hongying Sun, Chaolong L. Nitric oxide induces promyelocytic cell growth arrest and apoptosis through deactivation of Akt pathway. Leukemia research. vol 31. issue 5. 2007-06-12. PMID:16950511. |
nitric oxide induces promyelocytic cell growth arrest and apoptosis through deactivation of akt pathway. |
2007-06-12 |
2023-08-12 |
Not clear |
| Xiaojian Wang, Hongying Sun, Chaolong L. Nitric oxide induces promyelocytic cell growth arrest and apoptosis through deactivation of Akt pathway. Leukemia research. vol 31. issue 5. 2007-06-12. PMID:16950511. |
constitutively active akt overexpression reduces no-induced apoptosis and cell cycle arrest in hl-60 cells. |
2007-06-12 |
2023-08-12 |
Not clear |
| Xiaojian Wang, Hongying Sun, Chaolong L. Nitric oxide induces promyelocytic cell growth arrest and apoptosis through deactivation of Akt pathway. Leukemia research. vol 31. issue 5. 2007-06-12. PMID:16950511. |
we also demonstrate here that g0/g1 arrest is resulted from no-induced disruption of cell cycle balance, which is mediated by up-regulation of p21(waf/cip1), p27(kip1) and down-regulation of cyclin d1, cyclin e. in brief, no-induced apoptosis and g0/g1 arrest is mediated through regulation of apoptosis and cell cycle related protein, which may depend on akt deactivation by no, ultimately led to its inhibitory effect on hematopoiesis. |
2007-06-12 |
2023-08-12 |
Not clear |
| Aleksander Baldys, Priyadarshini Pande, Tariq Mosleh, Sun-Hee Park, Ann E Aus. Apoptosis induced by crocidolite asbestos in human lung epithelial cells involves inactivation of Akt and MAPK pathways. Apoptosis : an international journal on programmed cell death. vol 12. issue 2. 2007-06-07. PMID:17191120. |
apoptosis induced by crocidolite asbestos in human lung epithelial cells involves inactivation of akt and mapk pathways. |
2007-06-07 |
2023-08-12 |
human |
| Aleksander Baldys, Priyadarshini Pande, Tariq Mosleh, Sun-Hee Park, Ann E Aus. Apoptosis induced by crocidolite asbestos in human lung epithelial cells involves inactivation of Akt and MAPK pathways. Apoptosis : an international journal on programmed cell death. vol 12. issue 2. 2007-06-07. PMID:17191120. |
akt and all mitogen-activated protein kinases (mapks) (p38, erk1/2 and sapk/jnk), and subsequently to apoptosis. |
2007-06-07 |
2023-08-12 |
human |
| Oh Sang Kwon, Hyun Keol Pyo, Youn Jin Oh, Ji Hyun Han, Se Rah Lee, Jin Ho Chung, Hee Chul Eun, Kyu Han Ki. Promotive effect of minoxidil combined with all-trans retinoic acid (tretinoin) on human hair growth in vitro. Journal of Korean medical science. vol 22. issue 2. 2007-06-07. PMID:17449938. |
our results suggest that minoxidil plus atra would additively enhance hair growth by mediating dual functions: 1) the prolongation of cell survival by activating the erk and akt signaling pathways, and 2) the prevention of apoptosis of dpcs and epithelial cells by increasing the ratio of bcl-2/bax and downregulating the expressions of p53 and p21. |
2007-06-07 |
2023-08-12 |
human |
| André Tanel, Diana A Averill-Bate. P38 and ERK mitogen-activated protein kinases mediate acrolein-induced apoptosis in Chinese hamster ovary cells. Cellular signalling. vol 19. issue 5. 2007-06-06. PMID:17196791. |
jnk and akt kinases seem to be implicated in survival pathways against acrolein insult, since their respective inhibitors, sp600125 and ly294002/wortmannin switched the mode of cell death from apoptosis to total necrosis. |
2007-06-06 |
2023-08-12 |
human |
| André Tanel, Diana A Averill-Bate. P38 and ERK mitogen-activated protein kinases mediate acrolein-induced apoptosis in Chinese hamster ovary cells. Cellular signalling. vol 19. issue 5. 2007-06-06. PMID:17196791. |
these results provide new information demonstrating the implication of mapks and akt in acrolein-induced apoptosis, and this information may be useful for understanding the pathogenesis of a number of tissue diseases and environmental toxicity in response to acrolein. |
2007-06-06 |
2023-08-12 |
human |
| Dorrah Deeb, Hao Jiang, Xiaohua Gao, Shaza Al-Holou, Andrew L Danyluk, Scott A Dulchavsky, Subhash C Gauta. Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathway. The Journal of pharmacology and experimental therapeutics. vol 321. issue 2. 2007-06-06. PMID:17289836. |
curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; c21h20o6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/apo2l-induced apoptosis by suppressing nuclear factor-kappab via inhibition of the prosurvival akt signaling pathway. |
2007-06-06 |
2023-08-12 |
human |
| Xiaohong Zhou, Feng Li, Jian Ge, Steven R Sarkisian, Hiroshi Tomita, Alexander Zaharia, James Chodosh, Wei Ca. Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma. Developmental neurobiology. vol 67. issue 5. 2007-06-06. PMID:17443811. |
we have made several important observations showing that: (1) betae2 treatment reduced the loss of rgc and neurofibers through inhibition of ganglion cell apoptosis, (2) betae2 activated akt and camp-responsive-element-binding-protein (creb), (3) betae2 up-regulated thioredoxin-1 (trx-1) expression, (4) betae2 reduced the increased activations of mitogen-activated protein kinases (mapk) and nf-kappab, (5) betae2 inhibited the increased interleukin-18 (il-18) expression, and (6) treatment with tamoxifen, an estrogen receptor antagonist, blocked betae2-mediated activation of akt and inhibition of mapk phosphorylation in the retinas of dba/2j mice. |
2007-06-06 |
2023-08-12 |
mouse |
| Lin Yang, Mei Sun, Xia-meng Sun, George Z Cheng, Santo V Nicosia, Jin Q Chen. Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212. The Journal of biological chemistry. vol 282. issue 15. 2007-05-31. PMID:17311912. |
abolishing htra2/omi phosphorylation by akt through mutation of serine 212 to alanine (htra2/omi-s212a) retains its serine protease activity and induces more apoptosis as compared with wild-type htra2/omi. |
2007-05-31 |
2023-08-12 |
Not clear |
| Anice Moumen, Alessandro Ieraci, Salvatore Patané, Carme Solé, Joan X Comella, Rosanna Dono, Flavio Main. Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3k-Akt-dependent manner. Hepatology (Baltimore, Md.). vol 45. issue 5. 2007-05-25. PMID:17464994. |
thus, met acting on pi3k and akt ensures high levels of flipl, and disruption of this pathway contributes to hepatic apoptosis and possibly to fas-related liver diseases. |
2007-05-25 |
2023-08-12 |
Not clear |
| M Ceci, P Gallo, M Santonastasi, S Grimaldi, M V G Latronico, A Pitisci, E Missol-Kolka, M C Scimia, D Catalucci, D Hilfiker-Kleiner, G Condorell. Cardiac-specific overexpression of E40K active Akt prevents pressure overload-induced heart failure in mice by increasing angiogenesis and reducing apoptosis. Cell death and differentiation. vol 14. issue 5. 2007-05-23. PMID:17237758. |
cardiac-specific overexpression of e40k active akt prevents pressure overload-induced heart failure in mice by increasing angiogenesis and reducing apoptosis. |
2007-05-23 |
2023-08-12 |
mouse |
| Yu-Yu Yao, Hang Yin, Bo Shen, Lee Chao, Julie Cha. Tissue kallikrein infusion prevents cardiomyocyte apoptosis, inflammation and ventricular remodeling after myocardial infarction. Regulatory peptides. vol 140. issue 1-2. 2007-05-21. PMID:17196272. |
intramyocardial injection of kallikrein reduced myocardial infarct size and inhibited cardiomyocyte apoptosis at 1 day after mi associated with increased nitric oxide levels, akt and glycogen synthase kinase-3beta phosphorylation and decreased caspase-3 activation. |
2007-05-21 |
2023-08-12 |
rat |
| Chak-Ming Chan, Cheuk-Wing Ma, Wood-Yee Chan, Ho Yin Edwin Cha. The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway. Archives of biochemistry and biophysics. vol 459. issue 2. 2007-05-18. PMID:17306213. |
the sars-coronavirus membrane protein induces apoptosis through modulating the akt survival pathway. |
2007-05-18 |
2023-08-12 |
drosophila_melanogaster |
| Chak-Ming Chan, Cheuk-Wing Ma, Wood-Yee Chan, Ho Yin Edwin Cha. The SARS-Coronavirus Membrane protein induces apoptosis through modulating the Akt survival pathway. Archives of biochemistry and biophysics. vol 459. issue 2. 2007-05-18. PMID:17306213. |
altogether, our data show that sars-cov m protein induces apoptosis through the modulation of the cellular akt pro-survival pathway and mitochondrial cytochrome c release. |
2007-05-18 |
2023-08-12 |
drosophila_melanogaster |
| Ximeng Liu, Katia J Bruxvoort, Cassandra R Zylstra, Jiarong Liu, Rachel Cichowski, Marie-Claude Faugere, Mary L Bouxsein, Chao Wan, Bart O Williams, Thomas L Clemen. Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 7. 2007-05-17. PMID:17287359. |
in vitro osteoblasts lacking pten differentiated more rapidly than controls and exhibited greatly reduced apoptosis in association with markedly increased levels of phosphorylated akt and activation of signaling pathways downstream of activated akt. |
2007-05-17 |
2023-08-12 |
mouse |