| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laia Caja, Conrad Ortiz, Esther Bertran, Miguel M Murillo, M Jesús Miró-Obradors, Evangelina Palacios, Isabel Fabrega. Differential intracellular signalling induced by TGF-beta in rat adult hepatocytes and hepatoma cells: implications in liver carcinogenesis. Cellular signalling. vol 19. issue 4. 2007-04-18. PMID:17055226. |
in this work we show that tgf-beta plays a dual role in regulating apoptosis in fao rat hepatoma cells, since, in addition to its pro-apoptotic effect, tgf-beta also activates survival signals, such as akt, the epidermal growth factor receptor (egfr) being required for its activation. |
2007-04-18 |
2023-08-12 |
rat |
| Si-Yuan Tang, Hui Xie, Ling-Qing Yuan, Xiang-Hang Luo, Jiao Huang, Rong-Rong Cui, Hou-De Zhou, Xian-Ping Wu, Er-Yuan Lia. Apelin stimulates proliferation and suppresses apoptosis of mouse osteoblastic cell line MC3T3-E1 via JNK and PI3-K/Akt signaling pathways. Peptides. vol 28. issue 3. 2007-04-18. PMID:17109997. |
apelin activated c-jun n-terminal kinase (jnk) and akt (phosphatidylinositol 3-kinase downstream effector), and the jnk inhibitor sp600125, the phosphatidylinositol 3-kinase (pi3-k) inhibitor ly294002 or the akt inhibitor 1l-6-hydroxymethyl-chiro-inositol 2-(r)-2-o-methyl-3-o-octadecylcarbonate (himo) inhibited its effects on proliferation and serum deprivation-induced apoptosis. |
2007-04-18 |
2023-08-12 |
mouse |
| Jeffrey C Horowitz, David S Rogers, Vishal Sharma, Ragini Vittal, Eric S White, Zongbin Cui, Victor J Thannicka. Combinatorial activation of FAK and AKT by transforming growth factor-beta1 confers an anoikis-resistant phenotype to myofibroblasts. Cellular signalling. vol 19. issue 4. 2007-04-18. PMID:17113264. |
tgf-beta1 is able to activate akt in cells expressing mutant fak or in cells treated with an rgd-containing peptide that interferes with integrin signalling, inhibits fak activation and induces anoikis (apoptosis induced by loss of adhesion signalling). |
2007-04-18 |
2023-08-12 |
human |
| Young-Ho Kim, Yong J Le. TRAIL apoptosis is enhanced by quercetin through Akt dephosphorylation. Journal of cellular biochemistry. vol 100. issue 4. 2007-04-16. PMID:17031854. |
trail apoptosis is enhanced by quercetin through akt dephosphorylation. |
2007-04-16 |
2023-08-12 |
human |
| S Turkseven, G Drummond, R Rezzani, L Rodella, S Quan, S Ikehara, N G Abraha. Impact of silencing HO-2 on EC-SOD and the mitochondrial signaling pathway. Journal of cellular biochemistry. vol 100. issue 4. 2007-04-16. PMID:17131376. |
these findings suggest that ho-2 is critical in the maintenance of heme homeostasis and also the regulation of apoptosis by controlling levels of ec-sod, akt, 3-nt, and ask-1. |
2007-04-16 |
2023-08-12 |
Not clear |
| Pongali B Raghavendra, Yashin Sreenivasan, Sunil K Mann. Oleandrin induces apoptosis in human, but not in murine cells: dephosphorylation of Akt, expression of FasL, and alteration of membrane fluidity. Molecular immunology. vol 44. issue 9. 2007-04-11. PMID:17173971. |
oleandrin induces apoptosis in human, but not in murine cells: dephosphorylation of akt, expression of fasl, and alteration of membrane fluidity. |
2007-04-11 |
2023-08-12 |
human |
| Aaron Ruhland, Nicole Leal, Peter E Kim. Leishmania promastigotes activate PI3K/Akt signalling to confer host cell resistance to apoptosis. Cellular microbiology. vol 9. issue 1. 2007-04-10. PMID:16889626. |
then we found that inhibition of signalling through the pi3k/akt pathway with ly294002 and akt iv inhibitor reversed resistance of infected bone marrow-derived macrophages and raw 264.7 macrophages to potent inducers of apoptosis. |
2007-04-10 |
2023-08-12 |
Not clear |
| Aaron Ruhland, Nicole Leal, Peter E Kim. Leishmania promastigotes activate PI3K/Akt signalling to confer host cell resistance to apoptosis. Cellular microbiology. vol 9. issue 1. 2007-04-10. PMID:16889626. |
moreover, reduction of akt levels with small interfering rnas to akt resulted in the inability of infected macrophages to resist apoptosis. |
2007-04-10 |
2023-08-12 |
Not clear |
| S Morley, J Wagner, K Kauppinen, M Sherman, D Mano. Requirement for Akt-mediated survival in cell transformation by the dbl oncogene. Cellular signalling. vol 19. issue 1. 2007-04-10. PMID:16916597. |
dbl expression stimulated the phosphorylation of the anti-apoptotic akt substrate bad, and caused a marked decrease in basal levels of apoptosis. |
2007-04-10 |
2023-08-12 |
Not clear |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17196959. |
during apoptosis, pi suppressed akt phosphorylation, which was reversed by rhgas6. |
2007-04-05 |
2023-08-12 |
human |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17196959. |
wortmannin, a specific phosphatidylinositol 3-oh kinase (pi3k) inhibitor, abolished the increase in akt phosphorylation by rhgas6 and eliminated the inhibitory effect of rhgas6 on both pi-induced apoptosis and calcification, suggesting that pi3k-akt is a downstream signal of the gas6-mediated survival pathway. |
2007-04-05 |
2023-08-12 |
human |
| Bo-Kyung Son, Koichi Kozaki, Katsuya Iijima, Masato Eto, Toru Nakano, Masahiro Akishita, Yasuyoshi Ouch. Gas6/Axl-PI3K/Akt pathway plays a central role in the effect of statins on inorganic phosphate-induced calcification of vascular smooth muscle cells. European journal of pharmacology. vol 556. issue 1-3. 2007-04-05. PMID:17196959. |
the inhibitory effect of statins on pi-induced apoptosis was accompanied by restoration of the gas6-mediated survival signal pathway: upregulation of gas6 and axl expression, increased phosphorylation of akt and bcl2, and inhibition of bad and caspase 3 activation. |
2007-04-05 |
2023-08-12 |
human |
| Motoo Shinohara, Yun Jae Chung, Motoyasu Saji, Matthew D Ringe. AKT in thyroid tumorigenesis and progression. Endocrinology. vol 148. issue 3. 2007-04-04. PMID:16946008. |
akt activation regulates energy metabolism, apoptosis, proliferation, and migration in many cell systems. |
2007-04-04 |
2023-08-12 |
human |
| Yumiko Achiwa, Kiyoshi Hasegawa, Yasuhiro Udagaw. Regulation of the phosphatidylinositol 3-kinase-Akt and the mitogen-activated protein kinase pathways by ursolic acid in human endometrial cancer cells. Bioscience, biotechnology, and biochemistry. vol 71. issue 1. 2007-04-02. PMID:17213663. |
elevation in akt protects the cancer cell from apoptosis. |
2007-04-02 |
2023-08-12 |
human |
| D J A de Groot, E G E de Vries, H J M Groen, S de Jon. Non-steroidal anti-inflammatory drugs to potentiate chemotherapy effects: from lab to clinic. Critical reviews in oncology/hematology. vol 61. issue 1. 2007-03-27. PMID:16945549. |
studies investigating anti-cancer effects of nsaids on cell lines and xenograft models have shown modulation of the akt, nf-kappab, tyrosine kinase and the death receptor-mediated apoptosis pathways. |
2007-03-27 |
2023-08-12 |
Not clear |
| Hongzhe Li, Xiaojian Wang, Nan Li, Jianming Qiu, Yuanyuan Zhang, Xuetao Ca. hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways. The Journal of biological chemistry. vol 282. issue 7. 2007-03-26. PMID:17178731. |
hpebp4 resists trail-induced apoptosis of human prostate cancer cells by activating akt and deactivating erk1/2 pathways. |
2007-03-26 |
2023-08-12 |
human |
| Hongzhe Li, Xiaojian Wang, Nan Li, Jianming Qiu, Yuanyuan Zhang, Xuetao Ca. hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways. The Journal of biological chemistry. vol 282. issue 7. 2007-03-26. PMID:17178731. |
in contrast, silencing of hpebp4 in trail-resistant lncap cells inhibited akt activation but increased erk1/2 activation, resulting in their sensitivity to trail-induced apoptosis that was restored by the mek1 inhibitor. |
2007-03-26 |
2023-08-12 |
human |
| Hongzhe Li, Xiaojian Wang, Nan Li, Jianming Qiu, Yuanyuan Zhang, Xuetao Ca. hPEBP4 resists TRAIL-induced apoptosis of human prostate cancer cells by activating Akt and deactivating ERK1/2 pathways. The Journal of biological chemistry. vol 282. issue 7. 2007-03-26. PMID:17178731. |
we also demonstrated that hpebp4-mediated resistance to trail-induced apoptosis occurred downstream of caspase-8 and at the level of bid cleavage via the regulation of akt and erk pathways, and that hpebp4-regulated erk deactivation was upstream of akt activation in prostate cancer cells. |
2007-03-26 |
2023-08-12 |
human |
| Tateo Sawabu, Hiroshi Seno, Tomoko Kawashima, Akihisa Fukuda, Yoshito Uenoyama, Mayumi Kawada, Naoki Kanda, Akira Sekikawa, Hirokazu Fukui, Motoko Yanagita, Hiroshi Yoshibayashi, Seiji Satoh, Yoshiharu Sakai, Toru Nakano, Tsutomu Chib. Growth arrest-specific gene 6 and Axl signaling enhances gastric cancer cell survival via Akt pathway. Molecular carcinogenesis. vol 46. issue 2. 2007-03-26. PMID:17186543. |
with recombinant gas6 and a decoy-receptor of axl in vitro, we demonstrated that gas6-axl signaling pathway enhanced cellular survival and invasion and suppressed apoptosis via akt pathway. |
2007-03-26 |
2023-08-12 |
human |
| Hon-Wai Koon, Dezheng Zhao, Yanai Zhan, Mary P Moyer, Charalabos Pothoulaki. Substance P mediates antiapoptotic responses in human colonocytes by Akt activation. Proceedings of the National Academy of Sciences of the United States of America. vol 104. issue 6. 2007-03-22. PMID:17264209. |
sp exposure of ncm460-nk-1r colonocytes stimulated phosphorylation of the antiapoptotic molecule akt and inhibited tamoxifen-induced cell death and apoptosis evaluated by the cell viability assay and poly(adp-ribose) polymerase cleavage, respectively. |
2007-03-22 |
2023-08-12 |
mouse |