| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Atsuyoshi Nishina, Akihiro Sekiguchi, Ryo-hei Fukumoto, Mamoru Koketsu, Shoei Furukaw. Selenazoles (selenium compounds) facilitate survival of cultured rat pheochromocytoma PC12 cells after serum-deprivation and stimulate their neuronal differentiation via activation of Akt and mitogen-activated protein kinase, respectively. Biochemical and biophysical research communications. vol 352. issue 2. 2007-03-05. PMID:17126295. |
these results demonstrate that the cs-induced phosphorylation of akt and map kinase (receptor tyrosine kinase(s)-mek1/2-erk1/2) cascades was responsible for suppression of apoptosis and facilitation of neuronal differentiation of pc12 cells, respectively. |
2007-03-05 |
2023-08-12 |
rat |
| V S Deshpande, James P Kehre. Mechanisms of N-acetylcysteine-driven enhancement of MK886-induced apoptosis. Cell biology and toxicology. vol 22. issue 4. 2007-02-27. PMID:16817014. |
mk886, a 5-lipoxygenase activating protein (flap) inhibitor, induces apoptosis in many cell lines by an unknown mechanism that is independent of flap and lipoxygenase activity but is possibly related to effects on kinases such as akt. |
2007-02-27 |
2023-08-12 |
Not clear |
| Manchao Zhang, Xueliang Fang, Hongpeng Liu, Shaomeng Wang, Dajun Yan. Blockade of AKT activation in prostate cancer cells with a small molecule inhibitor, 9-chloro-2-methylellipticinium acetate (CMEP). Biochemical pharmacology. vol 73. issue 1. 2007-02-22. PMID:16950208. |
the inhibitory effects of a potent and selective akt/bkb small molecule inhibitor, 9-chloro-2-methylellipticinium acetate (cmep), on the activation of akt, its antiproliferation and apoptosis-inducing effects in prostate cancer cell lines: du-145, pc-3, lncap, and cl-1, an androgen-independent lncap variant, and cl-1 xenograft mouse model were assessed by western blot analysis, kinase assay, cell survival assay, and apoptosis assay in this report. |
2007-02-22 |
2023-08-12 |
mouse |
| Manchao Zhang, Xueliang Fang, Hongpeng Liu, Shaomeng Wang, Dajun Yan. Blockade of AKT activation in prostate cancer cells with a small molecule inhibitor, 9-chloro-2-methylellipticinium acetate (CMEP). Biochemical pharmacology. vol 73. issue 1. 2007-02-22. PMID:16950208. |
more importantly, it has been discovered that cmep inhibits cell proliferation, and induces apoptosis in prostate cancer cells which have high-levels of akt activation and lack pten or harbor pten mutation, such as cl-1, lncap, and pc-3; only shows a minimal activity in du-145 cancer cells which do not have akt activation. |
2007-02-22 |
2023-08-12 |
mouse |
| Manchao Zhang, Xueliang Fang, Hongpeng Liu, Shaomeng Wang, Dajun Yan. Blockade of AKT activation in prostate cancer cells with a small molecule inhibitor, 9-chloro-2-methylellipticinium acetate (CMEP). Biochemical pharmacology. vol 73. issue 1. 2007-02-22. PMID:16950208. |
in conclusion, by specific blockade of the activation of akt, cmep preferentially inhibits growth and induces apoptosis in prostate cancer cells which have high-levels of akt activation. |
2007-02-22 |
2023-08-12 |
mouse |
| Hua Jiang, Jingya Zhang, Hui Zhu, Hong Li, Xuejun Zhan. Nerve growth factor prevents the apoptosis-associated increase in acetylcholinesterase activity after hydrogen peroxide treatment by activating Akt. Acta biochimica et biophysica Sinica. vol 39. issue 1. 2007-02-21. PMID:17213958. |
when nerve growth factor (ngf) was present, with the maintenance of akt level, the elevation of ache, the cytochrome c diffusion, as well as apoptosis were markedly attenuated in h2o2-treated pc12 cells. |
2007-02-21 |
2023-08-12 |
Not clear |
| Hua Jiang, Jingya Zhang, Hui Zhu, Hong Li, Xuejun Zhan. Nerve growth factor prevents the apoptosis-associated increase in acetylcholinesterase activity after hydrogen peroxide treatment by activating Akt. Acta biochimica et biophysica Sinica. vol 39. issue 1. 2007-02-21. PMID:17213958. |
thus, ngf prevented apoptosis and elevation of ache activity by activating the akt pathway and stabilizing the function of mitochondria. |
2007-02-21 |
2023-08-12 |
Not clear |
| Ashwani Rajput, Alan P Koterba, Jeffrey I Kreisberg, Jason M Foster, James K V Willson, Michael G Brattai. A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo. Cancer research. vol 67. issue 2. 2007-02-20. PMID:17234777. |
the reversal of constitutive egfr activation results in the loss of downstream mitogen-activated protein kinase and akt activation, and a reduction in xenograft size that is associated with decreased proliferation and increased apoptosis. |
2007-02-20 |
2023-08-12 |
human |
| Daniela Opel, Christopher Poremba, Thorsten Simon, Klaus-Michael Debatin, Simone Fuld. Activation of Akt predicts poor outcome in neuroblastoma. Cancer research. vol 67. issue 2. 2007-02-20. PMID:17234785. |
parallel experiments in neuroblastoma cell lines revealed that activation of akt by insulin-like growth factor (igf)-i significantly inhibited tumor necrosis factor-related apoptosis-inducing ligand- or chemotherapy-induced apoptosis in a pi3k-dependent manner because the pi3k inhibitor ly294002 completely reversed the igf-i-mediated protection of neuroblastoma cells from apoptosis. |
2007-02-20 |
2023-08-12 |
human |
| Daniela Opel, Christopher Poremba, Thorsten Simon, Klaus-Michael Debatin, Simone Fuld. Activation of Akt predicts poor outcome in neuroblastoma. Cancer research. vol 67. issue 2. 2007-02-20. PMID:17234785. |
by showing that activation of akt correlates with poor prognosis in primary neuroblastoma in vivo and with apoptosis resistance in vitro, our findings indicate that akt presents a clinically relevant target in neuroblastoma that warrants further investigation. |
2007-02-20 |
2023-08-12 |
human |
| Alessandro Poggi, Maria Raffaella Zocch. HIV-1 Tat triggers TGF-beta production and NK cell apoptosis that is prevented by pertussis toxin B. Clinical & developmental immunology. vol 13. issue 2-4. 2007-02-15. PMID:17162379. |
tgf-beta enhances starvation-induced nk cell apoptosis, reduces the transcription of the antiapoptotic protein bcl-2 and inhibits akt phosphorylation induced by oligomerization of the triggering nk cell receptor nkg2d. |
2007-02-15 |
2023-08-12 |
Not clear |
| Shougang Zhuang, Yan Yan, Rebecca A Daubert, Jiahuai Han, Rick G Schnellman. ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. American journal of physiology. Renal physiology. vol 292. issue 1. 2007-02-12. PMID:16885155. |
erk promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of akt in renal epithelial cells. |
2007-02-12 |
2023-08-12 |
Not clear |
| Shougang Zhuang, Yan Yan, Rebecca A Daubert, Jiahuai Han, Rick G Schnellman. ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. American journal of physiology. Renal physiology. vol 292. issue 1. 2007-02-12. PMID:16885155. |
exposure of rptc to 1 mm h(2)o(2) resulted in apoptosis and activation of erk1/2 and akt. |
2007-02-12 |
2023-08-12 |
Not clear |
| Shougang Zhuang, Yan Yan, Rebecca A Daubert, Jiahuai Han, Rick G Schnellman. ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. American journal of physiology. Renal physiology. vol 292. issue 1. 2007-02-12. PMID:16885155. |
furthermore, blockade of erk1/2 resulted in an increase in akt phosphorylation and blockade of akt potentiated apoptosis and diminished the protective effect conferred by erk inhibition in h(2)o(2)-treated cells. |
2007-02-12 |
2023-08-12 |
Not clear |
| Shougang Zhuang, Yan Yan, Rebecca A Daubert, Jiahuai Han, Rick G Schnellman. ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. American journal of physiology. Renal physiology. vol 292. issue 1. 2007-02-12. PMID:16885155. |
we suggest that erk elicits apoptosis in epithelial cells by activating caspase-3 and inhibiting akt pathways and elicits nuclear condensation through caspase-3 and histone h2b phosophorylation during oxidant injury. |
2007-02-12 |
2023-08-12 |
Not clear |
| Zabeena P Shaik, E Kim Fifer, Grazyna Nowa. Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells. American journal of physiology. Renal physiology. vol 292. issue 1. 2007-02-12. PMID:16940564. |
protein kinase b (akt) activation is well known for its protective effects against apoptosis. |
2007-02-12 |
2023-08-12 |
Not clear |
| Zabeena P Shaik, E Kim Fifer, Grazyna Nowa. Protein kinase B/Akt modulates nephrotoxicant-induced necrosis in renal cells. American journal of physiology. Renal physiology. vol 292. issue 1. 2007-02-12. PMID:16940564. |
modulation of akt activity had no effect on dcvc-induced apoptosis. |
2007-02-12 |
2023-08-12 |
Not clear |
| Kento Tateishi, Eishi Ashihara, Shoken Honsho, Naofumi Takehara, Tetsuya Nomura, Tomosaburo Takahashi, Tomomi Ueyama, Masaaki Yamagishi, Hitoshi Yaku, Hiroaki Matsubara, Hidemasa O. Human cardiac stem cells exhibit mesenchymal features and are maintained through Akt/GSK-3beta signaling. Biochemical and biophysical research communications. vol 352. issue 3. 2007-02-12. PMID:17150190. |
inhibition of akt pathway impaired the hcsc proliferation and induced apoptosis, whereas inhibition of glycogen synthase kinase-3 (gsk-3) enhanced their growth and survival. |
2007-02-12 |
2023-08-12 |
human |
| Dong-Oh Moon, Cheol Park, Moon-Soo Heo, Yeong-Min Park, Yung Hyun Choi, Gi-Young Ki. PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway. International immunopharmacology. vol 7. issue 1. 2007-02-07. PMID:17161815. |
pd98059 triggers g1 arrest and apoptosis in human leukemic u937 cells through downregulation of akt signal pathway. |
2007-02-07 |
2023-08-12 |
human |
| Dong-Oh Moon, Cheol Park, Moon-Soo Heo, Yeong-Min Park, Yung Hyun Choi, Gi-Young Ki. PD98059 triggers G1 arrest and apoptosis in human leukemic U937 cells through downregulation of Akt signal pathway. International immunopharmacology. vol 7. issue 1. 2007-02-07. PMID:17161815. |
moreover, pd98059 down-regulated akt phosphorylation and produced a synergy effect of apoptosis with ly294002 co-treatment. |
2007-02-07 |
2023-08-12 |
human |