| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Makoto Orisaka, Sanae Orisaka, Jin-Yi Jiang, Jesse Craig, Yifang Wang, Fumikazu Kotsuji, Benjamin K Tsan. Growth differentiation factor 9 is antiapoptotic during follicular development from preantral to early antral stage. Molecular endocrinology (Baltimore, Md.). vol 20. issue 10. 2006-12-13. PMID:16740654. |
although granulosa cell apoptosis induced by ceramide was attenuated by the presence of gdf-9, this protective effect of gdf-9 was prevented by the phosphatidylinositol 3-kinase inhibitor ly294002 and a dominant negative form of akt. |
2006-12-13 |
2023-08-12 |
Not clear |
| Hirofumi Fujita, Tetsuya Ogino, Hirotsugu Kobuchi, Takuzo Fujiwara, Hiromi Yano, Jitsuo Akiyama, Kozo Utsumi, Junzo Sasak. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain research. vol 1113. issue 1. 2006-12-13. PMID:16945353. |
cell-permeable camp analog suppresses 6-hydroxydopamine-induced apoptosis in pc12 cells through the activation of the akt pathway. |
2006-12-13 |
2023-08-12 |
Not clear |
| Hirofumi Fujita, Tetsuya Ogino, Hirotsugu Kobuchi, Takuzo Fujiwara, Hiromi Yano, Jitsuo Akiyama, Kozo Utsumi, Junzo Sasak. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain research. vol 1113. issue 1. 2006-12-13. PMID:16945353. |
conversely, ly294002, an inhibitor of akt upstream molecule pi3-kinase, enhanced 6-ohda-induced apoptosis. |
2006-12-13 |
2023-08-12 |
Not clear |
| Hirofumi Fujita, Tetsuya Ogino, Hirotsugu Kobuchi, Takuzo Fujiwara, Hiromi Yano, Jitsuo Akiyama, Kozo Utsumi, Junzo Sasak. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain research. vol 1113. issue 1. 2006-12-13. PMID:16945353. |
these results indicated that the 6-ohda-induced apoptosis of pc12 cells was initiated by superoxide generation followed by caspase cascade activation, which was associated with the suppressed akt phosphorylation and increased p38 phosphorylation. |
2006-12-13 |
2023-08-12 |
Not clear |
| Christèle Desbois-Mouthon, Wulfran Cacheux, Marie-José Blivet-Van Eggelpoël, Véronique Barbu, Laetitia Fartoux, Raoul Poupon, Chantal Housset, Olivier Rosmordu. Impact of IGF-1R/EGFR cross-talks on hepatoma cell sensitivity to gefitinib. International journal of cancer. vol 119. issue 11. 2006-12-12. PMID:16988945. |
however, while gefitinib blocked akt activation by egf, it had no effect on akt activation by igf2 and did not cause apoptosis by its own. |
2006-12-12 |
2023-08-12 |
rat |
| Mahitosh Mandal, Maher Younes, Eric A Swan, Samar A Jasser, Dao Doan, Orhan Yigitbasi, Andrea McMurphey, James Ludwick, Adel K El-Naggar, Cora Bucana, Gordon B Mills, Jeffrey N Myer. The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck. Oral oncology. vol 42. issue 4. 2006-12-11. PMID:16442835. |
the akt inhibitor kp372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck. |
2006-12-11 |
2023-08-12 |
human |
| Mahitosh Mandal, Maher Younes, Eric A Swan, Samar A Jasser, Dao Doan, Orhan Yigitbasi, Andrea McMurphey, James Ludwick, Adel K El-Naggar, Cora Bucana, Gordon B Mills, Jeffrey N Myer. The Akt inhibitor KP372-1 inhibits proliferation and induces apoptosis and anoikis in squamous cell carcinoma of the head and neck. Oral oncology. vol 42. issue 4. 2006-12-11. PMID:16442835. |
treatment of hnscc cell lines with kp372-1 blocked the activation of akt, inhibited head and neck cancer cell proliferation, and induced apoptosis and anoikis in several hnscc cell lines. |
2006-12-11 |
2023-08-12 |
human |
| Yun-Lian Lin, Ting-Fang Lee, Yeh-Jeng Huang, Yi-Tsau Huan. Antiproliferative effect of salvianolic acid A on rat hepatic stellate cells. The Journal of pharmacy and pharmacology. vol 58. issue 7. 2006-12-11. PMID:16805953. |
sal a at 10 microm induced cell apoptosis in pdgf-bb-incubated hscs, together with a reduction of bcl-2 protein expression, induction of cell cycle inhibitory proteins p21 and p27, and down-regulation of cyclins d1 and e, suppression of akt phosphorylation, reduction in pdgf receptor phosphorylation, and an increase in caspase-3 activity. |
2006-12-11 |
2023-08-12 |
rat |
| Jorge G Gomez-Gutierrez, Vinicius Souza, Hong Ying Hao, Roberto Montes de Oca-Luna, Yan Bin Dong, H Sam Zhou, Kelly M McMaster. Adenovirus-mediated gene transfer of FKHRL1 triple mutant efficiently induces apoptosis in melanoma cells. Cancer biology & therapy. vol 5. issue 7. 2006-12-11. PMID:16861905. |
the forkhead family of transcription factors induce apoptosis in their unphosphorylated forms and were recently reported to be a substrate of akt kinase. |
2006-12-11 |
2023-08-12 |
Not clear |
| Jorge G Gomez-Gutierrez, Vinicius Souza, Hong Ying Hao, Roberto Montes de Oca-Luna, Yan Bin Dong, H Sam Zhou, Kelly M McMaster. Adenovirus-mediated gene transfer of FKHRL1 triple mutant efficiently induces apoptosis in melanoma cells. Cancer biology & therapy. vol 5. issue 7. 2006-12-11. PMID:16861905. |
in the present study, an adenovirus expressing a triple mutant (tm) of fkhrl1, which cannot be phosphorylated by akt, was assessed for its ability to induce apoptosis in melanoma cells. |
2006-12-11 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
however, during subsequent collagen matrix contraction, the level of phosphorylated akt progressively declines, triggering apoptosis. |
2006-12-11 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
here we show that pten phosphatase becomes activated during collagen matrix contraction and is responsible for antagonizing phosphatidylinositol 3-kinase activity and promoting a decline in phosphorylated akt and fibroblast apoptosis in response to collagen contraction. |
2006-12-11 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
pten null fibroblasts displayed enhanced levels of phosphorylated akt and were resistant to collagen matrix contraction-induced apoptosis. |
2006-12-11 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
consistent with this, knockdown of pten in pten(+/+) embryonic fibroblasts by small interfering rna augmented akt activity and suppressed apoptosis in contractile collagen matrices. |
2006-12-11 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
furthermore, inhibition of akt activity restored the sensitivity of pten null cells to collagen contraction-induced apoptosis, indicating that the mechanism by which pten alters fibroblast viability is through modulation of phosphorylated akt levels. |
2006-12-11 |
2023-08-12 |
Not clear |
| Kathryn Miller-Jensen, Kevin A Janes, Yun-Ling Wong, Linda G Griffith, Douglas A Lauffenburge. Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis. Journal of cell science. vol 119. issue Pt 18. 2006-12-08. PMID:16940353. |
adenoviral vector saturates akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis. |
2006-12-08 |
2023-08-12 |
human |
| Kathryn Miller-Jensen, Kevin A Janes, Yun-Ling Wong, Linda G Griffith, Douglas A Lauffenburge. Adenoviral vector saturates Akt pro-survival signaling and blocks insulin-mediated rescue of tumor necrosis-factor-induced apoptosis. Journal of cell science. vol 119. issue Pt 18. 2006-12-08. PMID:16940353. |
surprisingly, further activation of akt in adv-infected cells via insulin treatment did not significantly reduce apoptosis or mk2 activity. |
2006-12-08 |
2023-08-12 |
human |
| Chunrong Yu, Bret B Friday, Jin-Ping Lai, Lin Yang, Jann Sarkaria, Neil E Kay, Christopher A Carter, Lewis R Roberts, Scott H Kaufmann, Alex A Adje. Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Molecular cancer therapeutics. vol 5. issue 9. 2006-12-07. PMID:16985072. |
cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through akt and c-jun nh2-terminal kinase pathways. |
2006-12-07 |
2023-08-12 |
human |
| Chunrong Yu, Bret B Friday, Jin-Ping Lai, Lin Yang, Jann Sarkaria, Neil E Kay, Christopher A Carter, Lewis R Roberts, Scott H Kaufmann, Alex A Adje. Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Molecular cancer therapeutics. vol 5. issue 9. 2006-12-07. PMID:16985072. |
inhibition of akt was required for synergism, as a constitutively active akt protected cells against apoptosis induced by the combination. |
2006-12-07 |
2023-08-12 |
human |
| Chunrong Yu, Bret B Friday, Jin-Ping Lai, Lin Yang, Jann Sarkaria, Neil E Kay, Christopher A Carter, Lewis R Roberts, Scott H Kaufmann, Alex A Adje. Cytotoxic synergy between the multikinase inhibitor sorafenib and the proteasome inhibitor bortezomib in vitro: induction of apoptosis through Akt and c-Jun NH2-terminal kinase pathways. Molecular cancer therapeutics. vol 5. issue 9. 2006-12-07. PMID:16985072. |
alternatively, the jnk inhibitor sp600125 could also protect cells from apoptosis induced by the combination, indicating that both inhibition of akt and activation of jnk were required for the synergism. |
2006-12-07 |
2023-08-12 |
human |