| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Elisa Giovannetti, Valentina Mey, Sara Nannizzi, Giuseppe Pasqualetti, Mario Del Tacca, Romano Danes. Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer. Molecular cancer therapeutics. vol 5. issue 6. 2006-10-04. PMID:16818496. |
other studies showed the dysregulation of the expression of proteins involved in the control of cell cycle, proliferation, apoptosis, and invasiveness, such as bcl-2, akt, mdm2, and epidermal growth factor receptor. |
2006-10-04 |
2023-08-12 |
human |
| Maria Nyåkern, Alessandra Cappellini, Irina Mantovani, Alberto M Martell. Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathways. Molecular cancer therapeutics. vol 5. issue 6. 2006-10-04. PMID:16818515. |
synergistic induction of apoptosis in human leukemia t cells by the akt inhibitor perifosine and etoposide through activation of intrinsic and fas-mediated extrinsic cell death pathways. |
2006-10-04 |
2023-08-12 |
human |
| Keith R Brunt, Keith K Fenrich, Gholam Kiani, M Yat Tse, Stephen C Pang, Christopher A Ward, Luis G Mel. Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional codependence between HO-1 and AKT. Arteriosclerosis, thrombosis, and vascular biology. vol 26. issue 9. 2006-09-28. PMID:16840713. |
protection of human vascular smooth muscle cells from h2o2-induced apoptosis through functional codependence between ho-1 and akt. |
2006-09-28 |
2023-08-12 |
human |
| Keith R Brunt, Keith K Fenrich, Gholam Kiani, M Yat Tse, Stephen C Pang, Christopher A Ward, Luis G Mel. Protection of human vascular smooth muscle cells from H2O2-induced apoptosis through functional codependence between HO-1 and AKT. Arteriosclerosis, thrombosis, and vascular biology. vol 26. issue 9. 2006-09-28. PMID:16840713. |
this study examined the role of akt in mediating the cytoprotective effects of ho-1 in os-induced apoptosis of human aortic smooth muscle cells (hasmcs). |
2006-09-28 |
2023-08-12 |
human |
| Kunihiko Izuishi, Allan Tsung, Mohammad Akram Hossain, Masao Fujiwara, Hisao Wakabayashi, Tsutomu Masaki, Timothy R Billiar, Hajime Maet. Ischemic preconditioning of the murine liver protects through the Akt kinase pathway. Hepatology (Baltimore, Md.). vol 44. issue 3. 2006-09-28. PMID:16941697. |
akt activation associated with hepatic ipc suppressed the activity of several modulators of apoptosis, including bad, glycogen synthase kinase beta, and caspase-3. |
2006-09-28 |
2023-08-12 |
mouse |
| Seongah Han, Chien-Ping Liang, Tracie DeVries-Seimon, Mollie Ranalletta, Carrie L Welch, Kadesha Collins-Fletcher, Domenico Accili, Ira Tabas, Alan R Tal. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell metabolism. vol 3. issue 4. 2006-09-21. PMID:16581003. |
insr(-/-) macrophages showed diminished akt phosphorylation and an augmented er stress response, leading to induction of scavenger receptor a and increased apoptosis when challenged with cholesterol loading or nutrient deprivation. |
2006-09-21 |
2023-08-12 |
mouse |
| Seongah Han, Chien-Ping Liang, Tracie DeVries-Seimon, Mollie Ranalletta, Carrie L Welch, Kadesha Collins-Fletcher, Domenico Accili, Ira Tabas, Alan R Tal. Macrophage insulin receptor deficiency increases ER stress-induced apoptosis and necrotic core formation in advanced atherosclerotic lesions. Cell metabolism. vol 3. issue 4. 2006-09-21. PMID:16581003. |
these studies suggest that defective insulin signaling and reduced akt activity impair the ability of macrophages to deal with er stress-induced apoptosis within atherosclerotic plaques. |
2006-09-21 |
2023-08-12 |
mouse |
| Yan Wu, Andrea T Hooper, Zhaojing Zhong, Larry Witte, Peter Bohlen, Shahin Rafii, Daniel J Hickli. The vascular endothelial growth factor receptor (VEGFR-1) supports growth and survival of human breast carcinoma. International journal of cancer. vol 119. issue 7. 2006-09-21. PMID:16671089. |
histological examination of anti-vegfr-1 mab treated tumor xenografts showed a significant reduction of activation of the p44/42 mapk or akt pathways in tumor cells resulting in an increase in tumor cell apoptosis. |
2006-09-21 |
2023-08-12 |
mouse |
| Teresa Rasoulpour, Kathryn DiPalma, Branko Kolvek, Mary Hixo. Akt1 suppresses radiation-induced germ cell apoptosis in vivo. Endocrinology. vol 147. issue 9. 2006-09-21. PMID:16763066. |
we found that akt kinase activity increases in the testes of wild-type mice after ionizing radiation, and that loss of akt1 results in an earlier onset of germ cell apoptosis and enhanced sensitivity of mitotic spermatogonia to ionizing radiation. |
2006-09-21 |
2023-08-12 |
mouse |
| R B Robey, N Ha. Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt. Oncogene. vol 25. issue 34. 2006-09-20. PMID:16892082. |
we hypothesize that the enlistment of akt and hexokinase in the control of mammalian cell apoptosis evolved as a response to the recruitment of mitochondria to the apoptotic cascade. |
2006-09-20 |
2023-08-12 |
Not clear |
| Kwang Seok Ahn, Gautam Sethi, Abhinav K Jain, Anil K Jaiswal, Bharat B Aggarwa. Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis. The Journal of biological chemistry. vol 281. issue 29. 2006-09-19. PMID:16682409. |
genetic deletion of nad(p)h:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappab, ikappabalpha kinase, c-jun n-terminal kinase, akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis. |
2006-09-19 |
2023-08-12 |
mouse |
| Fukun Guo, Marcella Debidda, Linda Yang, David A Williams, Yi Zhen. Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. The Journal of biological chemistry. vol 281. issue 27. 2006-09-18. PMID:16698790. |
furthermore, rac1 deletion led to a marked increase in spontaneous apoptosis that could be rescued by active pak1, akt, or mek1 expression. |
2006-09-18 |
2023-08-12 |
mouse |
| Richard A Davies, Belinda Knight, Yan Wu Tian, George C T Yeoh, John K Olyny. Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor. Carcinogenesis. vol 27. issue 8. 2006-09-14. PMID:16497703. |
an immortalized oval cell line (pil-2) was used to study the in vitro effects of sc-236 on oval cell proliferation, apoptosis and akt phosphorylation. |
2006-09-14 |
2023-08-12 |
mouse |
| Richard A Davies, Belinda Knight, Yan Wu Tian, George C T Yeoh, John K Olyny. Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor. Carcinogenesis. vol 27. issue 8. 2006-09-14. PMID:16497703. |
in vitro oval cell death was associated with apoptosis and a 70% reduction in akt phosphorylation. |
2006-09-14 |
2023-08-12 |
mouse |
| Richard A Davies, Belinda Knight, Yan Wu Tian, George C T Yeoh, John K Olyny. Hepatic oval cell response to the choline-deficient, ethionine supplemented model of murine liver injury is attenuated by the administration of a cyclo-oxygenase 2 inhibitor. Carcinogenesis. vol 27. issue 8. 2006-09-14. PMID:16497703. |
these results suggest that the sc-236 induced reduction of m2pk-positive oval cell numbers may be due to cox-2 dependent inhibition of akt phosphorylation and induction of apoptosis. |
2006-09-14 |
2023-08-12 |
mouse |
| Jérôme Busserolles, Javier Megías, María Carmen Terencio, María José Alcara. Heme oxygenase-1 inhibits apoptosis in Caco-2 cells via activation of Akt pathway. The international journal of biochemistry & cell biology. vol 38. issue 9. 2006-09-14. PMID:16697692. |
heme oxygenase-1 inhibits apoptosis in caco-2 cells via activation of akt pathway. |
2006-09-14 |
2023-08-12 |
human |
| Jérôme Busserolles, Javier Megías, María Carmen Terencio, María José Alcara. Heme oxygenase-1 inhibits apoptosis in Caco-2 cells via activation of Akt pathway. The international journal of biochemistry & cell biology. vol 38. issue 9. 2006-09-14. PMID:16697692. |
serum deprivation induced apoptosis, reduced akt and p38 phosphorylation, and increased p21(cip/waf1) levels. |
2006-09-14 |
2023-08-12 |
human |
| Jérôme Busserolles, Javier Megías, María Carmen Terencio, María José Alcara. Heme oxygenase-1 inhibits apoptosis in Caco-2 cells via activation of Akt pathway. The international journal of biochemistry & cell biology. vol 38. issue 9. 2006-09-14. PMID:16697692. |
heme oxygenase-1 induction by treatment with cobalt protoporphyrin ix resulted in resistance to apoptosis, activation of akt, reduction in p21(cip/waf1) levels and modification of bcl2/bax ratio towards survival. |
2006-09-14 |
2023-08-12 |
human |
| Jing Zhao, Junying Miao, Baoxiang Zhao, Shangli Zhang, Deling Yi. Suppressing Akt phosphorylation and activating Fas by safrole oxide inhibited angiogenesis and induced vascular endothelial cell apoptosis in the presence of fibroblast growth factor-2 and serum. The international journal of biochemistry & cell biology. vol 38. issue 9. 2006-09-14. PMID:16702019. |
suppressing akt phosphorylation and activating fas by safrole oxide inhibited angiogenesis and induced vascular endothelial cell apoptosis in the presence of fibroblast growth factor-2 and serum. |
2006-09-14 |
2023-08-12 |
Not clear |
| Simone Grethe, Nadia Coltella, Maria Flavia Di Renzo, M Isabella Pörn-Are. p38 MAPK downregulates phosphorylation of Bad in doxorubicin-induced endothelial apoptosis. Biochemical and biophysical research communications. vol 347. issue 3. 2006-09-13. PMID:16843435. |
notably, we also found that doxorubicin-provoked apoptosis included p38 mapk-mediated inhibition of akt and bad phosphorylation. |
2006-09-13 |
2023-08-12 |
human |