| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dong-Oh Moon, Sung-Yong Park, Moon-Soo Heo, Ki-Cheon Kim, Cheol Park, Woo Shin Ko, Yung Hyun Choi, Gi-Young Ki. Key regulators in bee venom-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of ERK and Akt. International immunopharmacology. vol 6. issue 12. 2007-01-10. PMID:17052670. |
key regulators in bee venom-induced apoptosis are bcl-2 and caspase-3 in human leukemic u937 cells through downregulation of erk and akt. |
2007-01-10 |
2023-08-12 |
human |
| Dong-Oh Moon, Sung-Yong Park, Moon-Soo Heo, Ki-Cheon Kim, Cheol Park, Woo Shin Ko, Yung Hyun Choi, Gi-Young Ki. Key regulators in bee venom-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of ERK and Akt. International immunopharmacology. vol 6. issue 12. 2007-01-10. PMID:17052670. |
in the present study, we report that bv induces apoptosis in leukemic u937 cells through downregulation of erk and akt signal pathway. |
2007-01-10 |
2023-08-12 |
human |
| Dong-Oh Moon, Sung-Yong Park, Moon-Soo Heo, Ki-Cheon Kim, Cheol Park, Woo Shin Ko, Yung Hyun Choi, Gi-Young Ki. Key regulators in bee venom-induced apoptosis are Bcl-2 and caspase-3 in human leukemic U937 cells through downregulation of ERK and Akt. International immunopharmacology. vol 6. issue 12. 2007-01-10. PMID:17052670. |
the results indicated that key regulators in bv-induced apoptosis are bcl-2 and caspase-3 in human leukemic u937 cells through downregulation of the erk and akt signal pathway. |
2007-01-10 |
2023-08-12 |
human |
| Michal Hayun, Yaniv Naor, Merav Weil, Michael Albeck, Alpha Peled, Jeremy Don, Nechama Haran-Ghera, Benjamin Sredn. The immunomodulator AS101 induces growth arrest and apoptosis in multiple myeloma: association with the Akt/survivin pathway. Biochemical pharmacology. vol 72. issue 11. 2007-01-04. PMID:16889755. |
we also showed that as101 down-regulated akt phosphorylation and decreased expression of the inhibitor of apoptosis, survivin. |
2007-01-04 |
2023-08-12 |
Not clear |
| Cynthia C Tsui, Stuart J Shankland, Brian A Pierchal. Glial cell line-derived neurotrophic factor and its receptor ret is a novel ligand-receptor complex critical for survival response during podocyte injury. Journal of the American Society of Nephrology : JASN. vol 17. issue 6. 2007-01-03. PMID:16672314. |
knockdown of ret expression by small interference rna in podocytes exacerbated apoptosis that was induced by both ultraviolet c and pa. ret knockdown, upon injury, decreased akt phosphorylation, suggesting that the phosphoinositol-3 kinase/akt pathway mediated the survival effect of gdnf on podocytes. |
2007-01-03 |
2023-08-12 |
mouse |
| Arantxa Ortega, David Rámila, Juan Antonio Ardura, Vanesa Esteban, Marta Ruiz-Ortega, Antonio Barat, Rosa Gazapo, Ricardo J Bosch, Pedro Esbri. Role of parathyroid hormone-related protein in tubulointerstitial apoptosis and fibrosis after folic acid-induced nephrotoxicity. Journal of the American Society of Nephrology : JASN. vol 17. issue 6. 2007-01-03. PMID:16672315. |
in vitro studies in renal tubulointerstitial and fibroblastic cells strongly suggest that pthrp (1-36) (100 nm) reduced fa-induced apoptosis through a dual mechanism involving bcl-xl upregulation and akt and bad phosphorylation. |
2007-01-03 |
2023-08-12 |
mouse |
| Imke Peters, Irini Tossidou, Johannes Achenbach, Robert Woroniecki, Michael Mengel, Joon-Keun Park, Melanie Paschy, Kirsten de Groot, Hermann Haller, Mario Schiffe. IGF-binding protein-3 modulates TGF-beta/BMP-signaling in glomerular podocytes. Journal of the American Society of Nephrology : JASN. vol 17. issue 6. 2007-01-03. PMID:16672319. |
this effect is specific for the co-stimulation of igfbp-3 with tgf-beta1 because a combination of igfbp-3 with bone morphogenic protein-7 (bmp-7), another member of the tgf-beta superfamily, results in apoptosis opposing signaling effects with a strong increase of phosphorylated akt and subsequent functional effects. |
2007-01-03 |
2023-08-12 |
mouse |
| Hidenori Endo, Chikako Nito, Hiroshi Kamada, Tatsuro Nishi, Pak H Cha. Activation of the Akt/GSK3beta signaling pathway mediates survival of vulnerable hippocampal neurons after transient global cerebral ischemia in rats. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 26. issue 12. 2006-12-28. PMID:16538228. |
the serine-threonine kinase, akt, functions in the pi3-k pathway and prevents apoptosis by phosphorylation at ser473 after a variety of cell death stimuli. |
2006-12-28 |
2023-08-12 |
rat |
| Andrew D Burdick, Irena D Ivnitski-Steele, Fredine T Lauer, Scott W Burchie. PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells. Carcinogenesis. vol 27. issue 11. 2006-12-26. PMID:16774943. |
in addition, we found that bpde increased p53 activity and apoptosis in mcf-10a; however, transient transfection of constitutively active akt attenuated both bpde-dependent apoptosis and p53 activity. |
2006-12-26 |
2023-08-12 |
human |
| Andrew D Burdick, Irena D Ivnitski-Steele, Fredine T Lauer, Scott W Burchie. PYK2 mediates anti-apoptotic AKT signaling in response to benzo[a]pyrene diol epoxide in mammary epithelial cells. Carcinogenesis. vol 27. issue 11. 2006-12-26. PMID:16774943. |
this work demonstrates a novel mechanism for akt activation by bpde that occurs through increased ca2+ concentration, and implicates ca2+, pyk2, egfr and akt as a potential pathway by which bpde can inhibit apoptosis and act as a promoter of carcinogenesis. |
2006-12-26 |
2023-08-12 |
human |
| Shi Jin, Ramesh M Ray, Leonard R Johnso. Rac1 mediates intestinal epithelial cell apoptosis via JNK. American journal of physiology. Gastrointestinal and liver physiology. vol 291. issue 6. 2006-12-26. PMID:16798728. |
inhibition of erk1/2 and akt activity by u-0126 and ly-294002, respectively, increased tnf-alpha-induced apoptosis. |
2006-12-26 |
2023-08-12 |
Not clear |
| Shi Jin, Ramesh M Ray, Leonard R Johnso. Rac1 mediates intestinal epithelial cell apoptosis via JNK. American journal of physiology. Gastrointestinal and liver physiology. vol 291. issue 6. 2006-12-26. PMID:16798728. |
however, inhibition of rac1 significantly decreased apoptosis in the presence of erk1/2 and akt inhibitors, similar to the effect observed with nsc-23766 alone in response to tnf-alpha. |
2006-12-26 |
2023-08-12 |
Not clear |
| Shi Jin, Ramesh M Ray, Leonard R Johnso. Rac1 mediates intestinal epithelial cell apoptosis via JNK. American journal of physiology. Gastrointestinal and liver physiology. vol 291. issue 6. 2006-12-26. PMID:16798728. |
thus, rac1 inhibition protects cells independently of erk1/2 and akt activation during tnf-alpha-induced apoptosis. |
2006-12-26 |
2023-08-12 |
Not clear |
| Esmond J Sanders, Eve Parker, Steve Harve. Retinal ganglion cell survival in development: mechanisms of retinal growth hormone action. Experimental eye research. vol 83. issue 5. 2006-12-22. PMID:16893540. |
this was substantiated using wortmannin, which, like gh antiserum, inhibited akt phosphorylation and initiated apoptosis. |
2006-12-22 |
2023-08-12 |
chicken |
| Yu-Qian Yan, Qin-Zhi Xu, Lin Wang, Jian-Li Sui, Bei Bai, Ping-Kun Zho. Vanillin derivative 6-bromine-5-hydroxy-4-methoxybenzaldehyde-elicited apoptosis and G2/M arrest of Jurkat cells proceeds concurrently with DNA-PKcs cleavage and Akt inactivation. International journal of oncology. vol 29. issue 5. 2006-12-22. PMID:17016648. |
vanillin derivative 6-bromine-5-hydroxy-4-methoxybenzaldehyde-elicited apoptosis and g2/m arrest of jurkat cells proceeds concurrently with dna-pkcs cleavage and akt inactivation. |
2006-12-22 |
2023-08-12 |
human |
| Yabing Chen, Jianmin Xu, Nirag Jhala, Pritish Pawar, Zeng B Zhu, Liping Ma, Chang-Hyun Byon, Jay M McDonal. Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein. The American journal of pathology. vol 169. issue 5. 2006-12-20. PMID:17071604. |
fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of akt signaling and flice-like inhibitory protein. |
2006-12-20 |
2023-08-12 |
mouse |
| Yabing Chen, Jianmin Xu, Nirag Jhala, Pritish Pawar, Zeng B Zhu, Liping Ma, Chang-Hyun Byon, Jay M McDonal. Fas-mediated apoptosis in cholangiocarcinoma cells is enhanced by 3,3'-diindolylmethane through inhibition of AKT signaling and FLICE-like inhibitory protein. The American journal of pathology. vol 169. issue 5. 2006-12-20. PMID:17071604. |
by contrast, adenovirus-mediated constitutively activated akt protected cholangiocarcinoma cells from fas-mediated apoptosis. |
2006-12-20 |
2023-08-12 |
mouse |
| Yang Yang, Takayuki Ikezoe, Chie Nishioka, Takahiro Taguchi, Wei-Guo Zhu, H Phillip Koeffler, Hirokuni Taguch. ZD6474 induces growth arrest and apoptosis of GIST-T1 cells, which is enhanced by concomitant use of sunitinib. Cancer science. vol 97. issue 12. 2006-12-19. PMID:16995874. |
zd6474 induced growth arrest and apoptosis of gist-t1 cells in association with blockade of c-kit and its downstream effectors, including akt and extracellular signal-regulated kinase (erk). |
2006-12-19 |
2023-08-12 |
Not clear |
| Yon Jung Park, Jing Wen, Seungmin Bang, Seung Woo Park, Si Young Son. [6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. Yonsei medical journal. vol 47. issue 5. 2006-12-15. PMID:17066513. |
[6]-gingerol induced mostly apoptotic death in the mutant p53-expressing cells, while no signs of early apoptosis were detected in wild type p53-expressing cells and this was related to the increased phosphorylation of akt. |
2006-12-15 |
2023-08-12 |
human |
| Hongmei Wang, Jin-Yi Jiang, Cheng Zhu, Chun Peng, Benjamin K Tsan. Role and regulation of nodal/activin receptor-like kinase 7 signaling pathway in the control of ovarian follicular atresia. Molecular endocrinology (Baltimore, Md.). vol 20. issue 10. 2006-12-13. PMID:16709598. |
furthermore, alk7-ca-induced apoptosis was significantly attenuated by forced expression of activated akt, and akt rescued granulosa cells from undergoing apoptosis via proteasome-mediated alk7 degradation. |
2006-12-13 |
2023-08-12 |
Not clear |