| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yue-Feng Chen, Satoru Kobayashi, Jinghai Chen, Rebecca A Redetzke, Suleman Said, Qiangrong Liang, A Martin Gerde. Short term triiodo-L-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. Journal of molecular and cellular cardiology. vol 44. issue 1. 2008-03-06. PMID:17964598. |
we have previously shown that th can prevent myocyte apoptosis via akt signaling in cultured neonatal rat cardiomyocytes. |
2008-03-06 |
2023-08-12 |
rat |
| Yue-Feng Chen, Satoru Kobayashi, Jinghai Chen, Rebecca A Redetzke, Suleman Said, Qiangrong Liang, A Martin Gerde. Short term triiodo-L-thyronine treatment inhibits cardiac myocyte apoptosis in border area after myocardial infarction in rats. Journal of molecular and cellular cardiology. vol 44. issue 1. 2008-03-06. PMID:17964598. |
these results suggest that t3 can protect myocytes against ischemia-induced apoptosis, which may be mediated by akt signaling. |
2008-03-06 |
2023-08-12 |
rat |
| Maria V Guijarro, Wolfgang Link, Aránzazu Rosado, Juan F M Leal, Amancio Carner. MAP17 inhibits Myc-induced apoptosis through PI3K/AKT pathway activation. Carcinogenesis. vol 28. issue 12. 2008-03-04. PMID:17675338. |
importantly, modulation of ros by antioxidant treatment prevented activation of akt, restoring the level of apoptosis in serum-starved rat1/c-myc fibroblasts. |
2008-03-04 |
2023-08-12 |
human |
| Maria V Guijarro, Wolfgang Link, Aránzazu Rosado, Juan F M Leal, Amancio Carner. MAP17 inhibits Myc-induced apoptosis through PI3K/AKT pathway activation. Carcinogenesis. vol 28. issue 12. 2008-03-04. PMID:17675338. |
our data indicate that map17 protein activates akt through ros and this is determinant to confer resistance to myc-induced apoptosis in the absence of serum. |
2008-03-04 |
2023-08-12 |
human |
| Holly E Hollingshead, Renee L Killins, Michael G Borland, Elizabeth E Girroir, Andrew N Billin, Timothy M Willson, Arun K Sharma, Shantu Amin, Frank J Gonzalez, Jeffrey M Peter. Peroxisome proliferator-activated receptor-beta/delta (PPARbeta/delta) ligands do not potentiate growth of human cancer cell lines. Carcinogenesis. vol 28. issue 12. 2008-03-04. PMID:17693664. |
contradictory findings are also reported suggesting that pparbeta/delta ligands potentiate tumorigenesis by increasing cell proliferation, by inhibiting apoptosis through phosphorylation of akt and by increasing cyclooxygenase-2 (cox2) and vascular endothelial growth factor (vegf) expression. |
2008-03-04 |
2023-08-12 |
mouse |
| S-G Lee, Z-Z Su, L Emdad, D Sarkar, T F Franke, P B Fishe. Astrocyte elevated gene-1 activates cell survival pathways through PI3K-Akt signaling. Oncogene. vol 27. issue 8. 2008-03-03. PMID:17704808. |
aeg-1 also affected the phosphorylation state of akt substrates that are implicated in apoptosis suppression, including glycogen synthase kinase 3beta, c-myc, murine double minute 2, p53, p21/mda-6 and bad. |
2008-03-03 |
2023-08-12 |
Not clear |
| Sandra Koseoglu, Zhuomei Lu, Chandra Kumar, Paul Kirschmeier, Jun Zo. AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines. Cancer biology & therapy. vol 6. issue 5. 2008-02-28. PMID:17426444. |
knockdown of akt resulted in apoptosis in six out of 11 tumor cells with activated akt. |
2008-02-28 |
2023-08-12 |
human |
| Sandra Koseoglu, Zhuomei Lu, Chandra Kumar, Paul Kirschmeier, Jun Zo. AKT1, AKT2 and AKT3-dependent cell survival is cell line-specific and knockdown of all three isoforms selectively induces apoptosis in 20 human tumor cell lines. Cancer biology & therapy. vol 6. issue 5. 2008-02-28. PMID:17426444. |
in contrast, knockdown of akt induced apoptosis in three out of nine cell lines with a low level of active akt. |
2008-02-28 |
2023-08-12 |
human |
| E Ogawa, R Okuyama, S Ikawa, H Nagoshi, T Egawa, A Kurihara, M Yabuki, H Tagami, M Obinata, S Aib. p51/p63 Inhibits ultraviolet B-induced apoptosis via Akt activation. Oncogene. vol 27. issue 6. 2008-02-28. PMID:17653081. |
p51/p63 inhibits ultraviolet b-induced apoptosis via akt activation. |
2008-02-28 |
2023-08-12 |
Not clear |
| E Ogawa, R Okuyama, S Ikawa, H Nagoshi, T Egawa, A Kurihara, M Yabuki, H Tagami, M Obinata, S Aib. p51/p63 Inhibits ultraviolet B-induced apoptosis via Akt activation. Oncogene. vol 27. issue 6. 2008-02-28. PMID:17653081. |
the blockade of keratinocyte apoptosis by the p51 was dependent on the phosphorylation of akt, resulting in the activation of a survival pathway. |
2008-02-28 |
2023-08-12 |
Not clear |
| Florence Lefranc, Vincenzo Facchini, Robert Kis. Proautophagic drugs: a novel means to combat apoptosis-resistant cancers, with a special emphasis on glioblastomas. The oncologist. vol 12. issue 12. 2008-02-28. PMID:18165616. |
a number of potential common targets in autophagy and apoptosis resistance pathways, that is, mammalian target of rapamycin (mtor), phosphatidylinositol 3' kinase (pi3k), and akt have been identified. |
2008-02-28 |
2023-08-12 |
Not clear |
| Xavier Leleu, Xiaoying Jia, Judith Runnels, Hai T Ngo, Anne-Sophie Moreau, Mena Farag, Joel A Spencer, Costas M Pitsillides, Evdoxia Hatjiharissi, Aldo Roccaro, Garrett O'Sullivan, Douglas W McMillin, Daisy Moreno, Tanyel Kiziltepe, Ruben Carrasco, Steven P Treon, Teru Hideshima, Kenneth C Anderson, Charles P Lin, Irene M Ghobria. The Akt pathway regulates survival and homing in Waldenstrom macroglobulinemia. Blood. vol 110. issue 13. 2008-02-26. PMID:17761832. |
we demonstrate up-regulated akt activity in wm, and that akt down-regulation by akt knockdown and the inhibitor perifosine leads to significant inhibition of proliferation and induction of apoptosis in wm cells in vitro, but not in normal donor peripheral blood and hematopoietic progenitors. |
2008-02-26 |
2023-08-12 |
Not clear |
| Jonathan E McDunn, Jared T Muenzer, Latif Rachdi, Katherine C Chang, Chris G Davis, W Michael Dunne, David Piwnica-Worms, Ernesto Bernal-Mizrachi, Richard S Hotchkis. Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 2. 2008-02-25. PMID:17855622. |
peptide-mediated activation of akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis. |
2008-02-25 |
2023-08-12 |
Not clear |
| Jee-Yin Ahn, Keqiang Y. PIKE GTPase signaling and function. International journal of biological sciences. vol 1. issue 2. 2008-02-22. PMID:15951849. |
instead, pike-a specifically binds to active akt and upregulates its activity in a gtp-dependent manner, mediating human cancer cell invasion and preventing apoptosis. |
2008-02-22 |
2023-08-12 |
human |
| Soo-Jin Jeong, Arindam Dasgupta, Kyung-Jin Jung, Jee-Hyun Um, Aileen Burke, Hyeon Ung Park, John N Brad. PI3K/AKT inhibition induces caspase-dependent apoptosis in HTLV-1-transformed cells. Virology. vol 370. issue 2. 2008-02-20. PMID:17931677. |
in conclusion, the akt pathway is involved in targeting multiple proteins which regulate caspase- and p53-dependent apoptosis in htlv-1-transformed cells. |
2008-02-20 |
2023-08-12 |
Not clear |
| Zainab Jagani, Amrik Singh, Roya Khosravi-Fa. FoxO tumor suppressors and BCR-ABL-induced leukemia: a matter of evasion of apoptosis. Biochimica et biophysica acta. vol 1785. issue 1. 2008-02-15. PMID:17980712. |
as substrates of survival kinases such as akt, the foxo family of transcription factors, particularly foxo3a, has emerged as playing an important role in the cell cycle arrest and apoptosis of hematopoietic cells. |
2008-02-15 |
2023-08-12 |
Not clear |
| Jui-I Chao, Wen-Chi Su, Huei-Fang Li. Baicalein induces cancer cell death and proliferation retardation by the inhibition of CDC2 kinase and survivin associated with opposite role of p38 mitogen-activated protein kinase and AKT. Molecular cancer therapeutics. vol 6. issue 11. 2008-02-15. PMID:18025287. |
as a whole, these findings provide that the opposite role of p38 mapk and akt regulates cdc2 kinase and survivin and the inhibition of cdc2-survivin pathway by baicalein contributes to apoptosis and proliferation retardation in cancer cells. |
2008-02-15 |
2023-08-12 |
human |
| Jee Eun Yeo, Soo Kyung Kan. Selenium effectively inhibits ROS-mediated apoptotic neural precursor cell death in vitro and in vivo in traumatic brain injury. Biochimica et biophysica acta. vol 1772. issue 11-12. 2008-02-14. PMID:17997286. |
analysis of key apoptotic regulators during h(2)o(2)-induced apoptosis of npcs showed that selenite blocks the activation of c-jun n-terminal protein kinase (jnk)/p38 mitogen-activated protein kinase (mapk), and akt survival protein. |
2008-02-14 |
2023-08-12 |
mouse |
| Song Mao, Yoonsuk Park, Yoshiaki Hasegawa, Gena D Tribble, Chlöe E James, Martin Handfield, M Franci Stavropoulos, Ozlem Yilmaz, Richard J Lamon. Intrinsic apoptotic pathways of gingival epithelial cells modulated by Porphyromonas gingivalis. Cellular microbiology. vol 9. issue 8. 2008-02-12. PMID:17419719. |
sirna knockdown of jak1, in combination with knockdown of akt, abrogated the ability of p. gingivalis to block apoptosis. |
2008-02-12 |
2023-08-12 |
Not clear |
| Jungeun Park, Hyejin Kwon, Yup Kang, Youngsoo Ki. Proteomic analysis of O-GlcNAc modifications derived from streptozotocin and glucosamine induced beta-cell apoptosis. Journal of biochemistry and molecular biology. vol 40. issue 6. 2008-02-12. PMID:18047804. |
this observed beta cell dysfunction prompted us to examine akt and bcl-2 family member proteins to determine which proteins are o-glcnacylated under conditions of high hbp throughput, and how these proteins are associated with beta cell apoptosis. |
2008-02-12 |
2023-08-12 |
Not clear |