| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Moonkyoung Um, Harvey F Lodis. Antiapoptotic effects of erythropoietin in differentiated neuroblastoma SH-SY5Y cells require activation of both the STAT5 and AKT signaling pathways. The Journal of biological chemistry. vol 281. issue 9. 2006-05-23. PMID:16407271. |
most interestingly, prl treatment does not prevent apoptosis in cells expressing mutant prlr/epor chimeras in which either the stat5 or the akt signaling pathways are not activated. |
2006-05-23 |
2023-08-12 |
human |
| Ferry Sandra, Laifa Hendarmin, Yu Nakao, Norifumi Nakamura, Seiji Nakamur. Inhibition of Akt and MAPK pathways elevated potential of TNFalpha in inducing apoptosis in ameloblastoma. Oral oncology. vol 42. issue 1. 2006-05-22. PMID:16140562. |
inhibition of akt and mapk pathways elevated potential of tnfalpha in inducing apoptosis in ameloblastoma. |
2006-05-22 |
2023-08-12 |
Not clear |
| Ferry Sandra, Laifa Hendarmin, Yu Nakao, Norifumi Nakamura, Seiji Nakamur. Inhibition of Akt and MAPK pathways elevated potential of TNFalpha in inducing apoptosis in ameloblastoma. Oral oncology. vol 42. issue 1. 2006-05-22. PMID:16140562. |
these results suggested that tnfalpha induced both cell survival and apoptosis pathways in ameloblastoma and potential of tnfalpha in inducing apoptosis can be improved by inhibiting tnfalpha-induced akt and p44/42 mitogen-activated protein kinase (mapk) cell survival pathways. |
2006-05-22 |
2023-08-12 |
Not clear |
| Narasimman Gurusamy, Kenichi Watanabe, Meilei Ma, Paras Prakash, Kenichi Hirabayashi, Shaosong Zhang, Anthony J Muslin, Makoto Kodama, Yoshifusa Aizaw. Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol. FEBS letters. vol 580. issue 8. 2006-05-04. PMID:16530186. |
we found that gsk3beta became more active (less phosphorylated at serine 9) via decreased akt phosphorylation, in parallel to c-jun nh2 terminal kinase activation, which correlated with increased activated caspase 3 and myocardial apoptosis 3 days after streptozotocin (stz) injection in mice. |
2006-05-04 |
2023-08-12 |
mouse |
| Payaningal R Somanath, Olga V Razorenova, Juhua Chen, Tatiana V Byzov. Akt1 in endothelial cell and angiogenesis. Cell cycle (Georgetown, Tex.). vol 5. issue 5. 2006-05-04. PMID:16552185. |
akt, also known as protein kinase b (pkb), regulates essential cellular functions such as migration, proliferation, differentiation, apoptosis, and metabolism. |
2006-05-04 |
2023-08-12 |
Not clear |
| Feng Ming Ho, Wan Wan Lin, Bing Chang Chen, Chien M Chao, Chia-Ron Yang, Lian Y Lin, Chih Chang Lai, Shing H Liu, Chiau S Lia. High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway. Cellular signalling. vol 18. issue 3. 2006-05-03. PMID:15970429. |
in this study we further elucidated the roles of the transcriptional factor nf-kappab, phosphatidylinositol 3'-kinase (pi3k), akt and endothelial nitric oxide synthase (enos) in the apoptosis of huvecs induced by high glucose. |
2006-05-03 |
2023-08-12 |
human |
| Feng Ming Ho, Wan Wan Lin, Bing Chang Chen, Chien M Chao, Chia-Ron Yang, Lian Y Lin, Chih Chang Lai, Shing H Liu, Chiau S Lia. High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway. Cellular signalling. vol 18. issue 3. 2006-05-03. PMID:15970429. |
in contrast, apoptosis was markedly reduced by nf-kappab inhibitor (pyrrolidine dithiocarbamate, pdtc), nf-kappab antisense oligonucleotide, no donor (sodium nitroprusside, snp), and overexpression of akt. |
2006-05-03 |
2023-08-12 |
human |
| Feng Ming Ho, Wan Wan Lin, Bing Chang Chen, Chien M Chao, Chia-Ron Yang, Lian Y Lin, Chih Chang Lai, Shing H Liu, Chiau S Lia. High glucose-induced apoptosis in human vascular endothelial cells is mediated through NF-kappaB and c-Jun NH2-terminal kinase pathway and prevented by PI3K/Akt/eNOS pathway. Cellular signalling. vol 18. issue 3. 2006-05-03. PMID:15970429. |
taken together our results demonstrated that high glucose-induced huvecs apoptosis is through nf-kappab-dependent jnk activation and reactive oxygen species (ros)-dependent akt dephosphorylation. |
2006-05-03 |
2023-08-12 |
human |
| Yingyu Zhang, Jing Zhang, George P Studzinsk. AKT pathway is activated by 1, 25-dihydroxyvitamin D3 and participates in its anti-apoptotic effect and cell cycle control in differentiating HL60 cells. Cell cycle (Georgetown, Tex.). vol 5. issue 4. 2006-05-01. PMID:16479173. |
treatment of hl60 cells with pi3k inhibitors ly294002 and wortmannin, which decrease the activity of the akt pathway, induced apoptosis, but this effect was reduced in cells simultaneously treated with 1,25d. |
2006-05-01 |
2023-08-12 |
human |
| Catherine Jomary, Jason Cullen, Stephen E Jone. Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. Investigative ophthalmology & visual science. vol 47. issue 4. 2006-04-27. PMID:16565401. |
inactivation of the akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. |
2006-04-27 |
2023-08-12 |
mouse |
| Catherine Jomary, Jason Cullen, Stephen E Jone. Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. Investigative ophthalmology & visual science. vol 47. issue 4. 2006-04-27. PMID:16565401. |
previous work has indicated that the serine-threonine protein kinase akt is a general mediator of cellular survival signals and that loss of akt-mediated signaling can lead to the activation of apoptosis. |
2006-04-27 |
2023-08-12 |
mouse |
| Catherine Jomary, Jason Cullen, Stephen E Jone. Inactivation of the Akt survival pathway during photoreceptor apoptosis in the retinal degeneration mouse. Investigative ophthalmology & visual science. vol 47. issue 4. 2006-04-27. PMID:16565401. |
this study was conducted to establish whether regulation of the akt survival pathway mechanisms is implicated in the induction of apoptosis during photoreceptor cell death in the rd mouse model of retinal degeneration. |
2006-04-27 |
2023-08-12 |
mouse |
| Ulrich Maurer, Céline Charvet, Allan S Wagman, Emmanuel Dejardin, Douglas R Gree. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Molecular cell. vol 21. issue 6. 2006-04-26. PMID:16543145. |
we investigated the role of glycogen synthase kinase-3 (gsk-3), which is inactivated by akt, for its role in the regulation of apoptosis. |
2006-04-26 |
2023-08-12 |
Not clear |
| Ulrich Maurer, Céline Charvet, Allan S Wagman, Emmanuel Dejardin, Douglas R Gree. Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Molecular cell. vol 21. issue 6. 2006-04-26. PMID:16543145. |
the results demonstrate that the control of mcl-1 stability by gsk-3 is an important mechanism for the regulation of apoptosis by growth factors, pi3k, and akt. |
2006-04-26 |
2023-08-12 |
Not clear |
| Changlian Zhu, Xiaoyang Wang, Falin Xu, Lin Qiu, Xiuyong Cheng, George Simbruner, Klas Blomgre. Intraischemic mild hypothermia prevents neuronal cell death and tissue loss after neonatal cerebral hypoxia-ischemia. The European journal of neuroscience. vol 23. issue 2. 2006-04-25. PMID:16420446. |
these results indicate that intraischemic hypothermia diminished apoptosis through inhibition of both caspase-dependent and caspase-independent neuronal cell death pathways and promoted cell survival by inhibition of phosphorylated akt dephosphorylation in the neonatal brain, thereby preventing neuronal cell death. |
2006-04-25 |
2023-08-12 |
mouse |
| Hanqin Lei, Patrick J Furlong, Jin Hee Ra, Daniel Mullins, Robert Cantor, Douglas L Fraker, Francis R Spit. AKT activation and response to interferon-beta in human cancer cells. Cancer biology & therapy. vol 4. issue 7. 2006-04-20. PMID:15970687. |
the results demonstrate a correlation between akt activity, phosphorylation of bad and resistance to interferon-induced apoptosis in these cells. |
2006-04-20 |
2023-08-12 |
human |
| Hanqin Lei, Patrick J Furlong, Jin Hee Ra, Daniel Mullins, Robert Cantor, Douglas L Fraker, Francis R Spit. AKT activation and response to interferon-beta in human cancer cells. Cancer biology & therapy. vol 4. issue 7. 2006-04-20. PMID:15970687. |
the association of activation of akt, phosphorylation of bad and resistance to ifn-beta-induced apoptosis was further supported by the observation that disruption of the pathway in a more resistant cell line led to sensitization, and expression of an activated akt in a more sensitive cell line led to increased resistance. |
2006-04-20 |
2023-08-12 |
human |
| M Guzmá. Effects on cell viability. Handbook of experimental pharmacology. issue 168. 2006-04-19. PMID:16596790. |
the best-characterised example is cannabinoid-induced apoptosis of glioma cells, which occurs via sustained ceramide accumulation, extracellular signal-regulated kinase activation and akt inhibition. |
2006-04-19 |
2023-08-12 |
Not clear |
| Lin Hao Li, Li Jun Wu, Shin Ichi Tashiro, Satoshi Onodera, Fumiaki Uchiumi, Takashi Ikejim. The roles of Akt and MAPK family members in silymarin's protection against UV-induced A375-S2 cell apoptosis. International immunopharmacology. vol 6. issue 2. 2006-04-17. PMID:16399623. |
the roles of akt and mapk family members in silymarin's protection against uv-induced a375-s2 cell apoptosis. |
2006-04-17 |
2023-08-12 |
human |
| Lin Hao Li, Li Jun Wu, Shin Ichi Tashiro, Satoshi Onodera, Fumiaki Uchiumi, Takashi Ikejim. The roles of Akt and MAPK family members in silymarin's protection against UV-induced A375-S2 cell apoptosis. International immunopharmacology. vol 6. issue 2. 2006-04-17. PMID:16399623. |
consequently, silymarin partially reduced uv-induced apoptosis by activating the akt pathway, and silymarin's protective effect was also exerted by mapk family members. |
2006-04-17 |
2023-08-12 |
human |