| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clare C Davies, Danai Bem, Lawrence S Young, Aristides G Eliopoulo. NF-kappaB overrides the apoptotic program of TNF receptor 1 but not CD40 in carcinoma cells. Cellular signalling. vol 17. issue 6. 2005-06-20. PMID:15722197. |
similarly, whilst suppression of akt expression by rna interference sensitised tumour cells to cd40l-induced apoptosis, it had no effect on cd40-mediated ikappabalpha degradation. |
2005-06-20 |
2023-08-12 |
Not clear |
| Gwénola Boulday, Juliette Fitau, Stéphanie Coupel, Jean-Paul Soulillou, Béatrice Charrea. Exogenous tissue inhibitor of metalloproteinase-1 promotes endothelial cell survival through activation of the phosphatidylinositol 3-kinase/Akt pathway. Annals of the New York Academy of Sciences. vol 1030. 2005-06-16. PMID:15659777. |
in conclusion, our findings suggest that timp-1, generated upon inflammation, acts as an antiapoptotic molecule that can prevent ec apoptosis through activation of the pi3-kinase and phosphorylation of the akt kinase. |
2005-06-16 |
2023-08-12 |
human |
| M Mandal, S Kim, M N Younes, S A Jasser, A K El-Naggar, G B Mills, J N Myer. The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. British journal of cancer. vol 92. issue 10. 2005-06-16. PMID:15870708. |
the akt inhibitor kp372-1 suppresses akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. |
2005-06-16 |
2023-08-12 |
human |
| M Mandal, S Kim, M N Younes, S A Jasser, A K El-Naggar, G B Mills, J N Myer. The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. British journal of cancer. vol 92. issue 10. 2005-06-16. PMID:15870708. |
we demonstrated that akt is highly phosphorylated in thyroid cancer cell lines and human thyroid cancer specimens, and hypothesised that kp372-1, an akt inhibitor, would block signalling through the pi3k pathway and inhibit cell proliferation while inducing apoptosis of thyroid cancer cells. |
2005-06-16 |
2023-08-12 |
human |
| M Mandal, S Kim, M N Younes, S A Jasser, A K El-Naggar, G B Mills, J N Myer. The Akt inhibitor KP372-1 suppresses Akt activity and cell proliferation and induces apoptosis in thyroid cancer cells. British journal of cancer. vol 92. issue 10. 2005-06-16. PMID:15870708. |
kp372-1 blocked signalling downstream of akt in thyroid tumour cells, leading to inhibition of cell proliferation and increased apoptosis. |
2005-06-16 |
2023-08-12 |
human |
| Yasuhiro Nakagam. Inhibitors beta-amyloid-induced toxicity by modulating the Akt signaling pathway. Drug news & perspectives. vol 17. issue 10. 2005-06-14. PMID:15696230. |
the akt signaling pathway plays a crucial role in neuronal survival, leading to inhibition of apoptosis. |
2005-06-14 |
2023-08-12 |
Not clear |
| Yasuhiro Nakagam. Inhibitors beta-amyloid-induced toxicity by modulating the Akt signaling pathway. Drug news & perspectives. vol 17. issue 10. 2005-06-14. PMID:15696230. |
recent studies suggest that activation of akt inhibits toxicity of beta-amyloid and formation of neurofibrillary tangles, leading to protection of neurons against apoptosis. |
2005-06-14 |
2023-08-12 |
Not clear |
| Amelia Sánchez-Capel. Dual role for TGF-beta1 in apoptosis. Cytokine & growth factor reviews. vol 16. issue 1. 2005-06-10. PMID:15733830. |
nevertheless, tgf-beta1 signaling can also cooperate with the death receptor apoptotic pathway (fas, tnf), with the intracellular modulators of apoptosis jnk and p38 map kinases, akt, nf-kappab, and with the mitochondrial apoptotic pathway mediated by members of the bcl-2 family. |
2005-06-10 |
2023-08-12 |
Not clear |
| Ning Gao, Mohamed Rahmani, Paul Dent, Steven Gran. 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process. Oncogene. vol 24. issue 23. 2005-06-09. PMID:15782127. |
2me induced apoptosis in these cells in a dose-dependent manner associated with release of mitochondrial proteins (cytochrome c, aif), generation of reactive oxygen species (ros), downregulation of mcl-1 and xiap, and inactivation (dephosphorylation) of akt accompanied by activation of jnk. |
2005-06-09 |
2023-08-12 |
human |
| Ning Gao, Mohamed Rahmani, Paul Dent, Steven Gran. 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process. Oncogene. vol 24. issue 23. 2005-06-09. PMID:15782127. |
in these cells, enforced activation of akt by a constitutively active myristolated akt construct prevented 2me-mediated mitochondrial injury, xiap and mcl-1 downregulation, jnk activation, and apoptosis, but not ros generation. |
2005-06-09 |
2023-08-12 |
human |
| Ning Gao, Mohamed Rahmani, Paul Dent, Steven Gran. 2-Methoxyestradiol-induced apoptosis in human leukemia cells proceeds through a reactive oxygen species and Akt-dependent process. Oncogene. vol 24. issue 23. 2005-06-09. PMID:15782127. |
collectively, these findings suggest a hierarchical model of 2me-related apoptosis induction in human leukemia cells in which 2me-induced oxidative injury represents a primary event resulting in akt inactivation, leading, in turn, to jnk activation, and culminating in xiap and mcl-1 downregulation, mitochondrial injury, and apoptosis. |
2005-06-09 |
2023-08-12 |
human |
| Craig W Lindsley, Zhijian Zhao, William H Leister, Ronald G Robinson, Stanley F Barnett, Deborah Defeo-Jones, Raymond E Jones, George D Hartman, Joel R Huff, Hans E Huber, Mark E Dugga. Allosteric Akt (PKB) inhibitors: discovery and SAR of isozyme selective inhibitors. Bioorganic & medicinal chemistry letters. vol 15. issue 3. 2005-06-07. PMID:15664853. |
an iterative analog library synthesis approach quickly provided a highly selective akt1/akt2 inhibitor that induces apoptosis in tumor cells and inhibits akt phosphorylation in vivo. |
2005-06-07 |
2023-08-12 |
Not clear |
| V K Puduvalli, D Sampath, J M Bruner, J Nangia, R Xu, A P Kyritsi. TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation. Apoptosis : an international journal on programmed cell death. vol 10. issue 1. 2005-06-06. PMID:15711939. |
because the pro-survival pi3k/akt pathway is highly relevant to gliomas, we assessed whether akt could protect against trail-induced apoptosis. |
2005-06-06 |
2023-08-12 |
Not clear |
| V K Puduvalli, D Sampath, J M Bruner, J Nangia, R Xu, A P Kyritsi. TRAIL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation. Apoptosis : an international journal on programmed cell death. vol 10. issue 1. 2005-06-06. PMID:15711939. |
pretreatment with sh-6, a novel akt inhibitor, enhanced trail-induced apoptosis, suggesting a protective role for akt. |
2005-06-06 |
2023-08-12 |
Not clear |
| Javier A Menendez, Luciano Vellon, Ramon Colomer, Ruth Lup. Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity. International journal of cancer. vol 115. issue 1. 2005-05-31. PMID:15657900. |
we suggest that the alternate activation of both the pro-apoptotic p38 mapk-p53 signaling and the cytoprotective mek1/2 --> erk1/2 cascade, as well as the inactivation of the anti-apoptotic akt activity may explain, at least in part, the sequence-dependent enhancement of taxol-induced cytotoxicity and apoptosis that follows inhibition of fas activity in breast cancer cells. |
2005-05-31 |
2023-08-12 |
human |
| Jiazhi Sun, Michelle A Blaskovich, Richard Jove, Sandra K Livingston, Domenico Coppola, Saïd M Sebt. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. vol 24. issue 20. 2005-05-31. PMID:15735720. |
cuc q inhibits selectively the activation of stat3 and induces apoptosis without inhibition of jak2, src, akt, erk, or jnk activation. |
2005-05-31 |
2023-08-12 |
mouse |
| Juliet M Taylor, Ugur Ali, Rocco C Iannello, Paul Hertzog, Peter J Crac. Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death. Journal of neurochemistry. vol 92. issue 2. 2005-05-26. PMID:15663476. |
our results suggest that the increased susceptibility of gpx1-/- neurons to h2o2-induced apoptosis and neuronal cell death in vivo following cerebral ischaemia-reperfusion injury can be attributed in part to diminished activation of akt. |
2005-05-26 |
2023-08-12 |
mouse |
| Philip R Dash, Guy St J Whitley, Laura-Jo Ayling, Alan P Johnstone, Judith E Cartwrigh. Trophoblast apoptosis is inhibited by hepatocyte growth factor through the Akt and beta-catenin mediated up-regulation of inducible nitric oxide synthase. Cellular signalling. vol 17. issue 5. 2005-05-26. PMID:15683732. |
trophoblast apoptosis is inhibited by hepatocyte growth factor through the akt and beta-catenin mediated up-regulation of inducible nitric oxide synthase. |
2005-05-26 |
2023-08-12 |
Not clear |
| Philip R Dash, Guy St J Whitley, Laura-Jo Ayling, Alan P Johnstone, Judith E Cartwrigh. Trophoblast apoptosis is inhibited by hepatocyte growth factor through the Akt and beta-catenin mediated up-regulation of inducible nitric oxide synthase. Cellular signalling. vol 17. issue 5. 2005-05-26. PMID:15683732. |
we suggest that the akt mediated activation of beta-catenin leads to inhibition of trophoblast apoptosis following increased expression of inos. |
2005-05-26 |
2023-08-12 |
Not clear |
| V L Grandage, R E Gale, D C Linch, A Khwaj. PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. Leukemia. vol 19. issue 4. 2005-05-26. PMID:15703783. |
this is associated with a synergistic interaction between ly294002 and ara-c. an inducible activated form of akt protects normal myeloid cells from ara-c and etoposide-mediated apoptosis. |
2005-05-26 |
2023-08-12 |
Not clear |