| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Leigh A Knodler, B Brett Finlay, Olivia Steele-Mortime. The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt. The Journal of biological chemistry. vol 280. issue 10. 2005-04-19. PMID:15642738. |
failure to activate akt resulted in increased levels of apoptosis after infection with a sopb deletion mutant (deltasopb). |
2005-04-19 |
2023-08-12 |
Not clear |
| Leigh A Knodler, B Brett Finlay, Olivia Steele-Mortime. The Salmonella effector protein SopB protects epithelial cells from apoptosis by sustained activation of Akt. The Journal of biological chemistry. vol 280. issue 10. 2005-04-19. PMID:15642738. |
finally, small interfering rna was used to demonstrate the essential role of akt in sopb-mediated protection against apoptosis. |
2005-04-19 |
2023-08-12 |
Not clear |
| Maria R Zocchi, A Pogg. PECAM-1, apoptosis and CD34+ precursors. Leukemia & lymphoma. vol 45. issue 11. 2005-04-18. PMID:15512808. |
in particular, it has been shown that pecam-1 binds to different kinases and phosphatases, including the phosphatidylinositide-3-kinase that phosphorylates akt, which, in turn can upregulate transcription and function of antiapoptotic proteins, such as bcl-2 and bcl-x or a1, responsible for the rescue from mitochondrial apoptosis. |
2005-04-18 |
2023-08-12 |
Not clear |
| Adrian M Senderowic. Targeting cell cycle and apoptosis for the treatment of human malignancies. Current opinion in cell biology. vol 16. issue 6. 2005-04-18. PMID:15530779. |
several proteins relevant to oncogenic and proliferative processes, such as p53, bcl-2, akt, ras and epidermal growth factor receptor, are also important in blocking apoptosis. |
2005-04-18 |
2023-08-12 |
human |
| Diviya Sinha, Zhiyong Wang, Kathleen L Ruchalski, Jerrold S Levine, Selvi Krishnan, Wilfred Lieberthal, John H Schwartz, Steven C Borka. Lithium activates the Wnt and phosphatidylinositol 3-kinase Akt signaling pathways to promote cell survival in the absence of soluble survival factors. American journal of physiology. Renal physiology. vol 288. issue 4. 2005-04-18. PMID:15572521. |
in addition, li(+) or bio significantly increases the phosphorylation (activation) of akt, an anti-apoptotic protein, and inhibits apoptosis (decreases both annexin-v staining and caspase-3 activation), during serum deprivation. |
2005-04-18 |
2023-08-12 |
mouse |
| Akiko Inoue, Shikibu Muranaka, Hirofumi Fujita, Tomoko Kanno, Hiroshi Tamai, Kozo Utsum. Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway. Free radical biology & medicine. vol 37. issue 8. 2005-04-15. PMID:15451068. |
molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, akt, bid, cytochrome and caspase pathway. |
2005-04-15 |
2023-08-12 |
human |
| Akiko Inoue, Shikibu Muranaka, Hirofumi Fujita, Tomoko Kanno, Hiroshi Tamai, Kozo Utsum. Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway. Free radical biology & medicine. vol 37. issue 8. 2005-04-15. PMID:15451068. |
we report that diclofenac, a nsaid, induces growth inhibition and apoptosis of hl-60 cells through modulation of mitochondrial functions regulated by reactive oxygen species (ros), akt, caspase-8, and bid. |
2005-04-15 |
2023-08-12 |
human |
| Akiko Inoue, Shikibu Muranaka, Hirofumi Fujita, Tomoko Kanno, Hiroshi Tamai, Kozo Utsum. Molecular mechanism of diclofenac-induced apoptosis of promyelocytic leukemia: dependency on reactive oxygen species, Akt, Bid, cytochrome and caspase pathway. Free radical biology & medicine. vol 37. issue 8. 2005-04-15. PMID:15451068. |
these results suggest the sequential mechanism of diclofenac-induced apoptosis of hl-60 cells: ros generation suppresses akt activity, thereby activating caspase-8, which stimulates bid cleavage and induces cytochrome c release and the activation of caspase-9 and-3 in a csa-insensitive mechanism. |
2005-04-15 |
2023-08-12 |
human |
| Maria C Jacques-Silva, Richard Rodnight, Guido Lenz, Zhongji Liao, Qiongman Kong, Minh Tran, Yuan Kang, Fernando A Gonzalez, Gary A Weisman, Joseph T Near. P2X7 receptors stimulate AKT phosphorylation in astrocytes. British journal of pharmacology. vol 141. issue 7. 2005-04-14. PMID:15023862. |
thus, signaling by nucleotide receptors in astrocytes may be important in several cellular downstream effects related to the akt pathway, such as cell cycle and apoptosis regulation, protein synthesis, differentiation and glucose metabolism. |
2005-04-14 |
2023-08-12 |
rat |
| Laurenz Vormittag, Wolfgang Lamm, Boban M Erovic, Cornelia Czembirek, Gabriela Kornek, Dietmar Thurnhe. Expression levels of Akt in nimesulide-treated squamous carcinoma cell lines of the head and neck. Oncology reports. vol 13. issue 2. 2005-04-13. PMID:15643499. |
in both cell lines, nimesulide treatment induced apoptosis and resulted in a decrease of akt expression. |
2005-04-13 |
2023-08-12 |
Not clear |
| Amy Meyer, Cynthia M van Golen, Madanamohan Boyanapalli, Bhumsoo Kim, Mary E Soules, Eva L Feldma. Integrin-linked kinase complexes with caveolin-1 in human neuroblastoma cells. Biochemistry. vol 44. issue 3. 2005-04-12. PMID:15654749. |
overexpression of ilk leads to altered expression of cell cycle regulators, a decreased level of cell adhesion to the extracellular matrix, a decreased level of apoptosis, in vitro phosphorylation of akt, and tumor formation in nude mice. |
2005-04-12 |
2023-08-12 |
mouse |
| Smitha V Bava, Vineshkumar T Puliyappadamba, Ayswaria Deepti, Asha Nair, Devarajan Karunagaran, Ruby John Ant. Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization. The Journal of biological chemistry. vol 280. issue 8. 2005-04-08. PMID:15590651. |
sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappab and the serine/threonine kinase akt and is independent of tubulin polymerization. |
2005-04-08 |
2023-08-12 |
Not clear |
| Laura Suomalainen, Virve Pentikäinen, Leo Dunke. Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. The American journal of pathology. vol 166. issue 3. 2005-04-08. PMID:15743789. |
in a culture of human seminiferous tubules, s1p inhibited germ cell apoptosis, suppressed both nuclear factor kappab (nf-kappab) dna-binding activity and expression of phosphorylated akt, but did not affect activator protein-1 (ap-1) dna-binding activity. |
2005-04-08 |
2023-08-12 |
human |
| Laura Suomalainen, Virve Pentikäinen, Leo Dunke. Sphingosine-1-phosphate inhibits nuclear factor kappaB activation and germ cell apoptosis in the human testis independently of its receptors. The American journal of pathology. vol 166. issue 3. 2005-04-08. PMID:15743789. |
these results suggest that s1p inhibits male germ cell apoptosis independently of its receptors, possibly by inhibiting the transcription factor nf-kappab and akt phosphorylation. |
2005-04-08 |
2023-08-12 |
human |
| Hang Yin, Lee Chao, Julie Cha. Kallikrein/kinin protects against myocardial apoptosis after ischemia/reperfusion via Akt-glycogen synthase kinase-3 and Akt-Bad.14-3-3 signaling pathways. The Journal of biological chemistry. vol 280. issue 9. 2005-04-07. PMID:15611141. |
the protective effect of kallikrein on apoptosis and its signaling mediators was blocked by icatibant and dominant-negative akt, indicating a kinin b2 receptor-akt-mediated event. |
2005-04-07 |
2023-08-12 |
human |
| Yukitoshi Nagahara, Takahisa Shinomiya, Sachiko Kuroda, Naoki Kaneko, Reiji Nishio, Masahiko Ikekit. Phytosphingosine induced mitochondria-involved apoptosis. Cancer science. vol 96. issue 2. 2005-04-07. PMID:15723652. |
dephosphorylation of akt was partially inhibited by protein phosphatase inhibitor oa and oa attenuated phytosphingosine-induced apoptosis. |
2005-04-07 |
2023-08-12 |
human |
| Soichiro Honjo, Mitsuhiko Osaki, Tonang Dwi Ardyanto, Toshiki Hiramatsu, Noritaka Maeta, Hisao It. COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines. DNA and cell biology. vol 24. issue 3. 2005-04-07. PMID:15767780. |
these findings suggest that cox-2 might inhibit fas-mediated apoptosis in human gastric carcinoma cell lines, especially mkn-45, by modulating pten and akt. |
2005-04-07 |
2023-08-12 |
human |
| Dionisios Chrysis, Farasat Zaman, Andrei S Chagin, Masaharu Takigawa, Lars Sävendah. Dexamethasone induces apoptosis in proliferative chondrocytes through activation of caspases and suppression of the Akt-phosphatidylinositol 3'-kinase signaling pathway. Endocrinology. vol 146. issue 3. 2005-04-04. PMID:15576458. |
the akt inhibitor sh-6 (10 microm) increased apoptosis by 54% (p < 0.001). |
2005-04-04 |
2023-08-12 |
Not clear |
| G Tortora, R Bianco, G Daniel. Strategies for multiple signalling inhibition. Journal of chemotherapy (Florence, Italy). vol 16 Suppl 4. 2005-04-01. PMID:15688608. |
cancer cells hyperactivate signalling molecules, including egfr, akt and the angiogenic factor vegf to escape apoptosis, thus contributing also to resistance to treatment. |
2005-04-01 |
2023-08-12 |
Not clear |
| Gustavo Ayala, Timothy Thompson, Guang Yang, Anna Frolov, Rile Li, Peter Scardino, Makoto Ohori, Thomas Wheeler, Wade Harpe. High levels of phosphorylated form of Akt-1 in prostate cancer and non-neoplastic prostate tissues are strong predictors of biochemical recurrence. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 10. issue 19. 2005-03-29. PMID:15475446. |
akt is a serine-threonine-kinase that phosphorylates proteins in several pathways regulating aspects of metabolism, apoptosis, and proliferation. |
2005-03-29 |
2023-08-12 |
Not clear |