| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kwai Wa Cheng, John P Lahad, Wen-Lin Kuo, Anna Lapuk, Kyosuke Yamada, Nelly Auersperg, Jinsong Liu, Karen Smith-McCune, Karen H Lu, David Fishman, Joe W Gray, Gordon B Mill. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nature medicine. vol 10. issue 11. 2005-02-04. PMID:15502842. |
the inhibition of apoptosis was associated with a decrease in expression of the proapoptotic molecules, bak and bax, and activation of the antiapoptotic phosphatidylinositol 3 kinase (pi3k) and akt pathway, providing potential mechanisms for the effects of rab25 on tumor aggressiveness. |
2005-02-04 |
2023-08-12 |
Not clear |
| Annabel Rose, Pascal Froment, Valérie Perrot, Michael J Quon, Derek LeRoith, Joëlle Dupon. The luteinizing hormone-releasing hormone inhibits the anti-apoptotic activity of insulin-like growth factor-1 in pituitary alphaT3 cells by protein kinase Calpha-mediated negative regulation of Akt. The Journal of biological chemistry. vol 279. issue 50. 2005-02-01. PMID:15448167. |
finally, we showed that the inhibitory effect of lhrh on igf-1-induced pkcalpha-mediated akt activation was associated with a marked reduction in bad phosphorylation and a substantial decrease in the ability of igf-1 to rescue alphat3 cells from apoptosis induced by serum starvation. |
2005-02-01 |
2023-08-12 |
Not clear |
| Jei-Ming Peng, Shu-Mei Liang, Chi-Ming Lian. VP1 of foot-and-mouth disease virus induces apoptosis via the Akt signaling pathway. The Journal of biological chemistry. vol 279. issue 50. 2005-02-01. PMID:15466859. |
vp1 of foot-and-mouth disease virus induces apoptosis via the akt signaling pathway. |
2005-02-01 |
2023-08-12 |
human |
| Qing Shi, Shideng Bao, Jill A Maxwell, Elizabeth D Reese, Henry S Friedman, Darell D Bigner, Xiao-Fan Wang, Jeremy N Ric. Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation. The Journal of biological chemistry. vol 279. issue 50. 2005-02-01. PMID:15469933. |
furthermore, akt activation is essential for the anti-apoptotic effects of sparc as the decreased apoptosis and caspase activity associated with sparc expression can be blocked with dominant-negative akt or a specific akt inhibitor. |
2005-02-01 |
2023-08-12 |
human |
| Romaine Ingrid Fernando, Jay Wimalasen. Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and Akt. Molecular biology of the cell. vol 15. issue 7. 2005-01-31. PMID:15121878. |
estradiol abrogates apoptosis in breast cancer cells through inactivation of bad: ras-dependent nongenomic pathways requiring signaling through erk and akt. |
2005-01-31 |
2023-08-12 |
Not clear |
| Xia Xi, Ling Gao, Denise A Hatala, Dawn G Smith, Maria C Codispoti, Bendi Gong, Timothy S Kern, Jin-Zhong Zhan. Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells. Biochemical and biophysical research communications. vol 326. issue 3. 2005-01-31. PMID:15596134. |
chronically elevated glucose-induced apoptosis is mediated by inactivation of akt in cultured müller cells. |
2005-01-31 |
2023-08-12 |
rat |
| Xia Xi, Ling Gao, Denise A Hatala, Dawn G Smith, Maria C Codispoti, Bendi Gong, Timothy S Kern, Jin-Zhong Zhan. Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells. Biochemical and biophysical research communications. vol 326. issue 3. 2005-01-31. PMID:15596134. |
we report here that culture of rat retinal glial müller cells in 25 mm glucose for 72 h significantly inactivated akt and induced apoptosis. |
2005-01-31 |
2023-08-12 |
rat |
| Xia Xi, Ling Gao, Denise A Hatala, Dawn G Smith, Maria C Codispoti, Bendi Gong, Timothy S Kern, Jin-Zhong Zhan. Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells. Biochemical and biophysical research communications. vol 326. issue 3. 2005-01-31. PMID:15596134. |
upregulation of akt activity by overexpression of constitutively active akt inhibited elevated glucose-induced apoptosis, whereas downregulation of akt activity by overexpression of dominant negative akt exacerbated elevated glucose-induced apoptosis, as assessed by caspase activity and nucleic acid staining. |
2005-01-31 |
2023-08-12 |
rat |
| Xia Xi, Ling Gao, Denise A Hatala, Dawn G Smith, Maria C Codispoti, Bendi Gong, Timothy S Kern, Jin-Zhong Zhan. Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells. Biochemical and biophysical research communications. vol 326. issue 3. 2005-01-31. PMID:15596134. |
these data suggest that apoptosis induced by chronically elevated glucose is at least in part mediated by downregulation of akt survival pathway in cultured müller cells. |
2005-01-31 |
2023-08-12 |
rat |
| Xia Xi, Ling Gao, Denise A Hatala, Dawn G Smith, Maria C Codispoti, Bendi Gong, Timothy S Kern, Jin-Zhong Zhan. Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells. Biochemical and biophysical research communications. vol 326. issue 3. 2005-01-31. PMID:15596134. |
it has been reported that antiapoptotic effect of akt requires glucose in growth factor withdrawal-induced apoptosis. |
2005-01-31 |
2023-08-12 |
rat |
| Xia Xi, Ling Gao, Denise A Hatala, Dawn G Smith, Maria C Codispoti, Bendi Gong, Timothy S Kern, Jin-Zhong Zhan. Chronically elevated glucose-induced apoptosis is mediated by inactivation of Akt in cultured Müller cells. Biochemical and biophysical research communications. vol 326. issue 3. 2005-01-31. PMID:15596134. |
our data suggest that although acutely elevated glucose may be beneficial to the cell survival, chronically elevated glucose can cause apoptosis via downregulation of akt survival signaling. |
2005-01-31 |
2023-08-12 |
rat |
| Christopher L Murriel, Eric Churchill, Koichi Inagaki, Luke I Szweda, Daria Mochly-Rose. Protein kinase Cdelta activation induces apoptosis in response to cardiac ischemia and reperfusion damage: a mechanism involving BAD and the mitochondria. The Journal of biological chemistry. vol 279. issue 46. 2005-01-21. PMID:15339931. |
here, we demonstrate that pkcdelta activity and mitochondrial translocation at the onset of reperfusion mediates apoptosis by facilitating the accumulation and dephosphorylation of the pro-apoptotic bad (bcl-2-associated death promoter), dephosphorylation of akt, cytochrome c release, parp (poly(adp-ribose) polymerase) cleavage, and dna laddering. |
2005-01-21 |
2023-08-12 |
Not clear |
| Hyun-Joung Lim, Hyun-Young Park, Young-Guk Ko, Sea-Hyoung Lee, Seung-Yeon Cho, Eun Jig Lee, J Larry Jameson, Yangsoo Jan. Dominant negative insulin-like growth factor-1 receptor inhibits neointimal formation through suppression of vascular smooth muscle cell migration and proliferation, and induction of apoptosis. Biochemical and biophysical research communications. vol 325. issue 3. 2005-01-18. PMID:15541402. |
ad/igf-1rt infection inhibited vsmc migration and proliferation, and it also induced apoptosis by inhibiting phosphorylation of akt and phosphorylation of erk1/2. |
2005-01-18 |
2023-08-12 |
rat |
| Kyung Jin Woo, Yong-Jin Jeong, Jong-Wook Park, Taeg Kyu Kwo. Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochemical and biophysical research communications. vol 325. issue 4. 2005-01-18. PMID:15555556. |
chrysin-induced apoptosis is mediated through caspase activation and akt inactivation in u937 leukemia cells. |
2005-01-18 |
2023-08-12 |
human |
| Kyung Jin Woo, Yong-Jin Jeong, Jong-Wook Park, Taeg Kyu Kwo. Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochemical and biophysical research communications. vol 325. issue 4. 2005-01-18. PMID:15555556. |
we show that chrysin induces apoptosis in association with the activation of caspase 3 and that akt signal pathway plays a crucial role in chrysin-induced apoptosis in u937 cells. |
2005-01-18 |
2023-08-12 |
human |
| Kyung Jin Woo, Yong-Jin Jeong, Jong-Wook Park, Taeg Kyu Kwo. Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochemical and biophysical research communications. vol 325. issue 4. 2005-01-18. PMID:15555556. |
furthermore, we have shown that inhibition of akt phosphorylation in u937 cells by the specific pi3k inhibitor, ly294002 significantly, enhanced apoptosis. |
2005-01-18 |
2023-08-12 |
human |
| Kyung Jin Woo, Yong-Jin Jeong, Jong-Wook Park, Taeg Kyu Kwo. Chrysin-induced apoptosis is mediated through caspase activation and Akt inactivation in U937 leukemia cells. Biochemical and biophysical research communications. vol 325. issue 4. 2005-01-18. PMID:15555556. |
overexpression of a constitutively active akt (myr-akt) in u937 cells inhibited the induction of apoptosis, activation of caspase 3, and plc-gamma1 cleavage by chrysin. |
2005-01-18 |
2023-08-12 |
human |
| Yoko Takada, Masami Hashimoto, Jiro Kasahara, Kazuyuki Aihara, Kohji Fukunag. Cytoprotective effect of sodium orthovanadate on ischemia/reperfusion-induced injury in the rat heart involves Akt activation and inhibition of fodrin breakdown and apoptosis. The Journal of pharmacology and experimental therapeutics. vol 311. issue 3. 2005-01-13. PMID:15292457. |
cytoprotective effect of sodium orthovanadate on ischemia/reperfusion-induced injury in the rat heart involves akt activation and inhibition of fodrin breakdown and apoptosis. |
2005-01-13 |
2023-08-12 |
rat |
| Yoko Takada, Masami Hashimoto, Jiro Kasahara, Kazuyuki Aihara, Kohji Fukunag. Cytoprotective effect of sodium orthovanadate on ischemia/reperfusion-induced injury in the rat heart involves Akt activation and inhibition of fodrin breakdown and apoptosis. The Journal of pharmacology and experimental therapeutics. vol 311. issue 3. 2005-01-13. PMID:15292457. |
taken together, orthovanadate post-treatment rescued cardiomyocytes from ischemia/reperfusion injuries via akt activation and inhibition of fodrin breakdown, thereby inhibiting apoptosis. |
2005-01-13 |
2023-08-12 |
rat |
| Terence K Lee, Kwan Man, Joanna W Ho, Chris K Sun, Kevin T Ng, Xiang Hong Wang, Yong Chuan Wong, Irene O Ng, Ray Xu, Sheung Tat Fa. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis. vol 25. issue 12. 2005-01-13. PMID:15297371. |
fty720 induces apoptosis of human hepatoma cell lines through pi3-k-mediated akt dephosphorylation. |
2005-01-13 |
2023-08-12 |
mouse |