| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Odile David, James Jett, Helena LeBeau, Grace Dy, Janet Hughes, Mitchell Friedman, Arnold R Brod. Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 10. issue 20. 2005-03-29. PMID:15501963. |
akt is a signal transduction protein that plays a central role in inhibiting apoptosis in a variety of cell types including human cancer cells. |
2005-03-29 |
2023-08-12 |
human |
| Odile David, James Jett, Helena LeBeau, Grace Dy, Janet Hughes, Mitchell Friedman, Arnold R Brod. Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 10. issue 20. 2005-03-29. PMID:15501963. |
in cell lines derived from human non-small cell lung cancers (nsclcs), akt has been shown to confer chemoresistance by inhibition of apoptosis in response to different chemotherapeutic agents including platinum-based agents, which are often the first-line therapy for nsclcs. |
2005-03-29 |
2023-08-12 |
human |
| Walter S Kang, Frank J Tamarkin, Marcia A Wheeler, Robert M Weis. Rapid up-regulation of endothelial nitric-oxide synthase in a mouse model of Escherichia coli lipopolysaccharide-induced bladder inflammation. The Journal of pharmacology and experimental therapeutics. vol 310. issue 2. 2005-03-28. PMID:15082754. |
escherichia coli lipopolysaccharide (lps) induces an inflammatory response in the bladder and rapidly increases phosphorylation of akt/protein kinase b (akt), a key enzyme regulating proliferation, apoptosis, and inflammation. |
2005-03-28 |
2023-08-12 |
mouse |
| Yigang Wang, Nauman Ahmad, Maqsood A Wani, Muhammad Ashra. Hepatocyte growth factor prevents ventricular remodeling and dysfunction in mice via Akt pathway and angiogenesis. Journal of molecular and cellular cardiology. vol 37. issue 5. 2005-03-25. PMID:15522281. |
a significant reduction in apoptosis in the hgf-treated hearts was observed compared with control hearts, and was strongly associated with increased akt activation. |
2005-03-25 |
2023-08-12 |
mouse |
| Derek L Dai, Magdalena Martinka, Gang L. Prognostic significance of activated Akt expression in melanoma: a clinicopathologic study of 292 cases. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. vol 23. issue 7. 2005-03-25. PMID:15735123. |
akt is a serine/threonine kinase that leads to stimulation of cell cycle progression, cell proliferation, and inhibition of apoptosis. |
2005-03-25 |
2023-08-12 |
Not clear |
| Musaffe Tuna, Arturo Chavez-Reyes, Ana M Tar. HER2/neu increases the expression of Wilms' Tumor 1 (WT1) protein to stimulate S-phase proliferation and inhibit apoptosis in breast cancer cells. Oncogene. vol 24. issue 9. 2005-03-22. PMID:15674342. |
our data indicate that her2/neu engages akt to increase wt1 expression, and that wt1 protein plays a vital role in regulating cell cycle progression and apoptosis in her2/neu-overexpressing breast cancer cells. |
2005-03-22 |
2023-08-12 |
Not clear |
| Yue Wu, Ke Zu, Jing Ni, Shuyuan Yeh, Dhanalakshmi Kasi, Nadine S James, Sherry Chemler, Clement I. Cellular and molecular effects of alpha-tocopheryloxybutyrate: lessons for the design of vitamin E analog for cancer prevention. Anticancer research. vol 24. issue 6. 2005-03-22. PMID:15736414. |
in this study, we compared the potency of alpha-ts and alpha-tob using a panel of bioassays: cell growth, tunel labelling for apoptosis, parp cleavage, caspase-3 and caspase-9 activation, as well as akt and jnk phosphorylation. |
2005-03-22 |
2023-08-12 |
human |
| Jae-Bum Jun, Melanie Kuechle, Junki Min, Seung Cheol Shim, Giok Kim, Vivianne Montenegro, Joseph H Korn, Keith B Elko. Scleroderma fibroblasts demonstrate enhanced activation of Akt (protein kinase B) in situ. The Journal of investigative dermatology. vol 124. issue 2. 2005-03-21. PMID:15675946. |
akt activation may contribute to resistance to apoptosis, selection of disease-inducing fibroblasts, and, possibly, myofibroblasts. |
2005-03-21 |
2023-08-12 |
Not clear |
| Jason P Bailey, Kathryn M Nieport, Matthew P Herbst, Sunil Srivastava, Rosa A Serra, Nelson D Horsema. Prolactin and transforming growth factor-beta signaling exert opposing effects on mammary gland morphogenesis, involution, and the Akt-forkhead pathway. Molecular endocrinology (Baltimore, Md.). vol 18. issue 5. 2005-03-17. PMID:14963111. |
expression of dominant negative akt blocked the protective effect of prl in tgf-beta-induced apoptosis. |
2005-03-17 |
2023-08-12 |
mouse |
| Neeraj K Saxena, Mark A Titus, Xiaokun Ding, Jeffrey Floyd, Shanthi Srinivasan, Shanthi V Sitaraman, Frank A Anani. Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 13. 2005-03-14. PMID:15319373. |
leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (erk) and akt phosphorylation. |
2005-03-14 |
2023-08-12 |
Not clear |
| Neeraj K Saxena, Mark A Titus, Xiaokun Ding, Jeffrey Floyd, Shanthi Srinivasan, Shanthi V Sitaraman, Frank A Anani. Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 18. issue 13. 2005-03-14. PMID:15319373. |
akt was also protective against hsc apoptosis. |
2005-03-14 |
2023-08-12 |
Not clear |
| Gee-Chen Chang, Shih-Lan Hsu, Jia-Rong Tsai, Wen-Jun Wu, Chih-Yi Chen, Gwo-Tarng She. Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. European journal of pharmacology. vol 502. issue 3. 2005-03-08. PMID:15476743. |
taken together, our observations indicate that erk activation and akt inactivation mediated gemcitabine-induced apoptosis independently of p53 in human nsclc h1299 cells. |
2005-03-08 |
2023-08-12 |
human |
| Aleksandra Ellert-Miklaszewska, Bozena Kaminska, Liliana Konarsk. Cannabinoids down-regulate PI3K/Akt and Erk signalling pathways and activate proapoptotic function of Bad protein. Cellular signalling. vol 17. issue 1. 2005-03-07. PMID:15451022. |
in the present studies, c6 cells were exposed to a synthetic cannabinoid, win 55,212-2, which produced down-regulation of the akt and erk signalling pathways prior to appearance of any sign of apoptosis. |
2005-03-07 |
2023-08-12 |
Not clear |
| Qi-Wen Fan, William A Weis. RNA interference against a glioma-derived allele of EGFR induces blockade at G2M. Oncogene. vol 24. issue 5. 2005-03-07. PMID:15580296. |
sirna-mediated depletion of deltaegfr led to reduction in the levels of phosphorylated akt in glioma cells, was associated with increased apoptosis, and induced partial arrest at the g2m phase of the cell cycle. |
2005-03-07 |
2023-08-12 |
human |
| Qi-Wen Fan, William A Weis. RNA interference against a glioma-derived allele of EGFR induces blockade at G2M. Oncogene. vol 24. issue 5. 2005-03-07. PMID:15580296. |
importantly, cell cycle blockade could be reversed, and apoptosis rescued using a conditional allele of akt, implicating akt as a primary target of combination therapy. |
2005-03-07 |
2023-08-12 |
human |
| Rebecca R Foster, Moin A Saleem, Peter W Mathieson, David O Bates, Steven J Harpe. Vascular endothelial growth factor and nephrin interact and reduce apoptosis in human podocytes. American journal of physiology. Renal physiology. vol 288. issue 1. 2005-03-04. PMID:15339792. |
the akt signaling pathway has been implicated in nephrin-mediated inhibition of apoptosis in transfected cells, but the role of this pathway has not previously been shown in podocytes. |
2005-03-04 |
2023-08-12 |
human |
| Jin-Ping Liu, Ryan Schlosser, Wei-Ya Ma, Zigang Dong, Hao Feng, Long Lui, Xiao-Qing Huang, Yan Liu, Davis Wan-Cheng L. Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways. Experimental eye research. vol 79. issue 6. 2005-03-04. PMID:15669141. |
human alphaa- and alphab-crystallins prevent uva-induced apoptosis through regulation of pkcalpha, raf/mek/erk and akt signaling pathways. |
2005-03-04 |
2023-08-12 |
human |
| Jin-Ping Liu, Ryan Schlosser, Wei-Ya Ma, Zigang Dong, Hao Feng, Long Lui, Xiao-Qing Huang, Yan Liu, Davis Wan-Cheng L. Human alphaA- and alphaB-crystallins prevent UVA-induced apoptosis through regulation of PKCalpha, RAF/MEK/ERK and AKT signaling pathways. Experimental eye research. vol 79. issue 6. 2005-03-04. PMID:15669141. |
instead, it activated akt kinase pathway to promote survival and thus counteracted the uva-induced apoptosis. |
2005-03-04 |
2023-08-12 |
human |
| Yun Dai, Mohamed Rahmani, Xin-Yan Pei, Payal Khanna, Song Iy Han, Clint Mitchell, Paul Dent, Steven Gran. Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK. Blood. vol 105. issue 4. 2005-03-03. PMID:15494423. |
farnesyltransferase inhibitors interact synergistically with the chk1 inhibitor ucn-01 to induce apoptosis in human leukemia cells through interruption of both akt and mek/erk pathways and activation of sek1/jnk. |
2005-03-03 |
2023-08-12 |
human |
| Yun Dai, Mohamed Rahmani, Xin-Yan Pei, Payal Khanna, Song Iy Han, Clint Mitchell, Paul Dent, Steven Gran. Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK. Blood. vol 105. issue 4. 2005-03-03. PMID:15494423. |
ectopic expression of bcl-2 or bcl-xl but not dominant-negative caspase-8 blocked ucn-01/l744832-mediated mitochondrial dysfunction and apoptosis but did not prevent activation of p34(cdc2) and jnk or inactivation of mek/erk and akt. |
2005-03-03 |
2023-08-12 |
human |