| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Terence K Lee, Kwan Man, Joanna W Ho, Chris K Sun, Kevin T Ng, Xiang Hong Wang, Yong Chuan Wong, Irene O Ng, Ray Xu, Sheung Tat Fa. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis. vol 25. issue 12. 2005-01-13. PMID:15297371. |
in our in vivo model fty720 induced apoptosis of tumor cells by down-regulation of the akt pathway. |
2005-01-13 |
2023-08-12 |
mouse |
| Terence K Lee, Kwan Man, Joanna W Ho, Chris K Sun, Kevin T Ng, Xiang Hong Wang, Yong Chuan Wong, Irene O Ng, Ray Xu, Sheung Tat Fa. FTY720 induces apoptosis of human hepatoma cell lines through PI3-K-mediated Akt dephosphorylation. Carcinogenesis. vol 25. issue 12. 2005-01-13. PMID:15297371. |
in conclusion, fty720 is a novel anticancer agent that induces apoptosis of hepatoma cell lines both in vitro and in vivo through pi3-k-mediated akt dephosphorylation in a p53-independent manner. |
2005-01-13 |
2023-08-12 |
mouse |
| Morris J Birnbau. On the InterAktion between hexokinase and the mitochondrion. Developmental cell. vol 7. issue 6. 2005-01-13. PMID:15572122. |
the protein kinase akt is now well recognized as a potent inhibitor of apoptosis. |
2005-01-13 |
2023-08-12 |
Not clear |
| Nathan Majewski, Veronique Nogueira, Prashanth Bhaskar, Platina E Coy, Jennifer E Skeen, Kathrin Gottlob, Navdeep S Chandel, Craig B Thompson, R Brooks Robey, Nissim Ha. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Molecular cell. vol 16. issue 5. 2005-01-13. PMID:15574336. |
hexokinase-mitochondria interaction mediated by akt is required to inhibit apoptosis in the presence or absence of bax and bak. |
2005-01-13 |
2023-08-12 |
Not clear |
| Nathan Majewski, Veronique Nogueira, Prashanth Bhaskar, Platina E Coy, Jennifer E Skeen, Kathrin Gottlob, Navdeep S Chandel, Craig B Thompson, R Brooks Robey, Nissim Ha. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Molecular cell. vol 16. issue 5. 2005-01-13. PMID:15574336. |
the serine/threonine kinase akt inhibits mitochondrial cytochrome c release and apoptosis induced by a variety of proapoptotic stimuli. |
2005-01-13 |
2023-08-12 |
Not clear |
| Nathan Majewski, Veronique Nogueira, Prashanth Bhaskar, Platina E Coy, Jennifer E Skeen, Kathrin Gottlob, Navdeep S Chandel, Craig B Thompson, R Brooks Robey, Nissim Ha. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Molecular cell. vol 16. issue 5. 2005-01-13. PMID:15574336. |
targeted disruption of this association impairs the ability of growth factors and akt to inhibit cytochrome c release and apoptosis. |
2005-01-13 |
2023-08-12 |
Not clear |
| Nathan Majewski, Veronique Nogueira, Prashanth Bhaskar, Platina E Coy, Jennifer E Skeen, Kathrin Gottlob, Navdeep S Chandel, Craig B Thompson, R Brooks Robey, Nissim Ha. Hexokinase-mitochondria interaction mediated by Akt is required to inhibit apoptosis in the presence or absence of Bax and Bak. Molecular cell. vol 16. issue 5. 2005-01-13. PMID:15574336. |
these effects are inhibited by activated akt, but not by bcl-2, implying that changes in outer mitochondrial membrane (omm) permeability leading to apoptosis can occur in the absence of bax and bak and that akt inhibits these changes through maintenance of hexokinase association with mitochondria. |
2005-01-13 |
2023-08-12 |
Not clear |
| Marie Chaussepied, Doron Ginsber. Transcriptional regulation of AKT activation by E2F. Molecular cell. vol 16. issue 5. 2005-01-13. PMID:15574337. |
akt activation was shown to inhibit e2f1induced apoptosis. |
2005-01-13 |
2023-08-12 |
Not clear |
| Susana Solá, Rui E Castro, Pedro A Laires, Clifford J Steer, Cecília M P Rodrigue. Tauroursodeoxycholic acid prevents amyloid-beta peptide-induced neuronal death via a phosphatidylinositol 3-kinase-dependent signaling pathway. Molecular medicine (Cambridge, Mass.). vol 9. issue 9-12. 2005-01-12. PMID:15208744. |
moreover, wortmannin decreased tudca protection against abeta-induced apoptosis, reduced akt phosphorylation, and increased bax translocation to mitochondria. |
2005-01-12 |
2023-08-12 |
Not clear |
| G Sakuntala Warshamana-Greene, Julie Litz, Elisabeth Buchdunger, Francesco Hofmann, Carlos García-Echeverría, Geoffrey W Krysta. The insulin-like growth factor-I (IGF-I) receptor kinase inhibitor NVP-ADW742, in combination with STI571, delineates a spectrum of dependence of small cell lung cancer on IGF-I and stem cell factor signaling. Molecular cancer therapeutics. vol 3. issue 5. 2005-01-11. PMID:15141010. |
when these cell lines were treated with a combination of sti571 and nvp-adw742, no advantage was seen in the former group, whereas, in the latter group, a clearly synergistic response to the combination was seen when growth, apoptosis, or akt activation was assessed. |
2005-01-11 |
2023-08-12 |
Not clear |
| Chie Yasuoka, Yoshito Ihara, Satoshi Ikeda, Yoshiyuki Miyahara, Takahito Kondo, Shigeru Kohn. Antiapoptotic activity of Akt is down-regulated by Ca2+ in myocardiac H9c2 cells. Evidence of Ca(2+)-dependent regulation of protein phosphatase 2Ac. The Journal of biological chemistry. vol 279. issue 49. 2005-01-11. PMID:15375154. |
the inactivation of akt was well correlated with the susceptibility to oxidant-induced apoptosis in h9c2 cells. |
2005-01-11 |
2023-08-12 |
rat |
| Chie Yasuoka, Yoshito Ihara, Satoshi Ikeda, Yoshiyuki Miyahara, Takahito Kondo, Shigeru Kohn. Antiapoptotic activity of Akt is down-regulated by Ca2+ in myocardiac H9c2 cells. Evidence of Ca(2+)-dependent regulation of protein phosphatase 2Ac. The Journal of biological chemistry. vol 279. issue 49. 2005-01-11. PMID:15375154. |
a long term change of [ca2+]i regulates pp2acalpha gene transcription via cre, resulting in a change in the activation status of akt leading to an altered susceptibility to apoptosis. |
2005-01-11 |
2023-08-12 |
rat |
| Jiang-Yan Yang, David Michod, Joël Walicki, Brona M Murphy, Shailaja Kasibhatla, Seamus J Martin, Christian Widman. Partial cleavage of RasGAP by caspases is required for cell survival in mild stress conditions. Molecular and cellular biology. vol 24. issue 23. 2005-01-04. PMID:15542850. |
partial cleavage of rasgap is required for cell survival under stress conditions because cells expressing an uncleavable rasgap mutant cannot activate akt, cannot prevent amplification of caspase 3 activity, and eventually undergo apoptosis. |
2005-01-04 |
2023-08-12 |
Not clear |
| X Jin, D R Gossett, S Wang, D Yang, Y Cao, J Chen, R Guo, R K Reynolds, J Li. Inhibition of AKT survival pathway by a small molecule inhibitor in human endometrial cancer cells. British journal of cancer. vol 91. issue 10. 2004-12-27. PMID:15505622. |
we found that api-59cj-ome inhibits akt kinase activity and induces apoptosis in the ishikawa and rl95-2 cell lines with high akt activity, but has little effect on hec1a and kle cells without akt activity. |
2004-12-27 |
2023-08-12 |
human |
| Janet M D Plat. PI3-kinase regulates survival of chronic lymphocytic leukemia B-cells by preventing caspase 8 activation. Leukemia & lymphoma. vol 45. issue 8. 2004-12-21. PMID:15370202. |
inhibition of pi3-kinase with specific inhibitor, ly294002, led to the induction of apoptosis that was caspase 8 dependent, but independent of akt as ly294002 did not depress a high basal level of akt activity found in cll cells. |
2004-12-21 |
2023-08-12 |
Not clear |
| Neha Parikh, Hadassah Sade, Leo Kurian, Apurva Sari. The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 10. 2004-12-17. PMID:15528359. |
because inhibition of pi3k or its target akt also triggers mitochondrial translocation of bax in t cells and apoptosis in bax-transfected cell lines, we generated bax deletion mutants to identify the region(s) that confers sensitivity to regulation by mek1 and akt. |
2004-12-17 |
2023-08-12 |
Not clear |
| Neha Parikh, Hadassah Sade, Leo Kurian, Apurva Sari. The Bax N terminus is required for negative regulation by the mitogen-activated protein kinase kinase and Akt signaling pathways in T cells. Journal of immunology (Baltimore, Md. : 1950). vol 173. issue 10. 2004-12-17. PMID:15528359. |
a deletion mutant (bax(1-171)) without the c terminus mitochondrial targeting sequence or an akt target site (ser(184)) localizes to the cytoplasm and triggers low level apoptosis that is enhanced by dn-akt or dn-mek1. |
2004-12-17 |
2023-08-12 |
Not clear |
| Tarek Khreiss, Levente József, John S D Chan, János G File. Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils. Cellular signalling. vol 16. issue 7. 2004-12-16. PMID:15115659. |
by contrast, concurrent activation of erk and akt was required to inhibit caspase-3 activation and consequently to delay apoptosis. |
2004-12-16 |
2023-08-12 |
human |
| Qi Niu, Carole Perruzzi, Daniel Voskas, Jack Lawler, Daniel J Dumont, Laura E Benjami. Inhibition of Tie-2 signaling induces endothelial cell apoptosis, decreases Akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1. Cancer biology & therapy. vol 3. issue 4. 2004-12-15. PMID:14739779. |
inhibition of tie-2 signaling induces endothelial cell apoptosis, decreases akt signaling, and induces endothelial cell expression of the endogenous anti-angiogenic molecule, thrombospondin-1. |
2004-12-15 |
2023-08-12 |
Not clear |
| Tadaaki Miyazaki, Min Shen, Daisuke Fujikura, Noriko Tosa, Hyung-Ryong Kim, Shigeyuki Kon, Toshimitsu Uede, John C Ree. Functional role of death-associated protein 3 (DAP3) in anoikis. The Journal of biological chemistry. vol 279. issue 43. 2004-12-14. PMID:15302871. |
we also showed that dap3 is phosphorylated by kinase akt (pkb), and active akt can nullify apoptosis induction by dap3. |
2004-12-14 |
2023-08-12 |
Not clear |