| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aarti R Uzgare, John T Isaac. Enhanced redundancy in Akt and mitogen-activated protein kinase-induced survival of malignant versus normal prostate epithelial cells. Cancer research. vol 64. issue 17. 2004-10-05. PMID:15342404. |
in malignant cells, however, only jnk inhibition as monotherapy produces a consistent apoptotic response, although the combinatorial inhibition of jnk, erk, p38 plus akt results in statistically enhanced apoptosis. |
2004-10-05 |
2023-08-12 |
human |
| Yeng-Jeng Shaw, Ya-Ting Yang, Jason B Garrison, Natasha Kyprianou, Ching-Shih Che. Pharmacological exploitation of the alpha1-adrenoreceptor antagonist doxazosin to develop a novel class of antitumor agents that block intracellular protein kinase B/Akt activation. Journal of medicinal chemistry. vol 47. issue 18. 2004-09-24. PMID:15317457. |
replacement of the (2,3-dihydro-benzo[1,4]dioxane)-carbonyl moiety of doxazosin with aryl-sulfonyl functions dramatically improves the potency in facilitating akt deactivation and inducing apoptosis. |
2004-09-24 |
2023-08-12 |
Not clear |
| D E Johnso. Regulation of survival pathways by IL-3 and induction of apoptosis following IL-3 withdrawal. Frontiers in bioscience : a journal and virtual library. vol 3. 2004-09-23. PMID:9488657. |
these studies indicate that il-3 inhibits apoptosis by stimulating the activation of cellular kinases, including phophatidylinositol (pi) 3-kinase and akt kinase. |
2004-09-23 |
2023-08-12 |
Not clear |
| Sheela Vyas, Philippe Juin, David Hancock, Yasuyuki Suzuki, Ryosuke Takahashi, Antoine Triller, Gerard Eva. Differentiation-dependent sensitivity to apoptogenic factors in PC12 cells. The Journal of biological chemistry. vol 279. issue 30. 2004-09-21. PMID:15133027. |
in differentiated, but not undifferentiated cells, bcl-2 and akt also inhibited apoptosis downstream of holocytochrome c release. |
2004-09-21 |
2023-08-12 |
Not clear |
| Sheela Vyas, Philippe Juin, David Hancock, Yasuyuki Suzuki, Ryosuke Takahashi, Antoine Triller, Gerard Eva. Differentiation-dependent sensitivity to apoptogenic factors in PC12 cells. The Journal of biological chemistry. vol 279. issue 30. 2004-09-21. PMID:15133027. |
thus, undifferentiated pc12 cells showed marked sensitivity to induction of apoptosis by microinjected cytochrome c even in the presence of ngf, bcl-2, or akt. |
2004-09-21 |
2023-08-12 |
Not clear |
| Prosenjit Sen, Sebanti Mukherjee, Doel Ray, Sanghamitra Rah. Involvement of the Akt/PKB signaling pathway with disease processes. Molecular and cellular biochemistry. vol 253. issue 1-2. 2004-09-16. PMID:14619975. |
the substrates of akt/pkb, which promote the inhibition of apoptosis after being phosphorylated by akt, include the forkhead transcription factors and the bcl-2 family member bad. |
2004-09-16 |
2023-08-12 |
Not clear |
| Ursula Bommhardt, Katherine C Chang, Paul E Swanson, Tracey H Wagner, Kevin W Tinsley, Irene E Karl, Richard S Hotchkis. Akt decreases lymphocyte apoptosis and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 12. 2004-09-16. PMID:15187138. |
akt decreases lymphocyte apoptosis and improves survival in sepsis. |
2004-09-16 |
2023-08-12 |
mouse |
| Ursula Bommhardt, Katherine C Chang, Paul E Swanson, Tracey H Wagner, Kevin W Tinsley, Irene E Karl, Richard S Hotchkis. Akt decreases lymphocyte apoptosis and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 12. 2004-09-16. PMID:15187138. |
the purpose of this study was to determine whether overexpression of akt would prevent lymphocyte apoptosis and improve survival in sepsis. |
2004-09-16 |
2023-08-12 |
mouse |
| Ursula Bommhardt, Katherine C Chang, Paul E Swanson, Tracey H Wagner, Kevin W Tinsley, Irene E Karl, Richard S Hotchkis. Akt decreases lymphocyte apoptosis and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 12. 2004-09-16. PMID:15187138. |
akt overexpression also decreased sepsis-induced lymphocyte apoptosis via a non-bcl-2 mechanism. |
2004-09-16 |
2023-08-12 |
mouse |
| Ursula Bommhardt, Katherine C Chang, Paul E Swanson, Tracey H Wagner, Kevin W Tinsley, Irene E Karl, Richard S Hotchkis. Akt decreases lymphocyte apoptosis and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950). vol 172. issue 12. 2004-09-16. PMID:15187138. |
in conclusion, akt overexpression in lymphocytes prevents sepsis-induced apoptosis, causes a th1 cytokine propensity, and improves survival. |
2004-09-16 |
2023-08-12 |
mouse |
| Mònica Comalada, Jordi Xaus, Ester Sánchez, Annabel F Valledor, Antonio Celad. Macrophage colony-stimulating factor-, granulocyte-macrophage colony-stimulating factor-, or IL-3-dependent survival of macrophages, but not proliferation, requires the expression of p21(Waf1) through the phosphatidylinositol 3-kinase/Akt pathway. European journal of immunology. vol 34. issue 8. 2004-09-14. PMID:15259023. |
growth factors also activate akt kinase and a transient expression of the cdk inhibitor p21(waf1), which inhibits apoptosis but is not required for proliferation. |
2004-09-14 |
2023-08-12 |
mouse |
| Kishore Narayanan, Andrés Jaramillo, Donna L Phelan, T Mohanakuma. Pre-exposure to sub-saturating concentrations of HLA class I antibodies confers resistance to endothelial cells against antibody complement-mediated lysis by regulating Bad through the phosphatidylinositol 3-kinase/Akt pathway. European journal of immunology. vol 34. issue 8. 2004-09-14. PMID:15259028. |
using this model, we show that ec undergo caspase 3-dependent cell death by apoptosis upon exposure to saturating concentrations of hla class i antibodies and complement accompanied by loss of akt activation and phosphorylation of bad. |
2004-09-14 |
2023-08-12 |
human |
| Yigang Wang, Nauman Ahmad, Mitsuhiro Kudo, Muhammad Ashra. Contribution of Akt and endothelial nitric oxide synthase to diazoxide-induced late preconditioning. American journal of physiology. Heart and circulatory physiology. vol 287. issue 3. 2004-09-10. PMID:15142844. |
phosphorylation of endothelial no synthase (enos) increases no production and reduces apoptosis through the akt signaling pathway. |
2004-09-10 |
2023-08-12 |
mouse |
| Hong Xia, Richard Seonghun Nho, Judy Kahm, Jill Kleidon, Craig A Henk. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. The Journal of biological chemistry. vol 279. issue 31. 2004-09-10. PMID:15166238. |
dominant negative fak augmented fibroblast apoptosis during collagen contraction, and this was associated with diminished akt activity. |
2004-09-10 |
2023-08-12 |
Not clear |
| Hong Xia, Richard Seonghun Nho, Judy Kahm, Jill Kleidon, Craig A Henk. Focal adhesion kinase is upstream of phosphatidylinositol 3-kinase/Akt in regulating fibroblast survival in response to contraction of type I collagen matrices via a beta 1 integrin viability signaling pathway. The Journal of biological chemistry. vol 279. issue 31. 2004-09-10. PMID:15166238. |
constitutively active fak augmented levels of p85 subunit of pi3k and akt phosphorylation, and fibroblasts were protected from apoptosis. |
2004-09-10 |
2023-08-12 |
Not clear |
| Sai Latha Shankar, Melissa Krupski, Bhupesh Parashar, Chidi Okwuaka, Kathy O'Guin, Sridhar Mani, Bridget Shafit-Zagard. UCN-01 alters phosphorylation of Akt and GSK3beta and induces apoptosis in six independent human neuroblastoma cell lines. Journal of neurochemistry. vol 90. issue 3. 2004-09-10. PMID:15255949. |
ucn-01 alters phosphorylation of akt and gsk3beta and induces apoptosis in six independent human neuroblastoma cell lines. |
2004-09-10 |
2023-08-12 |
human |
| Raffaella Sordella, Daphne W Bell, Daniel A Haber, Jeffrey Settlema. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science (New York, N.Y.). vol 305. issue 5687. 2004-09-10. PMID:15284455. |
nsclc cells expressing mutant egfrs underwent extensive apoptosis after small interfering rna-mediated knockdown of the mutant egfr or treatment with pharmacological inhibitors of akt and stat signaling and were relatively resistant to apoptosis induced by conventional chemotherapeutic drugs. |
2004-09-10 |
2023-08-12 |
Not clear |
| S Cuní, P Pérez-Aciego, G Pérez-Chacón, J A Vargas, A Sánchez, F M Martín-Saavedra, S Ballester, J García-Marco, J Jordá, A Duránte. A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells. Leukemia. vol 18. issue 8. 2004-09-09. PMID:15175625. |
spontaneous apoptosis was associated with the loss of akt and nf-kappab activities. |
2004-09-09 |
2023-08-12 |
Not clear |
| S Cuní, P Pérez-Aciego, G Pérez-Chacón, J A Vargas, A Sánchez, F M Martín-Saavedra, S Ballester, J García-Marco, J Jordá, A Duránte. A sustained activation of PI3K/NF-kappaB pathway is critical for the survival of chronic lymphocytic leukemia B cells. Leukemia. vol 18. issue 8. 2004-09-09. PMID:15175625. |
cd40 crosslinking in b-cll cells did not further prevent murine fibroblasts-mediated apoptosis but induced cell proliferation, which was associated with an increase of akt and nf-kappab activation compared with cells cultured with fibroblasts alone. |
2004-09-09 |
2023-08-12 |
Not clear |
| Marie-Claude Dery, Valerie Leblanc, Carl Shooner, Eric Asseli. Regulation of Akt expression and phosphorylation by 17beta-estradiol in the rat uterus during estrous cycle. Reproductive biology and endocrinology : RB&E. vol 1. 2004-09-08. PMID:12816542. |
we have investigated the possibility that akt survival pathway might be involved in the regulation of apoptosis in the uterus during the estrous cycle. |
2004-09-08 |
2023-08-12 |
rat |