| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dawn M Flaherty, Sara L Hinde, Martha M Monick, Linda S Powers, Mary A Bradford, Timur Yarovinsky, Gary W Hunninghak. Adenovirus vectors activate survival pathways in lung epithelial cells. American journal of physiology. Lung cellular and molecular physiology. vol 287. issue 2. 2004-08-17. PMID:15107295. |
constitutive activation of either pi3-kinase or akt blocks apoptosis induced by c-myc, uv radiation, transforming growth factor-beta, fas, and respiratory syncytial virus infection. |
2004-08-17 |
2023-08-12 |
Not clear |
| Yukihiro Takemura, Keisuke Fukuo, Osamu Yasuda, Takahito Inoue, Norio Inomata, Toyohiko Yokoi, Hidenobu Kawamoto, Toshimitsu Suhara, Toshio Ogihar. Fas signaling induces Akt activation and upregulation of endothelial nitric oxide synthase expression. Hypertension (Dallas, Tex. : 1979). vol 43. issue 4. 2004-08-10. PMID:14967838. |
here, we report that fas engagement with fas ligand induced activation of akt and upregulation of endothelial nitric oxide synthase expression without induction of apoptosis. |
2004-08-10 |
2023-08-12 |
mouse |
| Zijuan Liu, Joy Falola, Xudong Zhu, Ying Gu, Lawrence T Kim, George A Sarosi, Thomas Anthony, Fiemu E Nwariak. Antiproliferative effects of Src inhibition on medullary thyroid cancer. The Journal of clinical endocrinology and metabolism. vol 89. issue 7. 2004-08-10. PMID:15240638. |
compared with controls, pp2 reduced dna synthesis, abolished akt phosphorylation, and increased apoptosis. |
2004-08-10 |
2023-08-12 |
human |
| Jiuxiang Zhu, Jui-Wen Huang, Ping-Hui Tseng, Ya-Ting Yang, Joseph Fowble, Chung-Wai Shiau, Yeng-Jeng Shaw, Samuel K Kulp, Ching-Shih Che. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer research. vol 64. issue 12. 2004-08-06. PMID:15205346. |
the blockade of akt activation through the inhibition of 3-phosphoinositide-dependent kinase-1 (pdk-1) represents a major signaling mechanism whereby celecoxib mediates apoptosis. |
2004-08-06 |
2023-08-12 |
Not clear |
| Jiuxiang Zhu, Jui-Wen Huang, Ping-Hui Tseng, Ya-Ting Yang, Joseph Fowble, Chung-Wai Shiau, Yeng-Jeng Shaw, Samuel K Kulp, Ching-Shih Che. From the cyclooxygenase-2 inhibitor celecoxib to a novel class of 3-phosphoinositide-dependent protein kinase-1 inhibitors. Cancer research. vol 64. issue 12. 2004-08-06. PMID:15205346. |
moreover, overexpression of constitutively active forms of pdk-1 and akt partially protected osu-03012-induced apoptosis. |
2004-08-06 |
2023-08-12 |
Not clear |
| Carmen Segrelles, Sergio Ruiz, Mirentxu Santos, Jesús Martínez-Palacio, M Fernanda Lara, Jesús M Parami. Akt mediates an angiogenic switch in transformed keratinocytes. Carcinogenesis. vol 25. issue 7. 2004-08-03. PMID:15001536. |
akt signaling is involved in tumorigenesis via a number of different mechanisms that result in increased proliferation and decreased apoptosis. |
2004-08-03 |
2023-08-12 |
Not clear |
| Satoshi Tanno, Nobuyuki Yanagawa, Atsuya Habiro, Kazuya Koizumi, Yasuhiro Nakano, Manabu Osanai, Yusuke Mizukami, Toshikatsu Okumura, Joseph R Testa, Yutaka Kohg. Serine/threonine kinase AKT is frequently activated in human bile duct cancer and is associated with increased radioresistance. Cancer research. vol 64. issue 10. 2004-08-02. PMID:15150102. |
furthermore, constitutively active akt also inhibited radiation-induced apoptosis. |
2004-08-02 |
2023-08-12 |
human |
| Michael V G Latronico, Stefan Costinean, Maria Luisa Lavitrano, Cesare Peschle, Gianluigi Condorell. Regulation of cell size and contractile function by AKT in cardiomyocytes. Annals of the New York Academy of Sciences. vol 1015. 2004-07-28. PMID:15201165. |
major effects of akt activation in the cardiomyocyte are increase in cell size, prevention of apoptosis, and regulation of glucose metabolism. |
2004-07-28 |
2023-08-12 |
mouse |
| Mark S Duxbury, Hiromichi Ito, Eric Benoit, Talat Waseem, Stanley W Ashley, Edward E Whan. A novel role for carcinoembryonic antigen-related cell adhesion molecule 6 as a determinant of gemcitabine chemoresistance in pancreatic adenocarcinoma cells. Cancer research. vol 64. issue 11. 2004-07-26. PMID:15173012. |
differential expression of ceacam6 modulates akt activity in a c-src-dependent manner, and ceacam6 overexpression appears to protect cells from cytochrome c-induced caspase 3 activation and apoptosis. |
2004-07-26 |
2023-08-12 |
Not clear |
| Pei Xiang Xing, Xiu Feng Hu, Geoffrey A Pietersz, Howard L Hosick, Ian F C McKenzi. Cripto: a novel target for antibody-based cancer immunotherapy. Cancer research. vol 64. issue 11. 2004-07-26. PMID:15173016. |
the mechanism of inhibitory effects of the cripto mabs includes both cancer cell apoptosis, activation of c-jun-nh(2)-terminal kinase and p38 kinase signaling pathways and blocking of akt phosphorylation. |
2004-07-26 |
2023-08-12 |
mouse |
| Sang-Gu Hwang, Je-Hwang Ryu, Il-Chul Kim, Eek-Hoon Jho, Ho-Chul Jung, Kwonseop Kim, Song-Ja Kim, Jang-Soo Chu. Wnt-7a causes loss of differentiated phenotype and inhibits apoptosis of articular chondrocytes via different mechanisms. The Journal of biological chemistry. vol 279. issue 25. 2004-07-23. PMID:15082716. |
wnt-7a induces dedifferentiation of articular chondrocytes by stimulating transcriptional activity of beta-catenin, whereas no-induced apoptosis is inhibited via the activation of cell survival signaling, such as phosphatidylinositol 3-kinase and akt, which block apoptotic signaling cascade. |
2004-07-23 |
2023-08-12 |
Not clear |
| Hedy H Ginzberg, Patrick T Shannon, Tomoko Suzuki, Ouyang Hong, Eric Vachon, Theo Moraes, Maria Teresa Herrera Abreu, Vera Cherepanov, Xiaomin Wang, Chung-Wai Chow, Gregory P Downe. Leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and Akt. American journal of physiology. Gastrointestinal and liver physiology. vol 287. issue 1. 2004-07-23. PMID:15194561. |
leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and akt. |
2004-07-23 |
2023-08-12 |
Not clear |
| Hedy H Ginzberg, Patrick T Shannon, Tomoko Suzuki, Ouyang Hong, Eric Vachon, Theo Moraes, Maria Teresa Herrera Abreu, Vera Cherepanov, Xiaomin Wang, Chung-Wai Chow, Gregory P Downe. Leukocyte elastase induces epithelial apoptosis: role of mitochondial permeability changes and Akt. American journal of physiology. Gastrointestinal and liver physiology. vol 287. issue 1. 2004-07-23. PMID:15194561. |
inhibition of epithelial akt before elastase treatment potentiated epithelial cell apoptosis, suggesting that the initial activation of akt represents a protective response by the epithelial cells to the proapoptotic effects of leukocyte elastase. |
2004-07-23 |
2023-08-12 |
Not clear |
| Lin Wang, James E Fortney, Laura F Gibso. Stromal cell protection of B-lineage acute lymphoblastic leukemic cells during chemotherapy requires active Akt. Leukemia research. vol 28. issue 7. 2004-07-22. PMID:15158095. |
all cells expressing dominant negative akt were not efficiently rescued from ara-c or etoposide-induced apoptosis by stromal cell co-culture. |
2004-07-22 |
2023-08-12 |
Not clear |
| Lin Wang, James E Fortney, Laura F Gibso. Stromal cell protection of B-lineage acute lymphoblastic leukemic cells during chemotherapy requires active Akt. Leukemia research. vol 28. issue 7. 2004-07-22. PMID:15158095. |
these data suggest a pivotal role for akt in mediating stromal cell regulation of all cell apoptosis. |
2004-07-22 |
2023-08-12 |
Not clear |
| Shyra J Gardai, David A Hildeman, Steve K Frankel, Ben B Whitlock, S Courtney Frasch, Niels Borregaard, Philippa Marrack, Donna L Bratton, Peter M Henso. Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. The Journal of biological chemistry. vol 279. issue 20. 2004-07-21. PMID:14766748. |
phosphorylation of bax ser184 by akt regulates its activity and apoptosis in neutrophils. |
2004-07-21 |
2023-08-12 |
Not clear |
| Sheila M Nielsen-Preiss, Selina R Silva, Jennifer M Gillett. Role of PTEN and Akt in the regulation of growth and apoptosis in human osteoblastic cells. Journal of cellular biochemistry. vol 90. issue 5. 2004-07-20. PMID:14624456. |
role of pten and akt in the regulation of growth and apoptosis in human osteoblastic cells. |
2004-07-20 |
2023-08-12 |
human |
| Anna M Joy, Christian E Beaudry, Nhan L Tran, Francisco A Ponce, David R Holz, Tim Demuth, Michael E Beren. Migrating glioma cells activate the PI3-K pathway and display decreased susceptibility to apoptosis. Journal of cell science. vol 116. issue Pt 21. 2004-07-19. PMID:13130092. |
treatment of migrating cells with a specific inhibitor of phosphoinositide 3-kinase (pi3-k), ly294002, blocked the phosphorylation of akt and increased the sensitivity to apoptosis. |
2004-07-19 |
2023-08-12 |
Not clear |
| Bhumsoo Kim, Cynthia M van Golen, Eva L Feldma. Degradation and dephosphorylation of focal adhesion kinase during okadaic acid-induced apoptosis in human neuroblastoma cells. Neoplasia (New York, N.Y.). vol 5. issue 5. 2004-07-12. PMID:14670178. |
these changes preceded caspase-3 activation, akt and map kinase activity loss, protein ubiquitination, and cellular apoptosis. |
2004-07-12 |
2023-08-12 |
human |
| Young E Whang, Xiu-Juan Yuan, Yuanbo Liu, Samarpan Majumder, Terrence D Lewi. Regulation of sensitivity to TRAIL by the PTEN tumor suppressor. Vitamins and hormones. vol 67. 2004-07-07. PMID:15110188. |
constitutively active akt protects cells from trail-induced apoptosis in multiple tumor types. |
2004-07-07 |
2023-08-12 |
human |