| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sung-Shin Park, Yong-Nyun Kim, Yoon Kyung Jeon, Young A Kim, Ji Eun Kim, Heejung Kim, Chul Woo Ki. Genistein-induced apoptosis via Akt signaling pathway in anaplastic large-cell lymphoma. Cancer chemotherapy and pharmacology. vol 56. issue 3. 2005-08-16. PMID:15883821. |
from these results, we conclude that inhibition of the akt signaling pathway and induction of apoptosis by genistein could be used as a new treatment modality for the prevention and/or treatment of t(2;5) alcl and other hematopoietic malignancies. |
2005-08-16 |
2023-08-12 |
Not clear |
| Eunok Im, Sandeep Akare, Ashley Powell, Jesse D Martine. Ursodeoxycholic acid can suppress deoxycholic acid-induced apoptosis by stimulating Akt/PKB-dependent survival signaling. Nutrition and cancer. vol 51. issue 1. 2005-08-11. PMID:15749637. |
we found that udca could suppress dca-induced apoptosis in a time- and dose-dependent manner and that this effect correlated with akt phosphorylation. |
2005-08-11 |
2023-08-12 |
Not clear |
| Yoshitaka Matsumoto, Hikaru Machida, Nobuo Kubot. Preferential sensitization of tumor cells to radiation by heat shock protein 90 inhibitor geldanamycin. Journal of radiation research. vol 46. issue 2. 2005-08-11. PMID:15988140. |
in addition, a combination of radiation and ga abolished akt activities and strongly enhanced the induction of apoptosis in tumour cells which depend on akt protein activities for cell survival. |
2005-08-11 |
2023-08-12 |
Not clear |
| Yu-Ting Su, Huei-Ling Chang, Song-Kun Shyue, Shih-Lan Hs. Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochemical pharmacology. vol 70. issue 2. 2005-08-09. PMID:15941563. |
conversely, pharmacologic erk and akt inhibition promoted emodin-induced apoptosis. |
2005-08-09 |
2023-08-12 |
human |
| Yu-Ting Su, Huei-Ling Chang, Song-Kun Shyue, Shih-Lan Hs. Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochemical pharmacology. vol 70. issue 2. 2005-08-09. PMID:15941563. |
furthermore, the free radical scavenger ascorbic acid and n-acetylcysteine attenuated emodin-mediated ros production, erk and akt inactivation, mitochondrial dysfunction, bcl-2/bax modulation, and apoptosis. |
2005-08-09 |
2023-08-12 |
human |
| Yu-Ting Su, Huei-Ling Chang, Song-Kun Shyue, Shih-Lan Hs. Emodin induces apoptosis in human lung adenocarcinoma cells through a reactive oxygen species-dependent mitochondrial signaling pathway. Biochemical pharmacology. vol 70. issue 2. 2005-08-09. PMID:15941563. |
take together, these findings suggest that in a549 cells, emodin-mediated oxidative injury acts as an early and upstream change in the cell death cascade to antagonize cytoprotective erk and akt signaling, triggers mitochondrial dysfunction, bcl-2 and bax modulation, mitochondrial cytochrome c release, caspase activation, and consequent leading to apoptosis. |
2005-08-09 |
2023-08-12 |
human |
| Craig D Albright, Kerry-Ann da Costa, Corneliu N Craciunescu, Erich Klem, Mei-Heng Mar, Steven H Zeise. Regulation of choline deficiency apoptosis by epidermal growth factor in CWSV-1 rat hepatocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 15. issue 1-4. 2005-08-04. PMID:15665516. |
in contrast, we show that egf stimulation blocks apoptosis by restoring mitochondrial membrane potential (delta psi(m)), as determined using the potential-sensitive dye chloromethyl-x-rosamine, and by preventing the release and nuclear localization of cytochrome c. we investigated whether egf rescue involves egf receptor phosphorylation and activation of the down-stream cell survival factor akt. |
2005-08-04 |
2023-08-12 |
rat |
| Leslie Gapter, Zaisen Wang, Jan Glinski, Ka-yun N. Induction of apoptosis in prostate cancer cells by pachymic acid from Poria cocos. Biochemical and biophysical research communications. vol 332. issue 4. 2005-08-04. PMID:15913545. |
we speculate that pa influenced apoptosis by reducing prostaglandin synthesis and akt activity. |
2005-08-04 |
2023-08-12 |
human |
| Elisa Giovannetti, Valentina Mey, Sara Nannizzi, Giuseppe Pasqualetti, Luca Marini, Mario Del Tacca, Romano Danes. Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells. Molecular pharmacology. vol 68. issue 1. 2005-08-01. PMID:15795320. |
synergistic cytotoxicity was demonstrated, and pemetrexed significantly decreased the amount of phosphorylated akt, enhanced apoptosis, and increased the expression of dck in a549 and calu-6 cells, as well as the expression of the human nucleoside equilibrative transporter 1 (hent1) in all cell lines. |
2005-08-01 |
2023-08-12 |
human |
| Elisa Giovannetti, Valentina Mey, Sara Nannizzi, Giuseppe Pasqualetti, Luca Marini, Mario Del Tacca, Romano Danes. Cellular and pharmacogenetics foundation of synergistic interaction of pemetrexed and gemcitabine in human non-small-cell lung cancer cells. Molecular pharmacology. vol 68. issue 1. 2005-08-01. PMID:15795320. |
these data demonstrated that 1) gemcitabine and pemetrexed synergistically interact against nsclc cells through the suppression of akt phosphorylation and induction of apoptosis; 2) the gene expression profile of critical genes may predict for drug chemosensitivity; and 3) pemetrexed enhances dck and hent1 expression, thus suggesting the role of gene-expression modulation for rational development of chemotherapy combinations. |
2005-08-01 |
2023-08-12 |
human |
| Mark S Duxbury, Hiromichi Ito, Eric Benoit, Talat Waseem, Stanley W Ashley, Edward E Whan. RNA interference demonstrates a novel role for integrin-linked kinase as a determinant of pancreatic adenocarcinoma cell gemcitabine chemoresistance. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 11. issue 9. 2005-08-01. PMID:15867245. |
we also examined the effects of modulating ilk expression on gemcitabine-induced caspase 3-mediated apoptosis, phosphorylation status of akt (ser473) and glycogen synthase kinase. |
2005-08-01 |
2023-08-12 |
Not clear |
| S-J Kim, Y Ha. Insulin inhibits AMPA-induced neuronal damage via stimulation of protein kinase B (Akt). Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 2. 2005-07-29. PMID:15657639. |
taken together, these results suggest that insulin exerts neuroprotective effects by inhibiting ampa-induced excitotoxicity and apoptosis, possibly by activating akt and blocking sapk/jnk. |
2005-07-29 |
2023-08-12 |
rat |
| Zhao Zhong Chong, Faqi Li, Kenneth Maies. Oxidative stress in the brain: novel cellular targets that govern survival during neurodegenerative disease. Progress in neurobiology. vol 75. issue 3. 2005-07-29. PMID:15882775. |
current work has identified exciting pathways, such as the wnt pathway and the serine-threonine kinase akt, as central modulators that oversee cellular apoptosis and their downstream substrates that include forkhead transcription factors, glycogen synthase kinase-3beta, mitochondrial dysfunction, bad, and bcl-x(l). |
2005-07-29 |
2023-08-12 |
Not clear |
| Tetsuya Mizutani, Shuetsu Fukushi, Masayuki Saijo, Ichiro Kurane, Shigeru Morikaw. JNK and PI3k/Akt signaling pathways are required for establishing persistent SARS-CoV infection in Vero E6 cells. Biochimica et biophysica acta. vol 1741. issue 1-2. 2005-07-29. PMID:15916886. |
previous studies also showed that the activation of p38 mapk by viral infection-induced apoptosis, and a weak activation of akt was not sufficient to protect from apoptosis. |
2005-07-29 |
2023-08-12 |
Not clear |
| Pier Paolo Sainaghi, Luigi Castello, Luca Bergamasco, Margherita Galletti, Paola Bellosta, Gian Carlo Avanz. Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor. Journal of cellular physiology. vol 204. issue 1. 2005-07-26. PMID:15605394. |
this effect is proportional to axl expression, not due to inhibition of apoptosis, and induces akt and mapk phosphorylation. |
2005-07-26 |
2023-08-12 |
human |
| Jin Zhong, Jixian Deng, Jennifer Phan, Stephen Dlouhy, Huangbing Wu, Weiguo Yao, Ping Ye, A Joseph D'Ercole, Wei-Hua Le. Insulin-like growth factor-I protects granule neurons from apoptosis and improves ataxia in weaver mice. Journal of neuroscience research. vol 80. issue 4. 2005-07-25. PMID:15846777. |
we found that, consistently with this hypothesis, exogenous igf-i partially protected cultured weaver granule neurons from apoptosis by activating akt and decreasing caspase-3 activity. |
2005-07-25 |
2023-08-12 |
mouse |
| Bo-Geon Yun, Robert L Matt. Differential effects of Hsp90 inhibition on protein kinases regulating signal transduction pathways required for myoblast differentiation. Experimental cell research. vol 307. issue 1. 2005-07-25. PMID:15922741. |
treatment of differentiating c2c12 myoblasts with geldanamycin blocked myogenin expression, inhibited myotubule formation, and led to the depletion of three hsp90-dependent protein kinases, erbb2, fyn, and akt, and induction of apoptosis. |
2005-07-25 |
2023-08-12 |
Not clear |
| Joell J Gills, Phillip A Denni. The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt. Expert opinion on investigational drugs. vol 13. issue 7. 2005-07-21. PMID:15212619. |
furthermore, they selectively induce apoptosis in cancer cell lines that depend on akt for survival. |
2005-07-21 |
2023-08-12 |
human |
| Shi-Yong Sun, Zhongmei Zhou, Ruoxiang Wang, Haian Fu, Fadlo R Khur. The farnesyltransferase inhibitor Lonafarnib induces growth arrest or apoptosis of human lung cancer cells without downregulation of Akt. Cancer biology & therapy. vol 3. issue 11. 2005-07-21. PMID:15467440. |
the farnesyltransferase inhibitor lonafarnib induces growth arrest or apoptosis of human lung cancer cells without downregulation of akt. |
2005-07-21 |
2023-08-12 |
human |
| Shi-Yong Sun, Zhongmei Zhou, Ruoxiang Wang, Haian Fu, Fadlo R Khur. The farnesyltransferase inhibitor Lonafarnib induces growth arrest or apoptosis of human lung cancer cells without downregulation of Akt. Cancer biology & therapy. vol 3. issue 11. 2005-07-21. PMID:15467440. |
therefore, we conclude that lonafarnib is effective in inhibiting the growth of nsclc cells either via growth arrest or induction of apoptosis without downregulation of akt. |
2005-07-21 |
2023-08-12 |
human |