| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Gong, Indira Unnikrishnan, Anuradha Raghavan, Kalindi Parmar, Naomi Rosenber. Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells. Journal of virology. vol 78. issue 4. 2004-03-05. PMID:14747529. |
active akt and functional p53 modulate apoptosis in abelson virus-transformed pre-b cells. |
2004-03-05 |
2023-08-12 |
Not clear |
| Li Gong, Indira Unnikrishnan, Anuradha Raghavan, Kalindi Parmar, Naomi Rosenber. Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells. Journal of virology. vol 78. issue 4. 2004-03-05. PMID:14747529. |
the p120/r273k mutant suppressed apoptosis at the nonpermissive temperature, a phenotype correlated with its ability to activate akt. |
2004-03-05 |
2023-08-12 |
Not clear |
| Li Gong, Indira Unnikrishnan, Anuradha Raghavan, Kalindi Parmar, Naomi Rosenber. Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells. Journal of virology. vol 78. issue 4. 2004-03-05. PMID:14747529. |
apoptosis also was suppressed at the nonpermissive temperature by constitutively active akt and in p53-null pre-b cells transformed with the ts kinase domain mutant. |
2004-03-05 |
2023-08-12 |
Not clear |
| Li Gong, Indira Unnikrishnan, Anuradha Raghavan, Kalindi Parmar, Naomi Rosenber. Active Akt and functional p53 modulate apoptosis in Abelson virus-transformed pre-B cells. Journal of virology. vol 78. issue 4. 2004-03-05. PMID:14747529. |
these data indicate that an intact src homology 2 (sh2) domain is not critical for apoptosis suppression and suggest that signals transmitted through akt and p53 play an important role in the response. |
2004-03-05 |
2023-08-12 |
Not clear |
| Christine C Tomlinson, Blossom Damani. The K1 protein of Kaposi's sarcoma-associated herpesvirus activates the Akt signaling pathway. Journal of virology. vol 78. issue 4. 2004-03-05. PMID:14747556. |
we also demonstrate that activation of akt by the k1 protein leads to the phosphorylation and inhibition of members of the forkhead (fkhr) transcription factor family, which are key regulators of cell cycle progression and apoptosis. |
2004-03-05 |
2023-08-12 |
Not clear |
| Hong Zhao, Joelle Dupont, Shoshana Yakar, Michael Karas, Derek LeRoit. PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells. Oncogene. vol 23. issue 3. 2004-03-03. PMID:14737113. |
pten appears to play a crucial role in modulating apoptosis by reducing the levels of ptdins(3,4,5)p3, a phospholipid that activates akt, a central regulator of apoptosis. |
2004-03-03 |
2023-08-12 |
human |
| Addanki P Kumar, Gretchen E Garcia, Rita Ghosh, Rajendran V Rajnarayanan, William L Alworth, Thomas J Slag. 4-Hydroxy-3-methoxybenzoic acid methyl ester: a curcumin derivative targets Akt/NF kappa B cell survival signaling pathway: potential for prostate cancer management. Neoplasia (New York, N.Y.). vol 5. issue 3. 2004-02-27. PMID:12869308. |
overexpression of constitutively active akt reversed the hmbme-induced growth inhibition and apoptosis, illustrating the direct role of akt signaling in hmbme-mediated growth inhibition and apoptosis. |
2004-02-27 |
2023-08-12 |
mouse |
| S Zhao, M Konopleva, M Cabreira-Hansen, Z Xie, W Hu, M Milella, Z Estrov, G B Mills, M Andreef. Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia. vol 18. issue 2. 2004-02-24. PMID:14628071. |
in this study, we tested the hypothesis that the inhibition of pi3k by ly294002 results in the dephosphorylation of akt and bad, and thus promote leukemia cell apoptosis. |
2004-02-24 |
2023-08-12 |
Not clear |
| S Zhao, M Konopleva, M Cabreira-Hansen, Z Xie, W Hu, M Milella, Z Estrov, G B Mills, M Andreef. Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia. vol 18. issue 2. 2004-02-24. PMID:14628071. |
in mo7e cells, ly294002 reduced akt kinase activity, induced dephosphorylation of akt and bad, and increased apoptosis. |
2004-02-24 |
2023-08-12 |
Not clear |
| W Liu, A A Akhand, K Takeda, Y Kawamoto, M Itoigawa, M Kato, H Suzuki, N Ishikawa, I Nakashim. Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal. Cell death and differentiation. vol 10. issue 7. 2004-02-23. PMID:12815460. |
we studied the signal pathways for regulation of serine/threonine protein kinase akt in jurkat cells that had been treated with 4-hydroxynonenal (hne) for caspase-dependent apoptosis induction. |
2004-02-23 |
2023-08-12 |
Not clear |
| W Liu, A A Akhand, K Takeda, Y Kawamoto, M Itoigawa, M Kato, H Suzuki, N Ishikawa, I Nakashim. Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal. Cell death and differentiation. vol 10. issue 7. 2004-02-23. PMID:12815460. |
in addition, activated caspase-3 partially cleaved akt at a late stage of the apoptosis. |
2004-02-23 |
2023-08-12 |
Not clear |
| Taiichiro Miyashita, Atsushi Kawakami, Mami Tamai, Yasumori Izumi, Huang Mingguo, Fumiko Tanaka, Seigou Abiru, Koto Nakashima, Nozomi Iwanaga, Koichiro Aratake, Makoto Kamachi, Kazuhiko Arima, Hiroaki Ida, Kiyoshi Migita, Tomoki Origuchi, Shuzo Tagashira, Fumio Nishikaku, Katsumi Eguch. Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells. Biochemical and biophysical research communications. vol 312. issue 2. 2004-02-20. PMID:14637151. |
akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells. |
2004-02-20 |
2023-08-12 |
Not clear |
| Taiichiro Miyashita, Atsushi Kawakami, Mami Tamai, Yasumori Izumi, Huang Mingguo, Fumiko Tanaka, Seigou Abiru, Koto Nakashima, Nozomi Iwanaga, Koichiro Aratake, Makoto Kamachi, Kazuhiko Arima, Hiroaki Ida, Kiyoshi Migita, Tomoki Origuchi, Shuzo Tagashira, Fumio Nishikaku, Katsumi Eguch. Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells. Biochemical and biophysical research communications. vol 312. issue 2. 2004-02-20. PMID:14637151. |
we examined here functional role of akt during tumor necrosis factor-related apoptosis inducing ligand (trail)-mediated apoptosis in rheumatoid synovial cells. |
2004-02-20 |
2023-08-12 |
Not clear |
| Taiichiro Miyashita, Atsushi Kawakami, Mami Tamai, Yasumori Izumi, Huang Mingguo, Fumiko Tanaka, Seigou Abiru, Koto Nakashima, Nozomi Iwanaga, Koichiro Aratake, Makoto Kamachi, Kazuhiko Arima, Hiroaki Ida, Kiyoshi Migita, Tomoki Origuchi, Shuzo Tagashira, Fumio Nishikaku, Katsumi Eguch. Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells. Biochemical and biophysical research communications. vol 312. issue 2. 2004-02-20. PMID:14637151. |
rheumatoid synovial cells in vitro were rapidly committed to apoptosis in response to trail in mitochondria-dependent manner whereas akt and extracellular signal-regulated kinase (erk) were also phosphorylated. |
2004-02-20 |
2023-08-12 |
Not clear |
| Taiichiro Miyashita, Atsushi Kawakami, Mami Tamai, Yasumori Izumi, Huang Mingguo, Fumiko Tanaka, Seigou Abiru, Koto Nakashima, Nozomi Iwanaga, Koichiro Aratake, Makoto Kamachi, Kazuhiko Arima, Hiroaki Ida, Kiyoshi Migita, Tomoki Origuchi, Shuzo Tagashira, Fumio Nishikaku, Katsumi Eguch. Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells. Biochemical and biophysical research communications. vol 312. issue 2. 2004-02-20. PMID:14637151. |
trail-mediated apoptosis in synovial cells was significantly increased through inactivation of akt by ly294002, however, that process was not so changed by adding erk inhibitor, pd98059. |
2004-02-20 |
2023-08-12 |
Not clear |
| Taiichiro Miyashita, Atsushi Kawakami, Mami Tamai, Yasumori Izumi, Huang Mingguo, Fumiko Tanaka, Seigou Abiru, Koto Nakashima, Nozomi Iwanaga, Koichiro Aratake, Makoto Kamachi, Kazuhiko Arima, Hiroaki Ida, Kiyoshi Migita, Tomoki Origuchi, Shuzo Tagashira, Fumio Nishikaku, Katsumi Eguch. Akt is an endogenous inhibitor toward tumor necrosis factor-related apoptosis inducing ligand-mediated apoptosis in rheumatoid synovial cells. Biochemical and biophysical research communications. vol 312. issue 2. 2004-02-20. PMID:14637151. |
platelet-derived growth factor (pdgf) clearly phosphorylated both akt and erk in synovial cells, and pdgf pretreatment markedly suppressed trail-mediated synovial cell apoptosis. |
2004-02-20 |
2023-08-12 |
Not clear |
| Nathan Majewski, Veronique Nogueira, R Brooks Robey, Nissim Ha. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Molecular and cellular biology. vol 24. issue 2. 2004-02-18. PMID:14701745. |
akt inhibits apoptosis downstream of bid cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. |
2004-02-18 |
2023-08-12 |
Not clear |
| Nathan Majewski, Veronique Nogueira, R Brooks Robey, Nissim Ha. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Molecular and cellular biology. vol 24. issue 2. 2004-02-18. PMID:14701745. |
the precise mechanisms by which akt prevents apoptosis are not completely understood, but akt may function to maintain mitochondrial integrity, thereby preventing cytochrome c release following an apoptotic insult. |
2004-02-18 |
2023-08-12 |
Not clear |
| Nathan Majewski, Veronique Nogueira, R Brooks Robey, Nissim Ha. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Molecular and cellular biology. vol 24. issue 2. 2004-02-18. PMID:14701745. |
activated akt inhibited mitochondrial cytochrome c release and apoptosis following bid cleavage. |
2004-02-18 |
2023-08-12 |
Not clear |
| Nathan Majewski, Veronique Nogueira, R Brooks Robey, Nissim Ha. Akt inhibits apoptosis downstream of BID cleavage via a glucose-dependent mechanism involving mitochondrial hexokinases. Molecular and cellular biology. vol 24. issue 2. 2004-02-18. PMID:14701745. |
akt also antagonized tbid-mediated bax activation and mitochondrial bak oligomerization, two downstream events thought to be critical for tbid-induced apoptosis. |
2004-02-18 |
2023-08-12 |
Not clear |