| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hae Jong Kim, Seung Koo Kang, Jung Yee Mun, Young Jin Chun, Kyung Hee Choi, Mie Young Ki. Involvement of Akt in mitochondria-dependent apoptosis induced by a cdc25 phosphatase inhibitor naphthoquinone analog. FEBS letters. vol 555. issue 2. 2004-01-13. PMID:14644418. |
involvement of akt in mitochondria-dependent apoptosis induced by a cdc25 phosphatase inhibitor naphthoquinone analog. |
2004-01-13 |
2023-08-12 |
human |
| Hae Jong Kim, Seung Koo Kang, Jung Yee Mun, Young Jin Chun, Kyung Hee Choi, Mie Young Ki. Involvement of Akt in mitochondria-dependent apoptosis induced by a cdc25 phosphatase inhibitor naphthoquinone analog. FEBS letters. vol 555. issue 2. 2004-01-13. PMID:14644418. |
overexpression of constitutively active akt protected cells from ddn-induced apoptosis, while dominant negative akt moderately enhanced cell death. |
2004-01-13 |
2023-08-12 |
human |
| Hae Jong Kim, Seung Koo Kang, Jung Yee Mun, Young Jin Chun, Kyung Hee Choi, Mie Young Ki. Involvement of Akt in mitochondria-dependent apoptosis induced by a cdc25 phosphatase inhibitor naphthoquinone analog. FEBS letters. vol 555. issue 2. 2004-01-13. PMID:14644418. |
taken together, ddn-induced apoptosis is associated with mitochondrial signaling which involves cytochrome c release via a mechanism inhibited by akt. |
2004-01-13 |
2023-08-12 |
human |
| Nathalie Baeza, Michael Weller, Yasuhiro Yonekawa, Paul Kleihues, Hiroko Ohgak. PTEN methylation and expression in glioblastomas. Acta neuropathologica. vol 106. issue 5. 2004-01-09. PMID:12904991. |
the tumor suppressor gene pten on chromosome 10q23.3 regulates the akt signaling pathway and modulates cell growth and apoptosis. |
2004-01-09 |
2023-08-12 |
Not clear |
| Thomas F Franke, Christoph P Hornik, Lisa Segev, Grigoriy A Shostak, Chizuru Sugimot. PI3K/Akt and apoptosis: size matters. Oncogene. vol 22. issue 56. 2004-01-09. PMID:14663477. |
here, we hope to establish the mechanisms of apoptosis suppression by akt kinase as a framework for a more general understanding of growth factor-dependent regulation of cell survival. |
2004-01-09 |
2023-08-12 |
Not clear |
| Maarten L Janmaat, Frank A E Kruyt, José A Rodriguez, Giuseppe Giaccon. Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 6. 2004-01-06. PMID:12796401. |
response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited antiproliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or akt kinase pathways. |
2004-01-06 |
2023-08-12 |
Not clear |
| Song-Ja Kim, Sang-Gu Hwang, Il-Chul Kim, Jang-Soo Chu. Actin cytoskeletal architecture regulates nitric oxide-induced apoptosis, dedifferentiation, and cyclooxygenase-2 expression in articular chondrocytes via mitogen-activated protein kinase and protein kinase C pathways. The Journal of biological chemistry. vol 278. issue 43. 2004-01-05. PMID:12907684. |
the down-regulation of pi 3-kinase and akt was blocked by cd treatment, and the cd effects on apoptosis, p38 kinase, and pkcalpha and -zeta were abolished by the inhibition of pi 3-kinase with ly294002. |
2004-01-05 |
2023-08-12 |
Not clear |
| Hui Qin Wang, Taihao Quan, Tianyuan He, Thomas F Franke, John J Voorhees, Gary J Fishe. Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:12952968. |
this inhibition of akt activation was associated with a 3-4-fold increase of uv-induced apoptosis, as measured by flow cytometry and dna fragmentation elisa. |
2003-12-24 |
2023-08-12 |
human |
| Hui Qin Wang, Taihao Quan, Tianyuan He, Thomas F Franke, John J Voorhees, Gary J Fishe. Epidermal growth factor receptor-dependent, NF-kappaB-independent activation of the phosphatidylinositol 3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases-3, -8, and -9 in human keratinocytes. The Journal of biological chemistry. vol 278. issue 46. 2003-12-24. PMID:12952968. |
however, adenovirus-mediated overexpression of constitutively active akt completely blocked uv-induced apoptosis observed with pi3k inhibition by ly294002, whereas adenovirus mediated overexpression of dominant negative akt increased uv-induced apoptosis by 2-fold. |
2003-12-24 |
2023-08-12 |
human |
| Takashi Murakami, Adela R Cardones, Steven E Finkelstein, Nicholas P Restifo, Brenda A Klaunberg, Frank O Nestle, S Sianna Castillo, Phillip A Dennis, Sam T Hwan. Immune evasion by murine melanoma mediated through CC chemokine receptor-10. The Journal of experimental medicine. vol 198. issue 9. 2003-12-24. PMID:14581607. |
in vitro, exposure of tumor cells to ccl27 led to rapid activation of akt, resistance to cell death induced by melanoma antigen-specific cytotoxic t cells, and phosphatidylinositol-3-kinase (pi3k)-dependent protection from apoptosis induced by fas cross-linking. |
2003-12-24 |
2023-08-12 |
human |
| Amanda Jetzt, John A Howe, Mark T Horn, Eugene Maxwell, Zhizhang Yin, Duane Johnson, C Chandra Kuma. Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice. Cancer research. vol 63. issue 20. 2003-12-22. PMID:14583464. |
adenoviral-mediated expression of a kinase-dead mutant of akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice. |
2003-12-22 |
2023-08-12 |
mouse |
| Amanda Jetzt, John A Howe, Mark T Horn, Eugene Maxwell, Zhizhang Yin, Duane Johnson, C Chandra Kuma. Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice. Cancer research. vol 63. issue 20. 2003-12-22. PMID:14583464. |
similarly, akt-dn mutant expression led to selective induction of apoptosis in tumor cells expressing activated akt. |
2003-12-22 |
2023-08-12 |
mouse |
| Tai-Xing Cui, Hironori Nakagami, Clara Nahmias, Tetsuya Shiuchi, Yuko Takeda-Matsubara, Jian-Mei Li, Lan Wu, Masaru Iwai, Masatsugu Horiuch. Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells. Molecular endocrinology (Baltimore, Md.). vol 16. issue 9. 2003-12-19. PMID:12198247. |
angiotensin ii subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and akt and induces apoptosis in pc12w cells. |
2003-12-19 |
2023-08-12 |
rat |
| Tai-Xing Cui, Hironori Nakagami, Clara Nahmias, Tetsuya Shiuchi, Yuko Takeda-Matsubara, Jian-Mei Li, Lan Wu, Masaru Iwai, Masatsugu Horiuch. Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells. Molecular endocrinology (Baltimore, Md.). vol 16. issue 9. 2003-12-19. PMID:12198247. |
in the present study, we identified novel negative cross-talk between the angiotensin ii subtype 2 (at2) receptor and insulin receptor signaling in the regulation of phosphoinositide 3-kinase (pi3k), akt, and apoptosis in rat pheochromocytoma cell line, pc12w cells, which exclusively express at2 receptor. |
2003-12-19 |
2023-08-12 |
rat |
| Tai-Xing Cui, Hironori Nakagami, Clara Nahmias, Tetsuya Shiuchi, Yuko Takeda-Matsubara, Jian-Mei Li, Lan Wu, Masaru Iwai, Masatsugu Horiuch. Angiotensin II subtype 2 receptor activation inhibits insulin-induced phosphoinositide 3-kinase and Akt and induces apoptosis in PC12W cells. Molecular endocrinology (Baltimore, Md.). vol 16. issue 9. 2003-12-19. PMID:12198247. |
taken together, these results indicate that at2 receptor-mediated activation of shp-1 and the consequent inhibition irs-2-associated pi3k activity contributed at least partly to the inhibition of akt phosphorylation, thereby inducing apoptosis. |
2003-12-19 |
2023-08-12 |
rat |
| Marco Marchisio, Federica Brugnoli, Eugenio Santavenere, Maya Paludi, Fausta Ciccocioppo, Sebastiano Misci. Mitigation of tumor necrosis factor alpha cytotoxicity by aurintricarboxylic acid in human peripheral B lymphocytes. Biochemical pharmacology. vol 66. issue 10. 2003-12-19. PMID:14599555. |
apoptosis effected by tnf-alpha alone was suppressed in the presence of ata, and this effect appeared essentially characterized by: (i) phosphorylation of phosphatidylinositol-3 kinase (pi-3k), influencing in turn protein kinase b/akt (akt) and bad phosphorylation; (ii) nuclear translocation of the nuclear factor kappa b (nf-kappab) and (iii) nuclear translocation of protein kinase c zed (pkczeta). |
2003-12-19 |
2023-08-12 |
human |
| Yumiko Matsuoka, Yukitoshi Nagahara, Masahiko Ikekita, Takahisa Shinomiy. A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells. British journal of pharmacology. vol 138. issue 7. 2003-12-15. PMID:12711631. |
overall, the results suggest that fty720 activated pp2a or pp2a-like phosphatase and dephosphorylated akt pathway factors resulting in the enhancement of apoptosis via mitochondria. |
2003-12-15 |
2023-08-12 |
human |
| K H Limesand, K A Barzen, D O Quissell, S M Anderso. Synergistic suppression of apoptosis in salivary acinar cells by IGF1 and EGF. Cell death and differentiation. vol 10. issue 3. 2003-12-12. PMID:12700634. |
transduction of c5 cells with an adenovirus expressing a constitutively activated mutant of akt-suppressed etoposide-induced apoptosis, whereas a kinase-inactive mutant of akt suppressed the protective effect of igf1. |
2003-12-12 |
2023-08-12 |
rat |
| K H Limesand, K A Barzen, D O Quissell, S M Anderso. Synergistic suppression of apoptosis in salivary acinar cells by IGF1 and EGF. Cell death and differentiation. vol 10. issue 3. 2003-12-12. PMID:12700634. |
these results suggest that a threshold of activated akt is required for suppression of apoptosis and the cooperative action of growth factors in regulating salivary gland homeostasis. |
2003-12-12 |
2023-08-12 |
rat |
| Guan-Hua Lai, Zichen Zhang, Alphonse E Siric. Celecoxib acts in a cyclooxygenase-2-independent manner and in synergy with emodin to suppress rat cholangiocarcinoma growth in vitro through a mechanism involving enhanced Akt inactivation and increased activation of caspases-9 and -3. Molecular cancer therapeutics. vol 2. issue 3. 2003-12-11. PMID:12657721. |
this prominent suppression of cell growth correlated with significant increases in the activation of caspases-9 and -3 and induction of apoptosis in the combination-treated cells, which was associated with an enhanced suppression of akt activation. |
2003-12-11 |
2023-08-12 |
rat |