| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yong Liao, Mien-Chie Hun. Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis. Molecular and cellular biology. vol 23. issue 19. 2003-11-04. PMID:12972603. |
here, we show that e1a-mediated sensitization to apoptosis by the inactivation of a key survival factor akt and the activation of a pro-apoptotic factor p38. |
2003-11-04 |
2023-08-12 |
human |
| Yong Liao, Mien-Chie Hun. Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis. Molecular and cellular biology. vol 23. issue 19. 2003-11-04. PMID:12972603. |
thus, activation of p38 and inactivation of akt may have general implications for tumor suppression and sensitization to apoptosis. |
2003-11-04 |
2023-08-12 |
human |
| Mohamed Rahmani, Chunrong Yu, Erin Reese, Wesam Ahmed, Karen Hirsch, Paul Dent, Steven Gran. Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21(CIP1/WAF1) induction rather than AKT inhibition. Oncogene. vol 22. issue 40. 2003-10-31. PMID:13679862. |
inhibition of pi-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 map kinase inactivation and abrogation of p21(cip1/waf1) induction rather than akt inhibition. |
2003-10-31 |
2023-08-12 |
human |
| Jie Zhang, Yong Choi, Blanche Mavromatis, Alan Lichtenstein, Weiqun L. Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway. Oncogene. vol 22. issue 40. 2003-10-31. PMID:13679867. |
to understand the biologic importance of the phosphatidylinositol 3 kinase (pi3k)/akt activation affected by pten deletion, we analysed apoptosis and growth inhibition by applying pi3k inhibitors to myeloma lines and by expressing akt constructs. |
2003-10-31 |
2023-08-12 |
Not clear |
| Jie Zhang, Yong Choi, Blanche Mavromatis, Alan Lichtenstein, Weiqun L. Preferential killing of PTEN-null myelomas by PI3K inhibitors through Akt pathway. Oncogene. vol 22. issue 40. 2003-10-31. PMID:13679867. |
expression of an active akt, but not its kinase dead mutant, reversed wortmannin- and dexamethasone-induced apoptosis and growth inhibition in pten-null myeloma lines, suggesting that akt lies downstream of pi3k for pten-null myeloma survival and dexamethasone resistance. |
2003-10-31 |
2023-08-12 |
Not clear |
| Anne Gingery, Elizabeth Bradley, Aubie Shaw, Merry Jo Oursle. Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/NFkappaB pathways to maintain osteoclast survival. Journal of cellular biochemistry. vol 89. issue 1. 2003-10-30. PMID:12682917. |
blocking mek, akt, or nfkappab activity resulted in apoptosis of many, but not all, of the osteoclasts in purified marrow-derived osteoclasts, marrow-derived osteoclasts co-cultured with stromal cells, and spleen-derived osteoclasts maintained with rankl and m-csf. |
2003-10-30 |
2023-08-12 |
Not clear |
| Anne Gingery, Elizabeth Bradley, Aubie Shaw, Merry Jo Oursle. Phosphatidylinositol 3-kinase coordinately activates the MEK/ERK and AKT/NFkappaB pathways to maintain osteoclast survival. Journal of cellular biochemistry. vol 89. issue 1. 2003-10-30. PMID:12682917. |
simultaneous blockage of both akt and mek1/2 caused rapid apoptosis of nearly all osteoclasts, mimicking the response to pi3k inhibition. |
2003-10-30 |
2023-08-12 |
Not clear |
| Timothy C Hallstrom, Joseph R Nevin. Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 19. 2003-10-29. PMID:12954980. |
we conclude that the unique capacity of e2f1 to trigger apoptosis reflects a specificity of transcriptional activation potential, and that this role for e2f1 is regulated through the action of the akt protein kinase. |
2003-10-29 |
2023-08-12 |
Not clear |
| A M Martelli, P L Tazzari, G Tabellini, R Bortul, A M Billi, L Manzoli, A Ruggeri, R Conte, L Cocc. A new selective AKT pharmacological inhibitor reduces resistance to chemotherapeutic drugs, TRAIL, all-trans-retinoic acid, and ionizing radiation of human leukemia cells. Leukemia. vol 17. issue 9. 2003-10-21. PMID:12970779. |
overall, our results indicate that selective akt pharmacological inhibitors might be used in the future for enhancing the sensitivity of leukemia cells to therapeutic treatments that induce apoptosis or for overcoming resistance to these treatments. |
2003-10-21 |
2023-08-12 |
human |
| Shozo Nishida, Yoshiki Fujii, Shohei Yoshioka, Sigeru Kikuichi, Masanobu Tsubaki, Kiyohiro Irimajir. A new bisphosphonate, YM529 induces apoptosis in HL60 cells by decreasing phosphorylation of single survival signal ERK. Life sciences. vol 73. issue 21. 2003-10-21. PMID:13679234. |
these results suggest that ym529, the new bisphosphonate, induced apoptosis when inhibit ggpp synthase and consequently decreased the levels of phosphorylated erk, which is a survival signal; moreover, during this process, there is no influence on nf-kappab, akt, p38, and bcl-2. |
2003-10-21 |
2023-08-12 |
Not clear |
| Yuichi Tanaka, M Veronica Gavrielides, Yasuhiro Mitsuuchi, Teruhiko Fujii, Marcelo G Kazaniet. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. The Journal of biological chemistry. vol 278. issue 36. 2003-10-07. PMID:12824193. |
protein kinase c promotes apoptosis in lncap prostate cancer cells through activation of p38 mapk and inhibition of the akt survival pathway. |
2003-10-07 |
2023-08-12 |
Not clear |
| Jing Leng, Chang Han, A Jake Demetris, George K Michalopoulos, Tong W. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology (Baltimore, Md.). vol 38. issue 3. 2003-10-07. PMID:12939602. |
cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through akt activation: evidence for akt inhibition in celecoxib-induced apoptosis. |
2003-10-07 |
2023-08-12 |
human |
| Jing Leng, Chang Han, A Jake Demetris, George K Michalopoulos, Tong W. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: evidence for Akt inhibition in celecoxib-induced apoptosis. Hepatology (Baltimore, Md.). vol 38. issue 3. 2003-10-07. PMID:12939602. |
furthermore, hcc cells treated with the cox-2 inhibitor celecoxib showed significant reduction of akt phosphorylation and marked morphologic and biochemical characteristics of apoptosis. |
2003-10-07 |
2023-08-12 |
human |
| Naoya Fujita, Takashi Tsuru. Survival-signaling pathway as a promising target for cancer chemotherapy. Cancer chemotherapy and pharmacology. vol 52 Suppl 1. 2003-09-30. PMID:12819931. |
the serine/threonine kinase akt, also known as pkb or rac-pk, is a key molecule for protecting cells from undergoing apoptosis. |
2003-09-30 |
2023-08-12 |
Not clear |
| Bin Tian, Jian Liu, Peter Bitterman, Robert J Bach. Angiotensin II modulates nitric oxide-induced cardiac fibroblast apoptosis by activation of AKT/PKB. American journal of physiology. Heart and circulatory physiology. vol 285. issue 3. 2003-09-26. PMID:12763754. |
the effects of ang ii on akt phosphorylation and no donor-induced cfb apoptosis were abrogated when cells were preincubated with the specific phosphatidylinositol 3-kinase inhibitors wortmannin or ly-294002. |
2003-09-26 |
2023-08-12 |
Not clear |
| Wenli Wang, Chengyu Z Prince, Xing Hu, Matthew J Pollma. HRT1 modulates vascular smooth muscle cell proliferation and apoptosis. Biochemical and biophysical research communications. vol 308. issue 3. 2003-09-26. PMID:12914792. |
resistance to apoptosis was associated with the induction of akt expression/activity, a well-described anti-apoptotic mediator. |
2003-09-26 |
2023-08-12 |
Not clear |
| Kyung-Hee Chun, Ho-Young Lee, Khaled Hassan, Fadlo Khuri, Waun Ki Hong, Reuben Lota. Implication of protein kinase B/Akt and Bcl-2/Bcl-XL suppression by the farnesyl transferase inhibitor SCH66336 in apoptosis induction in squamous carcinoma cells. Cancer research. vol 63. issue 16. 2003-09-24. PMID:12941797. |
infection of sqcc/y1 cells with an adenovirus that contained a constitutively active form of akt rescued cells from sch66336-induced apoptosis. |
2003-09-24 |
2023-08-12 |
human |
| Kyung-Hee Chun, Ho-Young Lee, Khaled Hassan, Fadlo Khuri, Waun Ki Hong, Reuben Lota. Implication of protein kinase B/Akt and Bcl-2/Bcl-XL suppression by the farnesyl transferase inhibitor SCH66336 in apoptosis induction in squamous carcinoma cells. Cancer research. vol 63. issue 16. 2003-09-24. PMID:12941797. |
these results suggest that sch66336 is a potent apoptosis inducer in hnscc cells and that it may act by suppressing the akt pathway. |
2003-09-24 |
2023-08-12 |
human |
| E Gabriella Barbacci, Leslie R Pustilnik, Ann Marie K Rossi, Erling Emerson, Penny E Miller, Brian P Boscoe, Eric D Cox, Kenneth K Iwata, Jitesh P Jani, Kathleen Provoncha, John C Kath, Zhengyu Liu, James D Moye. The biological and biochemical effects of CP-654577, a selective erbB2 kinase inhibitor, on human breast cancer cells. Cancer research. vol 63. issue 15. 2003-09-23. PMID:12907618. |
levels of activated akt, an important positive regulator of cell survival, are reduced within 2 h of exposure to 250 nm cp-654577, and this may contribute to the increased apoptosis. |
2003-09-23 |
2023-08-12 |
mouse |
| M Tanaka, H B Grossma. In vivo gene therapy of human bladder cancer with PTEN suppresses tumor growth, downregulates phosphorylated Akt, and increases sensitivity to doxorubicin. Gene therapy. vol 10. issue 19. 2003-09-17. PMID:12923562. |
direct injection of ad-mmac into established subcutaneous um-uc-3 (pten deleted, upregulation of phosphorylated akt) and um-uc-6dox (wild-type pten, upregulation of phosphorylated akt) tumors in nude mice resulted in pten expression, apoptosis, and significantly decreased growth compared to ad-ctr- or phosphate-buffered saline (pbs)-treated tumors. |
2003-09-17 |
2023-08-12 |
mouse |