| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kuntebommanahalli N Thimmaiah, John Easton, Shile Huang, Karen A Veverka, Glen S Germain, Franklin C Harwood, Peter J Houghto. Insulin-like growth factor I-mediated protection from rapamycin-induced apoptosis is independent of Ras-Erk1-Erk2 and phosphatidylinositol 3'-kinase-Akt signaling pathways. Cancer research. vol 63. issue 2. 2003-03-13. PMID:12543789. |
the prevention of rapamycin-induced apoptosis by igf-i was not inhibited by expression of dominant-negative akt either alone or under conditions in which ly 294002 inhibited pi3k signaling. |
2003-03-13 |
2023-08-12 |
human |
| Judith Haendeler, Jörg Hoffmann, Sandy Rahman, Andreas M Zeiher, Stefanie Dimmele. Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS letters. vol 536. issue 1-3. 2003-03-10. PMID:12586360. |
akt (t308d/s473d) prevented novobiocin-induced reduction of telomerase activity and the stimulation of apoptosis. |
2003-03-10 |
2023-08-12 |
Not clear |
| Judith Haendeler, Jörg Hoffmann, Sandy Rahman, Andreas M Zeiher, Stefanie Dimmele. Regulation of telomerase activity and anti-apoptotic function by protein-protein interaction and phosphorylation. FEBS letters. vol 536. issue 1-3. 2003-03-10. PMID:12586360. |
these data suggest that the association between hsp90, akt and tert in concert with the phosphorylation of tert is necessary for maintaining telomerase activity and inhibition of apoptosis. |
2003-03-10 |
2023-08-12 |
Not clear |
| M Alkhalaf, A El-Mowafy, S Kara. Growth inhibition of MCF-7 human breast cancer cells by progesterone is associated with cell differentiation and phosphorylation of Akt protein. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 11. issue 5. 2003-03-05. PMID:12394246. |
the purpose of this study was to investigate the capacity of progesterone to induce apoptosis and to alter the activity of a key regulator of cell growth and differentiation, the akt protein. |
2003-03-05 |
2023-08-12 |
human |
| M Alkhalaf, A El-Mowafy, S Kara. Growth inhibition of MCF-7 human breast cancer cells by progesterone is associated with cell differentiation and phosphorylation of Akt protein. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP). vol 11. issue 5. 2003-03-05. PMID:12394246. |
we show here that (i) growth inhibition of breast cancer cells by progesterone is due to the induction of cell differentiation and not to apoptosis; (ii) progesterone activates the pi3-kinase/akt pathway as shown by the increase in the phosphorylation of akt protein; (iii) inhibiting pi3-kinase/akt pathway with ly294002 causes stimulation of apoptosis; and (v) progesterone enhances ly294002 induced-growth inhibition and apoptosis. |
2003-03-05 |
2023-08-12 |
human |
| Devin S Gary, Ollivier Milhavet, Simonetta Camandola, Mark P Mattso. Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons. Journal of neurochemistry. vol 84. issue 4. 2003-03-05. PMID:12562530. |
we report that integrin signaling prevents apoptosis of embryonic hippocampal neurons by a mechanism involving integrin-linked kinase (ilk) that activates akt kinase. |
2003-03-05 |
2023-08-12 |
Not clear |
| Devin S Gary, Ollivier Milhavet, Simonetta Camandola, Mark P Mattso. Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons. Journal of neurochemistry. vol 84. issue 4. 2003-03-05. PMID:12562530. |
activation of integrins using a peptide containing the amino acid sequence eikllis derived from the alpha chain of laminin protected hippocampal neurons from apoptosis induced by glutamate or staurosporine, and increased akt activity in a beta1 integrin-dependent manner. |
2003-03-05 |
2023-08-12 |
Not clear |
| Kip A West, John Brognard, Amy S Clark, Ilona R Linnoila, Xiaowei Yang, Sandra M Swain, Curtis Harris, Steven Belinsky, Phillip A Denni. Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells. The Journal of clinical investigation. vol 111. issue 1. 2003-03-03. PMID:12511591. |
redundant akt activation by nicotine and nnk could contribute to tobacco-related carcinogenesis by regulating two processes critical for tumorigenesis, cell growth and apoptosis. |
2003-03-03 |
2023-08-12 |
mouse |
| Sherry Lynn Franklin, Robert J Ferry, Pinchas Cohe. Rapid insulin-like growth factor (IGF)-independent effects of IGF binding protein-3 on endothelial cell survival. The Journal of clinical endocrinology and metabolism. vol 88. issue 2. 2003-02-28. PMID:12574231. |
specific commercial elisas quantified cell proliferation and apoptosis, and akt phosphorylation was assessed by immunoblots and confocal microscopy. |
2003-02-28 |
2023-08-12 |
human |
| Fang Yan, D Brent Pol. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. The Journal of biological chemistry. vol 277. issue 52. 2003-02-27. PMID:12393915. |
furthermore, products recovered from lgg culture broth supernatant show concentration-dependent activation of akt and inhibition of cytokine-induced apoptosis. |
2003-02-27 |
2023-08-12 |
mouse |
| Akio Horiguchi, Mototsugu Oya, Atsushi Uchida, Ken Marumo, Masaru Mura. Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma. The Journal of urology. vol 169. issue 2. 2003-02-25. PMID:12544348. |
akt has been implicated in the pathogenesis and progression of numerous human malignant tumors because akt regulates many key effector molecules involved in controlling the balance of survival and apoptosis. |
2003-02-25 |
2023-08-12 |
human |
| Gianluca Baldanzi, Nicoletta Filigheddu, Santina Cutrupi, Filomena Catapano, Sara Bonissoni, Alberto Fubini, Daniela Malan, Germano Baj, Riccarda Granata, Fabio Broglio, Mauro Papotti, Nicola Surico, Federico Bussolino, Jorgen Isgaard, Romano Deghenghi, Fabiola Sinigaglia, Maria Prat, Giampiero Muccioli, Ezio Ghigo, Andrea Grazian. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT. The Journal of cell biology. vol 159. issue 6. 2003-02-21. PMID:12486113. |
here we show that both ghrelin and des-acyl ghrelin inhibit apoptosis of primary adult and h9c2 cardiomyocytes and endothelial cells in vitro through activation of extracellular signal-regulated kinase-1/2 and akt serine kinases. |
2003-02-21 |
2023-08-12 |
Not clear |
| Peng Zhang, Patrick Ng, Diana Caridha, Richard A Leach, Ludmila V Asher, Mark J Novak, William J Smith, Steven L Zeichner, Peter K Chian. Gene expressions in Jurkat cells poisoned by a sulphur mustard vesicant and the induction of apoptosis. British journal of pharmacology. vol 137. issue 2. 2003-02-20. PMID:12208782. |
akt (pkb), a pivotal protein kinase which can block apoptosis and promotes cell survival, was identified to be chiefly down-regulated in a dose-dependent manner following cees treatment. |
2003-02-20 |
2023-08-12 |
Not clear |
| Koji Ishida, Hikaru Nagahara, Tomomi Kogiso, Tomoko Aso, Naoaki Hayashi, Toshihiro Akaik. Cell adhesion aside from integrin system can abrogate anoikis in rat liver cells by down-regulation of FasL expression, not by activation of PI-3K/Akt and ERK signaling pathway. Biochemical and biophysical research communications. vol 300. issue 1. 2003-02-13. PMID:12480544. |
an adult rat liver cell line, arlj301-3, underwent apoptosis within 4h under suspension conditions even with active forms of akt and erk1/2. |
2003-02-13 |
2023-08-12 |
rat |
| E Schönherr, B Levkau, L Schaefer, H Kresse, K Wals. Decorin affects endothelial cells by Akt-dependent and -independent pathways. Annals of the New York Academy of Sciences. vol 973. 2003-02-13. PMID:12485853. |
dominant-negative akt also blocked the antiapoptotic effect of decorin on ecs, but induction of dominant-positive akt could not rescue the cells from apoptosis. |
2003-02-13 |
2023-08-12 |
Not clear |
| Katsuhiko Yamada, Kayo Arita, Hirotsugu Kobuchi, Shinji Yamamoto, Tamotsu Yoshioka, Hiroshi Tamai, Kozo Utsum. Cholesteryl-hemisuccinate-induced apoptosis of promyelocytic leukemia HL-60 cells through a cyclosporin A-insensitive mechanism. Biochemical pharmacology. vol 65. issue 3. 2003-02-13. PMID:12527327. |
these results suggested that cs-induced apoptosis of hl-60 cells might be caused by inhibiting akt phosphorylation following cleavage of bid through caspase-8 activation and subsequently via an apaf complex-caspase cascade pathway. |
2003-02-13 |
2023-08-12 |
human |
| Yan Zhou, Peter H Larsen, Chunhai Hao, V Wee Yon. CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. The Journal of biological chemistry. vol 277. issue 51. 2003-02-12. PMID:12388552. |
furthermore, sdf-1 induced the phosphorylation of akt (protein kinase b), a kinase associated with survival, and prevented the apoptosis of glioma cells when serum was withdrawn from the culture medium. |
2003-02-12 |
2023-08-12 |
human |
| Nirmala Chandrasekar, Sanjeeva Mohanam, Meena Gujrati, William C Olivero, Dzung H Dinh, Jasti S Ra. Downregulation of uPA inhibits migration and PI3k/Akt signaling in glioblastoma cells. Oncogene. vol 22. issue 3. 2003-02-12. PMID:12545160. |
decreased activation of pi3k and the antiapoptotic factor akt was not sufficient to induce apoptosis in the antisense-upa clones, but staurosporine sensitized them to apoptosis to a greater extent than control cells. |
2003-02-12 |
2023-08-12 |
human |
| Dorothee S M Antlsperger, Verena M Dirsch, Dulce Ferreira, Jen-Liang Su, Ming-Liang Kuo, Angelika M Vollma. Ajoene-induced cell death in human promyeloleukemic cells does not require JNK but is amplified by the inhibition of ERK. Oncogene. vol 22. issue 4. 2003-02-12. PMID:12555071. |
blockade of erk1/2 but not akt pathways leads to sensitization of cells against ajoene-mediated apoptosis supporting the view that inhibition of erk1/2 is a valuable strategy to increase the sensitivity of promyeloleukemic cells towards ajoene. |
2003-02-12 |
2023-08-12 |
human |
| Melinda E Wilson, Ying Liu, Phyllis M Wis. Estradiol enhances Akt activation in cortical explant cultures following neuronal injury. Brain research. Molecular brain research. vol 102. issue 1-2. 2003-02-11. PMID:12191493. |
to examine a possible mechanism by which estradiol prevents apoptosis, we examined the level of activation of akt kinase, which mediates antiapoptotic signals. |
2003-02-11 |
2023-08-12 |
rat |