| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marina V Kisseleva, Li Cao, Philip W Majeru. Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits Akt/protein kinase B phosphorylation and leads to apoptotic cell death. The Journal of biological chemistry. vol 277. issue 8. 2002-04-24. PMID:11706019. |
the inhibition of akt phosphorylation in cells expressing 5ptase iv makes them highly susceptible to fas-induced apoptosis, whereas overexpressing of the 4ptase i protects cells from apoptosis. |
2002-04-24 |
2023-08-12 |
Not clear |
| B Li, S A Desai, R A MacCorkle-Chosnek, L Fan, D M Spence. A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis. Gene therapy. vol 9. issue 4. 2002-04-19. PMID:11896462. |
a novel conditional akt 'survival switch' reversibly protects cells from apoptosis. |
2002-04-19 |
2023-08-12 |
Not clear |
| B Li, S A Desai, R A MacCorkle-Chosnek, L Fan, D M Spence. A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis. Gene therapy. vol 9. issue 4. 2002-04-19. PMID:11896462. |
once activated, akt can prevent or delay apoptosis by phosphorylation-dependent inhibition or activation of multiple signaling molecules involved in apoptosis, such as bad, caspase-9, gsk3, and nf-kappab and forkhead family transcription factors. |
2002-04-19 |
2023-08-12 |
Not clear |
| B Li, S A Desai, R A MacCorkle-Chosnek, L Fan, D M Spence. A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis. Gene therapy. vol 9. issue 4. 2002-04-19. PMID:11896462. |
finally, in jurkat t cells stably expressing iakt, cid-induced akt activation rescued cells from apoptosis triggered by multiple apoptotic stimuli, including staurosporine, anti-fas antibodies, pi3k inhibitors and the dna damaging agent, etoposide. |
2002-04-19 |
2023-08-12 |
Not clear |
| B Li, S A Desai, R A MacCorkle-Chosnek, L Fan, D M Spence. A novel conditional Akt 'survival switch' reversibly protects cells from apoptosis. Gene therapy. vol 9. issue 4. 2002-04-19. PMID:11896462. |
this novel inducible akt should be useful for identifying new akt substrates and for reversibly protecting tissue from apoptosis due to ischemic injury or immunological attack. |
2002-04-19 |
2023-08-12 |
Not clear |
| Yongjun Yu, James C Alwin. Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt. Journal of virology. vol 76. issue 8. 2002-04-19. PMID:11907212. |
human cytomegalovirus major immediate-early proteins and simian virus 40 large t antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-oh kinase pathway and the cellular kinase akt. |
2002-04-19 |
2023-08-12 |
human |
| Yongjun Yu, James C Alwin. Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt. Journal of virology. vol 76. issue 8. 2002-04-19. PMID:11907212. |
in the work presented, we show that activation of the cellular kinase akt alone can inhibit apoptosis in ts13 cells grown at the nonpermissive temperature. |
2002-04-19 |
2023-08-12 |
human |
| Yongjun Yu, James C Alwin. Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt. Journal of virology. vol 76. issue 8. 2002-04-19. PMID:11907212. |
more significantly, we show that the hcmv mieps can activate akt, resulting in the inhibition of apoptosis. |
2002-04-19 |
2023-08-12 |
human |
| Yongjun Yu, James C Alwin. Human cytomegalovirus major immediate-early proteins and simian virus 40 large T antigen can inhibit apoptosis through activation of the phosphatidylinositide 3'-OH kinase pathway and the cellular kinase Akt. Journal of virology. vol 76. issue 8. 2002-04-19. PMID:11907212. |
using a specific inhibitor of pi3 kinase, we show that the ability of the mieps and t antigen to activate akt and inhibit apoptosis is eliminated, suggesting that the viral proteins utilize the pi3 kinase pathway for akt activation. |
2002-04-19 |
2023-08-12 |
human |
| Motohiro Nishida, Shuichi Takagahara, Yoshiko Maruyama, Yoshiyuki Sugimoto, Taku Nagao, Hitoshi Kuros. G beta gamma counteracts G alpha(q) signaling upon alpha(1)-adrenergic receptor stimulation. Biochemical and biophysical research communications. vol 291. issue 4. 2002-04-15. PMID:11866464. |
however, activation of akt but not erk plays an important role in the protection against the g alpha(q)-induced cellular injury and apoptosis. |
2002-04-15 |
2023-08-12 |
rat |
| Francesco Turturro, Marilyn D Arnold, Audrey Y Frist, Karen Pulfor. Model of inhibition of the NPM-ALK kinase activity by herbimycin A. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 8. issue 1. 2002-04-11. PMID:11801565. |
sudhl-1 cells showed increasing percentage of cells in g(1) after 18 h of incubation with a dose of herbimycin a. npm-alk, akt, and pakt were down-regulated after 24 h of incubation with herbimycin a. apoptosis was observed only if the dose of inhibitor was given every 12 h for prolonged time. |
2002-04-11 |
2023-08-12 |
Not clear |
| Deirdre A Buckley, Alan Cheng, Patrick A Kiely, Michel L Tremblay, Rosemary O'Conno. Regulation of insulin-like growth factor type I (IGF-I) receptor kinase activity by protein tyrosine phosphatase 1B (PTP-1B) and enhanced IGF-I-mediated suppression of apoptosis and motility in PTP-1B-deficient fibroblasts. Molecular and cellular biology. vol 22. issue 7. 2002-04-03. PMID:11884589. |
reexpression of ptp-1b in spontaneously immortalized fibroblasts resulted in decreased igf-ir and akt activation, as well as decreased protection from apoptosis and decreased motility. |
2002-04-03 |
2023-08-12 |
mouse |
| Saori Sato, Naoya Fujita, Takashi Tsuru. Interference with PDK1-Akt survival signaling pathway by UCN-01 (7-hydroxystaurosporine). Oncogene. vol 21. issue 11. 2002-04-02. PMID:11896604. |
here we show that ucn-01 (7-hydroxystaurosporine), a drug now in clinical trials and with a unique fingerprint pattern, induced dephosphorylation and inactivation of akt, resulting in the turn-off of the survival signals and the induction of apoptosis. |
2002-04-02 |
2023-08-12 |
human |
| Kellie A Fecteau, Jianxun Mei, Hwa-Chain R Wan. Differential modulation of signaling pathways and apoptosis of ras-transformed 10T1/2 cells by the depsipeptide FR901228. The Journal of pharmacology and experimental therapeutics. vol 300. issue 3. 2002-03-28. PMID:11861795. |
induction of apoptosis of ras-transformed cells by fr901228 correlates with suppression of the extracellular signal-regulated kinase (erk) signaling pathway through reduction of raf expression and deactivation of mek and erk, inhibition of the phosphoinositide-3 kinase (pi3-k) pathway indexed by suppression of akt activity, suppression of p38 activity, and activation of caspase-3. |
2002-03-28 |
2023-08-12 |
Not clear |
| Shyra Gardai, Ben B Whitlock, Cheryl Helgason, Dan Ambruso, Valerie Fadok, Donna Bratton, Peter M Henso. Activation of SHIP by NADPH oxidase-stimulated Lyn leads to enhanced apoptosis in neutrophils. The Journal of biological chemistry. vol 277. issue 7. 2002-03-21. PMID:11724799. |
however, despite no such effect singly, combined anti- and proapoptotic stimuli inhibit akt activity, leaving the cells susceptible to accelerated apoptosis. |
2002-03-21 |
2023-08-12 |
mouse |
| Christopher D Kontos, Eugene H Cha, John D York, Kevin G Peter. The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Molecular and cellular biology. vol 22. issue 6. 2002-03-12. PMID:11865050. |
the endothelial receptor tyrosine kinase tie1 activates phosphatidylinositol 3-kinase and akt to inhibit apoptosis. |
2002-03-12 |
2023-08-12 |
Not clear |
| Christopher D Kontos, Eugene H Cha, John D York, Kevin G Peter. The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Molecular and cellular biology. vol 22. issue 6. 2002-03-12. PMID:11865050. |
moreover, both akt phosphorylation and inhibition of apoptosis were abrogated by mutation of tyrosine 1113 to phenylalanine, suggesting that this residue is an important pi 3-kinase binding site. |
2002-03-12 |
2023-08-12 |
Not clear |
| Tanya M Gottlieb, Juan Fernando Martinez Leal, Rony Seger, Yoichi Taya, Moshe Ore. Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene. vol 21. issue 8. 2002-03-08. PMID:11850850. |
cross-talk between akt, p53 and mdm2: possible implications for the regulation of apoptosis. |
2002-03-08 |
2023-08-12 |
Not clear |
| Tanya M Gottlieb, Juan Fernando Martinez Leal, Rony Seger, Yoichi Taya, Moshe Ore. Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene. vol 21. issue 8. 2002-03-08. PMID:11850850. |
on the one hand, the combination of ionizing radiation and survival factor deprivation, which leads to rapid apoptosis of il-3 dependent da-1 cells, entails a caspase- and p53-dependent destruction of akt. |
2002-03-08 |
2023-08-12 |
Not clear |
| Tanya M Gottlieb, Juan Fernando Martinez Leal, Rony Seger, Yoichi Taya, Moshe Ore. Cross-talk between Akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene. vol 21. issue 8. 2002-03-08. PMID:11850850. |
this destruction of akt is not a secondary consequence of apoptosis, since it is not seen when the same cells are triggered to undergo apoptosis under different conditions. |
2002-03-08 |
2023-08-12 |
Not clear |