| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Cuello, S A Ettenberg, A S Clark, M M Keane, R H Posner, M M Nau, P A Dennis, S Lipkowit. Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. Cancer research. vol 61. issue 12. 2001-07-12. PMID:11406568. |
expression of a constitutively active form of akt kinase in an erbb-2-overexpressing cell line completely abrogated the increase in trail-mediated apoptosis by trastuzumab and significantly reduced the biological effect of either reagent alone. |
2001-07-12 |
2023-08-12 |
Not clear |
| M Cuello, S A Ettenberg, A S Clark, M M Keane, R H Posner, M M Nau, P A Dennis, S Lipkowit. Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. Cancer research. vol 61. issue 12. 2001-07-12. PMID:11406568. |
therefore, down-regulation of the erbb-2 receptor by trastuzumab enhances trail-mediated apoptosis by inhibiting akt kinase activity. |
2001-07-12 |
2023-08-12 |
Not clear |
| R Strange, T Metcalfe, L Thackray, M Dan. Apoptosis in normal and neoplastic mammary gland development. Microscopy research and technique. vol 52. issue 2. 2001-07-05. PMID:11169865. |
one of the proteins whose expression is able to inhibit apoptosis, and is altered during mammary epithelial cell was the serine-threonine protein kinase, akt 1. |
2001-07-05 |
2023-08-12 |
Not clear |
| R Strange, T Metcalfe, L Thackray, M Dan. Apoptosis in normal and neoplastic mammary gland development. Microscopy research and technique. vol 52. issue 2. 2001-07-05. PMID:11169865. |
akt 1 activation peaked in pregnancy and lactation, and decreased significantly during apoptosis in mammary involution. |
2001-07-05 |
2023-08-12 |
Not clear |
| R Strange, T Metcalfe, L Thackray, M Dan. Apoptosis in normal and neoplastic mammary gland development. Microscopy research and technique. vol 52. issue 2. 2001-07-05. PMID:11169865. |
mechanisms of akt 1 action include modulation of the ratio bcl-2 family members implicated in control of apoptosis. |
2001-07-05 |
2023-08-12 |
Not clear |
| K Gottlob, N Majewski, S Kennedy, E Kandel, R B Robey, N Ha. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes & development. vol 15. issue 11. 2001-07-05. PMID:11390360. |
however, unlike bcl-2 and bcl-xl, the ability of activated akt to preserve mitochondrial integrity, and thereby inhibit apoptosis, requires glucose availability and is coupled to its metabolism. |
2001-07-05 |
2023-08-12 |
Not clear |
| K Gottlob, N Majewski, S Kennedy, E Kandel, R B Robey, N Ha. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes & development. vol 15. issue 11. 2001-07-05. PMID:11390360. |
finally, ectopic hexokinase expression mimics the ability of akt to inhibit cytochrome c release and apoptosis. |
2001-07-05 |
2023-08-12 |
Not clear |
| A Yamaguchi, M Tamatani, H Matsuzaki, K Namikawa, H Kiyama, M P Vitek, N Mitsuda, M Tohyam. Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. The Journal of biological chemistry. vol 276. issue 7. 2001-06-28. PMID:11054421. |
akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. |
2001-06-28 |
2023-08-12 |
Not clear |
| A Yamaguchi, M Tamatani, H Matsuzaki, K Namikawa, H Kiyama, M P Vitek, N Mitsuda, M Tohyam. Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. The Journal of biological chemistry. vol 276. issue 7. 2001-06-28. PMID:11054421. |
survival factors suppress apoptosis by activating the serine/threonine kinase akt. |
2001-06-28 |
2023-08-12 |
Not clear |
| J M Nelson, D W Fr. Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition. The Journal of biological chemistry. vol 276. issue 18. 2001-06-28. PMID:11278435. |
akt, mapk (erk1/2), and p38 act in concert to promote apoptosis in response to erbb receptor family inhibition. |
2001-06-28 |
2023-08-12 |
Not clear |
| J M Nelson, D W Fr. Akt, MAPK (Erk1/2), and p38 act in concert to promote apoptosis in response to ErbB receptor family inhibition. The Journal of biological chemistry. vol 276. issue 18. 2001-06-28. PMID:11278435. |
these data indicate that suppression of akt and mapk in the presence of activated p38 results in cell death and a possible mechanism for the enhanced apoptosis produced by the combination of ci-1033 and gemcitabine in mda-mb-453 cells. |
2001-06-28 |
2023-08-12 |
Not clear |
| L Simpson, J Li, D Liaw, I Hennessy, J Oliner, F Christians, R Parson. PTEN expression causes feedback upregulation of insulin receptor substrate 2. Molecular and cellular biology. vol 21. issue 12. 2001-06-28. PMID:11359902. |
pten expression rapidly reduced the activity of akt, which was followed by a g(1) arrest and eventually apoptosis. |
2001-06-28 |
2023-08-12 |
Not clear |
| E Asselin, Y Wang, B K Tsan. X-linked inhibitor of apoptosis protein activates the phosphatidylinositol 3-kinase/Akt pathway in rat granulosa cells during follicular development. Endocrinology. vol 142. issue 6. 2001-06-21. PMID:11356694. |
the increased apoptosis was accompanied by marked decreases in xiap expression and phosphorylation of akt protein. |
2001-06-21 |
2023-08-12 |
rat |
| E Asselin, Y Wang, B K Tsan. X-linked inhibitor of apoptosis protein activates the phosphatidylinositol 3-kinase/Akt pathway in rat granulosa cells during follicular development. Endocrinology. vol 142. issue 6. 2001-06-21. PMID:11356694. |
addition of the specific pi 3-k inhibitor ly294002 to the granulosa cell cultures decreased akt phosphorylation and induced apoptosis in a dose-dependent manner. |
2001-06-21 |
2023-08-12 |
rat |
| A I Flores, B S Mallon, T Matsui, W Ogawa, A Rosenzweig, T Okamoto, W B Mackli. Akt-mediated survival of oligodendrocytes induced by neuregulins. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 20. issue 20. 2001-06-07. PMID:11027222. |
overexpression of dominant negative akt but not of wild-type akt by adenoviral gene transfer in primary cultures of both oligodendrocytes and their progenitors induced significant apoptosis through activation of the caspase cascade. |
2001-06-07 |
2023-08-12 |
Not clear |
| J T Yu, R G Foster, D C Dea. Transcriptional repression by RB-E2F and regulation of anchorage-independent survival. Molecular and cellular biology. vol 21. issue 10. 2001-06-07. PMID:11313458. |
this facilitates assembly of a repressor complex containing histone deacetylase (hdac), rb, and e2f that blocks transcription of the gene for igf-1, leading to loss of akt activity, accumulation of active proapoptotic proteins, and apoptosis. |
2001-06-07 |
2023-08-12 |
Not clear |
| J T Yu, R G Foster, D C Dea. Transcriptional repression by RB-E2F and regulation of anchorage-independent survival. Molecular and cellular biology. vol 21. issue 10. 2001-06-07. PMID:11313458. |
this feedback loop containing gsk-3beta, cyclin d, hdac-rb-e2f, and igf-1 then determines how long akt will remain active after cells lose matrix contact, and thus it serves to regulate the onset of apoptosis in such cells. |
2001-06-07 |
2023-08-12 |
Not clear |
| M R Gold, R J Ingham, S J McLeod, S L Christian, M P Scheid, V Duronio, L Santos, L Matsuuch. Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap1 GTPase. Immunological reviews. vol 176. 2001-05-31. PMID:11043767. |
akt phosphorylates several transcription factors as well as proteins that regulate apoptosis and protein synthesis. |
2001-05-31 |
2023-08-12 |
Not clear |
| C P Paweletz, L Charboneau, V E Bichsel, N L Simone, T Chen, J W Gillespie, M R Emmert-Buck, M J Roth, E F Petricoin III, L A Liott. Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene. vol 20. issue 16. 2001-05-31. PMID:11360182. |
cancer progression was associated with increased phosphorylation of akt (p<0.04), suppression of apoptosis pathways (p<0.03), as well as decreased phosphorylation of erk (p<0.01). |
2001-05-31 |
2023-08-12 |
human |
| C P Paweletz, L Charboneau, V E Bichsel, N L Simone, T Chen, J W Gillespie, M R Emmert-Buck, M J Roth, E F Petricoin III, L A Liott. Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene. vol 20. issue 16. 2001-05-31. PMID:11360182. |
at the transition from histologically normal epithelium to pin we observed a statistically significant surge in phosphorylated akt (p<0.03) and a concomitant suppression of downstream apoptosis pathways which proceeds the transition into invasive carcinoma. |
2001-05-31 |
2023-08-12 |
human |