| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| O S Bang, B G Ha, E K Park, S S Kan. Activation of Akt is induced by heat shock and involved in suppression of heat-shock-induced apoptosis of NIH3T3 cells. Biochemical and biophysical research communications. vol 278. issue 2. 2001-01-04. PMID:11097835. |
moreover, overexpression of a dominant-negative akt mutant significantly inhibited the apoptosis-suppressive effect of heat shock, indicating the direct involvement of heat-shock-induced akt activation in the apoptosis suppression. |
2001-01-04 |
2023-08-12 |
Not clear |
| H Koh, K H Lee, D Kim, S Kim, J W Kim, J Chun. Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage. The Journal of biological chemistry. vol 275. issue 44. 2000-12-14. PMID:10926925. |
therefore, we hypothesized that a pathway leading to the inhibition of akt might be utilized in the process of apoptosis. |
2000-12-14 |
2023-08-12 |
Not clear |
| H Koh, K H Lee, D Kim, S Kim, J W Kim, J Chun. Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage. The Journal of biological chemistry. vol 275. issue 44. 2000-12-14. PMID:10926925. |
during early stages of apoptosis, the c-terminal region of prk2 is cleaved from the inhibitory n-terminal region and can bind akt. |
2000-12-14 |
2023-08-12 |
Not clear |
| P Navarro, A M Valverde, J L Rohn, M Benito, M Lorenz. Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 10. issue 5. 2000-12-14. PMID:11042022. |
akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. |
2000-12-14 |
2023-08-12 |
Not clear |
| P Navarro, A M Valverde, J L Rohn, M Benito, M Lorenz. Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 10. issue 5. 2000-12-14. PMID:11042022. |
insulin rescued serum-deprived immortalized brown adipocytes from apoptosis through phosphatidylinositol (pi) 3-kinase and akt pathways, but independently of p70s6-kinase, as demonstrated by the use of inhibitors such as ly294002 or rapamycin, and transfection experiments with dominant-negative constructs of akt or p85 subunit of pi 3-kinase. |
2000-12-14 |
2023-08-12 |
Not clear |
| P Navarro, A M Valverde, J L Rohn, M Benito, M Lorenz. Akt mediates insulin rescue from apoptosis in brown adipocytes: effect of ceramide. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society. vol 10. issue 5. 2000-12-14. PMID:11042022. |
ceramide also caused apoptosis in cells transfected with a constitutively active akt construct, since phosphorylation of akt was impaired under these experimental conditions. |
2000-12-14 |
2023-08-12 |
Not clear |
| S D Westfall, I R Hendry, K L Obholz, B R Rueda, J S Davi. Putative role of the phosphatidylinositol 3-kinase-Akt signaling pathway in the survival of granulosa cells. Endocrine. vol 12. issue 3. 2000-12-07. PMID:10963053. |
these data suggest that igf-i-induced phosphorylation of akt is mediated through pi 3-kinase and that inactivation of this pathway results in granulosa cell apoptosis. |
2000-12-07 |
2023-08-12 |
Not clear |
| Y Gao, R Yokota, S Tang, A W Ashton, J A War. Reversal of angiogenesis in vitro, induction of apoptosis, and inhibition of AKT phosphorylation in endothelial cells by thromboxane A(2). Circulation research. vol 87. issue 9. 2000-12-07. PMID:11055976. |
reversal of angiogenesis in vitro, induction of apoptosis, and inhibition of akt phosphorylation in endothelial cells by thromboxane a(2). |
2000-12-07 |
2023-08-12 |
human |
| Y Gao, R Yokota, S Tang, A W Ashton, J A War. Reversal of angiogenesis in vitro, induction of apoptosis, and inhibition of AKT phosphorylation in endothelial cells by thromboxane A(2). Circulation research. vol 87. issue 9. 2000-12-07. PMID:11055976. |
in this study, we demonstrate that the txa(2) mimetic ibop increases apoptosis of human ecs and inhibits the phosphorylation of akt kinase, an intracellular mediator required for cell survival. |
2000-12-07 |
2023-08-12 |
human |
| Y Gao, R Yokota, S Tang, A W Ashton, J A War. Reversal of angiogenesis in vitro, induction of apoptosis, and inhibition of AKT phosphorylation in endothelial cells by thromboxane A(2). Circulation research. vol 87. issue 9. 2000-12-07. PMID:11055976. |
ibop induced apoptosis and inhibited phosphorylation of akt kinase in both tpalpha and tpbeta. |
2000-12-07 |
2023-08-12 |
human |
| Y Gao, R Yokota, S Tang, A W Ashton, J A War. Reversal of angiogenesis in vitro, induction of apoptosis, and inhibition of AKT phosphorylation in endothelial cells by thromboxane A(2). Circulation research. vol 87. issue 9. 2000-12-07. PMID:11055976. |
in conclusion, apoptosis may be the mechanism by which txa(2)-mediated destruction of vascular structures in ecs occurs; although both tp isoforms induce apoptosis, possibly via inhibiting akt phosphorylation, the signaling differs in each isoform, in that activation of the adenylyl cyclase pathway prevents apoptosis caused by tpbeta, but not by tpalpha, stimulation. |
2000-12-07 |
2023-08-12 |
human |
| H Zhou, X M Li, J Meinkoth, R N Pittma. Akt regulates cell survival and apoptosis at a postmitochondrial level. The Journal of cell biology. vol 151. issue 3. 2000-12-07. PMID:11062251. |
akt regulates cell survival and apoptosis at a postmitochondrial level. |
2000-12-07 |
2023-08-12 |
Not clear |
| H Zhou, X M Li, J Meinkoth, R N Pittma. Akt regulates cell survival and apoptosis at a postmitochondrial level. The Journal of cell biology. vol 151. issue 3. 2000-12-07. PMID:11062251. |
however, the cellular mechanisms by which akt suppresses cell death and protects neurons from apoptosis remain unclear. |
2000-12-07 |
2023-08-12 |
Not clear |
| H Zhou, X M Li, J Meinkoth, R N Pittma. Akt regulates cell survival and apoptosis at a postmitochondrial level. The Journal of cell biology. vol 151. issue 3. 2000-12-07. PMID:11062251. |
here we show that stable expression of either constitutively active akt or bcl-2 inhibits apoptosis, but only bcl-2 prevents the release of cytochrome c from mitochondria, suggesting that akt regulates apoptosis at a postmitochondrial level. |
2000-12-07 |
2023-08-12 |
Not clear |
| H Zhou, X M Li, J Meinkoth, R N Pittma. Akt regulates cell survival and apoptosis at a postmitochondrial level. The Journal of cell biology. vol 151. issue 3. 2000-12-07. PMID:11062251. |
consistent with this, overexpressing active akt rescues cells from apoptosis without altering expression levels of endogenous bcl-2, bcl-x, or bax. |
2000-12-07 |
2023-08-12 |
Not clear |
| H Zhou, X M Li, J Meinkoth, R N Pittma. Akt regulates cell survival and apoptosis at a postmitochondrial level. The Journal of cell biology. vol 151. issue 3. 2000-12-07. PMID:11062251. |
akt inhibits apoptosis induced by microinjection of cytochrome c and lysates from cells expressing active akt inhibit cytochrome c induced caspase activation in a cell-free assay while lysates from bcl-2-expressing cells have no effect. |
2000-12-07 |
2023-08-12 |
Not clear |
| J Ding, T Takano, S Gao, W Han, C Noda, S Yanagi, H Yamamur. Syk is required for the activation of Akt survival pathway in B cells exposed to oxidative stress. The Journal of biological chemistry. vol 275. issue 40. 2000-11-13. PMID:10906139. |
these results suggest that syk is essential for the akt survival pathway in b cells and enhances cellular resistance to oxidative stress-induced apoptosis. |
2000-11-13 |
2023-08-12 |
Not clear |
| N L Ge, S Rudikof. Insulin-like growth factor I is a dual effector of multiple myeloma cell growth. Blood. vol 96. issue 8. 2000-11-09. PMID:11023522. |
the first included akt and bad, leading to an inhibition of apoptosis; the second included the mitogen-activated protein kinase (mapk), resulting in proliferation. |
2000-11-09 |
2023-08-12 |
mouse |
| A M Mirza, A D Kohn, R A Roth, M McMaho. Oncogenic transformation of cells by a conditionally active form of the protein kinase Akt/PKB. Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research. vol 11. issue 6. 2000-11-02. PMID:10910095. |
consistent with these observations, activation of m+ akt:er* suppressed the apoptosis of rat1 cells that occurs after the detachment of these cells from extracellular matrix. |
2000-11-02 |
2023-08-12 |
Not clear |
| I Kim, J H Kim, S O Moon, H J Kwak, N G Kim, G Y Ko. Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3'-kinase/Akt signal transduction pathway. Oncogene. vol 19. issue 39. 2000-10-17. PMID:11002428. |
these findings indicate that at high concentrations, ang2, like ang1, can be an apoptosis survival factor for endothelial cells through the activation of the tie2 receptor, pi 3'-kinase and akt, and thus may be a positive regulator of tumor angiogenesis. |
2000-10-17 |
2023-08-12 |
human |