| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Si C Tran, Tu M Pham, Lam N Nguyen, Eun-Mee Park, Yun-Sook Lim, Soon B Hwan. Nonstructural 3 Protein of Hepatitis C Virus Modulates the Tribbles Homolog 3/Akt Signaling Pathway for Persistent Viral Infection. Journal of virology. vol 90. issue 16. 2017-05-15. PMID:27252525. |
trib3 blocks the phosphorylation of akt and induces apoptosis under endoplasmic reticulum (er) stress conditions. |
2017-05-15 |
2023-08-13 |
Not clear |
| Yu Fan, Qian Zhan, Hongying Xu, Lili Li, Chen Li, Qian Xiao, Shili Xiang, Tianli Hui, Tingxiu Xiang, Guosheng Re. Epigenetic identification of ZNF545 as a functional tumor suppressor in multiple myeloma via activation of p53 signaling pathway. Biochemical and biophysical research communications. vol 474. issue 4. 2017-05-10. PMID:27150632. |
znf545 transcriptionally activated the p53 signaling pathway but had no effect on akt in mm, whereas ectopic expression of znf545 in silenced cells suppressed their proliferation and induced apoptosis. |
2017-05-10 |
2023-08-13 |
Not clear |
| O Kwon, S Y Cho, J-S Paick, S W Ki. Effects of the start time of glycemic control on erectile function in streptozotocin-induced diabetic rats. International journal of impotence research. vol 29. issue 1. 2017-05-10. PMID:27654033. |
apoptosis recovered significantly only in group 7w, comparable to group c. as start times became earlier, for all molecules (enos, akt, mypt1 and pecam-1), treatment groups' results neared those of group c. in conclusion, erectile function of diabetic rats recovered closer to normal controls if diabetic treatment started earlier. |
2017-05-10 |
2023-08-13 |
rat |
| Pei-Yu Wang, Wen-Jun Zeng, Jie Liu, Yun-Long Wu, Yinghui Ma, Zhiping Zeng, Ji-Yan Pang, Xiao-Kun Zhang, Xiaomei Yan, Alice Sze Tsai Wong, Jin-Zhang Zen. TRC4, an improved triptolide derivative, specifically targets to truncated form of retinoid X receptor-alpha in cancer cells. Biochemical pharmacology. vol 124. 2017-05-10. PMID:27810320. |
the capability of inhibiting trxrα expression was shown to be closely associated with its inactivation of akt and induction of apoptosis in various cancer cells. |
2017-05-10 |
2023-08-13 |
Not clear |
| Young-Sang Kim, Se-Kwon Kim, Sun Joo Par. Apoptotic effect of demethoxyfumitremorgin C from marine fungus Aspergillus fumigatus on PC3 human prostate cancer cells. Chemico-biological interactions. vol 269. 2017-05-09. PMID:28359723. |
demethoxyfumitremorgin c induced apoptosis was associated with downregulation of anti-apoptotic proteins: ras, pi3k, akt, bcl-xl, and bcl-2, and upregulation of pro-apoptotic bax. |
2017-05-09 |
2023-08-13 |
mouse |
| Whasun Lim, Changwon Yang, Fuller W Bazer, Gwonhwa Son. Chrysophanol Induces Apoptosis of Choriocarcinoma Through Regulation of ROS and the AKT and ERK1/2 Pathways. Journal of cellular physiology. vol 232. issue 2. 2017-05-08. PMID:27171670. |
chrysophanol induces apoptosis of choriocarcinoma through regulation of ros and the akt and erk1/2 pathways. |
2017-05-08 |
2023-08-13 |
human |
| Jintaek Im, Kyutae Kim, Polla Hergert, Richard Seonghun Nh. Idiopathic pulmonary fibrosis fibroblasts become resistant to Fas ligand-dependent apoptosis via the alteration of decoy receptor 3. The Journal of pathology. vol 240. issue 1. 2017-05-04. PMID:27218286. |
however, the inhibition of akt or nfatc1 decreases dcr3 mrna and protein levels, which sensitizes ipf fibroblasts to fasl-mediated apoptosis. |
2017-05-04 |
2023-08-13 |
human |
| Yogesh M Kulkarni, Vivek Kaushik, Neelam Azad, Clayton Wright, Yon Rojanasakul, George O'Doherty, Anand Krishnan V Iye. Autophagy-Induced Apoptosis in Lung Cancer Cells by a Novel Digitoxin Analog. Journal of cellular physiology. vol 231. issue 4. 2017-05-01. PMID:26264876. |
we investigated monod-dependent regulation of akt and bcl2, proteins that are known regulators of both autophagy and apoptosis. |
2017-05-01 |
2023-08-13 |
Not clear |
| Tung-Yi Lin, Hsien-Yeh Hsu, Wei-Hsuan Sun, Tsung-Han Wu, Shu-Ming Tsa. Induction of Cbl-dependent epidermal growth factor receptor degradation in Ling Zhi-8 suppressed lung cancer. International journal of cancer. vol 140. issue 11. 2017-05-01. PMID:28198003. |
in our study, we demonstrated that recombinant lz-8 (rlz-8), a medicinal mushroom ganoderma lucidum protein, induced cell cycle arrest and apoptosis by downregulating the expression of wild-type and mutated egfr and inhibiting egfr downstream effectors, akt and erk1/2 in lung cancer cells. |
2017-05-01 |
2023-08-13 |
mouse |
| Bei Zhang, Li-Ling Wang, Ru-Jing Ren, Eric B Dammer, Yong-Fang Zhang, Yue Huang, Sheng-Di Chen, Gang Wan. MicroRNA-146a represses LRP2 translation and leads to cell apoptosis in Alzheimer's disease. FEBS letters. vol 590. issue 14. 2017-04-28. PMID:27241555. |
overexpression of mirna-146a in sh-sy5y cells significantly decreased lrp2 expression, resulting in a reduction of akt activation and induction of proapoptotic caspase-3, thereby increasing cell apoptosis. |
2017-04-28 |
2023-08-13 |
Not clear |
| Gennaro Altamura, Annunziata Corteggio, Giuseppe Borzacchiell. Felis catus papillomavirus type 2 E6 oncogene enhances mitogen-activated protein kinases and Akt activation but not EGFR expression in an in vitro feline model of viral pathogenesis. Veterinary microbiology. vol 195. 2017-04-26. PMID:27771077. |
the activated molecules mek (pmek), erk (perk) and akt (pakt) are signaling transduction effectors regulating cell proliferation and inhibition of apoptosis, which are critical steps towards tumour formation. |
2017-04-26 |
2023-08-13 |
human |
| Shuai Yang, Xinmei Zhao, Hui Xu, Fan Chen, Yitao Xu, Zhe Li, Daniel Sanchis, Liang Jin, Yubin Zhang, Junmei Y. AKT2 Blocks Nucleus Translocation of Apoptosis-Inducing Factor (AIF) and Endonuclease G (EndoG) While Promoting Caspase Activation during Cardiac Ischemia. International journal of molecular sciences. vol 18. issue 3. 2017-04-25. PMID:28272306. |
the akt (protein kinase b, pkb) family has been shown to participate in diverse cellular processes, including apoptosis. |
2017-04-25 |
2023-08-13 |
Not clear |
| Ying-Ying Shao, Tao-Lan Zhang, Lan-Xiang Wu, He-Cun Zou, Shuang Li, Jin Huang, Hong-Hao Zho. AKT Axis, miR-21, and RECK Play Pivotal Roles in Dihydroartemisinin Killing Malignant Glioma Cells. International journal of molecular sciences. vol 18. issue 2. 2017-04-20. PMID:28208619. |
results showed that dha induced apoptosis of malignant glioma cells through protein kinase b (akt) axis, induced death of malignant glioma cells by downregulating mir-21, and inhibited the invasion of malignant glioma cells corresponding with up-regulation of the reversion-inducing-cysteine-rich protein with kazal motifs (reck). |
2017-04-20 |
2023-08-13 |
Not clear |
| Bin Zhang, Yaping Chen, Qiang Shen, Guiyan Liu, Jingxue Ye, Guibo Sun, Xiaobo Su. Myricitrin Attenuates High Glucose-Induced Apoptosis through Activating Akt-Nrf2 Signaling in H9c2 Cardiomyocytes. Molecules (Basel, Switzerland). vol 21. issue 7. 2017-04-18. PMID:27399653. |
in summary, these observations demonstrate that myricitrin activates nrf2-mediated anti-oxidant signaling and attenuates h9c2 cell apoptosis induced by high glucose via activation of akt signaling. |
2017-04-18 |
2023-08-13 |
Not clear |
| Chang-Fang Chiu, Jing-Ru Weng, Appaso Jadhav, Chia-Yung Wu, Aaron M Sargeant, Li-Yuan Ba. T315 Decreases Acute Myeloid Leukemia Cell Viability through a Combination of Apoptosis Induction and Autophagic Cell Death. International journal of molecular sciences. vol 17. issue 8. 2017-04-17. PMID:27537872. |
t315 down regulates protein kinase b (akt) and p-akt and induces caspase activation, poly-adp-ribose polymerase (parp) cleavage, apoptosis and autophagy through an ilk-independent manner. |
2017-04-17 |
2023-08-13 |
mouse |
| Zhen Liu, Qi Zheng, Wenzhu Chen, Meng Wu, Guojun Pan, Ke Yang, Xuzhe Li, Shuli Man, Yuou Teng, Peng Yu, Wenyuan Ga. Chemosensitizing effect of Paris Saponin I on Camptothecin and 10-hydroxycamptothecin in lung cancer cells via p38 MAPK, ERK, and Akt signaling pathways. European journal of medicinal chemistry. vol 125. 2017-04-12. PMID:27721159. |
collectively, our results demonstrated that psi functions as a chemosensitizer by enhancing apoptosis through influencing p38 mapk, erk, and akt pathways in lung cancer cells, and the combination with cpt/hcpt might be a promising strategy for the development of new therapeutic agents. |
2017-04-12 |
2023-08-13 |
Not clear |
| Tao Wang, Si-Dong Yang, Sen Liu, Hui Wang, Huan Liu, Wen Yuan Din. 17β-Estradiol Inhibites Tumor Necrosis Factor-α Induced Apoptosis of Human Nucleus Pulposus Cells via the PI3K/Akt Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-11. PMID:27847386. |
furthermore, western blot and qrt-pcr showed that 17β-e2 protects tnf-α which can induced apoptosis by upregulating p-akt, whereas akt was essentially constant. |
2017-04-11 |
2023-08-13 |
human |
| Xianbao Huang, Ling Qi, Wei Lu, Gangping Yang, Yan Chen, Rongyan Zhang, Jia Rao, Dexiang Ji, Ruibin Huang, Guoan Che. miRNA-301a induces apoptosis of chronic myelogenous leukemia cells by directly targeting TIMP2/ERK1/2 and AKT pathways. Oncology reports. vol 37. issue 2. 2017-04-11. PMID:28035415. |
mirna-301a induces apoptosis of chronic myelogenous leukemia cells by directly targeting timp2/erk1/2 and akt pathways. |
2017-04-11 |
2023-08-13 |
Not clear |
| Xianbao Huang, Ling Qi, Wei Lu, Gangping Yang, Yan Chen, Rongyan Zhang, Jia Rao, Dexiang Ji, Ruibin Huang, Guoan Che. miRNA-301a induces apoptosis of chronic myelogenous leukemia cells by directly targeting TIMP2/ERK1/2 and AKT pathways. Oncology reports. vol 37. issue 2. 2017-04-11. PMID:28035415. |
taken together, our results clearly suggested that mirna‑301a induces apoptosis of cml cells by directly targeting the timp2/erk1/2 and akt pathways. |
2017-04-11 |
2023-08-13 |
Not clear |
| Yu Di, Yiou Zhang, Linping Hui, Hongwei Yang, Yang Yang, Aiyuan Wang, Xiaolong Che. Cysteine‑rich 61 RNA interference inhibits pathological angiogenesis via the phosphatidylinositol 3‑kinase/Akt‑vascular endothelial growth factor signaling pathway in endothelial cells. Molecular medicine reports. vol 14. issue 5. 2017-04-10. PMID:27666419. |
ccn1 rnai inhibited the proliferation and induced the apoptosis of the huvecs under hypoxia, with hypoxia significantly increasing the mrna and protein expression levels of ccn1, akt and vegf. |
2017-04-10 |
2023-08-13 |
human |