| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rasika R Hudlikar, Varadha Balaji Venkadakrishnan, Rajiv Kumar, Rahul A Thorat, Sadhana Kannan, Arvind D Ingle, Saral Desai, Girish B Maru, Manoj B Mahimka. Polymeric black tea polyphenols (PBPs) inhibit benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced lung carcinogenesis potentially through down-regulation of p38 and Akt phosphorylation in A/J mice. Molecular carcinogenesis. vol 56. issue 2. 2017-09-01. PMID:27377358. |
inflammation, cell proliferation, and apoptosis markers along with signaling kinases like p38, akt, and their phosphorylated forms were studied using immunoblotting and immunohistochemistry at 4th, 10th, and 18th wk post-carcinogen treatment. |
2017-09-01 |
2023-08-13 |
mouse |
| Rasika R Hudlikar, Varadha Balaji Venkadakrishnan, Rajiv Kumar, Rahul A Thorat, Sadhana Kannan, Arvind D Ingle, Saral Desai, Girish B Maru, Manoj B Mahimka. Polymeric black tea polyphenols (PBPs) inhibit benzo(a)pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1- butanone-induced lung carcinogenesis potentially through down-regulation of p38 and Akt phosphorylation in A/J mice. Molecular carcinogenesis. vol 56. issue 2. 2017-09-01. PMID:27377358. |
pbps down-regulated the b(a)p and nnk-induced cell proliferation (diminished pcna expression, proliferation index, and bcl-2 expression) and enhanced apoptosis (increased bax expression and apoptotic index) potentially through phosphorylation of p38 and akt. |
2017-09-01 |
2023-08-13 |
mouse |
| J Zhang, K B Store. Insect cold hardiness: the role of mitogen-activated protein kinase and Akt signalling in freeze avoiding larvae of the goldenrod gall moth, Epiblema scudderiana. Insect molecular biology. vol 26. issue 2. 2017-08-28. PMID:27880024. |
additionally, activation of the akt pathway might also facilitate inhibition of apoptosis independently of gsk3. |
2017-08-28 |
2023-08-13 |
Not clear |
| Xing Du, Lifan Zhang, Xinyu Li, Zengxiang Pan, Honglin Liu, Qifa L. TGF-β signaling controls FSHR signaling-reduced ovarian granulosa cell apoptosis through the SMAD4/miR-143 axis. Cell death & disease. vol 7. issue 11. 2017-08-28. PMID:27882941. |
here, we showed that fshr knockdown induced porcine granulosa cell (pgc) apoptosis and follicular atresia, and attenuated the levels of intracellular signaling molecules such as pka, akt and p-akt. |
2017-08-28 |
2023-08-13 |
Not clear |
| Yueqi Wang, Zhihui Gao, Dexiang Zhang, Xiaobo Bo, Yaojie Wang, Jiwen Wang, Sheng Shen, Han Liu, Tao Suo, Hongtao Pan, Zhilong Ai, Houbao Li. Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178656. |
stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of erk and akt signaling. |
2017-08-24 |
2023-08-13 |
Not clear |
| Yueqi Wang, Zhihui Gao, Dexiang Zhang, Xiaobo Bo, Yaojie Wang, Jiwen Wang, Sheng Shen, Han Liu, Tao Suo, Hongtao Pan, Zhilong Ai, Houbao Li. Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178656. |
moreover, we found that stathmin promoted cancer cell proliferation and inhibited its apoptosis through protein kinase b (akt) and extracellular signal-regulated kinase (erk) signaling. |
2017-08-24 |
2023-08-13 |
Not clear |
| Yueqi Wang, Zhihui Gao, Dexiang Zhang, Xiaobo Bo, Yaojie Wang, Jiwen Wang, Sheng Shen, Han Liu, Tao Suo, Hongtao Pan, Zhilong Ai, Houbao Li. Stathmin decreases cholangiocarcinoma cell line sensitivity to staurosporine-triggered apoptosis via the induction of ERK and Akt signaling. Oncotarget. vol 8. issue 9. 2017-08-24. PMID:28178656. |
integrin, β1 appears to serve as a partner of stathmin induction of erk and akt signaling by inhibiting apoptosis in the cholangiocarcinoma cell. |
2017-08-24 |
2023-08-13 |
Not clear |
| Jing Guo, Nam-Hyung Kim, Xiang-Shun Cu. Inhibition of Fatty Acid Synthase Reduces Blastocyst Hatching through Regulation of the AKT Pathway in Pigs. PloS one. vol 12. issue 1. 2017-08-23. PMID:28107461. |
this inhibition of fasn resulted in the down-regulation of the akt pathway, thereby triggering apoptosis through the activation of the p53 pathway. |
2017-08-23 |
2023-08-13 |
Not clear |
| Hsien-Chuen Soo, Felicia Fei-Lei Chung, Kuan-Hon Lim, Veronica Alicia Yap, Tracey D Bradshaw, Ling-Wei Hii, Si-Hoey Tan, Sze-Jia See, Yuen-Fen Tan, Chee-Onn Leong, Chun-Wai Ma. Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway. PloS one. vol 12. issue 1. 2017-08-23. PMID:28107519. |
cud c also inhibited phosphorylation of akt independent of nfκb activity in crc cells, while ectopic expression of myristoylated akt completely abrogated the anti-proliferative effects, and apoptosis induced by cud c in crc. |
2017-08-23 |
2023-08-13 |
Not clear |
| Bo Guo, Wenjing Wang, Zhenghao Zhao, Qian Li, Kaiyue Zhou, Lingyu Zhao, Lumin Wang, Juan Yang, Chen Huan. Rab14 Act as Oncogene and Induce Proliferation of Gastric Cancer Cells via AKT Signaling Pathway. PloS one. vol 12. issue 1. 2017-08-23. PMID:28107526. |
when we overexpressed rab14 in sgc-7901 cells or silenced rab14 in bgc-823 cells, we found that rab14 could modify cell growth, cell cycle or apoptosis, which accompanied with an obvious regulation of ccnd1, cdk2 and bax involving in akt signaling pathway. |
2017-08-23 |
2023-08-13 |
human |
| Xintong Ge, Shan Huang, Huabin Gao, Zhaoli Han, Fanglian Chen, Shishuang Zhang, Zengguang Wang, Chunsheng Kang, Rongcai Jiang, Shuyuan Yue, Ping Lei, Jianning Zhan. miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis. Brain research. vol 1650. 2017-08-21. PMID:27421180. |
on the other hand, mir-21-5p inhibited cellular apoptosis by regulating the expression of apoptosis factors and akt signaling. |
2017-08-21 |
2023-08-13 |
rat |
| Xintong Ge, Shan Huang, Huabin Gao, Zhaoli Han, Fanglian Chen, Shishuang Zhang, Zengguang Wang, Chunsheng Kang, Rongcai Jiang, Shuyuan Yue, Ping Lei, Jianning Zhan. miR-21-5p alleviates leakage of injured brain microvascular endothelial barrier in vitro through suppressing inflammation and apoptosis. Brain research. vol 1650. 2017-08-21. PMID:27421180. |
taken together, mir-21-5p alleviates leakage of injured brain microvascular endothelial barrier through suppressing inflammation and apoptosis, while impacting the activities of nf-kb, akt and ang-1/tie-2 signaling. |
2017-08-21 |
2023-08-13 |
rat |
| Jeong-Seok Choi, Hyun-Soo Shin, Hye-Young An, Young-Mo Kim, Jae-Yol Li. Radioprotective effects of Keratinocyte Growth Factor-1 against irradiation-induced salivary gland hypofunction. Oncotarget. vol 8. issue 8. 2017-08-21. PMID:28086221. |
furthermore, keratinocyte growth factor-1 protected human parotid epithelial cells through the phosphoinositide 3-kinase - protein kinase b (akt) pathway and inhibition of p53-mediated apoptosis through activation of mouse double minute 2. |
2017-08-21 |
2023-08-13 |
mouse |
| Hiroki Kanazawa, Keisuke Imoto, Muneyoshi Okada, Hideyuki Yamawak. Canstatin inhibits hypoxia-induced apoptosis through activation of integrin/focal adhesion kinase/Akt signaling pathway in H9c2 cardiomyoblasts. PloS one. vol 12. issue 2. 2017-08-21. PMID:28235037. |
in summary, we for the first time clarified that canstatin inhibits hypoxia-induced apoptosis via fak and akt pathways through activating integrins in h9c2 cardiomyoblasts. |
2017-08-21 |
2023-08-13 |
Not clear |
| Tabea Erdmann, Pavel Klener, James T Lynch, Michael Grau, Petra Vočková, Jan Molinsky, Diana Tuskova, Kevin Hudson, Urszula M Polanska, Michael Grondine, Michele Mayo, Beiying Dai, Matthias Pfeifer, Kristian Erdmann, Daniela Schwammbach, Myroslav Zapukhlyak, Annette M Staiger, German Ott, Wolfgang E Berdel, Barry R Davies, Francisco Cruzalegui, Marek Trneny, Peter Lenz, Simon T Barry, Georg Len. Sensitivity to PI3K and AKT inhibitors is mediated by divergent molecular mechanisms in subtypes of DLBCL. Blood. vol 130. issue 3. 2017-08-16. PMID:28202458. |
the phosphatidylinositol-3-kinase (pi3k) α/δ (pi3kα/δ) inhibitor azd8835 showed marked potency in abc dlbcl models, whereas the protein kinase b (akt) inhibitor azd5363 induced apoptosis in pten-deficient dlbcls irrespective of their molecular subtype. |
2017-08-16 |
2023-08-13 |
mouse |
| Trinath P Das, Suman Suman, A M Sashi Papu John, Deeksha Pal, Angelena Edwards, Houda Alatassi, Murali K Ankem, Chendil Damodara. Activation of AKT negatively regulates the pro-apoptotic function of death-associated protein kinase 3 (DAPK3) in prostate cancer. Cancer letters. vol 377. issue 2. 2017-07-26. PMID:27126362. |
the activation of akt governs many signaling pathways and promotes cell growth and inhibits apoptosis in human malignancies including prostate cancer (cap). |
2017-07-26 |
2023-08-13 |
human |
| Hong-Li Cao, Zi-Jin Liu, Zheng Chan. Cordycepin induces apoptosis in human bladder cancer cells via activation of A3 adenosine receptors. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 7. 2017-07-26. PMID:28714368. |
cordyceps militaris hot water extracts containing cordycepin was used to treat human t24 bladder carcinoma cells, and we found that cordyceps militaris hot water extracts containing cordycepin decreased t24 cell survival in a dose-dependent manner, which was seemingly mediated by activation of a3 adenosine receptor and the subsequent inactivation of akt pathways, resulting in increases in cleaved caspase-3 and apoptosis. |
2017-07-26 |
2023-08-13 |
human |
| Ahmed Mohsen, Charles Saby, Philippe Collery, Gilane Mohamed Sabry, Rasha Elsherif Hassan, Abdelfattah Badawi, Pierre Jeannesson, Didier Desmaële, Hamid Morjan. Biological study of the effect of water soluble [N-(2-hydroxybenzyl)-L-aspartato] gallium complexes on breast carcinoma and fibrosarcoma cells. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. vol 21. issue 7. 2017-07-19. PMID:27484500. |
gs2 was able to induce apoptosis through downregulation of akt phosphorylation, g2m arrest in cell cycle, and caspase 3/7 pathway. |
2017-07-19 |
2023-08-13 |
human |
| Majid Safa, Leila Jafari, Fatemeh Alikarami, Rima Manafi Shabestari, Ahmad Kazem. Indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells through suppression of STAT5 and Akt signaling pathways. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. vol 39. issue 6. 2017-07-18. PMID:28631564. |
indole-3-carbinol induces apoptosis of chronic myelogenous leukemia cells through suppression of stat5 and akt signaling pathways. |
2017-07-18 |
2023-08-13 |
human |
| Yang Zeng, Meng Fu, Gang-Wei Wu, An-Zu Zhang, Jin-Ping Chen, Hong-Yue Lin, Yong-An Fu, Jing Jia, Zong-Da Cai, Xiao-Jian Wu, Ping La. Upregulation of microRNA-370 promotes cell apoptosis and inhibits proliferation by targeting PTEN in human gastric cancer. International journal of oncology. vol 49. issue 4. 2017-07-13. PMID:27499479. |
in addition, the combination of mir‑370 and pten inactivated akt, mdm2 and mtor while stimulated caspase-3, p53 and gsk3β expression, promoting apoptosis and suppressing proliferation of gastric cancer cells. |
2017-07-13 |
2023-08-13 |
human |