| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Qiong Wu, Shiyong W. The role of lipid raft translocation of prohibitin in regulation of Akt and Raf-protected apoptosis of HaCaT cells upon ultraviolet B irradiation. Molecular carcinogenesis. vol 56. issue 7. 2017-10-11. PMID:28218425. |
these results suggest that phb regulates uvb-induced apoptosis of keratinocytes via a mechanism that involves detachment from akt and raf on the plasma membrane, and sequential lipid raft translocation. |
2017-10-11 |
2023-08-13 |
human |
| Kai Jin, Lunliang Ruan, Jiujun Pu, Ailing Zhong, Fuchao Wang, Song Tan, Hua Huang, Jiamin Mou, Gang Yan. [Effect of metformin on proliferation and apoptosis of rat prolactinoma MMQ cells and related mechanisms]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 5. 2017-10-04. PMID:28502303. |
cck-8 assay was used to assess the cell proliferation ability; flow cytometry was used to analyze the cell cycle distribution and apoptosis; western blotting was performed to detect the expressions of ampkα1/2, p-ampkα, mtor, p-mtor, insulin like growth factor 1 receptor (igf-1r), erk1/2, p-erk1/2, akt, p-akt, p21, cdk4, cyclin d1, caspase-3, cleaved caspase-3(c-caspase-3), bcl-2 and bax. |
2017-10-04 |
2023-08-13 |
rat |
| Soumaya Allouch, Shankar Munusam. Metformin attenuates albumin-induced alterations in renal tubular cells in vitro. Journal of cellular physiology. vol 232. issue 12. 2017-10-02. PMID:28158902. |
the objectives of this study are to investigate the effects of activation of the energy-sensing molecule amp-activated kinase (ampk) in renal cells using metformin on endoplasmic reticulum (er) stress, akt, mtor, epithelial-to-mesenchymal transition (emt), autophagy, and apoptosis that are thought to mediate renal cell injury during proteinuria, and to dissect the ampk- and non-ampk mediated effects of metformin using an in vitro model of albumin-induced renal cell injury. |
2017-10-02 |
2023-08-13 |
rat |
| Soumaya Allouch, Shankar Munusam. Metformin attenuates albumin-induced alterations in renal tubular cells in vitro. Journal of cellular physiology. vol 232. issue 12. 2017-10-02. PMID:28158902. |
our studies suggest that metformin protects renal cells against proteinuric cytotoxicity via suppression of akt and mtor activation, inhibition of emt and apoptosis, and augmentation of autophagy and er defense response through ampk-independent and ampk-dependent mechanisms, respectively. |
2017-10-02 |
2023-08-13 |
rat |
| S Divakar, K Saravanan, P Karthikeyan, R Elancheran, S Kabilan, K K Balasubramanian, Rajlakshmi Devi, J Kotoky, M Ramanatha. Iminoenamine based novel androgen receptor antagonist exhibited anti-prostate cancer activity in androgen independent prostate cancer cells through inhibition of AKT pathway. Chemico-biological interactions. vol 275. 2017-09-26. PMID:28757136. |
the ara3 induces the apoptosis in aipc cells by preventing the ar mediated activation of akt pathway. |
2017-09-26 |
2023-08-13 |
Not clear |
| S Divakar, K Saravanan, P Karthikeyan, R Elancheran, S Kabilan, K K Balasubramanian, Rajlakshmi Devi, J Kotoky, M Ramanatha. Iminoenamine based novel androgen receptor antagonist exhibited anti-prostate cancer activity in androgen independent prostate cancer cells through inhibition of AKT pathway. Chemico-biological interactions. vol 275. 2017-09-26. PMID:28757136. |
the bicalutamide did not induce the apoptosis because it failed to prevent the ar mediated activation of akt. |
2017-09-26 |
2023-08-13 |
Not clear |
| Sudeshna Mukherjee, Sayan Ghosh, Dipesh Kr Das, Priyanka Chakraborty, Sreetama Choudhury, Payal Gupta, Arghya Adhikary, Sanjit Dey, Sreya Chattopadhya. Gold-conjugated green tea nanoparticles for enhanced anti-tumor activities and hepatoprotection--synthesis, characterization and in vitro evaluation. The Journal of nutritional biochemistry. vol 26. issue 11. 2017-09-25. PMID:26310506. |
these nps significantly decreased nuclear translocation of nf-κb, coupled with decreased phosphorylation of iĸb and down-regulation of nf-κb-dependent anti-apoptotic proteins bcl2 and akt in a dose-dependent manner, triggering onset of apoptosis. |
2017-09-25 |
2023-08-13 |
mouse |
| Claudia Schmidt, Cornelia Loos, Lu Jin, Michael Schmiech, Christoph Q Schmidt, Menna El Gaafary, Tatiana Syrovets, Thomas Simme. Acetyl-lupeolic acid inhibits Akt signaling and induces apoptosis in chemoresistant prostate cancer cells Oncotarget. vol 8. issue 33. 2017-09-25. PMID:28903409. |
acetyl-lupeolic acid inhibits akt signaling and induces apoptosis in chemoresistant prostate cancer cells the triterpenoid acetyl-lupeolic acid (ac-la) isolated from the oleogum resin of |
2017-09-25 |
2023-08-13 |
Not clear |
| Mugdha Vasireddi, Julia K Hilliar. Regulation of PI3K/Akt dependent apoptotic markers during b virus infection of human and macaque fibroblasts. PloS one. vol 12. issue 5. 2017-09-21. PMID:28558072. |
we, therefore, tested the hypothesis that b virus results in the phosphorylation of akt (s473), which prevents apoptosis, enhancing virus replication in b virus infected macaque dermal fibroblasts. |
2017-09-21 |
2023-08-13 |
human |
| Mugdha Vasireddi, Julia K Hilliar. Regulation of PI3K/Akt dependent apoptotic markers during b virus infection of human and macaque fibroblasts. PloS one. vol 12. issue 5. 2017-09-21. PMID:28558072. |
we observed markers of intrinsic apoptosis when pi3k activation of akt was inhibited in b virus infected macaque cells, while, these apoptotic markers were absent in b virus infected human fibroblasts under the same conditions. |
2017-09-21 |
2023-08-13 |
human |
| Mugdha Vasireddi, Julia K Hilliar. Regulation of PI3K/Akt dependent apoptotic markers during b virus infection of human and macaque fibroblasts. PloS one. vol 12. issue 5. 2017-09-21. PMID:28558072. |
from these data we suggest that pi3k activates akt in b virus infected macaque and human fibroblasts, but this enhances virus replication in macaque fibroblast cells by blocking apoptosis. |
2017-09-21 |
2023-08-13 |
human |
| Jian Dong, Yuanhang Zhou, Zhiwei Liao, Qi Huang, Shidong Feng, Yue L. Role of γ-glutamyl cyclotransferase as a therapeutic target for colorectal cancer based on the lentivirus-mediated system. Anti-cancer drugs. vol 27. issue 10. 2017-09-20. PMID:27500968. |
the results of the analysis indicated that ggct silencing significantly suppressed cell proliferation and arrested cell cycle at the g0/g1 phase by regulating the expression of p21, p27, and cyclin e. moreover, ggct silencing triggered the apoptosis of crc cells by activating caspase-3 and cleaved poly-adp-ribose polymerase pathways and downregulating the phosphorylation proline-rich akt substrate of 40 kda (pras40) expression levels. |
2017-09-20 |
2023-08-13 |
human |
| Zhemin Wang, Zewen Qiu, Chenxue Gao, Yijie Sun, Wei Dong, Yan Zhang, Ruolin Chen, Yuan Qi, Shuangyue Li, Yanjie Guo, Yongjun Piao, Sheng Li, Fengyuan Pia. 2,5-hexanedione downregulates nerve growth factor and induces neuron apoptosis in the spinal cord of rats via inhibition of the PI3K/Akt signaling pathway. PloS one. vol 12. issue 6. 2017-09-20. PMID:28654704. |
it was also found that ngf supplement repressed the induced apoptosis, and increased p-akt and p-bad level in 2,5-hd treated vsc4.1 cells, which could be antagonized by pi3k kinase (the upstream member of akt) inhibitor ly294002. |
2017-09-20 |
2023-08-13 |
rat |
| Wei-Zhang Wang, Xiang-Hua Lin, Qiao-Hong Pu, Man-Yu Liu, Li Li, Li-Rong Wu, Qing-Qing Wu, Jian-Wen Mao, Jia-Yong Zhu, Xiao-Bao Ji. Targeting miR-21 sensitizes Ph+ ALL Sup-b15 cells to imatinib-induced apoptosis through upregulation of PTEN. Biochemical and biophysical research communications. vol 454. issue 3. 2017-09-18. PMID:25451263. |
transient inhibition of mir-21 resulted in increased apoptosis, pten upregulation and akt dephosphorylation, whereas ectopic overexpression of mir-21 further conferred imatinib resistance. |
2017-09-18 |
2023-08-13 |
Not clear |
| Zhu Zhang, Bin Zhou, Kui Zhang, Yaping Song, Lin Zhang, Mingrong X. IL-27 suppresses SKOV3 cells proliferation by enhancing STAT3 and inhibiting the Akt signal pathway. Molecular immunology. vol 78. 2017-09-15. PMID:27639718. |
our data show that il-27 has direct antitumor capacity in ovarian cancer cells via enhancing apoptosis by inducing the stat3 pathway and restraining the akt pathway. |
2017-09-15 |
2023-08-13 |
Not clear |
| Xiuxian Lu, Chao Sun, Daofeng Zheng, Rui Liu, Xufu Wei, Zhongjun W. [The miR-21 attenuates hepatocyte hypoxia/reoxygenation injury via inhibiting PTEN/PI3K/AKT signaling pathway]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 33. issue 4. 2017-09-14. PMID:28395721. |
the inhibition of akt phosphorylation could downregulate the expression of bcl-2 and the ratio of bcl-2/bax, and upregulate the level of hepatocyte apoptosis. |
2017-09-14 |
2023-08-13 |
mouse |
| Alakananda Basu, Savitha Sridhara. Regulation of anti-apoptotic Bcl-2 family protein Mcl-1 by S6 kinase 2. PloS one. vol 12. issue 3. 2017-09-07. PMID:28301598. |
these results suggest that s6k2 regulates apoptosis via multiple mechanisms, and involves both akt and jnk. |
2017-09-07 |
2023-08-13 |
Not clear |
| Gokul Variar, Tarun Pant, Apoorva Singh, Abinaya Ravichandran, Sushant Swami, Balaraman Kalyanaraman, Anuradha Dhanasekara. Effect of mitochondrially targeted carboxy proxyl nitroxide on Akt-mediated survival in Daudi cells: Significance of a dual mode of action. PloS one. vol 12. issue 4. 2017-09-07. PMID:28426671. |
moreover, dual effects on mitochondrial bioenergetics and ros by mito-cp curtailed the cancer survival via akt inhibition, ampk-hif-1α activation and promoted apoptosis via increased bcl2-associated x protein and poly (adp-ribose) polymerase expression. |
2017-09-07 |
2023-08-13 |
human |
| Guodong Tie, Jinglian Yan, Julia A Messina, Robert L Raffai, Louis M Messin. Inhibition of p38 Mitogen-Activated Protein Kinase Enhances the Apoptosis Induced by Oxidized Low-Density Lipoprotein in Endothelial Progenitor Cells. Journal of vascular research. vol 52. issue 6. 2017-09-05. PMID:27031525. |
in agreement, inhibition of p38 mapk further attenuated akt phosphorylation and increased apoptosis in epcs isolated from hypercholesterolemic apoe-/- mice. |
2017-09-05 |
2023-08-13 |
mouse |
| R Bharti, G Dey, P K Ojha, S Rajput, S K Jaganathan, R Sen, M Manda. Diacerein-mediated inhibition of IL-6/IL-6R signaling induces apoptotic effects on breast cancer. Oncogene. vol 35. issue 30. 2017-09-01. PMID:26616855. |
the in vivo antitumor effect was correlated with decreased proliferation (ki-67), increased apoptosis (tunel) and inhibition of il-6/il-6r-mediated stat3, mapk and akt pathway in tumor remnants. |
2017-09-01 |
2023-08-13 |
Not clear |