| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lin Chen, Zhiping Ren, Xinbing Wei, Shuaishuai Wang, Yimeng Wang, Yanyan Cheng, Hua Gao, Huiqing Li. Losartan protects against cerebral ischemia/reperfusion-induced apoptosis through β-arrestin1-mediated phosphorylation of Akt. European journal of pharmacology. vol 815. 2018-02-08. PMID:28844872. |
losartan protects against cerebral ischemia/reperfusion-induced apoptosis through β-arrestin1-mediated phosphorylation of akt. |
2018-02-08 |
2023-08-13 |
rat |
| Peng Shen, Hong-Gang Wang, Miao-Miao Li, Qian-Yun Ma, Chuan-Wen Zhou, Feng Pan, Rui Xi. Isofraxidin inhibited proliferation and induced apoptosis via blockage of Akt pathway in human colorectal cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-02-05. PMID:28531803. |
isofraxidin inhibited proliferation and induced apoptosis via blockage of akt pathway in human colorectal cancer cells. |
2018-02-05 |
2023-08-13 |
human |
| Anuja Sathe, Géraldine Chalaud, Immanuel Oppolzer, Kit Yeng Wong, Margarita von Busch, Sebastian C Schmid, Zhichao Tong, Margitta Retz, Juergen E Gschwend, Wolfgang A Schulz, Roman Nawrot. Parallel PI3K, AKT and mTOR inhibition is required to control feedback loops that limit tumor therapy. PloS one. vol 13. issue 1. 2018-02-05. PMID:29357370. |
combining pi3k/mtor inhibitors with akt or pdk1 inhibitors suppressed this rephosphorylation, induced apoptosis, decreased colony formation, cell viability and growth of tumor xenografts. |
2018-02-05 |
2023-08-13 |
Not clear |
| Suman Suman, Trinath P Das, Jim Moselhy, Deeksha Pal, Venkatesh Kolluru, Houda Alatassi, Murali K Ankem, Chendil Damodara. Oral administration of withaferin A inhibits carcinogenesis of prostate in TRAMP model. Oncotarget. vol 7. issue 33. 2018-01-30. PMID:27447565. |
we previously reported that withaferin a (wa), a natural compound, deters prostate cancer by inhibiting akt while inducing apoptosis. |
2018-01-30 |
2023-08-13 |
mouse |
| Yiwei Yang, Yitong Huang, Zhantong Wang, Hsin-Tzu Wang, Baoyu Duan, Dan Ye, Chenxin Wang, Ruiqi Jing, Ye Leng, Jiajie Xi, Wen Chen, Guiying Wang, Wenwen Jia, Songcheng Zhu, Jiuhong Kan. HDAC10 promotes lung cancer proliferation via AKT phosphorylation. Oncotarget. vol 7. issue 37. 2018-01-30. PMID:27449083. |
mechanistic studies showed that hdac10 knockdown significantly decreased the phosphorylation of akt at ser473 and that akt expression significantly rescued the cell cycle arrest and apoptosis elicited by hdac10 knockdown. |
2018-01-30 |
2023-08-13 |
mouse |
| Yahui Yang, Shulin Deng, Qinsong Zeng, Weilie Hu, Tianfeng Che. Highly stable selenadiazole derivatives induce bladder cancer cell apoptosis and inhibit cell migration and invasion through the activation of ROS-mediated signaling pathways. Dalton transactions (Cambridge, England : 2003). vol 45. issue 46. 2018-01-30. PMID:27711726. |
mechanistic investigation revealed that compound 1b was able to enter the cells through endocytosis and then trigger reactive oxygen species (ros) overproduction, further causing dna damage-mediated p53 phosphorylation and promoting cancer cell apoptosis by regulating the akt and mapks signaling pathways. |
2018-01-30 |
2023-08-13 |
Not clear |
| Bing Xu, Minjie Zhou, Wencai Qiu, Jueming Ye, Qiming Fen. CCR7 mediates human breast cancer cell invasion, migration by inducing epithelial-mesenchymal transition and suppressing apoptosis through AKT pathway. Cancer medicine. vol 6. issue 5. 2018-01-29. PMID:28378417. |
ccr7 mediates human breast cancer cell invasion, migration by inducing epithelial-mesenchymal transition and suppressing apoptosis through akt pathway. |
2018-01-29 |
2023-08-13 |
human |
| Yanhao Zhang, Ruoqiu Fu, Yanxia Liu, Jing Li, Hongwei Zhang, Xiaoye Hu, Yibiao Chen, Xin Liu, Yunong Li, Ping Li, Ehu Liu, Ning Ga. Dephosphorylation and mitochondrial translocation of cofilin sensitizes human leukemia cells to cerulenin-induced apoptosis via the ROCK1/Akt/JNK signaling pathway. Oncotarget. vol 7. issue 15. 2018-01-24. PMID:26967395. |
these data are consistent with a hierarchical model in which induction of apoptosis by cerulenin primarily results from activation of rock1, inactivation of akt, and activation of jnk. |
2018-01-24 |
2023-08-13 |
mouse |
| Hsiao-Yun Chen, Liang-Ting Lin, Mong-Lien Wang, Shu-Hsien Lee, Ming-Long Tsai, Chi-Chang Tsai, Wei-Hsiu Liu, Tzu-Chien Chen, Yi-Ping Yang, Yi-Yen Lee, Yuh-Lih Chang, Pin-I Huang, Yi-Wei Chen, Wen-Liang Lo, Shih-Hwa Chiou, Ming-Teh Che. Musashi-1 regulates AKT-derived IL-6 autocrinal/paracrinal malignancy and chemoresistance in glioblastoma. Oncotarget. vol 7. issue 27. 2018-01-22. PMID:27285760. |
our results demonstrated that overexpression of msi1 effectively protected gbm cells from drug-induced apoptosis through down-regulating pro-apoptotic genes; whereas inhibition of akt withdrew the msi1-induced anti-apoptosis and cell survival. |
2018-01-22 |
2023-08-13 |
human |
| Hua-Dong Zhao, Hai-Li Tang, Ning-Ning Liu, Ya-Li Zhao, Qin-Qin Liu, Xiao-Shan Zhu, Lin-Tao Jia, Chun-Fang Gao, An-Gang Yang, Jun-Tang L. Targeting ubiquitin-specific protease 22 suppresses growth and metastasis of anaplastic thyroid carcinoma. Oncotarget. vol 7. issue 21. 2018-01-18. PMID:27145278. |
in vitro assays showed that usp22 depletion suppressed atc cell survival and proliferation by decreasing rb phosphorylation and cyclin d2, inactivating akt, and simultaneously upregulating rb; usp22 silencing restrained cell migration and invasion by inhibiting epithelial-mesenchymal transition; usp22 knockdown promoted mitochondrion- mediated and caspase-dependent apoptosis by upregulating bax and bid and promoting caspase-3 activation. |
2018-01-18 |
2023-08-13 |
Not clear |
| Kalanghad Puthankalam Srinivas, Remadevi Viji, Vipin Mohan Dan, Indira Sukumaran Sajitha, Rajappan Prakash, Puthan Valappil Rahul, Thankayyan R Santhoshkumar, Subhadra Lakshmi, Madhavan Radhakrishna Pilla. DEPTOR promotes survival of cervical squamous cell carcinoma cells and its silencing induces apoptosis through downregulating PI3K/AKT and by up-regulating p38 MAP kinase. Oncotarget. vol 7. issue 17. 2018-01-17. PMID:26992219. |
activation of akt signaling by overexpression of constitutively active-akt (ca-akt) failed to overcome the apoptosis caused by deptor silencing. |
2018-01-17 |
2023-08-13 |
Not clear |
| M Gómez-Suárez, I Z Gutiérrez-Martínez, J A Hernández-Trejo, M Hernández-Ruiz, D Suárez-Pérez, A Candelario, R Kamekura, O Medina-Contreras, M Schnoor, V Ortiz-Navarrete, N Villegas-Sepúlveda, C Parkos, A Nusrat, P Nav. 14-3-3 Proteins regulate Akt Thr308 phosphorylation in intestinal epithelial cells. Cell death and differentiation. vol 23. issue 6. 2018-01-16. PMID:26846144. |
our results suggest that 14-3-3 proteins control akt activation and regulate its biological functions, thereby providing a new mechanistic link between cell survival and apoptosis of intestinal epithelial cells during inflammation. |
2018-01-16 |
2023-08-13 |
Not clear |
| Jianbing Ren, Debin Yuan, Lili Xie, Xuelei Tao, Chenwei Duan, Yifeng Bao, Yunfeng He, Jianbin Ge, Hongjian L. Up-regulation of Vps4A promotes neuronal apoptosis after intracerebral hemorrhage in adult rats. Metabolic brain disease. vol 32. issue 2. 2018-01-12. PMID:28064406. |
additionaly, vps4a knockdown in vitro specifically leads to decreasing neuronal apoptosis coupled with increased akt phosphorylation. |
2018-01-12 |
2023-08-13 |
rat |
| Jianbing Ren, Debin Yuan, Lili Xie, Xuelei Tao, Chenwei Duan, Yifeng Bao, Yunfeng He, Jianbin Ge, Hongjian L. Up-regulation of Vps4A promotes neuronal apoptosis after intracerebral hemorrhage in adult rats. Metabolic brain disease. vol 32. issue 2. 2018-01-12. PMID:28064406. |
all datas suggested that vps4a was involved in promoting neuronal apoptosis via inhibiting akt phosphorylation after ich. |
2018-01-12 |
2023-08-13 |
rat |
| Anees Rahman, Faisal Thayyullathil, Siraj Pallichankandy, Sehamuddin Galadar. Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine. Free radical biology & medicine. vol 96. 2018-01-09. PMID:27154977. |
interestingly, inhibition of cer generation, using acid sphingomyelinase inhibitor, significantly reduced the sng-induced akt dephosphorylation and apoptosis, whereas, activation of cer generation using inhibitors of acid ceramidase and glucosylceramide synthase enhanced it. |
2018-01-09 |
2023-08-13 |
human |
| Anees Rahman, Faisal Thayyullathil, Siraj Pallichankandy, Sehamuddin Galadar. Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine. Free radical biology & medicine. vol 96. 2018-01-09. PMID:27154977. |
furthermore, using a group of ceramide activated protein phosphatases (capps) inhibitor (calyculin a, okadaic acid, and phosphatidic acid), the involvement of protein phosphatase 1 form of capp in sng-induced akt dephosphorylation and apoptosis was demonstrated. |
2018-01-09 |
2023-08-13 |
human |
| Guangxin Zhang, Chao Wang, Mei Sun, Jindong Li, Bin Wang, Chengyan Jin, Peiyan Hua, Ge Song, Yifan Zhang, Lisa L H Nguyen, Ranji Cui, Runhua Liu, Lizhong Wang, Xingyi Zhan. Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells. Oncotarget. vol 7. issue 20. 2018-01-08. PMID:26959116. |
cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through akt signaling pathway in human nonsmall cell lung cancer cells. |
2018-01-08 |
2023-08-13 |
human |
| Guangxin Zhang, Chao Wang, Mei Sun, Jindong Li, Bin Wang, Chengyan Jin, Peiyan Hua, Ge Song, Yifan Zhang, Lisa L H Nguyen, Ranji Cui, Runhua Liu, Lizhong Wang, Xingyi Zhan. Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells. Oncotarget. vol 7. issue 20. 2018-01-08. PMID:26959116. |
our results suggest that cb inhibits tumor growth by inducing intrinsic apoptosis through the akt signaling pathway in nsclc cells. |
2018-01-08 |
2023-08-13 |
human |
| Qiurong Wang, Jun Re. mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1. Pharmacological research. vol 111. 2018-01-05. PMID:27363949. |
these data suggest that trehalose may rescue against insulin resistance-induced myocardial contractile defect and apoptosis, via autophagy associated with dephosphorylation of p38 mapk and foxo1 without affecting phosphorylation of akt. |
2018-01-05 |
2023-08-13 |
mouse |
| Tanzhou Chen, Zhiming Huang, Runping Liu, Jing Yang, Phillip B Hylemon, Huiping Zho. Sphingosine-1 phosphate promotes intestinal epithelial cell proliferation via S1PR2. Frontiers in bioscience (Landmark edition). vol 22. 2018-01-05. PMID:27814635. |
previous studies have reported that s1p protects intestinal epithelial cell from apoptosis by activating the erk and akt signaling pathways. |
2018-01-05 |
2023-08-13 |
Not clear |