| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Hong Qin, Kun Wang, Xin-Lu Fu, Peng-Jun Zhou, Zhong Liu, Dan-Dan Xu, Yi-Fei Wang, De-Po Yang, Qiu-Ling Xie, Qiu-Ying Li. Hsp90 inhibitor induces KG-1a cell differentiation and apoptosis via Akt/NF-κB signaling. Oncology reports. vol 38. issue 3. 2018-04-17. PMID:28713903. |
thus, snx-2112 induced kg-1a cell differentiation, cell cycle arrest and apoptosis via modulation of akt and nf-κb signaling, suggesting that it is a promising therapeutic agent for the treatment of aml. |
2018-04-17 |
2023-08-13 |
human |
| Safa Tarhouni-Jabberi, Ons Zakraoui, Efstathia Ioannou, Ichrak Riahi-Chebbi, Meriam Haoues, Vassilios Roussis, Riadh Kharrat, Khadija Essafi-Benkhadi. Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-κB Signaling. Marine drugs. vol 15. issue 7. 2018-04-16. PMID:28726723. |
mertensene, a halogenated monoterpene, induces g2/m cell cycle arrest and caspase dependent apoptosis of human colon adenocarcinoma ht29 cell line through the modulation of erk-1/-2, akt and nf-κb signaling. |
2018-04-16 |
2023-08-13 |
human |
| Yanlin Song, Lingqi Kong, Bin Sun, Lei Gao, Peng Chu, Anil Ahsan, Eskandar Qaed, Yuan Lin, Jinyong Peng, Xiaodong Ma, Jianbin Zhang, Shisheng Wang, Zeyao Tan. Induction of autophagy by an oleanolic acid derivative, SZC017, promotes ROS-dependent apoptosis through Akt and JAK2/STAT3 signaling pathway in human lung cancer cells. Cell biology international. vol 41. issue 12. 2018-04-12. PMID:28880428. |
induction of autophagy by an oleanolic acid derivative, szc017, promotes ros-dependent apoptosis through akt and jak2/stat3 signaling pathway in human lung cancer cells. |
2018-04-12 |
2023-08-13 |
human |
| Lei Shen, Shanqiang Zhang, Xiaodong Zhang, Yuting Zhang, Liping Xie, Yang Jiang, Yong Ma, Guofeng L. [Enhancing the ability of autophagy and proliferation of bone marrow mesenchymal stem cells by interleukin-8 through Akt-STAT3 pathway in hypoxic environment]. Sheng wu gong cheng xue bao = Chinese journal of biotechnology. vol 32. issue 10. 2018-04-09. PMID:29027451. |
the results indicated that the proliferation and autophagy of hbmsc in il-8 group was higher than that in hypoxia control group and akt inhibitor group, and the apoptosis rate in il-8 group decreased. |
2018-04-09 |
2023-08-13 |
human |
| Zhenhuan Hou, Jun Mao, Ying Lu, Lianhong L. rApoptin induces apoptosis in human breast cancer cells via phosphorylation of Nur77 and Akt. Biochemical and biophysical research communications. vol 498. issue 1. 2018-04-06. PMID:29501489. |
rapoptin induces apoptosis in human breast cancer cells via phosphorylation of nur77 and akt. |
2018-04-06 |
2023-08-13 |
human |
| Zhenhuan Hou, Jun Mao, Ying Lu, Lianhong L. rApoptin induces apoptosis in human breast cancer cells via phosphorylation of Nur77 and Akt. Biochemical and biophysical research communications. vol 498. issue 1. 2018-04-06. PMID:29501489. |
furthermore, we found via western blot that rapoptin-induced apoptosis in mcf-7 and mda-mb-231 cells was associated with the phosphorylation of nur77 (p-nur77) and akt (p-akt). |
2018-04-06 |
2023-08-13 |
human |
| Zhenhuan Hou, Jun Mao, Ying Lu, Lianhong L. rApoptin induces apoptosis in human breast cancer cells via phosphorylation of Nur77 and Akt. Biochemical and biophysical research communications. vol 498. issue 1. 2018-04-06. PMID:29501489. |
together, our results are the first to demonstrate that rapoptin was able to effectively induce breast cancer cell apoptosis both in vitro and in vivo and that this activity could be regulated by the phosphorylation of nur77 and akt and the mitochondrial pathway. |
2018-04-06 |
2023-08-13 |
human |
| Chencheng Xie, Matthew J Freeman, Huarui Lu, Xiaohong Wang, Colleen L Forster, Aaron L Sarver, Timothy C Hallstro. Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235. Oncotarget. vol 8. issue 24. 2018-04-04. PMID:28445155. |
the objectives of this study were to determine if the akt pathway is activated in human retinoblastomas and the extent that anti-pi3k therapy induces apoptosis in retinoblastoma cells, alone or in combination with the dna damaging drugs carboplatin and topotecan. |
2018-04-04 |
2023-08-13 |
mouse |
| Chencheng Xie, Matthew J Freeman, Huarui Lu, Xiaohong Wang, Colleen L Forster, Aaron L Sarver, Timothy C Hallstro. Retinoblastoma cells activate the AKT pathway and are vulnerable to the PI3K/mTOR inhibitor NVP-BEZ235. Oncotarget. vol 8. issue 24. 2018-04-04. PMID:28445155. |
treatment with bez235, a dual pi3k/mtor inhibitor, reduced phosphorylation levels of the akt targets p-foxo and p-s6 and effectively induced apoptosis the y79 and weri-1 human retinoblastoma cell lines and in vivo in our retinoblastoma mouse model. |
2018-04-04 |
2023-08-13 |
mouse |
| Seong-Ho Ok, Mun Hwan Choi, Il-Woo Shin, Soo Hee Lee, Sebin Kang, Jiah Oh, Jeong Yeol Han, Ju-Tae Soh. Lipid Emulsion Inhibits Apoptosis Induced by a Toxic Dose of Verapamil via the Delta-Opioid Receptor in H9c2 Rat Cardiomyoblasts. Cardiovascular toxicology. vol 17. issue 3. 2018-04-03. PMID:27990618. |
these results suggest that le attenuates apoptosis induced by verapamil via activation of the delta-opioid receptor, phosphoinositide 3-kinase and akt. |
2018-04-03 |
2023-08-13 |
rat |
| Andreza Conceição Véras de Aguiar Guerra, Luiz Alberto Lira Soares, Magda Rhayanny Assunção Ferreira, Aurigena Antunes de Araújo, Hugo Alexandre de Oliveira Rocha, Juliana Silva de Medeiros, Rômulo Dos Santos Cavalcante, Raimundo Fernandes de Araújo Júnio. Libidibia ferrea presents antiproliferative, apoptotic and antioxidant effects in a colorectal cancer cell line. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 92. 2018-04-03. PMID:28586741. |
using methodologies that involved flow cytometry, spectrophotometry and rt-qpcr assays, crude extracts of the fruits of l. ferrea (20t, 40t, 60t and 80t) were evaluated at 24h and/or 48h for: their ability to inhibit cell proliferation; induce apoptosis through bcl-2, caspase-3 and apaf-1; their antioxidant activity and effects on important targets related to cell proliferation (egfr and akt) in the ht-29 human colorectal cancer lineage. |
2018-04-03 |
2023-08-13 |
human |
| Xiaoling Song, Zheng Wang, Haibin Liang, Wenjie Zhang, Yuanyuan Ye, HuaiFeng Li, Yunping Hu, Yijian Zhang, Hao Weng, Jianhua Lu, Xuefeng Wang, Maolan Li, Yingbin Liu, Jun G. Dioscin Induces Gallbladder Cancer Apoptosis by Inhibiting ROS-Mediated PI3K/AKT Signalling. International journal of biological sciences. vol 13. issue 6. 2018-04-03. PMID:28656003. |
western blot analysis showed that akt activity was significantly downregulated after dsn treatment, and that inhibition/ectopic expression of akt enhanced/abolished dsn-induced apoptosis but not migration. |
2018-04-03 |
2023-08-13 |
human |
| Yuan Jiang, Jinlu Dai, Zhi Yao, Greg Shelley, Evan T Kelle. Abituzumab Targeting of αV-Class Integrins Inhibits Prostate Cancer Progression. Molecular cancer research : MCR. vol 15. issue 7. 2018-04-02. PMID:28314844. |
to evaluate this, prostate cancer cells were treated with di17e6 and its effects on proliferation, apoptosis, cell-cycle, adhesion, detachment, migration, invasion and phosphorylation of downstream targets, including fak, akt, and erk, were determined. |
2018-04-02 |
2023-08-13 |
Not clear |
| Yan Dai, Shiguang Jin, Xueping Li, Daxin Wan. The involvement of Bcl-2 family proteins in AKT-regulated cell survival in cisplatin resistant epithelial ovarian cancer. Oncotarget. vol 8. issue 1. 2018-03-26. PMID:27935869. |
many studies involving patients with cisplatin-resistant ovarian cancer have shown that akt activation leads to inhibition of apoptosis. |
2018-03-26 |
2023-08-13 |
Not clear |
| Yan Dai, Shiguang Jin, Xueping Li, Daxin Wan. The involvement of Bcl-2 family proteins in AKT-regulated cell survival in cisplatin resistant epithelial ovarian cancer. Oncotarget. vol 8. issue 1. 2018-03-26. PMID:27935869. |
the activated akt (pakt-s473) in these cells inhibited the death signal induced by cisplatin thereby inhibiting cisplatin-mediated apoptosis. |
2018-03-26 |
2023-08-13 |
Not clear |
| Yan Dai, Shiguang Jin, Xueping Li, Daxin Wan. The involvement of Bcl-2 family proteins in AKT-regulated cell survival in cisplatin resistant epithelial ovarian cancer. Oncotarget. vol 8. issue 1. 2018-03-26. PMID:27935869. |
results from this study showed that the combination of cisplatin, dna-pk inhibitor nu7441, and akt inhibitor tcn can overcome drug resistance, increase apoptosis, and re-sensitize peo4 cells to cisplatin treatment. |
2018-03-26 |
2023-08-13 |
Not clear |
| Suthakar Ganapathy, Bo Peng, Ling Shen, Tianqi Yu, Jean Lafontant, Ping Li, Rui Xiong, Alexandros Makriyannis, Changyan Che. Suppression of PKC causes oncogenic stress for triggering apoptosis in cancer cells. Oncotarget. vol 8. issue 19. 2018-03-26. PMID:28415683. |
in order to further study the mechanisms of apoptosis induced by oncogenic ras, we employed the ras loop mutant genes and demonstrated that akt functioned downstream of ras in human pancreatic cancer or hpne cells ectopically expressing mutated k-ras for the induction of apoptosis after the concurrent suppression of pkc α and β. |
2018-03-26 |
2023-08-13 |
human |
| Gege Chen, Zhijian Xu, Gaomei Chang, Jun Hou, Liangning Hu, Yiwen Zhang, Dandan Yu, Bo Li, Shuaikang Chang, Yongsheng Xie, Yong Zhang, Rong Wei, Huiqun Wu, Wenqin Xiao, Xi Sun, Yi Tao, Lu Gao, Bojie Dai, Jumei Shi, Weiliang Zh. The blueberry component pterostilbene has potent anti-myeloma activity in bortezomib-resistant cells. Oncology reports. vol 38. issue 1. 2018-03-26. PMID:28560392. |
we found that pter inhibited proliferation of h929r cells and promoted apoptosis of the cells through a caspase-dependent pathway, loss of mitochondrial membrane potential, and activation of akt and p38 mitogen-activated protein kinase (mapk) signaling pathways. |
2018-03-26 |
2023-08-13 |
Not clear |
| Yong Zhao, Lin Lin, Yonghui Zhang, Dangmurenjiafu Gen. SHP-2 Activating Mutation Promotes Malignant Biological Behaviors of Glioma Cells. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-26. PMID:28620155. |
the proliferation ability of transfected cells, the apoptosis rate, the invasion ability, and the expression levels of phosphorylated erk1/2, akt, and p38 in the mutation group was significantly higher than in the empty vector group and the control group (p<0.05). |
2018-03-26 |
2023-08-13 |
Not clear |
| Emi Harada, Satoshi Serada, Minoru Fujimoto, Yusuke Takahashi, Tsuyoshi Takahashi, Hisashi Hara, Rie Nakatsuka, Takahito Sugase, Takahiko Nishigaki, Yurina Saito, Kosuke Hiramatsu, Satoshi Nojima, Risa Mitsuo, Tomoharu Ohkawara, Eiichi Morii, Masaki Mori, Yuichiro Doki, Yasufumi Kaneda, Tetsuji Nak. Glypican-1 targeted antibody-based therapy induces preclinical antitumor activity against esophageal squamous cell carcinoma. Oncotarget. vol 8. issue 15. 2018-03-23. PMID:28445969. |
knockdown of gpc1 decreased growth of escc cells and induced apoptosis via inhibition of egfr, akt and p44/42-mapk signaling pathways in vitro. |
2018-03-23 |
2023-08-13 |
mouse |