| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J-Y Ke, W-J Cen, X-Z Zhou, Y-R Li, W-D Kong, J-W Jian. Iron overload induces apoptosis of murine preosteoblast cells via ROS and inhibition of AKT pathway. Oral diseases. vol 23. issue 6. 2018-05-16. PMID:28248443. |
iron overload induces apoptosis of murine preosteoblast cells via ros and inhibition of akt pathway. |
2018-05-16 |
2023-08-13 |
Not clear |
| Xinyu Tian, Bo Huang, Xiao-Peng Zhang, Mingyang Lu, Feng Liu, José N Onuchic, Wei Wan. Modeling the response of a tumor-suppressive network to mitogenic and oncogenic signals. Proceedings of the National Academy of Sciences of the United States of America. vol 114. issue 21. 2018-05-14. PMID:28484034. |
p53 and e2f1 cooperate to induce apoptosis, whereas akt phosphorylates p21 to repress caspase activation. |
2018-05-14 |
2023-08-13 |
human |
| Sepideh Zununi Vahed, Abolfazl Barzegari, Yalda Rahbar Saadat, Ali Goreyshi, Yadollah Omid. Leuconostoc mesenteroides-derived anticancer pharmaceuticals hinder inflammation and cell survival in colon cancer cells by modulating NF-κB/AKT/PTEN/MAPK pathways. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 94. 2018-05-14. PMID:28821160. |
based on our findings, l. mesenteroides promoted apoptosis in colon cancer cell line by upregulation of mapk1, bax, and caspase 3, and downregulation of akt, nf-κb, bcl- |
2018-05-14 |
2023-08-13 |
Not clear |
| Mo-Han Zhang, Jing-Zhi Jiang, Ying-Lan Cai, Li-Hua Piao, Zheng Ji. Significance of dynamic changes in gastric smooth muscle cell apoptosis, PI3K-AKT-mTOR and AMPK-mTOR signaling in a rat model of diabetic gastroparesis. Molecular medicine reports. vol 16. issue 2. 2018-05-10. PMID:28627597. |
the aim of the present study was to investigate the significance of cell apoptosis, the phosphoinositide-3-kinase (pi3k)-protein kinase b (akt)-mammalian target of rapamycin (mtor) pathway, and the 5' adenosine monophosphate-activated protein kinase (ampk)‑mtor pathways in the process of diabetic gastroparesis. |
2018-05-10 |
2023-08-13 |
rat |
| Helen S Vethakanraj, Binny P Sesurajan, Vishnu P Padmanaban, Madhumathi Jayaprakasam, Suganthi Murali, Ashok K Seka. Anticancer effect of acid ceramidase inhibitor ceranib-2 in human breast cancer cell lines MCF-7, MDA MB-231 by the activation of SAPK/JNK, p38 MAPK apoptotic pathways, inhibition of the Akt pathway, downregulation of ERα. Anti-cancer drugs. vol 29. issue 1. 2018-05-10. PMID:29023248. |
further, ceranib-2 induced apoptosis by activating sapk/jnk (stress-activated protein kinase/c-jun n-terminal kinase), p38 mapk (mitogen-activated protein kinase) apoptotic pathways and by inhibiting the akt (antiapoptotic) pathway in both the cell lines. |
2018-05-10 |
2023-08-13 |
human |
| Arum Kim, Yoon Jeong Nam, Chung Soo Le. Taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-κB activation-mediated cell death. Brain research bulletin. vol 134. 2018-05-07. PMID:28710022. |
taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the akt and nf-κb activation-mediated cell death. |
2018-05-07 |
2023-08-13 |
human |
| Arum Kim, Yoon Jeong Nam, Chung Soo Le. Taxifolin reduces the cholesterol oxidation product-induced neuronal apoptosis by suppressing the Akt and NF-κB activation-mediated cell death. Brain research bulletin. vol 134. 2018-05-07. PMID:28710022. |
these results show that taxifolin may reduce the cholesterol oxidation product-induced neuronal apoptosis by suppressing the akt and nf-κb activation-mediated cell death. |
2018-05-07 |
2023-08-13 |
human |
| E V Berezhnaya, M Y Bibov, M A Komandirov, M A Neginskaya, M V Rudkovskii, A B Uzdensk. Involvement of MAPK, Akt/GSK-3β and AMPK/mTOR signaling pathways in protection of remote glial cells from axotomy-induced necrosis and apoptosis in the isolated crayfish stretch receptor. Molecular and cellular neurosciences. vol 83. 2018-05-03. PMID:28642089. |
inhibition of mek1/2, p38, akt, gsk-3β and mtor increased axotomy-induced apoptosis of remote glial cells, whereas inhibition of erk1/2 and gsk-3β enhanced necrosis. |
2018-05-03 |
2023-08-13 |
Not clear |
| Leonardo Romorini, Ximena Garate, Gabriel Neiman, Carlos Luzzani, Verónica Alejandra Furmento, Alejandra Sonia Guberman, Gustavo Emilio Sevlever, María Elida Scassa, Santiago Gabriel Miriuk. AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival. Scientific reports. vol 6. 2018-04-30. PMID:27762303. |
we found that inhibition of akt with three non-structurally related inhibitors (gsk690693, akt inhibitor viii and akt inhibitor iv) decreased cell viability and induced apoptosis. |
2018-04-30 |
2023-08-13 |
human |
| Leonardo Romorini, Ximena Garate, Gabriel Neiman, Carlos Luzzani, Verónica Alejandra Furmento, Alejandra Sonia Guberman, Gustavo Emilio Sevlever, María Elida Scassa, Santiago Gabriel Miriuk. AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival. Scientific reports. vol 6. 2018-04-30. PMID:27762303. |
importantly, we demonstrated by pharmacological inhibition and sirna knockdown that gsk3β signaling is responsible, at least in part, of the apoptosis triggered by akt inhibition. |
2018-04-30 |
2023-08-13 |
human |
| Leonardo Romorini, Ximena Garate, Gabriel Neiman, Carlos Luzzani, Verónica Alejandra Furmento, Alejandra Sonia Guberman, Gustavo Emilio Sevlever, María Elida Scassa, Santiago Gabriel Miriuk. AKT/GSK3β signaling pathway is critically involved in human pluripotent stem cell survival. Scientific reports. vol 6. 2018-04-30. PMID:27762303. |
in conclusion, we demonstrated that akt activation prevents apoptosis, partly through inhibition of gsk3β, and thus results relevant for psc survival. |
2018-04-30 |
2023-08-13 |
human |
| Yan Li, Xiaolin Ma, Yanpeng Wang, Guohua L. miR-489 inhibits proliferation, cell cycle progression and induces apoptosis of glioma cells via targeting SPIN1-mediated PI3K/AKT pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-30. PMID:28666210. |
meanwhile, akt inhibitor mk-2206 blocked activation of pi3k/akt pathway and resulted in reduced proliferation, cell cycle arrest and increased apoptosis in mir-489 down-regulating u87 cells. |
2018-04-30 |
2023-08-13 |
mouse |
| Shou-Chieh Wang, Shou-Tsung Wang, Hung-Te Liu, Xiang-Yu Wang, She-Ching Wu, Lei-Chin Chen, Yi-Wen Li. Trichostatin A induces bladder cancer cell death via intrinsic apoptosis at the early phase and Sp1‑survivin downregulation at the late phase of treatment. Oncology reports. vol 38. issue 3. 2018-04-25. PMID:28713892. |
tsa significantly suppressed akt activity at 12 h after treatment, suggesting that the apoptosis in the early phase was mediated by akt inhibition. |
2018-04-25 |
2023-08-13 |
Not clear |
| Siying Li, Guang Yang, Xiaosong Zhu, Lin Cheng, Yueyue Sun, Zhongxi Zha. Combination of rapamycin and garlic-derived S-allylmercaptocysteine induces colon cancer cell apoptosis and suppresses tumor growth in xenograft nude mice through autophagy/p62/Nrf2 pathway. Oncology reports. vol 38. issue 3. 2018-04-25. PMID:28737825. |
it was found that the combination therapy had enhanced tumor-suppressing ability with the upregulation of the bax/bcl-2 ratio as a consequence of activated apoptosis, inhibition of autophagic activity and prevention of akt phosphorylation. |
2018-04-25 |
2023-08-13 |
mouse |
| Li Yan, Rui Cao, YuanBo Liu, LianZhao Wang, Bo Pan, XiaoYan Lv, Hu Jiao, Qiang Zhuang, XueJian Sun, Ran Xia. MiR-21-5p Links Epithelial-Mesenchymal Transition Phenotype with Stem-Like Cell Signatures via AKT Signaling in Keloid Keratinocytes. Scientific reports. vol 6. 2018-04-24. PMID:27596120. |
to investigate the role of mir-21-5p in keloid pathogenesis, we transfected mir-21-5p mimic or inhibitor in keloid keratinocytes and examined the abilities of cell proliferation, apoptosis, migration and invasion, the expressions of emt-related markers vimentin and e-cadherin and stem-like cells-associated markers cd44 and aldh1, and the involvement of pten and the signaling of akt and erk. |
2018-04-24 |
2023-08-13 |
Not clear |
| Wan-Chi Tsai, Li-Yuan Bai, Yi-Jin Chen, Po-Chen Chu, Ya-Wen Hsu, Aaron M Sargeant, Jing-Ru Wen. OSU-A9 inhibits pancreatic cancer cell lines by modulating p38-JAK-STAT3 signaling. Oncotarget. vol 8. issue 17. 2018-04-24. PMID:28418923. |
osu-a9 treatment induced apoptosis, the down-regulation of akt phosphorylation, up-regulation of p38 phosphorylation and decreased phosphorylation of jak and stat3. |
2018-04-24 |
2023-08-13 |
mouse |
| Chang Li, Xiaoping Li, Shuohui Gao, Chang Li, Lianjun M. MicroRNA-133a Inhibits Proliferation of Gastric Cancer Cells by Downregulating ERBB2 Expression. Oncology research. vol 25. issue 7. 2018-04-23. PMID:28109082. |
interestingly, erbb2 silencing has a similar impact to mir-133a overexpression, in that it significantly induced apoptosis and inhibited erk and akt activation. |
2018-04-23 |
2023-08-13 |
human |
| Cheng Liu, Wei-Chang Lee, Bu-Miin Huang, Yi-Chen Chia, Yu-Chi Chen, Yung-Chia Che. 16-Hydroxycleroda-3, 13-dien-15, 16-olide inhibits the proliferation and induces mitochondrial-dependent apoptosis through Akt, mTOR, and MEK-ERK pathways in human renal carcinoma cells. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 36. 2018-04-23. PMID:29157834. |
16-hydroxycleroda-3, 13-dien-15, 16-olide inhibits the proliferation and induces mitochondrial-dependent apoptosis through akt, mtor, and mek-erk pathways in human renal carcinoma cells. |
2018-04-23 |
2023-08-13 |
human |
| Dongmei Su, Yunjun Zhou, Shanshan Hu, Lina Guan, Cuige Shi, Qi Wang, Yingyu Chen, Cailing Lu, Qian Li, Xu M. Role of GAB1/PI3K/AKT signaling high glucose-induced cardiomyocyte apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 93. 2018-04-20. PMID:28738535. |
ly294002, which is an effective inhibitor of the pi3k/akt signaling pathway, partly inhibited gab1 to suppress apoptosis induced by hg in cardiomyocytes, and partly suppressed gab1 to resist the decrease of xiap in response to hg, indicating akt signaling, xiap, and caspase3/7 participated in gab1-mediated cardiomyocyte apoptosis in response to hg. |
2018-04-20 |
2023-08-13 |
rat |
| Jin-Hong Qin, Kun Wang, Xin-Lu Fu, Peng-Jun Zhou, Zhong Liu, Dan-Dan Xu, Yi-Fei Wang, De-Po Yang, Qiu-Ling Xie, Qiu-Ying Li. Hsp90 inhibitor induces KG-1a cell differentiation and apoptosis via Akt/NF-κB signaling. Oncology reports. vol 38. issue 3. 2018-04-17. PMID:28713903. |
the results revealed that low concentrations of snx-2112 arrested the cells in the g2/m phase and induced their differentiation and apoptosis, possibly by suppressing akt and inhibitor of κb kinase, a component of the nuclear factor (nf)-κb signaling pathway. |
2018-04-17 |
2023-08-13 |
human |