| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jin-Song He, Ni Xie, Jian-Bo Yang, Hong Guan, Wei-Cai Chen, Chang Zou, Yi-Wen Ouyang, You-Sheng Mao, Xue-Ying Luo, Yue Pan, Li F. BCSG1 siRNA delivered by lentiviral vector suppressed proliferation and migration of MDA-MB-231 cells. International journal of molecular medicine. vol 41. issue 3. 2018-08-03. PMID:29286089. |
cell proliferation, migration and apoptosis were evaluated by using the cell counting kit‑8, transwell assay and flow cytometry, respectively, followed by western blotting to determine the relative levels of akt, extracellular signal‑regulated kinase (erk), p-akt and p-erk expression. |
2018-08-03 |
2023-08-13 |
human |
| Jiao Liu, Jianbin Bi, Zeliang Li, Zhenhua Li, Xiankui Liu, Chuize Kon. miR‑214 reduces cisplatin resistance by targeting netrin‑1 in bladder cancer cells. International journal of molecular medicine. vol 41. issue 3. 2018-08-03. PMID:29328435. |
netrin‑1 plasmid transfection inhibited cisplatin‑induced apoptosis, upregulated akt phosphorylation, and downregulated caspase‑3 and parp cleavage. |
2018-08-03 |
2023-08-13 |
Not clear |
| Misaki Ono, Kaoru Ejima, Takako Higuchi, Mikako Takeshima, Rei Wakimoto, Shuji Nakan. Equol Enhances Apoptosis-inducing Activity of Genistein by Increasing Bax/Bcl-xL Expression Ratio in MCF-7 Human Breast Cancer Cells. Nutrition and cancer. vol 69. issue 8. 2018-08-01. PMID:29095048. |
although apoptosis was not so evident with genistein alone, the combination made a drastic induction of apoptosis, accompanied by the increase of bax/bcl-xl expression ratio, without affecting the activities of akt and mtor. |
2018-08-01 |
2023-08-13 |
human |
| Jing Liu, Yi-de Zhang, Xiao-Lan Chen, Xue-Ling Zhu, Xu Chen, Jian-Hua Wu, Nai-Feng Gu. The protective effect of the EP2 receptor on TGF-β1 induced podocyte injury via the PI3K / Akt signaling pathway. PloS one. vol 13. issue 5. 2018-07-31. PMID:29746568. |
this causes the interaction of nephrin, podocin and cd2ap resulting the inhibition of apoptosis induced by activation of the pi3k / akt signaling pathway. |
2018-07-31 |
2023-08-13 |
mouse |
| Batzaya Davaadelger, Ricardo E Perez, Yalu Zhou, Lei Duan, Steven Gitelis, Carl G Mak. The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis. Cancer biology & therapy. vol 18. issue 11. 2018-07-25. PMID:28696156. |
igf-1r and akt inhibitors further increased apoptosis by nutlin-3a in parental mhm cells and the cisplatin-resistant clones, confirming igf-1r/akt signaling promotes apoptosis resistance. |
2018-07-25 |
2023-08-13 |
Not clear |
| Batzaya Davaadelger, Ricardo E Perez, Yalu Zhou, Lei Duan, Steven Gitelis, Carl G Mak. The IGF-1R/AKT pathway has opposing effects on Nutlin-3a-induced apoptosis. Cancer biology & therapy. vol 18. issue 11. 2018-07-25. PMID:28696156. |
however, igf-1r and akt inhibitors also reduced p53 accumulation in nutlin-3a treated cells and increased autophagy flux, which we showed can promote apoptosis resistance. |
2018-07-25 |
2023-08-13 |
Not clear |
| Mei Xue, Xu Chen, Zhija Guo, Xiaoqian Liu, Yanping Bi, Jie Yin, Haiyan Hu, Ping Zhu, Jian Zhuang, Courtney Cates, Thomas Rousselle, Ji L. L-Carnitine Attenuates Cardiac Dysfunction by Ischemic Insults Through Akt Signaling Pathway. Toxicological sciences : an official journal of the Society of Toxicology. vol 160. issue 2. 2018-07-25. PMID:28973678. |
the immunoblotting results showed that lc administration restrained myocardial apoptosis as evidenced by decreasing the level of bax expression, increasing the levels of phosphorylation of akt, pi3k, and bcl-2 protein expression, but these were blocked by lyc94002. |
2018-07-25 |
2023-08-13 |
mouse |
| Jing Zhong, Ya-Jun Chen, Ling Chen, Ying-Ying Shen, Qing-Hai Zhang, Jing Yang, Ren-Xian Cao, Xu-Yu Zu, Ge-Bo We. PRMT2β, a C-terminal splice variant of PRMT2, inhibits the growth of breast cancer cells. Oncology reports. vol 38. issue 2. 2018-07-23. PMID:28677794. |
in the present study, we determined the role of prmt2β in breast cancer cell proliferation, apoptosis and its effect on the akt signaling pathway. |
2018-07-23 |
2023-08-13 |
human |
| Wen-Di Zhou, Xiang Wang, Xing-Zhen Sun, Jian Hu, Rong-Rong Zhang, Ze Hon. Actein induces apoptosis in leukemia cells through suppressing RhoA/ROCK1 signaling pathway. International journal of oncology. vol 51. issue 6. 2018-07-23. PMID:29039493. |
in contrast, akt inactivity enhanced apoptosis levels, as well as caspase signaling pathway expression. |
2018-07-23 |
2023-08-13 |
human |
| Wen-Di Zhou, Xiang Wang, Xing-Zhen Sun, Jian Hu, Rong-Rong Zhang, Ze Hon. Actein induces apoptosis in leukemia cells through suppressing RhoA/ROCK1 signaling pathway. International journal of oncology. vol 51. issue 6. 2018-07-23. PMID:29039493. |
in vivo, u937-bearing tumor growth was suppressed by actein, which was related to rock1 suppression, akt dephosphorylation and apoptosis induction. |
2018-07-23 |
2023-08-13 |
human |
| Eun Young Lee, Hyun Cheol Bae, Hana Lee, Yeonsue Jang, Yoon-Hee Park, Jin Hee Kim, Woo-In Ryu, Byeong Hyeok Choi, Ji Hyun Kim, Sang Hoon Jeong, Sang Wook So. Intracellular ROS levels determine the apoptotic potential of keratinocyte by Quantum Dot via blockade of AKT Phosphorylation. Experimental dermatology. vol 26. issue 11. 2018-07-20. PMID:28418588. |
we also found that a decrease in cellular ros level by ros scavenger, n-acetylcysteine (nac), resulting in the abolishment of qds-induced akt de-phosphorylation and cellular apoptosis. |
2018-07-20 |
2023-08-13 |
human |
| Zujun Sun, Qi Liu, Dongxia Ye, Kaichuang Ye, Zhenhua Yang, Dong L. Role of c-Met in the progression of human oral squamous cell carcinoma and its potential as a therapeutic target. Oncology reports. vol 39. issue 1. 2018-07-20. PMID:29115556. |
additionally, the selective c-met inhibitor jnj was found to inhibit cell viability and migration and promote apoptosis in oscc cell lines, and also blocked the activation akt, erk1/2, and nf-κb p65; thus, suggesting that hgf/c-met signaling may play an important role in the tumorigenic properties of oscc cells via the akt, erk1/2, and nf-κb pathways. |
2018-07-20 |
2023-08-13 |
human |
| M Ito, T Yurube, K Kakutani, K Maeno, T Takada, Y Terashima, Y Kakiuchi, Y Takeoka, S Miyazaki, R Kuroda, K Nishid. Selective interference of mTORC1/RAPTOR protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with Akt and autophagy induction. Osteoarthritis and cartilage. vol 25. issue 12. 2018-07-18. PMID:28888905. |
selective interference of mtorc1/raptor protects against human disc cellular apoptosis, senescence, and extracellular matrix catabolism with akt and autophagy induction. |
2018-07-18 |
2023-08-13 |
human |
| Sunwoo Park, Whasun Lim, Fuller W Bazer, Gwonhwa Son. Naringenin induces mitochondria-mediated apoptosis and endoplasmic reticulum stress by regulating MAPK and AKT signal transduction pathways in endometriosis cells. Molecular human reproduction. vol 23. issue 12. 2018-07-18. PMID:29121349. |
naringenin induces mitochondria-mediated apoptosis and endoplasmic reticulum stress by regulating mapk and akt signal transduction pathways in endometriosis cells. |
2018-07-18 |
2023-08-13 |
human |
| Jixian Liu, Xinhuang Yao, Da Wu, Yiwang Ye, Qiang Wu, Suyue Liu, Hao W. Effect of TW37 on the growth of H1975 EGFR‑TKI‑resistant lung cancer cells and its underlying mechanisms. Molecular medicine reports. vol 17. issue 2. 2018-07-18. PMID:29207200. |
in conclusion, tw37 inhibited h1975/egfr‑tki cell growth and induced cell apoptosis potentially via suppression of akt signaling pathway activation. |
2018-07-18 |
2023-08-13 |
Not clear |
| Jae Young Lee, Min Joung Kim, Devy Deliyanti, Michael F Azari, Fernando Rossello, Adam Costin, Georg Ramm, Edouard G Stanley, Andrew G Elefanty, Jennifer L Wilkinson-Berka, Steven Petrato. Overcoming Monocarboxylate Transporter 8 (MCT8)-Deficiency to Promote Human Oligodendrocyte Differentiation and Myelination. EBioMedicine. vol 25. 2018-07-09. PMID:29111262. |
ditpa treatment limits ol apoptosis mediated by slc16a2 down-regulation primarily signaling through akt phosphorylation, driving myelination. |
2018-07-09 |
2023-08-13 |
human |
| Qiongyu Li, Zijun Lai, Zhaokun Yan, Jun Peng, Yiyi Jin, Lihui Wei, Jiumao Li. Hedyotis diffusa Willd inhibits proliferation and induces apoptosis of 5‑FU resistant colorectal cancer cells by regulating the PI3K/AKT signaling pathway. Molecular medicine reports. vol 17. issue 1. 2018-07-09. PMID:29115462. |
cancer cell resistance to apoptosis and activation of the phosphatidylinositol‑3‑kinase (pi3k)/protein kinase b (akt) signaling pathway have been implicated as major factors in the acquired resistance to chemotherapeutic anti‑cancer drugs. |
2018-07-09 |
2023-08-13 |
human |
| Shih-Hung Chan, Ching-Hsia Hung, Jhih-Yuan Shih, Pei-Ming Chu, Yung-Hsin Cheng, Huei-Chen Lin, Pei-Ling Hsieh, Kun-Ling Tsa. Exercise intervention attenuates hyperhomocysteinemia-induced aortic endothelial oxidative injury by regulating SIRT1 through mitigating NADPH oxidase/LOX-1 signaling. Redox biology. vol 14. 2018-07-06. PMID:28888894. |
moreover, we also reported that hhcy caused endothelium apoptosis involving akt inhibition and mitochondria-dependent apoptotic pathways. |
2018-07-06 |
2023-08-13 |
mouse |
| Chang-Rong Wan, Dan-Dan Han, Jian-Qin Xu, Peng Yin, Xiao-Long Xu, Chen Mei, Feng-Hua Liu, Zhao-Fei Xi. Jujuboside A attenuates norepinephrine-induced apoptosis of H9c2 cardiomyocytes by modulating MAPK and AKT signaling pathways. Molecular medicine reports. vol 17. issue 1. 2018-07-05. PMID:29115535. |
jujuboside a attenuates norepinephrine-induced apoptosis of h9c2 cardiomyocytes by modulating mapk and akt signaling pathways. |
2018-07-05 |
2023-08-13 |
rat |
| Chang-Rong Wan, Dan-Dan Han, Jian-Qin Xu, Peng Yin, Xiao-Long Xu, Chen Mei, Feng-Hua Liu, Zhao-Fei Xi. Jujuboside A attenuates norepinephrine-induced apoptosis of H9c2 cardiomyocytes by modulating MAPK and AKT signaling pathways. Molecular medicine reports. vol 17. issue 1. 2018-07-05. PMID:29115535. |
taken together, these data suggested that jua may protect against ne‑induced apoptosis of cardiomyocytes via modulation of the mitogen‑activated protein kinase and akt signaling pathways. |
2018-07-05 |
2023-08-13 |
rat |