| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pan Zhang, Ze-Lin Lai, Hui-Fen Chen, Min Zhang, An Wang, Tao Jia, Wen-Qin Sun, Xi-Min Zhu, Xiao-Feng Chen, Zheng Zhao, Jun Zhan. Curcumin synergizes with 5-fluorouracil by impairing AMPK/ULK1-dependent autophagy, AKT activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. Journal of experimental & clinical cancer research : CR. vol 36. issue 1. 2018-09-05. PMID:29273065. |
curcumin synergizes with 5-fluorouracil by impairing ampk/ulk1-dependent autophagy, akt activity and enhancing apoptosis in colon cancer cells with tumor growth inhibition in xenograft mice. |
2018-09-05 |
2023-08-13 |
mouse |
| Si-Wei Wang, Yi Xu, Yuan-Yuan Weng, Xue-Yu Fan, Yong-Feng Bai, Xiao-Yan Zheng, Li-Jun Lou, Feng Zhan. Astilbin ameliorates cisplatin-induced nephrotoxicity through reducing oxidative stress and inflammation. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 114. 2018-09-05. PMID:29471006. |
astilbin significantly decreased reactive oxygen species (ros) accumulation and alleviated ros-induced activation of p53, mapks and akt signaling cascades, which in turn attenuated cisplatin-induced hek-293 cell apoptosis. |
2018-09-05 |
2023-08-13 |
mouse |
| Tao Jia, Qing-Qing Cao, Xue-Mei Chen, Feng-Lei X. Effects of the Akt inhibitor Src-homology 5 on proliferation and apoptosis of the laryngeal squamous cell carcinoma. Journal of cancer research and therapeutics. vol 14. issue 1. 2018-08-30. PMID:29516987. |
effects of the akt inhibitor src-homology 5 on proliferation and apoptosis of the laryngeal squamous cell carcinoma. |
2018-08-30 |
2023-08-13 |
Not clear |
| Tao Jia, Qing-Qing Cao, Xue-Mei Chen, Feng-Lei X. Effects of the Akt inhibitor Src-homology 5 on proliferation and apoptosis of the laryngeal squamous cell carcinoma. Journal of cancer research and therapeutics. vol 14. issue 1. 2018-08-30. PMID:29516987. |
the aim of this study was to investigate the effect of the akt inhibitor src-homology 5 (sh-5) on the proliferation and apoptosis of laryngeal squamous cell carcinoma cells (lscc; hep-2 cells) and to elucidate the possible mechanisms of such effects. |
2018-08-30 |
2023-08-13 |
Not clear |
| Wenjun Zeng, Chunyun Zhang, Hongwei Cheng, Yun-Long Wu, Jie Liu, Zekun Chen, Jian-Gang Huang, Russell Erick Ericksen, Liqun Chen, Haiping Zhang, Alice Sze Tsai Wong, Xiao-Kun Zhang, Weiping Han, Jin-Zhang Zen. Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma. Scientific reports. vol 7. issue 1. 2018-08-29. PMID:28336971. |
acacetin induces cancer cell apoptosis through antagonizing the non-genomic effect of rarγ on akt and p53. |
2018-08-29 |
2023-08-13 |
Not clear |
| Alejandro Ciocci Pardo, Sergio Scuri, Luisa F González Arbeláez, Claudia Caldiz, Juliana Fantinelli, Susana M Mosc. Survival kinase-dependent pathways contribute to gender difference in the response to myocardial ischemia-reperfusion and ischemic post-conditioning. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology. vol 33. 2018-08-28. PMID:29414428. |
superoxide production, antioxidant systems, and expressions of phosphorylated forms of serine/threonine kinase (akt), glycogen synthase kinase 3β (gsk-3β), protein kinase c ε (pkcε), endothelial nitric oxide synthase (enos), and apoptosis were measured. |
2018-08-28 |
2023-08-13 |
human |
| Anja Urbschat, Patrick Baer, Kai Zacharowski, Vera Sprunck, Bertram Scheller, Florian Raimann, Thorsten Jürgen Maier, Axel Hegele, Rainer Hofmann, Jan Mersman. Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney. Basic & clinical pharmacology & toxicology. vol 122. issue 2. 2018-08-27. PMID:28857508. |
systemic tlr2 antibody application in renal ischaemia and reperfusion injury decreases akt phosphorylation and increases apoptosis in the mouse kidney. |
2018-08-27 |
2023-08-13 |
mouse |
| Anja Urbschat, Patrick Baer, Kai Zacharowski, Vera Sprunck, Bertram Scheller, Florian Raimann, Thorsten Jürgen Maier, Axel Hegele, Rainer Hofmann, Jan Mersman. Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney. Basic & clinical pharmacology & toxicology. vol 122. issue 2. 2018-08-27. PMID:28857508. |
inhibition of tlr2 and its signalling pathway by a single application of tlr2 antibody results in reduced phosphorylation of akt and consecutively increased apoptosis. |
2018-08-27 |
2023-08-13 |
mouse |
| L Zhang, X-R Liu, J-Z Liu, Y-X Song, Z-Q Zhou, B-Y Ca. miR-182 selectively targets HOXA10 in goat endometrial epithelium cells in vitro. Reproduction in domestic animals = Zuchthygiene. vol 52. issue 6. 2018-08-24. PMID:28758253. |
what's more, hoxa10 gene silencing (hoxa10-sirna) resulted in geecs apoptosis in vitro, and it regulated the protein levels of oestrogen receptor a (era), progesterone receptor b (prb), insulin-like growth factor 1 receptor (igf1r), bcl-2, pleiotrophin (ptn), akt and p-jnk in geecs. |
2018-08-24 |
2023-08-13 |
Not clear |
| Kenta Yokoi, Akira Kobayashi, Hiroaki Motoyama, Masato Kitazawa, Akira Shimizu, Tsuyoshi Notake, Takahide Yokoyama, Tomio Matsumura, Michiko Takeoka, Shin-Ichi Miyagaw. Survival pathway of cholangiocarcinoma via AKT/mTOR signaling to escape RAF/MEK/ERK pathway inhibition by sorafenib. Oncology reports. vol 39. issue 2. 2018-08-23. PMID:29251327. |
disassembly of the mtorc2 complex in rbe cells with sirna targeting rictor resulted in the downregulation of akt ser473 phosphorylation and enhanced apoptosis presumably via increased foxo1, which consequently suppressed rbe cell proliferation. |
2018-08-23 |
2023-08-13 |
Not clear |
| Sarah A Altınoğlu, Ming Wang, Kathleen Q Li, Yuyang Li, Qiaobing X. Intracellular delivery of the PTEN protein using cationic lipidoids for cancer therapy. Biomaterials science. vol 4. issue 12. 2018-08-22. PMID:27748775. |
intracellular delivery of pten with ec16-80 to the pten deficient prostate cancer cell line pc-3 resulted in a significant decrease in activated akt and induced apoptosis. |
2018-08-22 |
2023-08-13 |
human |
| Da Zhao, Xinyan Zhan. Selenium Antagonizes the Lead-Induced Apoptosis of Chicken Splenic Lymphocytes In Vitro by Activating the PI3K/Akt Pathway. Biological trace element research. vol 182. issue 1. 2018-08-20. PMID:28681127. |
however, se supplementation during pb exposure observably attenuated pb-induced apoptosis; increased the levels of the pi3k, akt, and bcl-2 mrnas and proteins; and decrease the levels of the p53, bax, cyt-c, caspase 3, and caspase 9 mrnas and proteins in the chicken spleen. |
2018-08-20 |
2023-08-13 |
cat |
| Shenwen Liu, Sheng Chen, Jing Ren, Baijun Li, Bo Qi. Ghrelin protects retinal ganglion cells against rotenone via inhibiting apoptosis, restoring mitochondrial function, and activating AKT-mTOR signaling. Neuropeptides. vol 67. 2018-08-16. PMID:29174113. |
in addition, both rapamycin and akt inhibitor iv pre-treatment significantly attenuated the effects of ghrelin on rotenone-induced changes in cell viability and cell apoptosis. |
2018-08-16 |
2023-08-13 |
rat |
| Yangang Cheng, Jinyan Tan, Huifeng Li, Xiangpeng Kong, Yan Liu, Rui Guo, Guoyan Li, Bingyou Yang, Miaorong Pe. Cardioprotective effects of total flavonoids from Jinhe Yangxin prescription by activating the PI3K/Akt signaling pathway in myocardial ischemia injury. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 98. 2018-08-14. PMID:29274587. |
furthermore, jhtf inhibited myocardial apoptosis, which may be related to downregulated caspase-3 and bax, upregulated bcl-2, and increased the protein levels of phosphorylated akt, gsk-3β and endothelial nitric oxide synthase (enos). |
2018-08-14 |
2023-08-13 |
rat |
| Mingfeng Shao, Zexiang Ren, Rongjun Zhan. MYBL2 protects against H9c2 injury induced by hypoxia via AKT and NF‑κB pathways. Molecular medicine reports. vol 17. issue 3. 2018-08-14. PMID:29328450. |
the results indicated that mybl2 may improve cell viability and inhibit h9c2 apoptosis via the inhibition of akt and nf‑κb pathways. |
2018-08-14 |
2023-08-13 |
Not clear |
| Xiu-Ying Qin, Ya-Nan Wang, Xin-Ping Yang, Juan-Juan Liang, Ji-Lin Liu, Zhao-Hui Lu. Synthesis, characterization, and anticancer activity of two mixed ligand copper(ii) complexes by regulating the VEGF/VEGFR2 signaling pathway. Dalton transactions (Cambridge, England : 2003). vol 46. issue 47. 2018-08-13. PMID:29143014. |
these complexes can remarkably induce apoptosis, inhibit proliferation, suppress migration and metastasis, and inhibit angiogenesis to inhibit the growth of cervical cancer by down-regulating the expressions of the important proteins fak, akt and erk1/2 or their phosphorylated proteins p-fak, p-akt, and p-erk1/2 downstream of the vegf/vegfr2 signaling pathway. |
2018-08-13 |
2023-08-13 |
Not clear |
| Amel Djehal, Mohammad Krayem, Ahmad Najem, Hassan Hammoud, Thierry Cresteil, Canan G Nebigil, Dong Wang, Peng Yu, Embarek Bentouhami, Ghanem E Ghanem, Laurent Désaubr. Targeting prohibitin with small molecules to promote melanogenesis and apoptosis in melanoma cells. European journal of medicinal chemistry. vol 155. 2018-08-07. PMID:29960207. |
besides, in addition to their promelanogenic activities, we uncovered that melanogenin and its active analogs induce apoptosis in several cancer cell lines, including melanoma cells, and that this effect is caused by an inhibition of akt survival pathway. |
2018-08-07 |
2023-08-13 |
Not clear |
| Mehlika Dilek Altıntop, Belgin Sever, Gülşen Akalın Çiftçi, Gülhan Turan-Zitouni, Zafer Asım Kaplancıklı, Ahmet Özdemi. Design, synthesis, in vitro and in silico evaluation of a new series of oxadiazole-based anticancer agents as potential Akt and FAK inhibitors. European journal of medicinal chemistry. vol 155. 2018-08-07. PMID:29966916. |
compounds 2, 6 and 9 were found to be the most potent anticancer agents against a549 and c6 cell lines and therefore their effects on apoptosis, caspase-3 activation, akt, fak, mitochondrial membrane potential and ultrastructural morphological changes were evaluated. |
2018-08-07 |
2023-08-13 |
mouse |
| Xiaoyuan Deng, Bo Chen, Bin Wang, Junfang Zhang, Hongliang Li. TNF-α Mediates the Intrinsic and Extrinsic Pathway in Propofol-Induced Neuronal Apoptosis Via PI3K/Akt Signaling Pathway in Rat Prefrontal Cortical Neurons. Neurotoxicity research. vol 32. issue 3. 2018-08-06. PMID:28540664. |
this study reveals that propofol at clinically relevant concentrations increases the tnf-α synthesis and release in neurons, and induces neuronal apoptosis; etanercept significantly reduces neuronal apoptosis, the elevation of cleaved caspase-8 and cleaved caspase-9, or the akt phosphorylation induced by propofol, while the selective pi3k antagonist blocks the neuroprotection of etanercept. |
2018-08-06 |
2023-08-13 |
rat |
| Xiao-Xue Jiang, Guan-Yu Liu, Han Lei, Zuo-Ling Li, Qing-Ping Feng, Wei Huan. Activation of transient receptor potential vanilloid 1 protects the heart against apoptosis in ischemia/reperfusion injury through upregulating the PI3K/Akt signaling pathway. International journal of molecular medicine. vol 41. issue 3. 2018-08-03. PMID:29286076. |
the present study aimed to investigate whether the cardioprotective effects of trpv1 were associated with the inhibition of apoptosis via the phosphatidylinositol 3‑kinase (pi3k)/protein kinase b (akt) and extracellular signal‑regulated protein kinase 1/2 (erk1/2) signaling pathways. |
2018-08-03 |
2023-08-13 |
mouse |