| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ting Ma, Bo-Yi Fan, Chao Zhang, Hui-Jun Zhao, Chao Han, Cai-Yun Gao, Jian-Guang Luo, Ling-Yi Kon. Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway. Scientific reports. vol 6. 2018-06-04. PMID:27416811. |
furthermore, the increased level of p53 and decreased expression of p-akt were observed, and the attenuated glycolysis and enhanced apoptosis were reversed in the presence of akt cdna or p53 sirna. |
2018-06-04 |
2023-08-13 |
Not clear |
| Tao Wang, Zhenyu Cai, Guolin Hong, Gangsen Zheng, Yu Huang, Shun Zhang, Jinhua Da. MicroRNA‑21 increases cell viability and suppresses cellular apoptosis in non‑small cell lung cancer by regulating the PI3K/Akt signaling pathway. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901419. |
mir‑21 inhibited apoptosis by modulating the activation of the phosphatidylinositol 3‑kinase/rac‑α serine/threonine protein kinase (akt) pathway in a549 cells. |
2018-06-04 |
2023-08-13 |
human |
| Tao Wang, Zhenyu Cai, Guolin Hong, Gangsen Zheng, Yu Huang, Shun Zhang, Jinhua Da. MicroRNA‑21 increases cell viability and suppresses cellular apoptosis in non‑small cell lung cancer by regulating the PI3K/Akt signaling pathway. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901419. |
correspondingly, inhibition of akt decreased the apoptosis of a549 cells in mir‑21 sirna‑treated cells. |
2018-06-04 |
2023-08-13 |
human |
| Tao Wang, Zhenyu Cai, Guolin Hong, Gangsen Zheng, Yu Huang, Shun Zhang, Jinhua Da. MicroRNA‑21 increases cell viability and suppresses cellular apoptosis in non‑small cell lung cancer by regulating the PI3K/Akt signaling pathway. Molecular medicine reports. vol 16. issue 5. 2018-06-04. PMID:28901419. |
therefore, the results of the present study demonstrated that mir‑21 increased cell viability by inhibiting apoptosis, through regulation of akt activation. |
2018-06-04 |
2023-08-13 |
human |
| Shibao Li, Zhiyuan Wu, Ping Ma, Yinhai Xu, Yuming Chen, Hua Wang, Ping He, Zhihua Kang, Lingyu Yin, Yao Zhao, Xinju Zhang, Xiao Xu, Xiaochao Ma, Ming Gua. Ligand-dependent EphA7 signaling inhibits prostate tumor growth and progression. Cell death & disease. vol 8. issue 10. 2018-06-04. PMID:29022918. |
this protein can also induce pca cell apoptosis that correlated with increasing the protein expression levels of bax, elevating the caspase-3 activities, reducing the protein expression levels of bcl-2 and facilitating the dephosphorylation of akt, which is further increased by the stimulation of ephrina5-fc. |
2018-06-04 |
2023-08-13 |
human |
| Ying Yin, Jialin Duan, Chao Guo, Guo Wei, Yanhua Wang, Yue Guan, Fei Mu, Minna Yao, Miaomiao Xi, Aidong We. Danshensu accelerates angiogenesis after myocardial infarction in rats and promotes the functions of endothelial progenitor cells through SDF-1α/CXCR4 axis. European journal of pharmacology. vol 814. 2018-06-01. PMID:28864209. |
on the one hand, danshensu provided significant cytoprotection against hypoxia insult by boosting epcs viability and inhibiting apoptosis, and upregulated akt phosphorylation. |
2018-06-01 |
2023-08-13 |
rat |
| Soon Yong Park, Ae-Jin Jeong, Geun-Young Kim, Ara Jo, Joo Eon Lee, Sun-Hee Leem, Joung-Hahn Yoon, Sang Kyu Ye, Jin Woong Chun. Lactoferrin Protects Human Mesenchymal Stem Cells from Oxidative Stress-Induced Senescence and Apoptosis. Journal of microbiology and biotechnology. vol 27. issue 10. 2018-06-01. PMID:28870012. |
in addition, lactoferrin reduced hydrogen peroxide-induced apoptosis via inhibition of caspase-3 and akt activation. |
2018-06-01 |
2023-08-13 |
human |
| Jing Ni, Yuanmin Li, Weiming Li, Rong Gu. Salidroside protects against foam cell formation and apoptosis, possibly via the MAPK and AKT signaling pathways. Lipids in health and disease. vol 16. issue 1. 2018-06-01. PMID:29017559. |
salidroside protects against foam cell formation and apoptosis, possibly via the mapk and akt signaling pathways. |
2018-06-01 |
2023-08-13 |
human |
| Adriana M Airo, Matt D Urbanowski, Joaquin Lopez-Orozco, Jae Hwan You, Tamara D Skene-Arnold, Charles Holmes, Vladimir Yamshchikov, Natasha Malik-Soni, Lori Frappier, Tom C Hobma. Expression of flavivirus capsids enhance the cellular environment for viral replication by activating Akt-signalling pathways. Virology. vol 516. 2018-06-01. PMID:29358114. |
all of the tested capsid proteins protected cells from fas-dependent apoptosis through a mechanism that requires activated akt. |
2018-06-01 |
2023-08-13 |
Not clear |
| Jia-Huan Hu, Xiao-Yu Cheng, Jin-Xin Li, Bin Xue, Jiang-Hai Tian, Jing-Sheng Hu, Bing L. Apoptosis of posterior silk gland of Bombyx mori during spinning period and the role of PI3K/Akt pathway. Archives of insect biochemistry and physiology. vol 98. issue 1. 2018-05-31. PMID:29400415. |
in order to study the occurrence of apoptosis in psg and the role of pi3k/akt signaling pathway during spinning period, changes in morphology of silk gland, expressions of fibroin components fib-h, fib-l and p25 and akt, tor2, p70s6k and s6 in pi3k/akt pathway, expressions of apoptosis related genes caspase-3, caspase-9 and activity of caspase-3 were explored. |
2018-05-31 |
2023-08-13 |
Not clear |
| Chengyi Tu, Robert Xu, Meghana Koleti, Janet Zolda. Glycogen synthase kinase-3 inhibition sensitizes human induced pluripotent stem cells to thiol-containing antioxidants induced apoptosis. Stem cell research. vol 23. 2018-05-30. PMID:28772167. |
akt dysregulation was also found to partially contribute to cell apoptosis but was not the primary cause. |
2018-05-30 |
2023-08-13 |
mouse |
| Junsei Taira, Miki Sonamoto, Masatsugu Uehar. Dual Biological Functions of a Cytoprotective Effect and Apoptosis Induction by Bioavailable Marine Carotenoid Fucoxanthinol through Modulation of the Nrf2 Activation in RAW264.7 Macrophage Cells. Marine drugs. vol 15. issue 10. 2018-05-29. PMID:28984834. |
on the other hand, the high concentrations of both compounds (>10 μm) induced apoptosis with caspase 3/7 activation during suppression of the anti-apoptotic proteins, such as bcl-xl and phosphorous akt (pakt). |
2018-05-29 |
2023-08-13 |
Not clear |
| Esmat Fathi, Fatemeh Hedayati Katouli, Gholam Hossein Riazi, Marzieh Dehghan Shasaltaneh, Elham Parandavar, Samaneh Bayati, Ali Afrasiabi, Reza Nazar. The Effects of Alpha Boswellic Acid on Reelin Expression and Tau Phosphorylation in Human Astrocytes. Neuromolecular medicine. vol 19. issue 1. 2018-05-28. PMID:27567921. |
for this aim, we used streptozotocin (stz), in which from an outlook generates alzheimer's hallmarks in astrocytes, and assayed reelin expression, tau and akt phosphorylation as well as reactive oxygen species (ros) generation and apoptosis in the presences of aba. |
2018-05-28 |
2023-08-13 |
human |
| Daseul Yoon, Kieun Bae, Min-Kyeong Lee, Jin Hee Kim, Kyong-Ah Yoo. Galanin is an epigenetically silenced tumor suppressor gene in gastric cancer cells. PloS one. vol 13. issue 2. 2018-05-24. PMID:29462183. |
exogenous galanin expression in silenced cells induced apoptosis and decreased phosphorylated akt expression. |
2018-05-24 |
2023-08-13 |
human |
| Li Lu, Ke Li, Yun-Hua Mao, Hu Qu, Bing Yao, Wen-Wen Zhong, Bo Ma, Zhong-Yang Wan. Gold-chrysophanol nanoparticles suppress human prostate cancer progression through inactivating AKT expression and inducing apoptosis and ROS generation in vitro and in vivo. International journal of oncology. vol 51. issue 4. 2018-05-22. PMID:28849003. |
gold-chrysophanol nanoparticles suppress human prostate cancer progression through inactivating akt expression and inducing apoptosis and ros generation in vitro and in vivo. |
2018-05-22 |
2023-08-13 |
mouse |
| Cheol Park, Won Sup Lee, Min-Ho Han, Kyoung Seob Song, Su-Hyun Hong, Arulkumar Nagappan, Gi-Young Kim, Gon Sup Kim, Jin-Myung Jung, Chung Ho Ryu, Sung Chul Shin, Soon Chan Hong, Yung Hyun Cho. Lonicera japonica Thunb. Induces caspase-dependent apoptosis through death receptors and suppression of AKT in U937 human leukemic cells. Phytotherapy research : PTR. vol 32. issue 3. 2018-05-22. PMID:29193390. |
induces caspase-dependent apoptosis through death receptors and suppression of akt in u937 human leukemic cells. |
2018-05-22 |
2023-08-13 |
human |
| Bao-Long Pan, Zong-Wu Tong, Ling Wu, Li Pan, Jun-E Li, You-Guang Huang, Shu-De Li, Shi-Xun Du, Xu-Dong L. Effects of MicroRNA-206 on Osteosarcoma Cell Proliferation, Apoptosis, Migration and Invasion by Targeting ANXA2 Through the AKT Signaling Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 45. issue 4. 2018-05-22. PMID:29462818. |
effects of microrna-206 on osteosarcoma cell proliferation, apoptosis, migration and invasion by targeting anxa2 through the akt signaling pathway. |
2018-05-22 |
2023-08-13 |
Not clear |
| Bao-Long Pan, Zong-Wu Tong, Ling Wu, Li Pan, Jun-E Li, You-Guang Huang, Shu-De Li, Shi-Xun Du, Xu-Dong L. Effects of MicroRNA-206 on Osteosarcoma Cell Proliferation, Apoptosis, Migration and Invasion by Targeting ANXA2 Through the AKT Signaling Pathway. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 45. issue 4. 2018-05-22. PMID:29462818. |
this study aimed to investigate the mechanism by which microrna-206 (mir-206) affects the proliferation, apoptosis, migration and invasion of osteosarcoma (os) cells by targeting anxa2 via the akt signaling pathway. |
2018-05-22 |
2023-08-13 |
Not clear |
| Bin Song, Hong Song, Weiguo Wang, Hongru Wang, Hanyuan Peng, Jing Cui, Rong Wang, Hua Huang, Wei Wang, Lili Wan. Beclin 1 overexpression inhibits chondrocyte apoptosis and downregulates extracellular matrix metabolism in osteoarthritis. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28731147. |
after transfection for 48, 72 and 96 h, cell viability, apoptosis, the phosphatidylinositol-3-kinase (pi3k)/protein kinase b (akt)/mammalian target of rapamycin (mtor) signaling pathway and mmps were examined. |
2018-05-21 |
2023-08-13 |
Not clear |
| Lijuan Zhang, Gang Feng, Xinyan Zhang, Yawen Ding, Xiaojuan Wan. microRNA‑630 promotes cell proliferation and inhibits apoptosis in the HCT116 human colorectal cancer cell line. Molecular medicine reports. vol 16. issue 4. 2018-05-21. PMID:28791386. |
in conclusion, the present findings suggested that mir‑630 may function as an oncogenic mirna in colorectal cancer, and may promote cellular proliferation and inhibit apoptosis, through the regulation of the expression of p27 and the akt signaling pathway. |
2018-05-21 |
2023-08-13 |
human |