| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tianshu Wu, Qingling Zhan, Ting Zhang, Shengjun Ang, Jiali Ying, Keyu He, Shihan Zhang, Yuying Xue, Meng Tan. The protective effects of resveratrol, H Toxicology in vitro : an international journal published in association with BIBRA. vol 41. 2018-03-22. PMID:28219723. |
apart from qd-induced oxidative stress indicated by excessive ros generation, three signal transductions, including akt, p38 and jnk, played important roles on the regulation of cell apoptosis by cdte qds exposure as well. |
2018-03-22 |
2023-08-13 |
Not clear |
| Hong Sui, Kaibing Wang, Rui Xie, Xi Li, Kunpeng Li, Yuxian Bai, Xishan Wang, Bin Bai, Dan Chen, Jiazhuang Li, Baozhong She. NDV-D90 suppresses growth of gastric cancer and cancer-related vascularization. Oncotarget. vol 8. issue 21. 2018-03-22. PMID:28388537. |
the increases in cell apoptosis and reduction in cell growth in ndv-d90-treated gastric cancer cells seemingly resulted from augmentation of p38 signaling and suppression of erk1/2 and akt signaling. |
2018-03-22 |
2023-08-13 |
Not clear |
| Jing Li, Jia Li, Guowei Cai, Lin Shen, Furong L. Proapoptotic and Growth-inhibitory Effects of Plumbagin on Human Gastric Cancer Cells Via Suppression of Signal Transducer and Activator of Transcription 3 and Protein Kinase B. Alternative therapies in health and medicine. vol 23. issue 5. 2018-03-21. PMID:28236621. |
conclusions • plumbagin inhibits cell apoptosis in human gc cells, and that effect may be related with its ability to suppress phosphorylation of stat3 and akt. |
2018-03-21 |
2023-08-13 |
human |
| Sara Ramezani, Nasim Vousooghi, Fatemeh Ramezani Kapourchali, Mohammad Taghi Joghatae. Perifosine enhances bevacizumab-induced apoptosis and therapeutic efficacy by targeting PI3K/AKT pathway in a glioblastoma heterotopic model. Apoptosis : an international journal on programmed cell death. vol 22. issue 8. 2018-03-21. PMID:28616662. |
prf and bvz separately slowed down tumor growth along with the cell apoptosis induction associated with a profound increase in caspase3 activity through an akt inhibition-related pathway for prf but not bvz. |
2018-03-21 |
2023-08-13 |
mouse |
| Wei Peng, Zhuo Wang, Hong Fa. LncRNA NEAT1 Impacts Cell Proliferation and Apoptosis of Colorectal Cancer via Regulation of Akt Signaling. Pathology oncology research : POR. vol 23. issue 3. 2018-03-20. PMID:28013491. |
lncrna neat1 impacts cell proliferation and apoptosis of colorectal cancer via regulation of akt signaling. |
2018-03-20 |
2023-08-13 |
Not clear |
| Ulkan Kilic, Ahmet Burak Caglayan, Mustafa Caglar Beker, Mehmet Yalcin Gunal, Berrak Caglayan, Esra Yalcin, Taha Kelestemur, Reyhan Zeynep Gundogdu, Burak Yulug, Bayram Yılmaz, Bilal Ersen Kerman, Ertugrul Kili. Particular phosphorylation of PI3K/Akt on Thr308 via PDK-1 and PTEN mediates melatonin's neuroprotective activity after focal cerebral ischemia in mice. Redox biology. vol 12. 2018-03-20. PMID:28395173. |
our data suggest that akt phosphorylation, preferably at the thr308 site of the activation loop via pdk1 and pten, mediates melatonin's neuroprotective activity and increased akt phosphorylation leads to reduced apoptosis. |
2018-03-20 |
2023-08-13 |
mouse |
| Yali Ma, Fang Chen, Suxia Yang, Yurui Duan, Zhiqiang Sun, Jun Sh. Silencing of TRB3 Ameliorates Diabetic Tubule Interstitial Nephropathy via PI3K/AKT Signaling in Rats. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-19. PMID:28600485. |
development of nephropathologic lesions has been shown to be associated with suppressed akt phosphorylation and elevated level of apoptosis. |
2018-03-19 |
2023-08-13 |
rat |
| Yali Ma, Fang Chen, Suxia Yang, Yurui Duan, Zhiqiang Sun, Jun Sh. Silencing of TRB3 Ameliorates Diabetic Tubule Interstitial Nephropathy via PI3K/AKT Signaling in Rats. Medical science monitor : international medical journal of experimental and clinical research. vol 23. 2018-03-19. PMID:28600485. |
moreover, it has been established that the trb3 gene is capable of inhibiting akt phosphorylation and promoting apoptosis. |
2018-03-19 |
2023-08-13 |
rat |
| Jin Li, Qiulian Zhou, Tingting Yang, Yongqin Li, Yuhui Zhang, Jinhua Wang, Zheng Jia. SGK1 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells. Biochemical and biophysical research communications. vol 496. issue 4. 2018-03-14. PMID:29412164. |
finally, the results of the rescue experiment showed that mk2206 (akt inhibitor) could rescue the impact of sgk1 on a549 cell apoptosis, while pd98059 (erk1/2 inhibitor) could not further aggravate the impact. |
2018-03-14 |
2023-08-13 |
human |
| Jin Li, Qiulian Zhou, Tingting Yang, Yongqin Li, Yuhui Zhang, Jinhua Wang, Zheng Jia. SGK1 inhibits PM2.5-induced apoptosis and oxidative stress in human lung alveolar epithelial A549 cells. Biochemical and biophysical research communications. vol 496. issue 4. 2018-03-14. PMID:29412164. |
taken together, our results suggest that sgk1 inhibits pm2.5-induced cell apoptosis and ros generation via erk1/2 and akt signaling pathway in human lung alveolar epithelial a549 cells. |
2018-03-14 |
2023-08-13 |
human |
| Zhiwen Zeng, Xue Wang, Sanjeev K Bhardwaj, Xuanhe Zhou, Peter J Little, Remi Quirion, Lalit K Srivastava, Wenhua Zhen. The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway. Molecular neurobiology. vol 54. issue 5. 2018-03-09. PMID:27173157. |
our results showed that corticosterone decreases the phosphorylation of akt and foxo3a, leading to the nuclear localization of foxo3a and the apoptosis of pc12 cells, while clozapine concentration dependently protected pc12 cells against corticosterone insult. |
2018-03-09 |
2023-08-13 |
Not clear |
| Xiaoli Lou, Bin Sun, Jianxing Song, Yicun Wang, Junhao Jiang, Yang Xu, Zeqiang Ren, Changqing S. Human sulfatase 1 exerts anti-tumor activity by inhibiting the AKT/ CDK4 signaling pathway in melanoma. Oncotarget. vol 7. issue 51. 2018-03-06. PMID:27806323. |
in this study, we found that hsulf-1 overexpression in melanoma cells can inhibit cell proliferation and induce cell cycle arrest and apoptosis by decreasing the protein kinase b (akt) phosphorylation and limiting cdk4 nuclear import. |
2018-03-06 |
2023-08-13 |
mouse |
| Wei Hu, Peng Zhang, Jun Gu, Qiang Yu, Dadong Zhan. NEDD4-1 protects against ischaemia/reperfusion-induced cardiomyocyte apoptosis via the PI3K/Akt pathway. Apoptosis : an international journal on programmed cell death. vol 22. issue 3. 2018-03-06. PMID:27837380. |
overexpression of nedd4-1 activated the akt pathway and regulated apoptosis-related proteins in h9c2 cardiomyocytes, attenuating si/r-induced cell apoptosis and caspase 3/7 activities. |
2018-03-06 |
2023-08-13 |
rat |
| Ming-Horng Tsai, Ju-Fang Liu, Yao-Chang Chiang, Stephen Chu-Sung Hu, Lee-Fen Hsu, Yu-Ching Lin, Zih-Chan Lin, Hui-Chun Lee, Mei-Chuan Chen, Chieh-Liang Huang, Chiang-Wen Le. Artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ROS-mediated MAPKs and Akt activation in non-small cell lung cancer cells. Oncotarget. vol 8. issue 17. 2018-03-05. PMID:28423703. |
artocarpin, an isoprenyl flavonoid, induces p53-dependent or independent apoptosis via ros-mediated mapks and akt activation in non-small cell lung cancer cells. |
2018-03-05 |
2023-08-13 |
Not clear |
| B Shalmon, M Drendel, M Wolf, A Hirshberg, Y Cohe. Mutational analysis of PI3K/AKT and RAS/RAF pathway activation in malignant salivary gland tumours with a new mutation of PIK3CA. International journal of oral and maxillofacial surgery. vol 45. issue 6. 2018-03-01. PMID:26811072. |
the phosphoinositide 3-kinase (pik3)/v-akt murine thymoma (akt) oncogene pathway and the ras/raf pathway are involved in regulating the signalling of multiple biological processes, including apoptosis, metabolism, cell proliferation, and cell growth. |
2018-03-01 |
2023-08-13 |
Not clear |
| Shuyi Li, Jianling Chen, Xiaoling Fang, Xiaomeng Xi. Sphingosine-1-phosphate activates the AKT pathway to inhibit chemotherapy induced human granulosa cell apoptosis. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. vol 33. issue 6. 2018-03-01. PMID:28277139. |
sphingosine-1-phosphate activates the akt pathway to inhibit chemotherapy induced human granulosa cell apoptosis. |
2018-03-01 |
2023-08-13 |
human |
| Kwang-Youn Kim, Kwang-Il Park, Sang-Hun Kim, Sun-Nyoung Yu, Sul-Gi Park, Young Woo Kim, Young-Kyo Seo, Jin-Yeul Ma, Soon-Cheol Ah. Inhibition of Autophagy Promotes Salinomycin-Induced Apoptosis via Reactive Oxygen Species-Mediated PI3K/AKT/mTOR and ERK/p38 MAPK-Dependent Signaling in Human Prostate Cancer Cells. International journal of molecular sciences. vol 18. issue 5. 2018-02-28. PMID:28524116. |
pretreatment with ly294002, an autophagy and pi3k inhibitor, enhanced the salinomycin-induced apoptosis by decreasing the akt and mtor activities and suppressing autophagy. |
2018-02-28 |
2023-08-13 |
human |
| Fen Chang, Jing Liu, Hui Fu, Jinlan Wang, Fang Li, Hongwei Yue, Wenjing Li, Jing Zhao, Deling Yi. GSK-3β promotes PA-induced apoptosis through changing β-arrestin 2 nucleus location in H9c2 cardiomyocytes. Apoptosis : an international journal on programmed cell death. vol 21. issue 9. 2018-02-27. PMID:27431999. |
akt participates in pa-induced cardiomyocyte apoptosis. |
2018-02-27 |
2023-08-13 |
Not clear |
| Fen Chang, Jing Liu, Hui Fu, Jinlan Wang, Fang Li, Hongwei Yue, Wenjing Li, Jing Zhao, Deling Yi. GSK-3β promotes PA-induced apoptosis through changing β-arrestin 2 nucleus location in H9c2 cardiomyocytes. Apoptosis : an international journal on programmed cell death. vol 21. issue 9. 2018-02-27. PMID:27431999. |
gsk-3β is a substrate of akt, we investigated its role in pa-induced apoptosis. |
2018-02-27 |
2023-08-13 |
Not clear |
| Yun Cai, Boxin Zhao, Qianying Liang, Yunqi Zhang, Jieying Cai, Guofeng L. The selective effect of glycyrrhizin and glycyrrhetinic acid on topoisomerase IIα and apoptosis in combination with etoposide on triple negative breast cancer MDA-MB-231 cells. European journal of pharmacology. vol 809. 2018-02-26. PMID:28506909. |
our experiments showed that gsh depletion, modulation of mapk and akt pathways accounted for the regulation of topoisomerase iiα and apoptosis. |
2018-02-26 |
2023-08-13 |
Not clear |