| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Daowen Li, Chongshan Dai, Xiayun Yang, Fuyun Wang, Xiaohong Yu, Xilong Xiao, Shusheng Tan. Critical role of p21 on olaquindox-induced mitochondrial apoptosis and S-phase arrest involves activation of PI3K/AKT and inhibition of Nrf2/HO-1pathway. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 108. issue Pt A. 2018-01-05. PMID:28757460. |
meanwhile, olaquindox activated akt and nrf2/ho-1 pathway, up-regulated bax/bcl-2 ratio, disrupted mitochondrial membrane potential (mmp) and subsequently caused cytochrome c release and a cascade activation of caspase, eventually induced apoptosis. |
2018-01-05 |
2023-08-13 |
human |
| Nadezda Dolgikh, Simone Fuld. Rhabdomyosarcoma cells are susceptible to cell death by LDK378 alone or in combination with sorafenib independently of anaplastic lymphoma kinase status. Anti-cancer drugs. vol 28. issue 10. 2018-01-03. PMID:29045271. |
before the onset of apoptosis, ldk378 reduces phosphorylation of akt, s6 ribosomal protein, stat3 and - to a lesser extent - phosphorylation of erk, showing that it suppresses key survival pathways. |
2018-01-03 |
2023-08-13 |
Not clear |
| Sudha Sravanti Kotapalli, Chandrashekhar Dasari, Divya Duscharla, Karthik Reddy Kami Reddy, Manjula Kasula, Ramesh Ummann. All-Trans-Retinoic Acid Stimulates Overexpression of Tumor Protein D52 (TPD52, Isoform 3) and Neuronal Differentiation of IMR-32 Cells. Journal of cellular biochemistry. vol 118. issue 12. 2018-01-02. PMID:28436114. |
furthermore, we show that tpd52 protects cells from apoptosis and arrest cell proliferation by varying expression of p27kip1, activation of akt and erk1/2 thus promoting cell differentiation. |
2018-01-02 |
2023-08-13 |
Not clear |
| Hong Zhang, Xiuli Wang, Xinxin Che. Potential Role of Long Non-Coding RNA ANRIL in Pediatric Medulloblastoma Through Promotion on Proliferation and Migration by Targeting miR-323. Journal of cellular biochemistry. vol 118. issue 12. 2018-01-02. PMID:28513871. |
anril inhibition repressed cell proliferation and migration but promoted cell apoptosis through mir-323-mediated regulation of bri3, which could activate p38 mapk, erk, and akt as well as wnt signaling pathway. |
2018-01-02 |
2023-08-13 |
Not clear |
| Kenneth Maies. Targeting molecules to medicine with mTOR, autophagy and neurodegenerative disorders. British journal of clinical pharmacology. vol 82. issue 5. 2017-12-29. PMID:26469771. |
coupled to the cellular biology of mtor are a number of considerations for the development of novel treatments involving the fine control of mtor signalling, tumourigenesis, complexity of the apoptosis and autophagy relationship, functional outcome in the nervous system, and the intimately linked pathways of growth factors, phosphoinositide 3-kinase (pi 3-k), protein kinase b (akt), amp activated protein kinase (ampk), silent mating type information regulation two homologue one (saccharomyces cerevisiae) (sirt1) and others. |
2017-12-29 |
2023-08-13 |
Not clear |
| Maria Beatrice Morelli, Massimo Nabissi, Consuelo Amantini, Daniele Tomassoni, Francesco Rossi, Claudio Cardinali, Matteo Santoni, Antonietta Arcella, Maria Antonietta Oliva, Angela Santoni, Carlo Polidori, Maria Paola Mariani, Giorgio Santon. Overexpression of transient receptor potential mucolipin-2 ion channels in gliomas: role in tumor growth and progression. Oncotarget. vol 7. issue 28. 2017-12-29. PMID:27248469. |
the dna damage and apoptosis induced by trpml-2 loss increased ser139 h2ax phosphorylation and induced caspase-3 activation; furthermore, knock-down of trpml-2 in t98 and u251 glioma cell lines completely abrogated akt and erk1/2 phosphorylation, as compared to untreated cells. |
2017-12-29 |
2023-08-13 |
human |
| Kirstine Jacobsen, Jordi Bertran-Alamillo, Miguel Angel Molina, Cristina Teixidó, Niki Karachaliou, Martin Haar Pedersen, Josep Castellví, Mónica Garzón, Carles Codony-Servat, Jordi Codony-Servat, Ana Giménez-Capitán, Ana Drozdowskyj, Santiago Viteri, Martin R Larsen, Ulrik Lassen, Enriqueta Felip, Trever G Bivona, Henrik J Ditzel, Rafael Rosel. Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer. Nature communications. vol 8. issue 1. 2017-12-26. PMID:28871105. |
combined treatment with an egfr tyrosine kinase inhibitor and akt inhibitor causes apoptosis and synergistic growth inhibition in multiple egfr tyrosine kinase inhibitor-resistant non-small-cell lung cancer models. |
2017-12-26 |
2023-08-13 |
Not clear |
| Lei Yang, Yan Zhang, Mengmeng Zhu, Qiong Zhang, Xiaoling Wang, Yanjiao Wang, Jincai Zhang, Jing Li, Liang Yang, Jie Liu, Fei Liu, Yinan Yang, Licheng Kang, Yanna Shen, Zhi Q. Resveratrol attenuates myocardial ischemia/reperfusion injury through up-regulation of vascular endothelial growth factor B. Free radical biology & medicine. vol 101. 2017-12-25. PMID:27667182. |
we also found that the inhibition of vegf-b abolished the cardioprotective effect of rsv, increased apoptosis, and led to the down-regulation of phosphorylated akt, gsk3β, and mnsod in h9c2 cells. |
2017-12-25 |
2023-08-13 |
rat |
| Ge-Liang Liu, Han-Jie Yang, Bo Liu, Tian Li. Effects of MicroRNA-19b on the Proliferation, Apoptosis, and Migration of Wilms' Tumor Cells Via the PTEN/PI3K/AKT Signaling Pathway. Journal of cellular biochemistry. vol 118. issue 10. 2017-12-21. PMID:28322459. |
mtt assay, propidium iodide (pi) staining, annexin-v/pi double-staining, transwell assay and western blotting were performed to examine cell proliferation, cycle, apoptosis, migration, and invasion, and the protein expressions of pten, p13k, akt, and p-akt. |
2017-12-21 |
2023-08-13 |
human |
| Francesca De Iuliis, Ludovica Taglieri, Gerardo Salerno, Anna Giuffrida, Bernardina Milana, Sabrina Giantulli, Simone Carradori, Ida Silvestri, Susanna Scarp. The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells. Investigational new drugs. vol 34. issue 4. 2017-12-13. PMID:26994617. |
we then performed a negative regulation of survivin expression, with the utilization of wortmannin, an akt inhibitor, and obtained a significant increase of k858-dependent apoptosis. |
2017-12-13 |
2023-08-13 |
Not clear |
| Francesca De Iuliis, Ludovica Taglieri, Gerardo Salerno, Anna Giuffrida, Bernardina Milana, Sabrina Giantulli, Simone Carradori, Ida Silvestri, Susanna Scarp. The kinesin Eg5 inhibitor K858 induces apoptosis but also survivin-related chemoresistance in breast cancer cells. Investigational new drugs. vol 34. issue 4. 2017-12-13. PMID:26994617. |
this anti-proliferative response of tumor cells to k858 can be limited by the contemporaneous over-expression of survivin; consequently, the reduction of survivin levels, obtained with akt inhibitors, can sensitize tumor cells to k858-induced apoptosis. |
2017-12-13 |
2023-08-13 |
Not clear |
| Purnima Gupta, Supriya Srivastav, Shriya Saha, Pijush K Das, Anindita Uki. Leishmania donovani inhibits macrophage apoptosis and pro-inflammatory response through AKT-mediated regulation of β-catenin and FOXO-1. Cell death and differentiation. vol 23. issue 11. 2017-12-11. PMID:27662364. |
l. donovani-infected raw264.7 and bone marrow-derived macrophages (bmdm) treated with akt inhibitor or dominant negative akt constructs showed decreased anti-inflammatory cytokine production and increased host cell apoptosis resulting in reduced parasite survival. |
2017-12-11 |
2023-08-13 |
Not clear |
| Purnima Gupta, Supriya Srivastav, Shriya Saha, Pijush K Das, Anindita Uki. Leishmania donovani inhibits macrophage apoptosis and pro-inflammatory response through AKT-mediated regulation of β-catenin and FOXO-1. Cell death and differentiation. vol 23. issue 11. 2017-12-11. PMID:27662364. |
collectively our findings revealed that l. donovani triggered akt activation to regulate gsk-3β/β-catenin/foxo-1 axis, thus ensuring inhibition of both host cell apoptosis and immune response essential for its intra-macrophage survival. |
2017-12-11 |
2023-08-13 |
Not clear |
| Nouf Mohamed Al-Rasheed, Laila Mohamed Fadda, Hala A Attia, Hanaa Mahmoud Ali, Nawal Mohamed Al-Rashee. Quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing Bax, HIF1-α, TGF-β, Smad-2, and AKT pathways. Journal of biochemical and molecular toxicology. vol 31. issue 5. 2017-12-11. PMID:28000380. |
quercetin inhibits sodium nitrite-induced inflammation and apoptosis in different rats organs by suppressing bax, hif1-α, tgf-β, smad-2, and akt pathways. |
2017-12-11 |
2023-08-13 |
rat |
| Mei Gao, Qingbin Kong, Hui Hua, Yancun Yin, Jiao Wang, Ting Luo, Yangfu Jian. AMPK-mediated up-regulation of mTORC2 and MCL-1 compromises the anti-cancer effects of aspirin. Oncotarget. vol 7. issue 13. 2017-12-05. PMID:26918349. |
combination of aspirin and ampk, akt or mek inhibitor results in more significant inhibition of cell proliferation and induction of apoptosis than single agent. |
2017-12-05 |
2023-08-13 |
Not clear |
| Tingting Qin, Fang Fang, Meiting Song, Ruipeng Li, Zhanqiang Ma, Shiping M. Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced rats by attenuating neuronal apoptosis via regulating ROCK/Akt pathway. Behavioural brain research. vol 317. 2017-12-05. PMID:27646771. |
rats under cums stimulation treated with umbelliferone (15mg/kg, 30mg/kg) showed reduced neuronal apoptosis, as well as inhibited inflammatory cytokines levels by down-regulating rho-associated protein kinase (rock) signaling and up-regulating protein kinase b (akt) signaling. |
2017-12-05 |
2023-08-13 |
rat |
| Fenfen Ma, Wenwen Li, Xinghui Li, Ba Hieu Tran, Rinkiko Suguro, Ruijuan Guan, Cuilan Hou, Huijuan Wang, Aijie Zhang, Yichun Zhu, YiZhun Zh. Novel protective effects of pulsed electromagnetic field ischemia/reperfusion injury rats. Bioscience reports. vol 36. issue 6. 2017-12-05. PMID:27780890. |
in particular, pemf increased the phosphorylation of protein kinase b (akt) and endothelial nitric oxide synthase (enos), which might be closely related to attenuated cell apoptosis by increasing the releasing of nitric oxide (no). |
2017-12-05 |
2023-08-13 |
rat |
| Rui-Min Liu, Dan-Ni Sun, Ye-Lin Jiao, Pan Wang, Juan Zhang, Ming Wang, Jin Ma, Man Sun, Bian-Li Gu, Pan Chen, Ke Liu, Heng Ma, She-Gan Gao, Yuan-Fang Ma, Yi-Jun Q. Macrophage migration inhibitory factor promotes tumor aggressiveness of esophageal squamous cell carcinoma via activation of Akt and inactivation of GSK3β. Cancer letters. vol 412. 2017-12-05. PMID:29079416. |
moreover, blockage of mif expression decreased the activation of the akt, mek/erk, and nf-κb pathways and enhanced sensitivity to apoptosis. |
2017-12-05 |
2023-08-13 |
Not clear |
| James T Lynch, Robert McEwen, Claire Crafter, Ultan McDermott, Mathew J Garnett, Simon T Barry, Barry R Davie. Identification of differential PI3K pathway target dependencies in T-cell acute lymphoblastic leukemia through a large cancer cell panel screen. Oncotarget. vol 7. issue 16. 2017-12-04. PMID:26989080. |
induction of apoptosis only occurred following akti treatment in cell lines with pten protein loss and high levels of active akt. |
2017-12-04 |
2023-08-13 |
Not clear |
| Yu-Wen Zhuang, Cun-En Wu, Jin-Yong Zhou, Xu Chen, Jian Wu, Shan Jiang, Hai-Yan Peng, Xi Zou, Jia-Yun Liu, Da-Peng Wu, Tao Gong, Ming-Hao Qi, Tian Xue, Shen-Lin Liu, Hui Ca. Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase-3β/β-catenin pathway. Cancer science. vol 108. issue 11. 2017-11-28. PMID:28803443. |
when cells were pretreated with akt activator (insulin-like growth factor-1) followed by solasodine, the solasodine-induced apoptosis was partially abrogated by insulin-like growth factor-1. |
2017-11-28 |
2023-08-13 |
human |