| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuan Xing, Wanqing Sun, Yishi Wang, Feng Gao, Heng M. Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart. Aging. vol 8. issue 5. 2017-11-21. PMID:27019292. |
in cultured rat ventricular myocytes, phlpp-1 knockdown significantly enhanced insulin-induced akt phosphorylation and reduced simulated hypoxia/reoxygenation-induced apoptosis. |
2017-11-21 |
2023-08-13 |
rat |
| Yuan Xing, Wanqing Sun, Yishi Wang, Feng Gao, Heng M. Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart. Aging. vol 8. issue 5. 2017-11-21. PMID:27019292. |
contrary, phlpp-1 overexpression terminated akt phosphorylation and deteriorated myocytes apoptosis. |
2017-11-21 |
2023-08-13 |
rat |
| Yubin Wang, Joshua Hersheson, Dulce Lopez, Monia Hammer, Yan Liu, Ka-Hung Lee, Vanessa Pinto, Jeff Seinfeld, Sarah Wiethoff, Jiandong Sun, Rim Amouri, Faycal Hentati, Neema Baudry, Jennifer Tran, Andrew B Singleton, Marie Coutelier, Alexis Brice, Giovanni Stevanin, Alexandra Durr, Xiaoning Bi, Henry Houlden, Michel Baudr. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell reports. vol 16. issue 1. 2017-11-21. PMID:27320912. |
enhanced apoptosis is due to absence of calpain-1-mediated cleavage of ph domain and leucine-rich repeat protein phosphatase 1 (phlpp1), which results in inhibition of the akt pro-survival pathway in developing granule cells. |
2017-11-21 |
2023-08-13 |
mouse |
| Yubin Wang, Joshua Hersheson, Dulce Lopez, Monia Hammer, Yan Liu, Ka-Hung Lee, Vanessa Pinto, Jeff Seinfeld, Sarah Wiethoff, Jiandong Sun, Rim Amouri, Faycal Hentati, Neema Baudry, Jennifer Tran, Andrew B Singleton, Marie Coutelier, Alexis Brice, Giovanni Stevanin, Alexandra Durr, Xiaoning Bi, Henry Houlden, Michel Baudr. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell reports. vol 16. issue 1. 2017-11-21. PMID:27320912. |
injection of neonatal mice with the indirect akt activator, bisperoxovanadium, or crossing calpain-1 ko mice with phlpp1 ko mice prevented increased postnatal cerebellar granule cell apoptosis and restored granule cell density and motor coordination in adult mice. |
2017-11-21 |
2023-08-13 |
mouse |
| Li Zhang, Yuemeng Huang, Yanjun Wu, Jinglei Si, Yanna Huang, Qinyang Jiang, Ganqiu Lan, Yafen Guo, Hesheng Jian. Scriptaid Upregulates Expression of Development-Related Genes, Inhibits Apoptosis, and Improves the Development of Somatic Cell Nuclear Transfer Mini-Pig Embryos. Cellular reprogramming. vol 19. issue 1. 2017-11-21. PMID:28055234. |
after scriptaid treatment, histone deacetylase gene hdac5 expression level was significantly decreased in four-cell embryos and blastocysts, while the expression levels of the embryos' development-related genes akt, oct4, and apoptosis inhibited gene pgc-1α were significantly increased in blastocysts (p < 0.05). |
2017-11-21 |
2023-08-13 |
Not clear |
| Li Zhang, Yuemeng Huang, Yanjun Wu, Jinglei Si, Yanna Huang, Qinyang Jiang, Ganqiu Lan, Yafen Guo, Hesheng Jian. Scriptaid Upregulates Expression of Development-Related Genes, Inhibits Apoptosis, and Improves the Development of Somatic Cell Nuclear Transfer Mini-Pig Embryos. Cellular reprogramming. vol 19. issue 1. 2017-11-21. PMID:28055234. |
these results indicate that scriptaid repressed hdca5 gene expression, increased the acetylation level of h3k14, upregulated the expression of akt, oct4, and pgc-1α genes, improved embryos' development, and reduced apoptosis, which favors development of the scnt mini-pig embryos to blastocysts. |
2017-11-21 |
2023-08-13 |
Not clear |
| Jiyeon Ham, Whasun Lim, Fuller W Bazer, Gwonhwa Son. Silibinin stimluates apoptosis by inducing generation of ROS and ER stress in human choriocarcinoma cells. Journal of cellular physiology. vol 233. issue 2. 2017-11-21. PMID:28657208. |
furthermore, silibinin-induced apoptosis in choriocarcinoma cells via akt, mitogen-activated protein kinases (mapk) and unfolded protein response (upr) signal transduction. |
2017-11-21 |
2023-08-13 |
human |
| Tianyang Xi, Feng Jin, Ying Zhu, Jialu Wang, Ling Tang, Yanzhe Wang, David S Liebeskind, Zhiyi H. MicroRNA-126-3p attenuates blood-brain barrier disruption, cerebral edema and neuronal injury following intracerebral hemorrhage by regulating PIK3R2 and Akt. Biochemical and biophysical research communications. vol 494. issue 1-2. 2017-11-21. PMID:29042193. |
furthermore, in vitro assays confirmed upregulation of pik3r2 upon knockdown of mir-126-3p in rat brain microvascular endothelial cells (bmecs), and silencing of mir-126-3p resulted in impaired bmec barrier permeability and reversed vascular endothelial growth factor (vegf)- and angiopoietin-1 (ang-1)-induced activation of akt and inhibition of bmec apoptosis. |
2017-11-21 |
2023-08-13 |
rat |
| Jocelyn P Wong, Jason R Todd, Martina A Finetti, Frank McCarthy, Malgorzata Broncel, Simon Vyse, Maciej T Luczynski, Stephen Crosier, Karen A Ryall, Kate Holmes, Leo S Payne, Frances Daley, Patty Wai, Andrew Jenks, Barbara Tanos, Aik-Choon Tan, Rachael C Natrajan, Daniel Williamson, Paul H Huan. Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors. Cell reports. vol 17. issue 5. 2017-11-20. PMID:27783942. |
inhibitor combinations targeting both receptors and the dual inhibitor ponatinib suppress the akt and erk1/2 pathways leading to apoptosis. |
2017-11-20 |
2023-08-13 |
Not clear |
| Linlin Cai, Yonghua Li, Qingqing Zhang, Haijing Sun, Xiaodi Yan, Tong Hua, Qiufeng Zhu, Haitao Xu, Hailong F. Salidroside protects rat liver against ischemia/reperfusion injury by regulating the GSK-3β/Nrf2-dependent antioxidant response and mitochondrial permeability transition. European journal of pharmacology. vol 806. 2017-11-17. PMID:28411054. |
mechanistic studies have revealed that salidroside inhibits glycogen synthase kinase-3 beta (gsk-3β) activity and enhances the nf-e2-related factor (nrf2)-dependent antioxidant response by activating the akt signaling pathway, thereby reducing mitochondrial reactive oxygen species generation, increasing mptp resistance and preventing apoptosis by suppressing cytochrome c release and caspase activation during reperfusion. |
2017-11-17 |
2023-08-13 |
rat |
| Nicole Tegtmeyer, Matthias Neddermann, Carmen Isabell Asche, Steffen Backer. Subversion of host kinases: a key network in cellular signaling hijacked by Helicobacter pylori CagA. Molecular microbiology. vol 105. issue 3. 2017-11-16. PMID:28508421. |
here we review the signal transmission by translocated caga on multiple receptor kinases (c-met and egfr) and non-receptor kinases (src, abl, csk, apkc, par1, pi3k, akt, fak, gsk-3, jak, pak1, pak2 and map kinases), manipulating a selection of fundamental processes in the human gastric epithelium such as cell adhesion, polarity, proliferation, motility, receptor endocytosis, cytoskeletal rearrangements, apoptosis, inflammation and cell cycle progression. |
2017-11-16 |
2023-08-13 |
human |
| Yuta Adachi, Kazuyoshi Watanabe, Kenji Kita, Hidenori Kitai, Hiroshi Kotani, Yuki Sato, Naohiko Inase, Seiji Yano, Hiromichi Eb. Resistance mediated by alternative receptor tyrosine kinases in FGFR1-amplified lung cancer. Carcinogenesis. vol 38. issue 11. 2017-11-08. PMID:28968756. |
combinatorial inhibition of alternative rtks and fgfr1 was required to suppress both akt and extracellular signal-regulated kinase phosphorylation and to induce key pro-apoptotic proteins bim and p53 upregulated modulator of apoptosis (puma). |
2017-11-08 |
2023-08-13 |
Not clear |
| Yanjun Long, Xin Zhen, Fengxin Zhu, Zheng Hu, Wenjing Lei, Shuang Li, Yan Zha, Jing Ni. Hyperhomocysteinemia Exacerbates Cisplatin-induced Acute Kidney Injury. International journal of biological sciences. vol 13. issue 2. 2017-11-07. PMID:28255274. |
stimulating cultured nrk-52e cells with hcy significantly increased the fraction of cells in g2/m phase and cell apoptosis together with decreased akt kinase activity. |
2017-11-07 |
2023-08-13 |
mouse |
| Yanjun Long, Xin Zhen, Fengxin Zhu, Zheng Hu, Wenjing Lei, Shuang Li, Yan Zha, Jing Ni. Hyperhomocysteinemia Exacerbates Cisplatin-induced Acute Kidney Injury. International journal of biological sciences. vol 13. issue 2. 2017-11-07. PMID:28255274. |
akt agonist igf-1 rescued hhcy-induced cell cycle arrest and cell apoptosis. |
2017-11-07 |
2023-08-13 |
mouse |
| Y Nishida, A Maeda, M J Kim, L Cao, Y Kubota, J Ishizawa, A AlRawi, Y Kato, A Iwama, M Fujisawa, K Matsue, M Weetall, M Dumble, M Andreeff, T W Davis, A Branstrom, S Kimura, K Kojim. The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. Blood cancer journal. vol 7. issue 2. 2017-11-06. PMID:28211885. |
ptc596 induced apoptosis along with the reduction of mcl-1 and phosphorylated akt in patient-derived cd34 |
2017-11-06 |
2023-08-13 |
Not clear |
| Jose L Viñas, Dylan Burger, Joseph Zimpelmann, Randa Haneef, William Knoll, Pearl Campbell, Alex Gutsol, Anthony Carter, David S Allan, Kevin D Burn. Transfer of microRNA-486-5p from human endothelial colony forming cell-derived exosomes reduces ischemic kidney injury. Kidney international. vol 90. issue 6. 2017-11-03. PMID:27650731. |
exposure of hypoxic endothelial cells to conditioned medium from ecfcs pretreated with anti-mir-486-5p blocked increases in mir-486-5p and phosphorylated akt, restored expression of pten, and enhanced apoptosis. |
2017-11-03 |
2023-08-13 |
mouse |
| Sharon K Kuss-Duerkop, Juan Wang, Ignacio Mena, Kris White, Giorgi Metreveli, Ramanavelan Sakthivel, Miguel A Mata, Raquel Muñoz-Moreno, Xiang Chen, Florian Krammer, Michael S Diamond, Zhijian J Chen, Adolfo García-Sastre, Beatriz M A Fontour. Influenza virus differentially activates mTORC1 and mTORC2 signaling to maximize late stage replication. PLoS pathogens. vol 13. issue 9. 2017-10-26. PMID:28953980. |
on the other hand, the viral ns1 protein promotes phosphorylation of akt at a different site via mtorc2, which is an activity dispensable for mtorc1 stimulation but known to regulate apoptosis. |
2017-10-26 |
2023-08-13 |
Not clear |
| Manikanta Murahari, Karanam Vanitha Prakash, Godefridus J Peters, Y C Mayu. Acridone-pyrimidine hybrids- design, synthesis, cytotoxicity studies in resistant and sensitive cancer cells and molecular docking studies. European journal of medicinal chemistry. vol 139. 2017-10-16. PMID:28886509. |
also further results of western blotting assay with akt kinase identified that hybrid compounds have the ability to inhibit the akt kinase activity and induce apoptosis, with abcc1 suggests that active compounds too have the ability to modulate multidrug resistance (mdr) associated with abcc1/mrp1. |
2017-10-16 |
2023-08-13 |
Not clear |
| Qiong Wu, Shiyong W. The role of lipid raft translocation of prohibitin in regulation of Akt and Raf-protected apoptosis of HaCaT cells upon ultraviolet B irradiation. Molecular carcinogenesis. vol 56. issue 7. 2017-10-11. PMID:28218425. |
the role of lipid raft translocation of prohibitin in regulation of akt and raf-protected apoptosis of hacat cells upon ultraviolet b irradiation. |
2017-10-11 |
2023-08-13 |
human |
| Qiong Wu, Shiyong W. The role of lipid raft translocation of prohibitin in regulation of Akt and Raf-protected apoptosis of HaCaT cells upon ultraviolet B irradiation. Molecular carcinogenesis. vol 56. issue 7. 2017-10-11. PMID:28218425. |
reduced expression of phb leads to a decreased phosphorylation of akt and erk, as well as a decreased activity of akt, and increased apoptosis of the cells upon uvb irradiation. |
2017-10-11 |
2023-08-13 |
human |