| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yun Cai, Boxin Zhao, Qianying Liang, Yunqi Zhang, Jieying Cai, Guofeng L. The selective effect of glycyrrhizin and glycyrrhetinic acid on topoisomerase IIα and apoptosis in combination with etoposide on triple negative breast cancer MDA-MB-231 cells. European journal of pharmacology. vol 809. 2018-02-26. PMID:28506909. |
however, gl showed protection and detoxication by decreasing reactive oxygen species generation, maintaining gsh and differentially modulating apoptosis, akt pathway, erk and jnk of mapk pathway. |
2018-02-26 |
2023-08-13 |
Not clear |
| Chun Yan Wang, Su Tang Guo, Jia Yu Wang, Xu Guang Yan, Margaret Farrelly, Yuan Yuan Zhang, Fen Liu, Hamed Yari, Ting La, Fu Xi Lei, Lei Jin, Xu Dong Zhang, Chen Chen Jian. Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922. Oncotarget. vol 7. issue 31. 2018-02-23. PMID:27391062. |
although auy922 triggered rapid reduction in erk and akt activation in both wild-type and mutant braf colon cancer cells, activation of erk and akt rebounded shortly in the latter leading to resistance of the cells to auy922-induced apoptosis. |
2018-02-23 |
2023-08-13 |
Not clear |
| Yang Yu, Feng Lv, Dong Liang, Qinheng Yang, Bin Zhang, Hong Lin, Xiaofang Wang, Guo Qian, Jinzhong Xu, Wei Yo. HOTAIR may regulate proliferation, apoptosis, migration and invasion of MCF-7 cells through regulating the P53/Akt/JNK signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-23. PMID:28407576. |
mcf-7 cells were cultured and transfected with hotair sirna, and the proliferation rate of cells was determined using mtt and colony-forming assay; moreover, the apoptosis as well as cell cycles were determined using annexin v/propidium iodide staining methods and analyzed using flow cytometery; furthermore, cell scratch and transwell assays have been performed to examine the migration and invasion of mcf-7 cells; next, cells were collected, and rt-qpcr as well as western blotting assay were performed to examine the expression of p53, mdm2, akt, jnk, mmp-2 and mmp-9. |
2018-02-23 |
2023-08-13 |
human |
| Sreevidya Santha, Gantulga Davaakhuu, Aninda Basu, Rong Ke, Subhasis Das, Ajay Rana, Basabi Ran. Modulation of glycogen synthase kinase-3β following TRAIL combinatorial treatment in cancer cells. Oncotarget. vol 7. issue 41. 2018-02-22. PMID:27602497. |
our results indicated an increase in inhibitory gsk3βser9 phosphorylation during apoptosis, mediated via akt. |
2018-02-22 |
2023-08-13 |
Not clear |
| Ying Tan, Ning Huang, Xiang Zhang, Jiangang Hu, Si Cheng, Li Pi, Yuan Chen. KIAA0247 suppresses the proliferation, angiogenesis and promote apoptosis of human glioma through inactivation of the AKT and Stat3 signaling pathway. Oncotarget. vol 7. issue 52. 2018-02-22. PMID:27893430. |
kiaa0247 suppresses the proliferation, angiogenesis and promote apoptosis of human glioma through inactivation of the akt and stat3 signaling pathway. |
2018-02-22 |
2023-08-13 |
human |
| Chengfang Zhou, Xiang Chen, Weiqi Zeng, Cong Peng, Gang Huang, Xian'an Li, Zhengxiao Ouyang, Yi Luo, Xuezheng Xu, Biaobo Xu, Weili Wang, Ruohui He, Xu Zhang, Liyang Zhang, Jie Liu, Todd C Knepper, Yijing He, Howard L McLeo. Propranolol induced G0/G1/S phase arrest and apoptosis in melanoma cells via AKT/MAPK pathway. Oncotarget. vol 7. issue 42. 2018-02-21. PMID:27582542. |
these are the first data to demonstrate that propranolol might inhibit melanoma by activating the intrinsic apoptosis pathway and inactivating the mapk and akt pathways. |
2018-02-21 |
2023-08-13 |
mouse |
| Jui-Chieh Chen, Ming-Ju Hsieh, Chih-Jung Chen, Jen-Tsun Lin, Yu-Sheng Lo, Yi-Ching Chuang, Su-Yu Chien, Mu-Kuan Che. Polyphyllin G induce apoptosis and autophagy in human nasopharyngeal cancer cells by modulation of AKT and mitogen-activated protein kinase pathways in vitro and in vivo. Oncotarget. vol 7. issue 43. 2018-02-21. PMID:27602962. |
polyphyllin g induce apoptosis and autophagy in human nasopharyngeal cancer cells by modulation of akt and mitogen-activated protein kinase pathways in vitro and in vivo. |
2018-02-21 |
2023-08-13 |
human |
| Jui-Chieh Chen, Ming-Ju Hsieh, Chih-Jung Chen, Jen-Tsun Lin, Yu-Sheng Lo, Yi-Ching Chuang, Su-Yu Chien, Mu-Kuan Che. Polyphyllin G induce apoptosis and autophagy in human nasopharyngeal cancer cells by modulation of AKT and mitogen-activated protein kinase pathways in vitro and in vivo. Oncotarget. vol 7. issue 43. 2018-02-21. PMID:27602962. |
to further clarify whether polyphyllin g-induced apoptosis and autophagy depended on akt/erk/jnk/p38 mapk signaling pathways, cells were combined treated with akt inhibitor (ly294002), erk1/2 inhibitor (u0126), p38 mapk inhibitor (sb203580), or jnk inhibitor (sp600125). |
2018-02-21 |
2023-08-13 |
human |
| Jui-Chieh Chen, Ming-Ju Hsieh, Chih-Jung Chen, Jen-Tsun Lin, Yu-Sheng Lo, Yi-Ching Chuang, Su-Yu Chien, Mu-Kuan Che. Polyphyllin G induce apoptosis and autophagy in human nasopharyngeal cancer cells by modulation of AKT and mitogen-activated protein kinase pathways in vitro and in vivo. Oncotarget. vol 7. issue 43. 2018-02-21. PMID:27602962. |
these results demonstrated that polyphyllin g induced apoptosis in npc cells through activation of erk, while akt, p38 mapk and jnk were responsible for polyphyllin g-induced autophagy. |
2018-02-21 |
2023-08-13 |
human |
| Shanmin Zhao, Li Li, Shiyong Wang, Chenlin Yu, Bang Xiao, Lifang Lin, Wei Cong, Jishuai Cheng, Wenjing Yang, Wei Sun, Shufang Cu. H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway. Oncotarget. vol 7. issue 51. 2018-02-21. PMID:27863375. |
these data show that inhibiting the akt pathway promotes autophagy and apoptosis in nmr skin fibroblasts. |
2018-02-21 |
2023-08-13 |
Not clear |
| Shanmin Zhao, Li Li, Shiyong Wang, Chenlin Yu, Bang Xiao, Lifang Lin, Wei Cong, Jishuai Cheng, Wenjing Yang, Wei Sun, Shufang Cu. H2O2 treatment or serum deprivation induces autophagy and apoptosis in naked mole-rat skin fibroblasts by inhibiting the PI3K/Akt signaling pathway. Oncotarget. vol 7. issue 51. 2018-02-21. PMID:27863375. |
cq-induced inhibition of late autophagy stages also prevented akt activation and induced apoptosis. |
2018-02-21 |
2023-08-13 |
Not clear |
| Zafar Gholinejad, Nejat Kheiripour, Mitra Nourbakhsh, Davod Ilbeigi, Kiarash Behroozfar, Zahra Hesari, Abolfazl Golestani, Mohammad Shabani, Nahid Einollah. Extracellular NAMPT/Visfatin induces proliferation through ERK1/2 and AKT and inhibits apoptosis in breast cancer cells. Peptides. vol 92. 2018-02-21. PMID:28442350. |
extracellular nampt/visfatin induces proliferation through erk1/2 and akt and inhibits apoptosis in breast cancer cells. |
2018-02-21 |
2023-08-13 |
Not clear |
| Changjiang Ying, Lei Chen, Shanshan Wang, Yizhen Mao, Hongwei Ling, Wei Li, Xiaoyan Zho. Zeaxanthin ameliorates high glucose-induced mesangial cell apoptosis through inhibiting oxidative stress via activating AKT signalling-pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-16. PMID:28431381. |
zeaxanthin ameliorates high glucose-induced mesangial cell apoptosis through inhibiting oxidative stress via activating akt signalling-pathway. |
2018-02-16 |
2023-08-13 |
Not clear |
| Changjiang Ying, Lei Chen, Shanshan Wang, Yizhen Mao, Hongwei Ling, Wei Li, Xiaoyan Zho. Zeaxanthin ameliorates high glucose-induced mesangial cell apoptosis through inhibiting oxidative stress via activating AKT signalling-pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-16. PMID:28431381. |
in conclusion, zeaxanthin ameliorated mesangial cell apoptosis may be involved in inhibiting oxidative stress through activating of the akt signalling pathway. |
2018-02-16 |
2023-08-13 |
Not clear |
| Tao Xu, Qiuying Pang, Yang Wang, Xiufeng Ya. Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells. International journal of molecular medicine. vol 40. issue 6. 2018-02-14. PMID:29039440. |
in the present study, results indicated that ba was highly effective against hela cells via induction of time-dependent apoptosis, and the authors demonstrated that the ba treatment acted through downregulating a phosphatidylinositol 3-kinase (pi3k) subunit and suppressing the akt phosphorylation at thr308 and ser473 after increasing the generation of intracellular reactive oxygen species. |
2018-02-14 |
2023-08-13 |
human |
| Yongqiang Yue, Ke Ma, Zhen Li, Zhonggao Wan. Angiotensin II type 1 receptor-associated protein regulates carotid intimal hyperplasia through controlling apoptosis of vascular smooth muscle cells. Biochemical and biophysical research communications. vol 495. issue 2. 2018-02-14. PMID:29247644. |
under the condition of angiotensin-ii stimulation, atrap overexpression induced the apoptosis of rat vsmcs by depressing the pi3k-akt signaling; whereas up-regulation of akt by pten inhibitor abolished the apoptotic death. |
2018-02-14 |
2023-08-13 |
rat |
| Julian C Bahr, Robert W Robey, Victoria Luchenko, Agnes Basseville, Arup R Chakraborty, Hanna Kozlowski, Gary T Pauly, Paresma Patel, Joel P Schneider, Michael M Gottesman, Susan E Bate. Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget. vol 7. issue 43. 2018-02-13. PMID:27634878. |
we treated 18 ras mutant or wild-type cell lines with romidepsin in the presence of a mek inhibitor (pd-0325901) and/or an akt inhibitor (mk-2206) and examined apoptosis by flow cytometry. |
2018-02-13 |
2023-08-13 |
Not clear |
| Julian C Bahr, Robert W Robey, Victoria Luchenko, Agnes Basseville, Arup R Chakraborty, Hanna Kozlowski, Gary T Pauly, Paresma Patel, Joel P Schneider, Michael M Gottesman, Susan E Bate. Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget. vol 7. issue 43. 2018-02-13. PMID:27634878. |
romidepsin in combination with a mek and an akt inhibitor induced apoptosis preferentially in cells harboring mutant versus wild-type ras (69.1% vs. 21.1%, p < 0.0001). |
2018-02-13 |
2023-08-13 |
Not clear |
| Lei-Lei Ma, Fei-Juan Kong, Jun-Jie Guo, Jian-Bing Zhu, Hong-Tao Shi, Yang Li, Ren-Hua Sun, Jun-Bo G. Hypercholesterolemia Abrogates Remote Ischemic Preconditioning-Induced Cardioprotection: Role of Reperfusion Injury Salvage Kinase Signals. Shock (Augusta, Ga.). vol 47. issue 3. 2018-02-12. PMID:27559699. |
in contrast, ripc failed to reduce myocardial necrosis and apoptosis as well as to increase the phosphorylated akt and gsk3β in hypercholestorolemic myocardium. |
2018-02-12 |
2023-08-13 |
rat |
| Lei Chen, Yue Meng, Xiaoqing Guo, Xiaotong Sheng, Guihua Tai, Fenglei Zhang, Hairong Cheng, Yifa Zho. Gefitinib enhances human colon cancer cells to TRAIL-induced apoptosis of via autophagy- and JNK-mediated death receptors upregulation. Apoptosis : an international journal on programmed cell death. vol 21. issue 11. 2018-02-12. PMID:27629794. |
in summary, our results indicate that gefitinib effectively enhances trail-induced apoptosis, likely via autophagy and jnk- mediated death receptor expression and phosphorylation of akt and erk. |
2018-02-12 |
2023-08-13 |
human |