| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Amir M Hossini, Annika S Quast, Michael Plötz, Katharina Grauel, Tarik Exner, Judit Küchler, Harald Stachelscheid, Jürgen Eberle, Anja Rabien, Evgenia Makrantonaki, Christos C Zoubouli. PI3K/AKT Signaling Pathway Is Essential for Survival of Induced Pluripotent Stem Cells. PloS one. vol 11. issue 5. 2017-07-11. PMID:27138223. |
furthermore, wortmannin, an inhibitor of phosphoinositid-3 kinase / akt signaling (pi3k-akt), dramatically and rapidly induced apoptosis in ipscs. |
2017-07-11 |
2023-08-13 |
human |
| Junqing Gao, Tao Chen, Deqiang Zhao, Jianpu Zheng, Zongjun Li. Ginkgolide B Exerts Cardioprotective Properties against Doxorubicin-Induced Cardiotoxicity by Regulating Reactive Oxygen Species, Akt and Calcium Signaling Pathways In Vitro and In Vivo. PloS one. vol 11. issue 12. 2017-07-11. PMID:27973574. |
the in vitro experimental results indicated that pretreatment with gb significantly decreases the viability and apoptosis of h9c2 cells by decreasing ros and intracellular calcium levels and activating akt phosphorylation. |
2017-07-11 |
2023-08-13 |
mouse |
| Victor Hugo Villar, Oliver Vögler, Francisca Barceló, Javier Martín-Broto, Jordi Martínez-Serra, Valentina Ruiz-Gutiérrez, Regina Aleman. Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma. PloS one. vol 11. issue 5. 2017-07-10. PMID:27219337. |
down-regulation of akt signalling by ursolic acid induces intrinsic apoptosis and sensitization to doxorubicin in soft tissue sarcoma. |
2017-07-10 |
2023-08-13 |
human |
| Victor Hugo Villar, Oliver Vögler, Francisca Barceló, Javier Martín-Broto, Jordi Martínez-Serra, Valentina Ruiz-Gutiérrez, Regina Aleman. Down-Regulation of AKT Signalling by Ursolic Acid Induces Intrinsic Apoptosis and Sensitization to Doxorubicin in Soft Tissue Sarcoma. PloS one. vol 11. issue 5. 2017-07-10. PMID:27219337. |
in conclusion, ua is able to induce intrinsic apoptosis in human sts cells and also to sensitize these cells to dxr by blocking the akt signalling pathway. |
2017-07-10 |
2023-08-13 |
human |
| Yiying Wu, Xing Zhang, Zhengzhao Li, Haibiao Yan, Jian Qin, Tianyu L. Formononetin inhibits human bladder cancer cell proliferation and invasiveness via regulation of miR-21 and PTEN. Food & function. vol 8. issue 3. 2017-07-10. PMID:28139790. |
t24 cells were treated with different concentrations of formononetin, and then the cell proliferation was assessed by mtt assay, cell apoptosis by hoechst 33258 stain assay, cell invasiveness by transwell invasion assay, microrna-21 (mir-21) expression by real-time pcr and the protein level of phosphatase and tensin homolog (pten) and phosphorylated homolog of akt (p-akt) by western blotting. |
2017-07-10 |
2023-08-13 |
human |
| Yun Xia, Ying Li, Kenneth D Westover, Jiaming Sun, Hongxiang Chen, Jianming Zhang, David E Fishe. Inhibition of Cell Proliferation in an NRAS Mutant Melanoma Cell Line by Combining Sorafenib and α-Mangostin. PloS one. vol 11. issue 5. 2017-07-07. PMID:27152946. |
the synergistic effects of α-mangostin and sorafenib were associated with enhanced inhibition of activated akt and erk, induced er stress, and reduced autophagy, eventually leading to apoptosis. |
2017-07-07 |
2023-08-13 |
Not clear |
| Cezary Treda, Marta Popeda, Magdalena Ksiazkiewicz, Dawid P Grzela, Maciej P Walczak, Mateusz Banaszczyk, Joanna Peciak, Ewelina Stoczynska-Fidelus, Piotr Riesk. EGFR Activation Leads to Cell Death Independent of PI3K/AKT/mTOR in an AD293 Cell Line. PloS one. vol 11. issue 5. 2017-07-07. PMID:27153109. |
moreover, apoptosis was not prevented by inhibiting egfr downstream proteins (pi3k, akt and mtor). |
2017-07-07 |
2023-08-13 |
human |
| François Cauchy, Mouniya Mebarki, Benjamin Leporq, Samira Laouirem, Miguel Albuquerque, Simon Lambert, Pierre Bourgoin, Olivier Soubrane, Bernard E Van Beers, Sandrine Faivre, Pierre Bedossa, Valérie Paradi. Strong antineoplastic effects of metformin in preclinical models of liver carcinogenesis. Clinical science (London, England : 1979). vol 131. issue 1. 2017-07-07. PMID:27803295. |
metformin had a dose-dependent inhibitory effect on cell proliferation and apoptosis in vitro through the deregulation of mtor/ampk, akt and extracellular signal regulated kinase (erk) signalling pathways. |
2017-07-07 |
2023-08-13 |
mouse |
| Zhiguang Ren, Xiaoke Gu, Bin Lu, Yaqiong Chen, Guojiang Chen, Jiannan Feng, Jizhen Lin, Yihua Zhang, Hui Pen. Anticancer efficacy of a nitric oxide-modified derivative of bifendate against multidrug-resistant cancer cells. Journal of cellular and molecular medicine. vol 20. issue 6. 2017-07-05. PMID:26864945. |
the mechanism of ddb-nitric oxide appears to be in two modes of actions by inducing mitochondrial tyrosine nitration and apoptosis, as well as by down-regulating hif-1α expression and protein kinase b (akt), extracellular signal-regulated kinases (erk), nuclear factor κb (nf-κb) activation in mdr cells. |
2017-07-05 |
2023-08-13 |
Not clear |
| Kunbin Ke, Hongjian Li, Hong Yao, Xi-Nan Shi, Chao Dong, Ying Zhu, Xu Liu, Ling Li, Kwong-Sak Leung, Man-Hon Wong, Xiao-Dong Liu, Hsiang-Fu Kung, Marie Chia-Mi Li. In silico prediction and in vitro and in vivo validation of acaricide fluazuron as a potential inhibitor of FGFR3 and a candidate anticancer drug for bladder carcinoma. Chemical biology & drug design. vol 89. issue 4. 2017-07-04. PMID:27664399. |
we further demonstrated that fluazuron treatment significantly increased the percentage of apoptosis cells, and decreased the phosphorylation level of fgfr3 and its downstream proteins frs2-α, akt, and erk. |
2017-07-04 |
2023-08-13 |
mouse |
| Xianhui Wang, Jason Wong, Christopher J Sevinsky, Leila Kokabee, Faiza Khan, Yan Sun, Douglas S Conkli. Bruton's Tyrosine Kinase Inhibitors Prevent Therapeutic Escape in Breast Cancer Cells. Molecular cancer therapeutics. vol 15. issue 9. 2017-06-29. PMID:27256378. |
consequently, the activation of akt and erk signaling pathways are also blocked leading to a g1-s cell-cycle delay and increased apoptosis. |
2017-06-29 |
2023-08-13 |
human |
| Jia-Hua Feng, Kyoko Nakagawa-Goto, Kuo-Hsiung Lee, Lie-Fen Shyu. A Novel Plant Sesquiterpene Lactone Derivative, DETD-35, Suppresses BRAFV600E Mutant Melanoma Growth and Overcomes Acquired Vemurafenib Resistance in Mice. Molecular cancer therapeutics. vol 15. issue 6. 2017-06-27. PMID:27048951. |
mechanistic studies suggested that detd-35 overcame acquired vemurafenib resistance at least in part through deregulating mek-erk, akt, and stat3 signaling pathways and promoting apoptosis of cancer cells. |
2017-06-27 |
2023-08-13 |
mouse |
| Yun-Ji Jeung, Han-Gyeul Kim, Jiwon Ahn, Ho-Joon Lee, Sae-Bhom Lee, Misun Won, Cho-Rock Jung, Joo-Young Im, Bo-Kyung Kim, Seung-Kiel Park, Myung Jin Son, Kyung-Sook Chun. Shikonin induces apoptosis of lung cancer cells via activation of FOXO3a/EGR1/SIRT1 signaling antagonized by p300. Biochimica et biophysica acta. vol 1863. issue 11. 2017-06-26. PMID:27452907. |
we found that inhibition of akt by shikonin activated the forkhead box (fox)o3a/early growth response protein (egr)1 signaling cascade and enhanced the expression of the target gene bim, leading to apoptosis in lung cancer cells. |
2017-06-26 |
2023-08-13 |
Not clear |
| Dah Ihm Kim, Ki Hoon Lee, Amr Ahmed Gabr, Gee Euhn Choi, Jun Sung Kim, So Hee Ko, Ho Jae Ha. Aβ-Induced Drp1 phosphorylation through Akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis. Biochimica et biophysica acta. vol 1863. issue 11. 2017-06-26. PMID:27599716. |
aβ-induced drp1 phosphorylation through akt activation promotes excessive mitochondrial fission leading to neuronal apoptosis. |
2017-06-26 |
2023-08-13 |
Not clear |
| Wei-Syun Hu, Yueh-Min Lin, Wei-Wen Kuo, Lung-Fa Pan, Yu-Lan Yeh, Yi-Hui Li, Chia-Hua Kuo, Ray-Jade Chen, V. Vijaya Padma, Tung-Sheng Chen, Chih-Yang Huan. Suppression of isoproterenol-induced apoptosis in H9c2 cardiomyoblast cells by daidzein through activation of Akt. The Chinese journal of physiology. vol 59. issue 6. 2017-06-22. PMID:27817194. |
suppression of isoproterenol-induced apoptosis in h9c2 cardiomyoblast cells by daidzein through activation of akt. |
2017-06-22 |
2023-08-13 |
Not clear |
| C Li, C Zhang, T Wang, J Xuan, C Su, Y Wan. Heme oxygenase 1 induction protects myocardiac cells against hypoxia/reoxygenation-induced apoptosis : The role of JNK/c-Jun/Caspase-3 inhibition and Akt signaling enhancement. Herz. vol 41. issue 8. 2017-06-20. PMID:27220977. |
heme oxygenase 1 induction protects myocardiac cells against hypoxia/reoxygenation-induced apoptosis : the role of jnk/c-jun/caspase-3 inhibition and akt signaling enhancement. |
2017-06-20 |
2023-08-13 |
Not clear |
| C Li, C Zhang, T Wang, J Xuan, C Su, Y Wan. Heme oxygenase 1 induction protects myocardiac cells against hypoxia/reoxygenation-induced apoptosis : The role of JNK/c-Jun/Caspase-3 inhibition and Akt signaling enhancement. Herz. vol 41. issue 8. 2017-06-20. PMID:27220977. |
therefore, the aim of this study was to investigate the cytoprotective mechanisms of ho-1 against h/r-induced myocardiac cell apoptosis and to explore whether the akt signaling pathway contributed to the protection provided by ho-1. |
2017-06-20 |
2023-08-13 |
Not clear |
| Byongsun Lee, Tae-Hee Lee, Jaekyung Shi. Emerin suppresses Notch signaling by restricting the Notch intracellular domain to the nuclear membrane. Biochimica et biophysica acta. Molecular cell research. vol 1864. issue 2. 2017-06-20. PMID:27865926. |
emerin knockdown induced the phosphorylation of erk and akt, increased endogenous notch signaling, and inhibited hydrogen peroxide-induced apoptosis in hela cells. |
2017-06-20 |
2023-08-13 |
Not clear |
| Jing Cai, Tiande Liu, Peng Huang, Wei Yan, Changkuo Guo, Le Xiong, Anwen Li. USP39, a direct target of microRNA-133a, promotes progression of pancreatic cancer via the AKT pathway. Biochemical and biophysical research communications. vol 486. issue 1. 2017-06-19. PMID:28286270. |
besides, our experimental data revealed that knockdown of usp39 induced cell apoptosis through inhibition of akt signaling pathway in pc cells. |
2017-06-19 |
2023-08-13 |
Not clear |
| Shunya Tsuji, Ryotaro Yabe, Tatsuya Usui, Takuya Mizuno, Takashi Ohama, Koichi Sat. Anti-tumor effects of perphenazine on canine lymphoma. The Journal of veterinary medical science. vol 78. issue 8. 2017-06-15. PMID:27150024. |
the present results for the first time revealed that ppz induced canine lymphoma cells apoptosis through akt dephosphorylation via pp2a activation. |
2017-06-15 |
2023-08-13 |
human |