| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jun-Jie Wang, Yu Tian, Kai-Lin Xu, Rui-Xue Fu, Ming-Shan Niu, Kai Zha. [Statins Regulate the Proliferation and Apoptosis of T-ALL Cells through the Inhibition of Akt Pathway]. Zhongguo shi yan xue ye xue za zhi. vol 26. issue 2. 2018-10-25. PMID:29665899. |
[statins regulate the proliferation and apoptosis of t-all cells through the inhibition of akt pathway]. |
2018-10-25 |
2023-08-13 |
human |
| Jae Hee Lee, Hyo-Jung Lee, Deok Yong Sim, Ji Hoon Jung, Ka Ram Kim, Sung-Hoon Ki. Apoptotic effect of lambertianic acid through AMPK/FOXM1 signaling in MDA-MB231 breast cancer cells. Phytotherapy research : PTR. vol 32. issue 9. 2018-10-25. PMID:29722086. |
here, la increased cytotoxicity in mcf-7 and mda-mb-231 cells; enhanced sub-g1 population, g2/m arrest, and cleaved poly(adp-ribose) polymerase; activated phosphorylation of amp-activated protein kinase (ampk)/acetyl-coa carboxylase pathway; and also suppressed phosphorylation of akt and the expression of forkhead box m1 (foxm1), x-linked inhibitor of apoptosis protein, b-cell lymphoma 2, and cyclinb1 in mda-mb-231 cells. |
2018-10-25 |
2023-08-13 |
Not clear |
| Ruixue Wang, Xuelian Zheng, Lei Zhang, Bin Zhou, Huaizhong Hu, Zhiping Li, Lin Zhang, Yong Lin, Xia Wan. Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade. Scientific reports. vol 7. 2018-10-24. PMID:28139737. |
extended from our previous studies showing that concurrent blockage of the nf-κb and akt signaling pathways sensitizes lung cancer cells to cisplatin-induced apoptosis, we for the first time found that knockdown of akt1 and the nf-κb-activating kinase ikkβ cooperatively downregulated histone h4 expression, which increased cisplatin-induced apoptosis in lung cancer cells. |
2018-10-24 |
2023-08-13 |
Not clear |
| Ruixue Wang, Xuelian Zheng, Lei Zhang, Bin Zhou, Huaizhong Hu, Zhiping Li, Lin Zhang, Yong Lin, Xia Wan. Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade. Scientific reports. vol 7. 2018-10-24. PMID:28139737. |
these results establish a novel mechanism by which nf-κb and akt contribute to chemoresistance involving a signaling pathway consisting of histone h4, dna-pk, rip1 and iaps that attenuates ros-mediated apoptosis, and targeting this pathway may improve the anticancer efficacy of platinum-based chemotherapy. |
2018-10-24 |
2023-08-13 |
Not clear |
| Hong Wang, Xu Yang, Anna Liu, Guocan Wang, Maarten C Bosland, Chung S Yan. δ-Tocopherol inhibits the development of prostate adenocarcinoma in prostate specific Pten-/- mice. Carcinogenesis. vol 39. issue 2. 2018-10-24. PMID:29121168. |
our previous studies demonstrated that δ-tocopherol (δ-t) attenuates the activation of akt by growth factor in prostate cancer cell lines, leading to inhibition of proliferation and induction of apoptosis. |
2018-10-24 |
2023-08-13 |
mouse |
| Quan Fang, Songxue Guo, Hanlei Zhou, Rui Han, Pan Wu, Chunmao Ha. Astaxanthin protects against early burn-wound progression in rats by attenuating oxidative stress-induced inflammation and mitochondria-related apoptosis. Scientific reports. vol 7. 2018-10-22. PMID:28128352. |
furthermore, atx dose-dependently attenuated burn-induced apoptosis in the wound areas, and this effect was accompanied by increases in akt and bad phosphorylation and a downregulation of cytochrome c and caspase expression. |
2018-10-22 |
2023-08-13 |
rat |
| Yu Jiang, Gang Liu, Li Zhang, Sheng Cheng, Chun Luo, Yang Liao, Shuliang Gu. Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29901139. |
the pi3k/protein kinase b (akt) pathway is an important signaling pathway that may activate downstream of a series of extracellular signals and impact on cellular processes including cell proliferation, apoptosis and survival. |
2018-10-19 |
2023-08-13 |
Not clear |
| Yu Jiang, Gang Liu, Li Zhang, Sheng Cheng, Chun Luo, Yang Liao, Shuliang Gu. Therapeutic efficacy of hydrogen‑rich saline alone and in combination with PI3K inhibitor in non‑small cell lung cancer. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29901139. |
the results further suggested that the combination therapy may reduce cell proliferation and promote cell apoptosis by downregulating akt phosphorylation and inhibiting the pi3k pathway in nsclc cell lines. |
2018-10-19 |
2023-08-13 |
Not clear |
| Mingliang Wang, Min Liu, Ting Ni, Qiliang Li. miR‑214 mediates vascular inflammation and apoptosis via PTEN expression. Molecular medicine reports. vol 18. issue 2. 2018-10-19. PMID:29916551. |
the results demonstrated that anti‑mir‑214 mimics inhibited cell proliferation, increased apoptosis and inflammatory factors (tnf‑α, il‑1β, il‑6 and il‑18 levels), inhibited cell proliferation, and induced bax protein expression in tnf‑α‑induced vascular endothelial cells through induction of pten and nf‑κb protein expression and inhibition of akt protein expression. |
2018-10-19 |
2023-08-13 |
Not clear |
| Jingyao Chen, Jie Zhou, Fei Li, Yanfeng Zhu, Weiwei Zhang, Xiaoping Y. [Delphinidin induces autophagy in HER-2+ breast cancer cells via inhibition of AKT/mTOR pathway]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 42. issue 3. 2018-10-15. PMID:28364098. |
delphinidin inhibited the expression of proteins in mtor signaling pathway, including akt, mtor, eif4e and p70s6k.
conclusion: delphinidin induced apoptosis and autophagy by inhibition of akt/mtor pathway in her positive breast cancer cells. |
2018-10-15 |
2023-08-13 |
human |
| Maliheh Moradzadeh, Alijan Tabarraei, Hamid Reza Sadeghnia, Ahmad Ghorbani, Ashraf Mohamadkhani, Saiedeh Erfanian, Amirhossein Sahebka. Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes. Journal of cellular biochemistry. vol 119. issue 2. 2018-10-15. PMID:28865123. |
furthermore, the expression levels of genes involved in apoptosis (pi3 k, akt, bcl2, bax, p53, p21, pten, casp3, casp8, and casp9), differentiation (pml-rar and hdac1), and multi-drug resistance (abcb1 and abcc1) were determined using quantitative real-time pcr. |
2018-10-15 |
2023-08-13 |
human |
| Ya-Ping Jiang, Hui Guo, Xin-Bo Wan. Nobiletin (NOB) suppresses autophagic degradation via over-expressing AKT pathway and enhances apoptosis in multidrug-resistant SKOV3/TAX ovarian cancer cells. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-15. PMID:29635125. |
nobiletin (nob) suppresses autophagic degradation via over-expressing akt pathway and enhances apoptosis in multidrug-resistant skov3/tax ovarian cancer cells. |
2018-10-15 |
2023-08-13 |
human |
| Tao Wang, Chao Han, Peng Tian, Peng-Fei Li, Xin-Long M. Role of Teriparatide in Glucocorticoid-induced Osteoporosis through Regulating Cellular Reactive Oxygen Species. Orthopaedic surgery. vol 10. issue 2. 2018-10-15. PMID:29745033. |
to determine the signaling pathways mediated by teriparatide in mlo-y4 cell lines based on the evaluation of reactive oxygen species (ros) through akt pathways, which regulate apoptosis of bone cells. |
2018-10-15 |
2023-08-13 |
Not clear |
| Aida M Hamdi, Zhen-Zhou Jiang, Mounia Guerram, Bashir A Yousef, Hozeifa M Hassan, Jia-Wei Ling, Lu-Yong Zhan. Biochemical and computational evaluation of Triptolide-induced cytotoxicity against NSCLC. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 103. 2018-10-11. PMID:29864943. |
in vitro, triptolide treatment induced apoptosis in nsclc cell lines and down-regulated the phosphorylation of akt, mtor, and p70s6k. |
2018-10-11 |
2023-08-13 |
Not clear |
| Hongwei Guo, Hua Luo, Hebao Yuan, Yudui Xia, Pan Shu, Xin Huang, Yi Lu, Xia Liu, Evan T Keller, Duxin Sun, Jiagang Deng, Jian Zhan. Litchi seed extracts diminish prostate cancer progression via induction of apoptosis and attenuation of EMT through Akt/GSK-3β signaling. Scientific reports. vol 7. 2018-10-10. PMID:28134352. |
nls induced cell apoptosis and cell cycle g1/s phase arrest by inactivating akt signaling pathway, which were associated with activation of mitochondrial caspase-dependent apoptotic cascades, up-regulation of cyclin-dependent kinase (cdk) inhibitors p21 and p27, and inhibition of correlated cyclin/cdk network. |
2018-10-10 |
2023-08-13 |
mouse |
| Nittiya Chowchaikong, Sirinun Nilwarangkoon, Surat Laphookhieo, Chantra Tanunyutthawongse, Ramida Watanapokasi. p38 inhibitor inhibits the apoptosis of cowanin-treated human colorectal adenocarcinoma cells. International journal of oncology. vol 52. issue 6. 2018-10-09. PMID:29620273. |
the expression levels of bcl2 apoptosis regulator (bcl‑2) family, mapk and akt serine/threonine kinase 1 (akt) pathway proteins following cowanin treatment were determined by western blot analysis. |
2018-10-09 |
2023-08-13 |
human |
| Nittiya Chowchaikong, Sirinun Nilwarangkoon, Surat Laphookhieo, Chantra Tanunyutthawongse, Ramida Watanapokasi. p38 inhibitor inhibits the apoptosis of cowanin-treated human colorectal adenocarcinoma cells. International journal of oncology. vol 52. issue 6. 2018-10-09. PMID:29620273. |
in conclusion, cowanin inhibited cell proliferation and induced apoptosis of lovo cells via the mapk and akt signaling pathways. |
2018-10-09 |
2023-08-13 |
human |
| Jie Mao, Hongbao Yang, Tingting Cui, Pan Pan, Nadia Kabir, Duo Chen, Jinyan Ma, Xingyi Chen, Yijun Chen, Yong Yan. Combined treatment with sorafenib and silibinin synergistically targets both HCC cells and cancer stem cells by enhanced inhibition of the phosphorylation of STAT3/ERK/AKT. European journal of pharmacology. vol 832. 2018-10-08. PMID:29782854. |
as determined by fluorescence staining and western blots, the combination of the two drugs inhibited the phosphorylation of rac-alpha serine/threonine-protein kinase (akt) and signal transducer and activator of transcription 3 (stat3) together with the expression of antiapoptotic proteins including myeloid leukemia cell differentiation protein mcl-1 (mcl-1) and apoptosis regulator bcl-2 (bcl-2), resulting in the death of cancer cells. |
2018-10-08 |
2023-08-13 |
Not clear |
| Jie Xia, Cheng-Yan Li, Hui Wang, Qi-Mei Zhang, Zhong-Mou Ha. Therapeutic effects of scoparone on pilocarpine (Pilo)-induced seizures in mice. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 97. 2018-10-05. PMID:29793313. |
in vitro, we confirmed that scoparone inhibited lps-caused astrocytes activation as proved by the reduced glial fibrillary acidic protein (gfap) levels, inflammation and apoptosis, which were at least partly dependent on akt suppression. |
2018-10-05 |
2023-08-13 |
mouse |
| Jiaxiu Yin, Xinxin Li, Zaili Zhang, Xiaohua Luo, Li Wang, Lin Li. SPAG6 silencing induces apoptosis in the myelodysplastic syndrome cell line SKM‑1 via the PTEN/PI3K/AKT signaling pathway in vitro and in vivo. International journal of oncology. vol 53. issue 1. 2018-10-02. PMID:29749435. |
lentivirus-mediated knockdown of spag6 in skm‑1 cells increased phosphatase and tensin homolog (pten) expression and reduced protein kinase b (akt) phosphorylation, which in turn resulted in cell apoptosis as evidenced by induced myeloid leukaemia cell differentiation protein mcl‑1 downregulation, cytochrome c release and increased caspase‑9 expression. |
2018-10-02 |
2023-08-13 |
mouse |