| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jang-Hyuk Yun, Young Jun Koh, Han-Seok Jeong, Da-Hye Lee, Eun Hui Lee, Chung-Hyun Ch. Propranolol increases vascular permeability through pericyte apoptosis and exacerbates oxygen-induced retinopathy. Biochemical and biophysical research communications. vol 503. issue 4. 2019-01-08. PMID:30100069. |
mechanistically, pericyte apoptosis by propranolol was due to the inhibition of akt signaling pathway. |
2019-01-08 |
2023-08-13 |
mouse |
| Wei Liu, Zi-Qiang Luo, Lu Ren, Mei Sun, Ju-Qin Yao, Jing-Xia Wang, Zun Wang, Si-Yuan Tan. [ERα36 is involved in the proliferation promotion and anti-apoptosis effects of icaritin on MG63 cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 5. 2019-01-08. PMID:30377685. |
cell proliferation was detected by cck-8, the apoptosis was detected by flow cytometry, and the activation of erk and akt signaling pathways was detected by western blot. |
2019-01-08 |
2023-08-13 |
human |
| Wei Liu, Zi-Qiang Luo, Lu Ren, Mei Sun, Ju-Qin Yao, Jing-Xia Wang, Zun Wang, Si-Yuan Tan. [ERα36 is involved in the proliferation promotion and anti-apoptosis effects of icaritin on MG63 cells]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 5. 2019-01-08. PMID:30377685. |
the results showed that the effects of icaritin on the proliferation and apoptosis of mg63 cells were significantly decreased after erα36 knockdown, and icaritin could up-regulate the levels of erk and akt phosphorylation in mg63 cells, which could be reduced by erα36 knockdown. |
2019-01-08 |
2023-08-13 |
human |
| Li-Jun Wang, Shi-Guang Wang, Tong-Xing Den. [Wogonoside reverses cisplatin resistance in SGC7901/cDDP cells through inhibition of PI3K/Akt/Nrf2/ARE signaling pathway]. Sheng li xue bao : [Acta physiologica Sinica]. vol 70. issue 4. 2019-01-07. PMID:30112565. |
wgs and ly294002 (pi3k inhibitor) both remarkably decreased the phosphorylation level of akt (p < 0.05), down-regulated the protein level of nrf2 (p < 0.05), increased the content of ros (p < 0.05), up-regulated the protein level of cleaved caspase-3 (p < 0.05), and induced apoptosis (p < 0.05). |
2019-01-07 |
2023-08-13 |
human |
| Ning Wang, Bin Zhang, Feng Jin, Dan Gao, Feng Liu, Hongxia Liu, Yuyang Jian. Combing metabolomics with bioanalysis methods to study the antitumor mechanism of the new acridone derivative 8q on CCRF-CEM cells: 8q induced mitochondrial-mediated apoptosis and targeted the PI3K/AKT/FOXO1 pathway. Journal of pharmaceutical and biomedical analysis. vol 160. 2019-01-07. PMID:30114609. |
furthermore, pi3k, akt and foxo1 were inactivated, and the expression of total akt was also inhibited by 8q treatment, which promoted intrinsic apoptosis. |
2019-01-07 |
2023-08-13 |
Not clear |
| Chang Liu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Xue-Yuan Jiang, Ling-Qi Meng, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Jin-Qian Li, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Yu-Dong Cui, Nan-Zhu Fang, Cheng-Hao Ji. Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells. The international journal of biochemistry & cell biology. vol 96. 2019-01-03. PMID:29326072. |
novel 1,4-naphthoquinone derivatives induce apoptosis via ros-mediated p38/mapk, akt and stat3 signaling in human hepatoma hep3b cells. |
2019-01-03 |
2023-08-13 |
mouse |
| Chang Liu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Xue-Yuan Jiang, Ling-Qi Meng, Yue Wang, Yi Zhang, Jia-Ru Wang, Hao Wang, Wan-Ting Xu, Jin-Qian Li, Yang Liu, Yi-Qin Wu, Hu-Nan Sun, Ying-Hao Han, Mei-Hua Jin, Yu-Dong Cui, Nan-Zhu Fang, Cheng-Hao Ji. Novel 1,4-naphthoquinone derivatives induce apoptosis via ROS-mediated p38/MAPK, Akt and STAT3 signaling in human hepatoma Hep3B cells. The international journal of biochemistry & cell biology. vol 96. 2019-01-03. PMID:29326072. |
these results indicate that bsnq and osnq induce apoptosis in human hepatoma hep3b cells via ros-mediated p38/mapk, akt and stat3 signaling pathways, suggesting that these 1,4-naphthoquinone derivatives may provide promising new anticancer agents to treat hcc. |
2019-01-03 |
2023-08-13 |
mouse |
| Ying Xu, Qin Gu, Jian Tang, Yajun Qian, Xiao Tan, Zhuxi Yu, Chen Q. Substance P Attenuates Hypoxia/Reoxygenation-Induced Apoptosis via the Akt Signalling Pathway and the NK1-Receptor in H9C2Cells. Heart, lung & circulation. vol 27. issue 12. 2019-01-02. PMID:29107510. |
substance p attenuates hypoxia/reoxygenation-induced apoptosis via the akt signalling pathway and the nk1-receptor in h9c2cells. |
2019-01-02 |
2023-08-13 |
Not clear |
| Cheng-Yi Chang, Jian-Ri Li, Chih-Cheng Wu, Jiaan-Der Wang, Ching-Ping Yang, Wen-Ying Chen, Wen-Yi Wang, Chun-Jung Che. Indomethacin induced glioma apoptosis involving ceramide signals. Experimental cell research. vol 365. issue 1. 2019-01-02. PMID:29470962. |
we found that the induced apoptosis was accompanied by a series of biochemical events, including intracellular ceramide generation, pp2a activation, akt dephosphorylation, mcl-1 and flice inhibiting protein (flip) transcriptional downregulation, bax mitochondrial distribution, and caspase 3 activation. |
2019-01-02 |
2023-08-13 |
human |
| Cheng-Yi Chang, Jian-Ri Li, Chih-Cheng Wu, Jiaan-Der Wang, Ching-Ping Yang, Wen-Ying Chen, Wen-Yi Wang, Chun-Jung Che. Indomethacin induced glioma apoptosis involving ceramide signals. Experimental cell research. vol 365. issue 1. 2019-01-02. PMID:29470962. |
pharmacological inhibition of ceramide synthase by fumonisin b1 and pp2a by okadaic acid moderately attenuated indomethacin-induced akt dephosphorylation along with the apoptosis. |
2019-01-02 |
2023-08-13 |
human |
| Xueyi Shen, Changmin Niu, Jiaqian Guo, Mengmeng Xia, Jing Xia, Yanqiu Hu, Ying Zhen. Stra8 may inhibit apoptosis during mouse spermatogenesis via the AKT signaling pathway. International journal of molecular medicine. vol 42. issue 5. 2019-01-02. PMID:30106128. |
stra8 may inhibit apoptosis during mouse spermatogenesis via the akt signaling pathway. |
2019-01-02 |
2023-08-13 |
mouse |
| Zhe Zhang, Xiaohua Zhong, Yipin Xiao, Chao Che. MicroRNA-296 inhibits colorectal cancer cell growth and enhances apoptosis by targeting ARRB1-mediated AKT activation. Oncology reports. vol 41. issue 1. 2018-12-28. PMID:30365090. |
microrna-296 inhibits colorectal cancer cell growth and enhances apoptosis by targeting arrb1-mediated akt activation. |
2018-12-28 |
2023-08-13 |
Not clear |
| Corey J Ketchem, Cory Kucera, Aditya Barve, Levi J Beverl. The Antiarrhythmic Drug, Amiodarone, Decreases AKT Activity and Sensitizes Human Acute Myeloid Leukemia Cells to Apoptosis by ABT-263. The American journal of the medical sciences. vol 355. issue 5. 2018-12-18. PMID:29753379. |
the antiarrhythmic drug, amiodarone, decreases akt activity and sensitizes human acute myeloid leukemia cells to apoptosis by abt-263. |
2018-12-18 |
2023-08-13 |
human |
| Yuming Zou, Quan Li, Denghui Liu, Jia Li, Qing Cai, Chao Li, Qingjie Zhao, Weidong X. Therapeutic effects of matrine derivate MASM in mice with collagen-induced arthritis and on fibroblast-like synoviocytes. Scientific reports. vol 7. issue 1. 2018-12-17. PMID:28550307. |
additionally, masm could induce apoptosis of ra-fls via mitochondrial and akt signaling pathways in human ra-fls. |
2018-12-17 |
2023-08-13 |
mouse |
| Yuan-Yuan Zhao, Ying Tian, Lin Liu, Jian-Hua Zhan, Xue Hou, Xi Chen, Ting Zhou, Yan Huang, Li Zhan. Inhibiting eEF-2 kinase-mediated autophagy enhanced the cytocidal effect of AKT inhibitor on human nasopharyngeal carcinoma. Drug design, development and therapy. vol 12. 2018-12-17. PMID:30214154. |
our previous research showed that akt inactivation via small molecule inhibitors did not induce significant apoptosis, but rather markedly increased autophagy in nasopharyngeal carcinoma (npc). |
2018-12-17 |
2023-08-13 |
human |
| Chen Cheng, Wang Xiaohua, Jiang Ning, Zong Dan, Yao Chengyun, Zhao Lijun, Yin Li, Huang Shengfu, Ji Hong, Xia H. MiR-122 exerts anti-proliferative and apoptotic effects on nasopharyngeal carcinoma cells via the PI3K/AKT signaling pathway. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 13. 2018-12-17. PMID:30403591. |
to investigate the effects of microrna-122 (mir-122) on the proliferation and apoptosis of nasopharyngeal carcinoma (npc) hone-1 cells, and its correlation with the phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2018-12-17 |
2023-08-13 |
human |
| Wei Peng, Bao-An Che. Gambogic acid induces cell apoptosis through endoplasmic reticulum stress triggered inhibition of Akt signaling pathways in extranodal NK/T-cell lymphoma cells. Chinese journal of natural medicines. vol 16. issue 9. 2018-12-14. PMID:30269846. |
gambogic acid induces cell apoptosis through endoplasmic reticulum stress triggered inhibition of akt signaling pathways in extranodal nk/t-cell lymphoma cells. |
2018-12-14 |
2023-08-13 |
Not clear |
| Sunwoo Park, Whasun Lim, Fuller W Bazer, Gwonhwa Son. Apigenin induces ROS-dependent apoptosis and ER stress in human endometriosis cells. Journal of cellular physiology. vol 233. issue 4. 2018-12-11. PMID:28617956. |
furthermore, the apigenin-induced apoptosis in endometriosis cells was regulated via the erk1/2, jnk, and akt cell signaling pathways. |
2018-12-11 |
2023-08-13 |
human |
| Bing-Gang Zhou, Chang-Sheng Wei, Song Zhang, Zhi Zhang, Huan-Min Ga. Matrine reversed multidrug resistance of breast cancer MCF-7/ADR cells through PI3K/AKT signaling pathway. Journal of cellular biochemistry. vol 119. issue 5. 2018-12-11. PMID:29130495. |
matrine inhibited mcf-7/adr cell growth, induced apoptosis, and reversed multidrug resistance for breast cancer cells through the regulation of downstream apoptosis factors of pi3k/akt signaling pathway by decreasing cell phosphorylation of akt level. |
2018-12-11 |
2023-08-13 |
Not clear |
| Soyeon Park, Robert E Burke, Tatyana Kareva, Nikolai Kholodilov, Pascaline Aimé, Thomas F Franke, Oren Levy, Lloyd A Green. Context-dependent expression of a conditionally-inducible form of active Akt. PloS one. vol 13. issue 6. 2018-12-11. PMID:29920520. |
the induced akt(e40k) protected cells from apoptosis evoked by serum deprivation and was neuroprotective in two cellular models of parkinson's disease (6-ohda and mpp+ exposure). |
2018-12-11 |
2023-08-13 |
mouse |