| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Dan Guo, Jiangtao Xie, Junjie Zhao, Tingqin Huang, Xiaoye Guo, Jinning Son. Resveratrol protects early brain injury after subarachnoid hemorrhage by activating autophagy and inhibiting apoptosis mediated by the Akt/mTOR pathway. Neuroreport. vol 29. issue 5. 2019-04-05. PMID:29360689. |
akt, also known as protein kinase b, and mammalian target of rapamycin (mtor), the downstream protein of akt, play key roles in cell survival and apoptosis, cell cycle regulation, and cellular protein homeostasis. |
2019-04-05 |
2023-08-13 |
rat |
| Jiguang Han, Baojuan Han, Xueya Wu, Jie Hao, Xiaoqun Dong, Qiang Shen, Hui Pan. Knockdown of lncRNA H19 restores chemo-sensitivity in paclitaxel-resistant triple-negative breast cancer through triggering apoptosis and regulating Akt signaling pathway. Toxicology and applied pharmacology. vol 359. 2019-04-01. PMID:30244121. |
knockdown of lncrna h19 restores chemo-sensitivity in paclitaxel-resistant triple-negative breast cancer through triggering apoptosis and regulating akt signaling pathway. |
2019-04-01 |
2023-08-13 |
Not clear |
| Yayun Zhang, Yanxiao Xiang, Xi Wang, Lin Zhu, Hao Li, Songgang Wang, Xin Pan, Hua Zha. Cerebral dopamine neurotrophic factor protects microglia by combining with AKT and by regulating FoxO1/mTOR signaling during neuroinflammation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 109. 2019-04-01. PMID:30551485. |
akt is a serine-threonine protein kinase widely expressed in mammals through which the downstream pathway foxo1/mtor is closely related to cell inflammation, apoptosis, metabolism, etc. |
2019-04-01 |
2023-08-13 |
Not clear |
| Yannan Liu, Daidi Fa. Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model. Food & function. vol 9. issue 11. 2019-03-29. PMID:30207362. |
further studies showed that rg5 in a dose-dependent manner induced apoptosis and autophagy through the inhibition of the pi3k/akt signaling pathway as indicated by the reduced phosphorylation level of pi3k and akt. |
2019-03-29 |
2023-08-13 |
mouse |
| Bin Li, Peng Chen, Jialin Wang, Linxia Wang, Mingzhi Ren, Ruisan Zhang, Jianjun H. MicroRNA-1254 exerts oncogenic effects by directly targeting RASSF9 in human breast cancer. International journal of oncology. vol 53. issue 5. 2019-03-28. PMID:30132526. |
taken together, these results demonstrate that mir-1254 accelerates breast cancer cell growth by activating the akt signaling pathway and suppresses apoptosis by inhibiting p53 expression through the targeting of rassf9. |
2019-03-28 |
2023-08-13 |
human |
| Wei Wu, Deepkamal Karelia, Kartick Pramanik, Shantu G Amin, Arun K Sharma, Cheng Jiang, Junxuan L. Phenylbutyl isoselenocyanate induces reactive oxygen species to inhibit androgen receptor and to initiate p53-mediated apoptosis in LNCaP prostate cancer cells. Molecular carcinogenesis. vol 57. issue 8. 2019-03-26. PMID:29668110. |
our results show that isc-4 was more potent at inducing apoptosis than its sulfur analog phenylbutyl isothiocyanate (pbitc) without suppressing protein kinase akt ser |
2019-03-26 |
2023-08-13 |
mouse |
| Xiao Liu, Yinping Sun, Wei Tian, Fuli Wang, Xiao Lv, Min Wang, Tiantian Sun, Jingjing Zhang, Lin Wang, Mingyong Ha. Sema4A Responds to Hypoxia and Is Involved in Breast Cancer Progression. Biological & pharmaceutical bulletin. vol 41. issue 12. 2019-03-25. PMID:30270262. |
in addition, silencing sema4a could inhibit the proliferation, vascular endothelial growth factor (vegf) production and the phosphorylation of akt, extracellular signal-regulated kinase (erk)1/2 mitogen-activated protein kinase (mapk) and signal transduction and activator of transcription (stat)3, but induce apoptosis of bca cells in the presence of hypoxia. |
2019-03-25 |
2023-08-13 |
human |
| Ye He, Liping Sun, Yongping Xu, Li Fu, Yun Li, Xubin Bao, Haoyu Fu, Chengying Xie, Liguang Lo. Combined inhibition of PI3Kδ and FLT3 signaling exerts synergistic antitumor activity and overcomes acquired drug resistance in FLT3-activated acute myeloid leukemia. Cancer letters. vol 420. 2019-03-22. PMID:29409989. |
combined treatment with pi3kδ and flt3 inhibitors more effectively inhibited akt and erk phosphorylation, and induced apoptosis more efficiently than either agent alone. |
2019-03-22 |
2023-08-13 |
Not clear |
| Robert J Henning, Marie Bourgeois, Raymond D Harbiso. Poly(ADP-ribose) Polymerase (PARP) and PARP Inhibitors: Mechanisms of Action and Role in Cardiovascular Disorders. Cardiovascular toxicology. vol 18. issue 6. 2019-03-14. PMID:29968072. |
inhibition of parp decreases vascular endothelial cell adhesion p-selectin and icam-1 molecules, inflammatory cells, pro-death caspase-3, and c-jun n-terminal kinase (jnk) activation and upregulates prosurvival extracellular signal-regulated kinases and akt, which decrease vascular cell apoptosis and necrosis and limit atherosclerosis and plaque disruption. |
2019-03-14 |
2023-08-13 |
Not clear |
| Jing Zhang, Junmei Zhao, Yani Chen, Haiyan Shi, Xiaoyong Huang, Yanfeng Wang, Yu Wang, Yameng Wei, Wanjuan Xue, Jiming Ha. Effect of mGluR7 on proliferation of human embryonic neural stem cells. Medicine. vol 98. issue 9. 2019-03-07. PMID:30817600. |
this effect may be mediated by promoting cell cycle progression, inhibiting cell apoptosis, activating the akt signaling pathway, and inhibiting the caspase-3/9 signaling pathway. |
2019-03-07 |
2023-08-13 |
human |
| Tianjiao Xu, Chengu Niu, Xiaojie Zhang, Miaoxian Don. β-Ecdysterone protects SH-SY5Y cells against β-amyloid-induced apoptosis via c-Jun N-terminal kinase- and Akt-associated complementary pathways. Laboratory investigation; a journal of technical methods and pathology. vol 98. issue 4. 2019-03-05. PMID:29330470. |
the aim of this study was to evaluate hypothesis that β-ecdysterone (β-ecd) protects sh-sy5y cells from aβ-induced apoptosis by separate signaling pathways involving protein kinase b (akt) and c-jun n-terminal kinase (jnk). |
2019-03-05 |
2023-08-13 |
Not clear |
| Yanlin Tan, Xingwang Yao, Zhehao Dai, Yunhua Wang, Guohua L. Bone morphogenetic protein 2 alleviated intervertebral disc degeneration through mediating the degradation of ECM and apoptosis of nucleus pulposus cells via the PI3K/Akt pathway. International journal of molecular medicine. vol 43. issue 1. 2019-03-05. PMID:30387830. |
in addition, the levels of phosphorylation of phosphoinositide 3‑kinase (pi3k) and protein kinase b (akt), and the levels of apoptosis‑associated proteins and apoptosis ratio of np cells were also determined by western blot analysis and flow cytometry, respectively. |
2019-03-05 |
2023-08-13 |
human |
| Mingli Hu, Shixuan Zhu, Shengwei Xiong, Xingxing Xue, Xiaodong Zho. MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer (Review). Oncology reports. vol 41. issue 3. 2019-03-05. PMID:30628706. |
recently, results of previous studies regarding mechanisms underlying mirnas generally converged on pathways critical in cellular processes, including cell proliferation, apoptosis and invasion, among which phosphatase and tensin homolog (pten)/phosphatidylinositol 3‑kinase (pi3k)/protein kinase b (akt) signaling is a fundamental one, with frequent oncogenic alterations in gc. |
2019-03-05 |
2023-08-13 |
human |
| Francesca Pentimalli, Iris M Forte, Luca Esposito, Paola Indovina, Carmelina A Iannuzzi, Luigi Alfano, Caterina Costa, Daniela Barone, Gaetano Rocco, Antonio Giordan. RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines. Oncogene. vol 37. issue 27. 2019-03-04. PMID:29606701. |
rbl2/p130 is a direct akt target and is required to induce apoptosis upon akt inhibition in lung cancer and mesothelioma cell lines. |
2019-03-04 |
2023-08-13 |
Not clear |
| Francesca Pentimalli, Iris M Forte, Luca Esposito, Paola Indovina, Carmelina A Iannuzzi, Luigi Alfano, Caterina Costa, Daniela Barone, Gaetano Rocco, Antonio Giordan. RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines. Oncogene. vol 37. issue 27. 2019-03-04. PMID:29606701. |
consistently, akt inhibition reduced cell viability, induced cell accumulation in g0/g1, and triggered apoptosis, which proved to be largely dependent on rbl2/p130 itself, as shown upon rbl2/p130 silencing. |
2019-03-04 |
2023-08-13 |
Not clear |
| Francesca Pentimalli, Iris M Forte, Luca Esposito, Paola Indovina, Carmelina A Iannuzzi, Luigi Alfano, Caterina Costa, Daniela Barone, Gaetano Rocco, Antonio Giordan. RBL2/p130 is a direct AKT target and is required to induce apoptosis upon AKT inhibition in lung cancer and mesothelioma cell lines. Oncogene. vol 37. issue 27. 2019-03-04. PMID:29606701. |
akt inhibition induced rbl2/p130-dependent apoptosis also in hek-293 cells, in which re-expression of a short hairpin-resistant rbl2/p130 was able to rescue aktiviii-induced apoptosis upon rbl2/p130 silencing. |
2019-03-04 |
2023-08-13 |
Not clear |
| Rong Yan, Kang Li, Da-Wei Yuan, Hao-Nan Wang, Yong Zhang, Cheng-Xue Dang, Kun Zh. Downregulation of microRNA-4295 enhances cisplatin-induced gastric cancer cell apoptosis through the EGFR/PI3K/Akt signaling pathway by targeting LRIG1. International journal of oncology. vol 53. issue 6. 2019-03-04. PMID:30320337. |
the aim of the present study was to investigate the mechanism of microrna-4295 (mir-4295), which regulates cisplatin (ddp)-induced apoptosis in gc cells through the leucine-rich repeats and immunoglobulin-like domains 1 (lrig1)-mediated epidermal growth factor receptor (egfr)/phosphoinositide 3-kinase (pi3k)/protein kinase b (akt) signaling pathway. |
2019-03-04 |
2023-08-13 |
human |
| George Mihai Nitulescu, Maryna Van De Venter, Georgiana Nitulescu, Anca Ungurianu, Petras Juzenas, Qian Peng, Octavian Tudorel Olaru, Daniela Grădinaru, Aristides Tsatsakis, Dimitris Tsoukalas, Demetrios A Spandidos, Denisa Margin. The Akt pathway in oncology therapy and beyond (Review). International journal of oncology. vol 53. issue 6. 2019-03-04. PMID:30334567. |
protein kinase b (akt), similar to many other protein kinases, is at the crossroads of cell death and survival, playing a pivotal role in multiple interconnected cell signaling mechanisms implicated in cell metabolism, growth and division, apoptosis suppression and angiogenesis. |
2019-03-04 |
2023-08-13 |
Not clear |
| Wei Cui, Bin Leng, Wei Liu, GaoPin Wan. Suppression of Apoptosis in Human Umbilical Vein Endothelial Cells (HUVECs) by Klotho Protein is Associated with Reduced Endoplasmic Reticulum Oxidative Stress and Activation of the PI3K/AKT Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 24. 2019-02-25. PMID:30471224. |
klotho protein reduced the rate of apoptosis of h₂o₂-treated huvecs and downregulated the expression of proteins associated with endoplasmic reticulum oxidative stress, grp78 and chop, and the expression of the apoptotic proteins, caspase-3, caspase-9, and caspase-12, and activated the phosphorylation of akt. |
2019-02-25 |
2023-08-13 |
human |
| Wei Zhou, Lei Chen, Xiqing Hu, Shanshan Cao, Junxiu Yan. Effects and mechanism of epigallocatechin-3-gallate on apoptosis and mTOR/AKT/GSK-3β pathway in substantia nigra neurons in Parkinson rats. Neuroreport. vol 30. issue 2. 2019-02-25. PMID:30571663. |
compared with the model group, the egcg group significantly reduced the rotation speed; increased the left forelimb usage (p<0.01); reduced the neuron apoptosis (p<0.01); decreased α-synuclein expression (p<0.01); and decreased the mtor, akt, and gsk-3β protein expressions (p<0.01). |
2019-02-25 |
2023-08-13 |
rat |