| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xu-Hua Ge, Li Shao, Guo-Ji Zh. Oxymatrine attenuates brain hypoxic-ischemic injury from apoptosis and oxidative stress: role of p-Akt/GSK3β/HO-1/Nrf-2 signaling pathway. Metabolic brain disease. vol 33. issue 6. 2019-05-13. PMID:30032345. |
to conclude, our results suggested that oxymatrine could exert efficacious neuroprotective effect against h/i injury by inhibiting apoptosis and oxidative stress, which might be related to the activation of akt and gsk3β and modulation of nrf-2/ho-1 signaling pathway. |
2019-05-13 |
2023-08-13 |
rat |
| Wan-Ting Xu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Yu-Chao Feng, Yu Zhang, Tong Zhang, Shi-Nong Wang, Chang-Yuan Wang, Cheng-Hao Ji. New naphthalene derivatives induce human lung cancer A549 cell apoptosis via ROS-mediated MAPKs, Akt, and STAT3 signaling pathways. Chemico-biological interactions. vol 304. 2019-05-13. PMID:30871965. |
new naphthalene derivatives induce human lung cancer a549 cell apoptosis via ros-mediated mapks, akt, and stat3 signaling pathways. |
2019-05-13 |
2023-08-13 |
human |
| Wan-Ting Xu, Gui-Nan Shen, Ying-Hua Luo, Xian-Ji Piao, Jia-Ru Wang, Hao Wang, Yi Zhang, Jin-Qian Li, Yu-Chao Feng, Yu Zhang, Tong Zhang, Shi-Nong Wang, Chang-Yuan Wang, Cheng-Hao Ji. New naphthalene derivatives induce human lung cancer A549 cell apoptosis via ROS-mediated MAPKs, Akt, and STAT3 signaling pathways. Chemico-biological interactions. vol 304. 2019-05-13. PMID:30871965. |
in conclusion, bsq and osq induce human lung cancer a549 cell apoptosis by ros-mediated mapks, akt, and stat3 signaling pathways. |
2019-05-13 |
2023-08-13 |
human |
| Hayley J Donnella, James T Webber, Rebecca S Levin, Roman Camarda, Olga Momcilovic, Nora Bayani, Khyati N Shah, James E Korkola, Kevan M Shokat, Andrei Goga, John D Gordan, Sourav Bandyopadhya. Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer. Nature chemical biology. vol 14. issue 8. 2019-05-07. PMID:29942081. |
incomplete inhibition of aurka was a common source of therapy failure, and combinations of pi3k, akt or mtor inhibitors with the aurka inhibitor mln8237 were highly synergistic and durably suppressed mtor signaling, resulting in apoptosis and tumor regression in vivo. |
2019-05-07 |
2023-08-13 |
Not clear |
| Xinwei Jiang, Chunting Cao, Weiwei Sun, Zisheng Chen, Xusheng Li, Lutfun Nahar, Satyajit D Sarker, Milen I Georgiev, Weibin Ba. Scandenolone from Cudrania tricuspidata fruit extract suppresses the viability of breast cancer cells (MCF-7) in vitro and in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 126. 2019-05-06. PMID:30753858. |
additionally, this isoflavone promoted cell apoptosis and induced a sustained activation of the phosphorylation of p38 and erk, but not jnk and akt. |
2019-05-06 |
2023-08-13 |
human |
| Shaurya Joshi, Jianqin Wei, Nanette H Bishopri. A cardiac myocyte-restricted Lin28/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the AKT signaling suppressor PIK3IP1. Biochimica et biophysica acta. vol 1862. issue 2. 2019-05-03. PMID:26655604. |
a cardiac myocyte-restricted lin28/let-7 regulatory axis promotes hypoxia-mediated apoptosis by inducing the akt signaling suppressor pik3ip1. |
2019-05-03 |
2023-08-13 |
Not clear |
| Haiying Guo, Hongyu Ren, Shanshan Liang, Yaoting Ji, Han Jiang, Ping Zhang, Minquan D. Phosphatidylinositol 3-Kinase/Akt signal pathway resists the apoptosis and inflammation in human extravillous trophoblasts induced by Porphyromonas gingivalis. Molecular immunology. vol 104. 2019-04-30. PMID:30448607. |
in this study, we investigated the effect of p. gingivalis on human extravillous trophoblasts and observed that it triggered apoptosis and inflammation and that akt was activated in this process. |
2019-04-30 |
2023-08-13 |
human |
| Haiying Guo, Hongyu Ren, Shanshan Liang, Yaoting Ji, Han Jiang, Ping Zhang, Minquan D. Phosphatidylinositol 3-Kinase/Akt signal pathway resists the apoptosis and inflammation in human extravillous trophoblasts induced by Porphyromonas gingivalis. Molecular immunology. vol 104. 2019-04-30. PMID:30448607. |
in addition, when akt activation was inhibited, apoptosis and inflammation was significantly increased. |
2019-04-30 |
2023-08-13 |
human |
| Siying Chen, Ti Meng, Xiaowei Zheng, Jiangxia Cai, Weipeng Zhang, Haisheng You, Jianfeng Xing, Yalin Don. Contribution of nucleophosmin overexpression to multidrug resistance in breast carcinoma. Journal of drug targeting. vol 26. issue 1. 2019-04-24. PMID:28562134. |
then, npm level was attenuated by rna interfering technology, the sensitivity of mcf-7/mtx cells to methotrexate was obviously increased, factor level of mitochondria apoptosis pathway was significantly augmented, and akt phosphorylation was inhibited. |
2019-04-24 |
2023-08-13 |
Not clear |
| Siying Chen, Ti Meng, Xiaowei Zheng, Jiangxia Cai, Weipeng Zhang, Haisheng You, Jianfeng Xing, Yalin Don. Contribution of nucleophosmin overexpression to multidrug resistance in breast carcinoma. Journal of drug targeting. vol 26. issue 1. 2019-04-24. PMID:28562134. |
furthermore, examination of akt and npm level demonstrated that akt inhibitor mk-2206 sensitised resistant cells to methotrexate and induced mcf-7/mtx cell apoptosis by pi3k/akt pathway and mitochondria apoptosis pathway. |
2019-04-24 |
2023-08-13 |
Not clear |
| Siying Chen, Ti Meng, Xiaowei Zheng, Jiangxia Cai, Weipeng Zhang, Haisheng You, Jianfeng Xing, Yalin Don. Contribution of nucleophosmin overexpression to multidrug resistance in breast carcinoma. Journal of drug targeting. vol 26. issue 1. 2019-04-24. PMID:28562134. |
npm has a crucial function in mdr of breast cancer through influencing akt activity and resistant cell apoptosis, and it could be expected to become a therapeutic target for chemoresistance in breast cancer. |
2019-04-24 |
2023-08-13 |
Not clear |
| Toshiaki Totoki, Corina N D' Alessandro-Gabazza, Masaaki Toda, Prince Baffour Tonto, Atsuro Takeshita, Taro Yasuma, Kota Nishihama, Motoh Iwasa, Noriyuki Horiki, Yoshiyuki Takei, Esteban C Gabazz. Protein S Exacerbates Chronic Liver Injury and Fibrosis. The American journal of pathology. vol 188. issue 5. 2019-04-22. PMID:29454753. |
human protein s inhibited apoptosis and increased akt pathway activation in hepatic stellate cells. |
2019-04-22 |
2023-08-13 |
mouse |
| Wei Liu, Zhen-Tang Jing, Shu-Xiang Wu, Yun He, Yan-Ting Lin, Wan-Nan Chen, Xin-Jian Lin, Xu Li. A Novel AKT Activator, SC79, Prevents Acute Hepatic Failure Induced by Fas-Mediated Apoptosis of Hepatocytes. The American journal of pathology. vol 188. issue 5. 2019-04-22. PMID:29673487. |
a novel akt activator, sc79, prevents acute hepatic failure induced by fas-mediated apoptosis of hepatocytes. |
2019-04-22 |
2023-08-13 |
mouse |
| Wei Liu, Zhen-Tang Jing, Shu-Xiang Wu, Yun He, Yan-Ting Lin, Wan-Nan Chen, Xin-Jian Lin, Xu Li. A Novel AKT Activator, SC79, Prevents Acute Hepatic Failure Induced by Fas-Mediated Apoptosis of Hepatocytes. The American journal of pathology. vol 188. issue 5. 2019-04-22. PMID:29673487. |
we report here that a novel akt activator, sc79, protects hepatocytes from apoptosis induced by agonistic anti-fas antibody ch11 (for humans) or jo2 (for mice) and significantly prolongs the survival of mice given a lethal dose of jo2. |
2019-04-22 |
2023-08-13 |
mouse |
| Duoduo Zhang, Jie Zhang, Jie Zeng, Zhubo Li, Hua Zuo, Chengzhi Huang, Xiaoyan Zha. Nano-Gold Loaded with Resveratrol Enhance the Anti-Hepatoma Effect of Resveratrol Journal of biomedical nanotechnology. vol 15. issue 2. 2019-04-22. PMID:30596551. |
res-gnps induced apoptosis in hepg2 cells by down-regulating pro-caspase-9, pro-caspase-3, pi3k and akt and upregulating caspase-8 and bax. |
2019-04-22 |
2023-08-13 |
Not clear |
| Lulu Liu, Yun Huang, Xiangling Feng, Jihua Chen, Yanying Dua. Overexpressed Hsp70 alleviated formaldehyde-induced apoptosis partly via PI3K/Akt signaling pathway in human bronchial epithelial cells. Environmental toxicology. vol 34. issue 4. 2019-04-22. PMID:30600586. |
apoptosis and the expression levels of pi3k, akt, p-akt, mek, p-mek, and gli2 were detected by annexin-apc/7aad double-labeled flow cytometry and western blot. |
2019-04-22 |
2023-08-13 |
human |
| Hai-Tao Xiao, Bo Wen, Zi-Wan Ning, Li-Xiang Zhai, Cheng-Hui Liao, Cheng-Yuan Lin, Huai-Xue Mu, Zhao-Xiang Bia. Cyclocarya paliurus tea leaves enhances pancreatic β cell preservation through inhibition of apoptosis. Scientific reports. vol 7. issue 1. 2019-04-18. PMID:28831132. |
in vivo and in vitro studies also showed the extract of c. paliurus leaves significantly inhibited pancreatic β cell apoptosis by suppressing the expression of caspase 8, caspase 9 and cleaved caspase-3, as well as bax/bcl-2 ratio, down-regulating p38, erk and jnk phosphorylation, and up-regulating akt phosphorylation. |
2019-04-18 |
2023-08-13 |
mouse |
| Cheng-Jie Liang, Jia-Huang Li, Zhen Zhang, Ju-Yan Zhang, Shu-Qun Liu, Jie Yan. Suppression of MIF-induced neuronal apoptosis may underlie the therapeutic effects of effective components of Fufang Danshen in the treatment of Alzheimer's disease. Acta pharmacologica Sinica. vol 39. issue 9. 2019-04-15. PMID:29770796. |
we observed the characteristics of a "pendular state" of mif, where mif (8 ng/ml) increased the ratio of p-bad/bad by activating akt and the ikkα/β signaling pathway to assure cell survival, whereas mif (50 ng/ml) up-regulated the expression of bad to trigger apoptosis of sh-sy5y cells. |
2019-04-15 |
2023-08-13 |
human |
| Yen-Yu Chen, Yuh-Ming Chang, Kuan-Yi Wang, Pei-Ni Chen, You-Cheng Hseu, Ke-Min Chen, Kun-Tu Yeh, Chih-Jung Chen, Li-Sung Hs. Naringenin inhibited migration and invasion of glioblastoma cells through multiple mechanisms. Environmental toxicology. vol 34. issue 3. 2019-04-09. PMID:30431227. |
naringenin inhibits the migration of bladder and lung cancer via modulation of mmp-2 and/or mmp-9 activities, naringenin inhibits migration and trigger apoptosis in gastric cancer cells through downregulation of akt pathway. |
2019-04-09 |
2023-08-13 |
Not clear |
| Manisha Majhi, Meer Asif Ali, Akanksha Limaye, Kritika Sinha, Praveena Bairagi, Megha Chouksey, Ruchi Shukla, Nisha Kanwar, Tajamul Hussain, Anuraj Nayarisseri, Sanjeev Kumar Sing. An In Silico Investigation of Potential EGFR Inhibitors for the Clinical Treatment of Colorectal Cancer. Current topics in medicinal chemistry. vol 18. issue 27. 2019-04-08. PMID:30499396. |
epidermal growth factor receptor (egfr), a transmembrane protein, participates in plc gamma-1, ras-raf-mek-mapks, phosphatidylinositol-3 kinase, akt pathways and plays a key role in normal functioning of cell division, cell differentiation, apoptosis and migration. |
2019-04-08 |
2023-08-13 |
Not clear |