| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Danyang Zhou, Wenjing Liu, Songhe Liang, Banghao Sun, Anqi Liu, Zhongqi Cui, Xue Han, Lijie Yua. Apoptin-derived peptide reverses cisplatin resistance in gastric cancer through the PI3K-AKT signaling pathway. Cancer medicine. vol 7. issue 4. 2019-08-07. PMID:29522284. |
additionally, adp inhibited the expression of p85, akt, p-p85, p-akt, multidrug resistance 1 (mdr1), and aryl hydrocarbon nuclear translocator (arnt) in the pi3k/akt/arnt signaling pathway, which promoted apoptosis and necrosis in gc cells. |
2019-08-07 |
2023-08-13 |
Not clear |
| Qianying Liu, Zhixin Lei, Kaixiang Zhou, Huiru Yu, Shenhe Liu, Qiliang Sun, Xu Wang, Menghong Dai, Zonghui Yua. N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox. Chemical research in toxicology. vol 31. issue 11. 2019-08-06. PMID:30265530. |
additionally, the activated p53 pathway, hyperactivated akt, and apoptosis were found in l02 cells after incubation with 100 μm cyadox. |
2019-08-06 |
2023-08-13 |
Not clear |
| Qianying Liu, Zhixin Lei, Kaixiang Zhou, Huiru Yu, Shenhe Liu, Qiliang Sun, Xu Wang, Menghong Dai, Zonghui Yua. N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox. Chemical research in toxicology. vol 31. issue 11. 2019-08-06. PMID:30265530. |
our data demonstrated that akt promoted cell survival when it was mildly activated by cyadox at 2 μm, and akt leads to apoptosis when it was severely activated by cyadox at 100 μm. |
2019-08-06 |
2023-08-13 |
Not clear |
| L A L Maués, G M Alves, N M G Couto, B J M da Silva, M S P Arruda, B M Macchi, C B C Sena, A F Prado, M E Crespo-Lopez, E O Silva, J L M do Nasciment. Flavonoids from the Amazon plant Brosimum acutifolium induce C6 glioma cell line apoptosis by disrupting mitochondrial membrane potential and reducing AKT phosphorylation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 113. 2019-08-06. PMID:30856536. |
flavonoids from the amazon plant brosimum acutifolium induce c6 glioma cell line apoptosis by disrupting mitochondrial membrane potential and reducing akt phosphorylation. |
2019-08-06 |
2023-08-13 |
Not clear |
| L A L Maués, G M Alves, N M G Couto, B J M da Silva, M S P Arruda, B M Macchi, C B C Sena, A F Prado, M E Crespo-Lopez, E O Silva, J L M do Nasciment. Flavonoids from the Amazon plant Brosimum acutifolium induce C6 glioma cell line apoptosis by disrupting mitochondrial membrane potential and reducing AKT phosphorylation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 113. 2019-08-06. PMID:30856536. |
bas-4 treatment did not induce cytotoxicity in primary glial cells; however, in glioma cells, it suppressed migration and invasion and led to apoptosis through mitochondrial damage, ΔΨm loss, cell cycle arrest, and reduced akt phosphorylation, which is a component of the main cell survival pathway. |
2019-08-06 |
2023-08-13 |
Not clear |
| L A L Maués, G M Alves, N M G Couto, B J M da Silva, M S P Arruda, B M Macchi, C B C Sena, A F Prado, M E Crespo-Lopez, E O Silva, J L M do Nasciment. Flavonoids from the Amazon plant Brosimum acutifolium induce C6 glioma cell line apoptosis by disrupting mitochondrial membrane potential and reducing AKT phosphorylation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 113. 2019-08-06. PMID:30856536. |
we conclude that bas-4 showed potential activity against glioma by inducing apoptosis mediated by ΔΨm loss and akt pathway disruption, and future studies should further evaluate bas-4 as a promising antineoplastic agent against glioblastoma. |
2019-08-06 |
2023-08-13 |
Not clear |
| Qiang Li, Zifan He, Jiming Liu, Jianlong Wu, Guixiang Tan, Jianwei Jiang, Zexuan Su, Mingrong Ca. Paris polyphylla 26 triggers G2/M phase arrest and induces apoptosis in HepG2 cells via inhibition of the Akt signaling pathway. The Journal of international medical research. vol 47. issue 4. 2019-08-05. PMID:30819018. |
paris polyphylla 26 triggers g2/m phase arrest and induces apoptosis in hepg2 cells via inhibition of the akt signaling pathway. |
2019-08-05 |
2023-08-13 |
Not clear |
| Yanlin Huang, Hongbo Wang, Yifan Lian, Xiaojuan Wu, Liang Zhou, Jialiang Wang, Meihai Deng, Yuehua Huan. Upregulation of kinesin family member 4A enhanced cell proliferation via activation of Akt signaling and predicted a poor prognosis in hepatocellular carcinoma. Cell death & disease. vol 9. issue 2. 2019-08-02. PMID:29396392. |
in addition, we demonstrated that kif4a depletion was related to inhibition of akt kinase activity and induction of intrinsic apoptosis signaling pathway. |
2019-08-02 |
2023-08-13 |
human |
| Sangetha Vijayan P, Rekha P D, Arun A . Role of PI3K-Akt and MAPK Signaling in Uranyl Nitrate-Induced Nephrotoxicity. Biological trace element research. vol 189. issue 2. 2019-08-02. PMID:30302617. |
the result of the current study suggests that uranyl nitrate induces acute renal injury by activation of apoptosis through jnk pathway, while the early activation of signaling molecules akt and erk promotes the tubular cell proliferation and cell survival. |
2019-08-02 |
2023-08-13 |
mouse |
| Wenjun Zhang, Xiping Liang, Yi Gong, Chunyan Xiao, Bingling Guo, Tao Yan. The Signal Transducer and Activator of Transcription 5B (STAT5B) Gene Promotes Proliferation and Drug Resistance of Human Mantle Cell Lymphoma Cells by Activating the Akt Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-08-02. PMID:30964854. |
flow cytometry was used to investigate the cell cycle in mcl cells treated with the specific inhibitor of the akt pathway, ly294002, and assessed cell cycle and cell apoptosis. |
2019-08-02 |
2023-08-13 |
human |
| Wenjun Zhang, Xiping Liang, Yi Gong, Chunyan Xiao, Bingling Guo, Tao Yan. The Signal Transducer and Activator of Transcription 5B (STAT5B) Gene Promotes Proliferation and Drug Resistance of Human Mantle Cell Lymphoma Cells by Activating the Akt Signaling Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-08-02. PMID:30964854. |
increased expression of stat5b was associated with increased mcl cell proliferation and reduced cell apoptosis and was associated with drug resistance and activation of akt. |
2019-08-02 |
2023-08-13 |
human |
| Jia Yan, Jingjie Li, Lei Zhang, Yu Sun, Jue Jiang, Yan Huang, Hui Xu, Hong Jiang, Rong H. Nrf2 protects against acute lung injury and inflammation by modulating TLR4 and Akt signaling. Free radical biology & medicine. vol 121. 2019-08-01. PMID:29678610. |
analysis of lung tissues in nrf2-knockout mice by western blotting, immunohistochemistry, and tunel assay, and analysis of bronchoalveolar lavage fluid showed that nrf2 deficiency upregulated tlr4, enhanced i/r-induced lung injury, apoptosis, inflammation, and autophagy, and increased the i/r-induced inactivation of akt. |
2019-08-01 |
2023-08-13 |
mouse |
| Mei-Lang Kung, Pei-Ying Lin, Shih-Tsung Huang, Ming-Hong Tai, Shu-Ling Hsieh, Chih-Chung Wu, Bi-Wen Yeh, Wen-Jeng Wu, Shuchen Hsie. Zingerone Nanotetramer Strengthened the Polypharmacological Efficacy of Zingerone on Human Hepatoma Cell Lines. ACS applied materials & interfaces. vol 11. issue 1. 2019-07-31. PMID:30566322. |
our results demonstrated that zingerone nps significantly inhibit akt activity and nfκb expression as well as activate the caspases cascade signaling pathway which are involved in the antiproliferation, antitumorigenicity, disturbing cell cycle progression, and induction of dna damage as well as cell apoptosis. |
2019-07-31 |
2023-08-13 |
human |
| Zheng-Luan Liao, Heng Su, Yun-Fei Tan, Ya-Ju Qiu, Jun-Peng Zhu, Yan Chen, Si-Si Lin, Ming-Hao Wu, Yan-Ping Mao, Jiao-Jiao Hu, En-Yan Y. Salidroside protects PC-12 cells against amyloid β-induced apoptosis by activation of the ERK1/2 and AKT signaling pathways. International journal of molecular medicine. vol 43. issue 4. 2019-07-30. PMID:30720058. |
salidroside protects pc-12 cells against amyloid β-induced apoptosis by activation of the erk1/2 and akt signaling pathways. |
2019-07-30 |
2023-08-13 |
Not clear |
| Sumia Mohamed Essid, Alan Bevington, Nigel J Brunskil. Proinsulin C-Peptide Enhances Cell Survival and Protects against Simvastatin-Induced Myotoxicity in L6 Rat Myoblasts. International journal of molecular sciences. vol 20. issue 7. 2019-07-30. PMID:30987105. |
simvastatin strongly impaired akt signaling and stimulated the reactive oxygen species (ros) production; suggesting that akt signaling and oxidative stress are important factors in statin-induced apoptosis in l6 myoblasts. |
2019-07-30 |
2023-08-13 |
rat |
| Sung Min Cho, Ho Jeong Kwo. Acid ceramidase, an emerging target for anti-cancer and anti-angiogenesis. Archives of pharmacal research. vol 42. issue 3. 2019-07-25. PMID:30661200. |
acid ceramidase (ac) is a promising target protein in the development of multi-targeted anticancer drugs as its inhibition can simultaneously inhibit angiogenesis via the akt and erk 1/2 pathway and limit cancer growth through ceramide-induced apoptosis. |
2019-07-25 |
2023-08-13 |
human |
| Zhen-Tang Jing, Wei Liu, Shu-Xiang Wu, Yun He, Yan-Ting Lin, Wan-Nan Chen, Xin-Jian Lin, Xu Li. Hepatitis B Virus Surface Antigen Enhances the Sensitivity of Hepatocytes to Fas-Mediated Apoptosis via Suppression of AKT Phosphorylation. Journal of immunology (Baltimore, Md. : 1950). vol 201. issue 8. 2019-07-22. PMID:30171166. |
hepatitis b virus surface antigen enhances the sensitivity of hepatocytes to fas-mediated apoptosis via suppression of akt phosphorylation. |
2019-07-22 |
2023-08-13 |
Not clear |
| Qi Wang, Ruolin Chen, Cong Zhang, Inam-U-Llah, Fengyuan Piao, Xiaoxia Sh. NGF protects bone marrow mesenchymal stem cells against 2,5-hexanedione-induced apoptosis in vitro via Akt/Bad signal pathway. Molecular and cellular biochemistry. vol 457. issue 1-2. 2019-07-18. PMID:30911955. |
however, k252a and mk-2206 (trka and akt inhibitor, respectively) suppressed the anti-apoptosis of ngf, indicating the protective effect of ngf on bmscs apoptosis via a novel akt/bad pathway. |
2019-07-18 |
2023-08-13 |
Not clear |
| Yaxin Xie, Xiaoning Pen. [Effects of chrysin on the apoptosis in oral squamous carcinoma KB cell line and the underlying mechanisms]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 44. issue 5. 2019-07-18. PMID:31303615. |
to investigate the effect of chrysin on apoptosis of oral squamous carcinoma kb cell line and the possible mechanisms, and to provide new ideas for the treatment of oral cancer.
methods: oral cancer kb cells were treated with different concentrations of chrysin (1, 2, 4, 8, 16, and 32 μmol/l) for 24 h. cell proliferation was detected by mmt assay; apoptosis was detected by flow cytometry; the activity of caspase-3/7 was detected by chemiluminescent assay; mitochondrial membrane potential in kb cells was determined by jc-1 assay; and western blotting was used to determine the activation of protein kinase b (akt) and phosphoinositide-3-kinase (pi3k).
results: chrysin inhibited the proliferation of kb cells in a concentration-dependent manner, accompanied by increase in apoptosis of kb cells, activation of caspase-3/7, decrease in mitochondrial membrane potential, and suppression of the phosphorylation of akt and pi3k.
conclusion: the effect of chrysin on kb cell apoptosis may be related to mitochondrial dysfunction and inhibition of pi3k/akt pathway. |
2019-07-18 |
2023-08-13 |
Not clear |
| Peng Liu, Ruizhi Yao, Hongzhao Shi, Yang Liu, Shuai Lian, Yuying Yang, Huanmin Yang, Shize L. Effects of Cold-inducible RNA-binding Protein (CIRP) on Liver Glycolysis during Acute Cold Exposure in C57BL/6 Mice. International journal of molecular sciences. vol 20. issue 6. 2019-07-17. PMID:30909542. |
taken together, these findings indicate that acute cold exposure increased the expression of cirp protein, which regulates mouse hepatic glucose metabolism and maintains hepatocyte energy balance through the akt signaling pathway, thereby slowing the liver cell apoptosis caused by cold exposure. |
2019-07-17 |
2023-08-13 |
mouse |