| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ling Zhou, Yuetao Yi, Qing Yuan, Jing Zhang, Youjie Li, Pingyu Wang, Maolei Xu, Shuyang Xi. VAOS, a novel vanadyl complexes of alginate saccharides, inducing apoptosis via activation of AKT-dependent ROS production in NSCLC. Free radical biology & medicine. vol 129. 2019-09-30. PMID:30223019. |
vaos was further identified to induce nsclc cell apoptosis through activating protein kinase b (akt) to elevate intracellular reactive oxygen species (ros) levels by increasing in oxygen consumption and impairing the ros-scavenging system. |
2019-09-30 |
2023-08-13 |
mouse |
| Ling Zhou, Yuetao Yi, Qing Yuan, Jing Zhang, Youjie Li, Pingyu Wang, Maolei Xu, Shuyang Xi. VAOS, a novel vanadyl complexes of alginate saccharides, inducing apoptosis via activation of AKT-dependent ROS production in NSCLC. Free radical biology & medicine. vol 129. 2019-09-30. PMID:30223019. |
neither silencing of ptp1b by sirna nor transient overexpression of ptp1b had an effect on the akt phosphorylation triggered by vaos, indicating that ptp1b inhibition was not involved in vaos-induced apoptosis. |
2019-09-30 |
2023-08-13 |
mouse |
| Zydrune Polianskyte-Prause, Tuomas A Tolvanen, Sonja Lindfors, Vincent Dumont, Mervi Van, Hong Wang, Surjya N Dash, Mika Berg, Jette-Britt Naams, Laura C Hautala, Harry Nisen, Tuomas Mirtti, Per-Henrik Groop, Kristiina Wähälä, Jukka Tienari, Sanna Lehtone. Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 33. issue 2. 2019-09-30. PMID:30321069. |
ship2 overexpression reduces akt activity and enhances podocyte apoptosis, and both are restored to normal levels by metformin. |
2019-09-30 |
2023-08-13 |
mouse |
| Magda Gharbiya, Alice Bruscolini, Marta Sacchetti, Pamela Rosso, Valentina Carito, Marco Segatto, Elena Fico, Paola Tirassa, Alessandro Lambias. In vivo antivascular endothelial growth factor treatment induces corneal endothelium apoptosis in rabbits through changes in p75NTR-proNGF pathway. Journal of cellular physiology. vol 233. issue 11. 2019-09-26. PMID:29856479. |
in line with these data, ic administration of both anti-vegf agents induced the activation of apoptotic signals in endothelial cells, including an increase in c-casp3, decrease in bad ser 112 phosphorylation, and unbalance of akt phosphorylation. these results demonstrated that administration of anti-vegf in the anterior chamber of rabbit affects endothelial cell survival by inducing apoptosis through alteration of ngf pathway. |
2019-09-26 |
2023-08-13 |
rabbit |
| Xiaoyun Zhang, Tong Jin, Xiaoxi Huang, Xinjuan Liu, Zheng Liu, Yanjun Jia, Jianyu Ha. Effects of the tumor suppressor PTEN on biological behaviors of activated pancreatic stellate cells in pancreatic fibrosis. Experimental cell research. vol 373. issue 1-2. 2019-09-24. PMID:30321515. |
in vitro, pten appears to prevent pscs from further activation and promotes apoptosis through regulation of the akt and fak/erk pathways. |
2019-09-24 |
2023-08-13 |
rat |
| Wei He, Xiang Li, Shuyue Xi. Lupeol triterpene exhibits potent antitumor effects in A427 human lung carcinoma cells via mitochondrial mediated apoptosis, ROS generation, loss of mitochondrial membrane potential and downregulation of m-TOR/PI3Ksol;AKT signalling pathway. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. vol 23. issue 3. 2019-09-23. PMID:30003730. |
lupeol triterpene exhibits potent antitumor effects in a427 human lung carcinoma cells via mitochondrial mediated apoptosis, ros generation, loss of mitochondrial membrane potential and downregulation of m-tor/pi3ksol;akt signalling pathway. |
2019-09-23 |
2023-08-13 |
human |
| Rashideh N Mobaraki, Maryam Karimi, Fatemeh Alikarami, Elham Farhadi, Ali Amini, Davood Bashash, Mostafa Paridar, Parviz Kokhaei, Mohammad R Rezvani, Ahmad Kazemi, Majid Saf. RITA induces apoptosis in p53-null K562 leukemia cells by inhibiting STAT5, Akt, and NF-κB signaling pathways. Anti-cancer drugs. vol 29. issue 9. 2019-09-20. PMID:30157040. |
rita induces apoptosis in p53-null k562 leukemia cells by inhibiting stat5, akt, and nf-κb signaling pathways. |
2019-09-20 |
2023-08-13 |
Not clear |
| Kathryn L Garner, Virginie M S Betin, Vanda Pinto, Mark Graham, Emmanuelle Abgueguen, Matt Barnes, David C Bedford, Craig A McArdle, Richard J M Cowar. Enhanced insulin receptor, but not PI3K, signalling protects podocytes from ER stress. Scientific reports. vol 8. issue 1. 2019-09-19. PMID:29500363. |
however, contrary to this, knockdown of the negative regulator of pi3k-akt signalling, phosphatase and tensin homolog deleted from chromosome 10 (pten), sensitizes podocytes to er stress and apoptosis, despite increasing akt phosphorylation. |
2019-09-19 |
2023-08-13 |
Not clear |
| Inam-U-Llah, Xiaoxia Shi, Mengren Zhang, Kaixin Li, Pingan Wu, Raheel Suleman, Muhammad Shahbaz, Ayaz Taj, Fengyuan Pia. Protective Effect of Taurine on Apoptosis of Spinal Cord Cells in Diabetic Neuropathy Rats. Advances in experimental medicine and biology. vol 1155. 2019-09-19. PMID:31468454. |
the results showed that dm increased apoptosis, decreased phosphorylated akt and bad. |
2019-09-19 |
2023-08-13 |
rat |
| Wenxiang Fan, Xiang Li, Liangliang Huang, Shucheng He, Zhicheng Xie, Yuxin Fu, Weirong Fang, Yunman L. S-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nAChR and PI3K / Akt / GSK3β signal pathway in rats. Neurochemistry international. vol 115. 2019-09-17. PMID:29355569. |
s-oxiracetam ameliorates ischemic stroke induced neuronal apoptosis through up-regulating α7 nachr and pi3k / akt / gsk3β signal pathway in rats. |
2019-09-17 |
2023-08-13 |
rat |
| Jie Li, Bing Xu, Zhi Chen, Chanjuan Zhou, Li Liao, Yinghua Qin, Chuangchuang Yang, Xiaodong Zhang, Zicheng Hu, Lin Sun, Dan Zhu, Peng Xi. PI3K/AKT/JNK/p38 signalling pathway-mediated neural apoptosis in the prefrontal cortex of mice is involved in the antidepressant-like effect of pioglitazone. Clinical and experimental pharmacology & physiology. vol 45. issue 6. 2019-09-16. PMID:29359338. |
additionally, neural apoptosis, and the expression of apoptosis-related (cleaved caspase-3, bax, bcl-2, cyt c) and signalling proteins (akt, jnk, p38) were assessed in the prefrontal cortex (pfc) of these mice. |
2019-09-16 |
2023-08-13 |
mouse |
| Xiangmin Wang, Bin Pan, Yuko Hashimoto, Hiroshi Ohkawara, Kailin Xu, Lingyu Zeng, Takayuki Ikezo. Defibrotide Stimulates Angiogenesis and Protects Endothelial Cells from Calcineurin Inhibitor-Induced Apoptosis via Upregulation of AKT/Bcl-xL. Thrombosis and haemostasis. vol 118. issue 1. 2019-09-12. PMID:29304536. |
more importantly, df alleviated calcineurin inhibitor-induced growth inhibition and apoptosis of human umbilical vein endothelial cells and human hepatic sinusoidal endothelial cells in parallel with upregulation of anti-apoptotic protein b-cell lymphoma-extra-large (bcl-xl), which was mediated by akt (protein kinase b). |
2019-09-12 |
2023-08-13 |
human |
| Subhadip Das, Kirti Kaul, Sanjay Mishra, Manish Charan, Ramesh K Ganj. Cannabinoid Signaling in Cancer. Advances in experimental medicine and biology. vol 1162. 2019-09-11. PMID:31332734. |
several of these pathways including akt, egfr, and mtor are known to contribute to tumor development and metastasis, and cannabinoids may reverse their effects, thereby by inducing apoptosis, autophagy and modulating the immune system. |
2019-09-11 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Ling Chen, Lothar A Blatter, Carl G Mak. p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. Journal of molecular cell biology. vol 10. issue 4. 2019-09-10. PMID:29190376. |
p53 promotes akt and sp1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to nutlin-3a. |
2019-09-10 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Ling Chen, Lothar A Blatter, Carl G Mak. p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. Journal of molecular cell biology. vol 10. issue 4. 2019-09-10. PMID:29190376. |
knockdown or inhibition of akt, sp1, or the ppp sensitized mdm2-non-amplified cells to apoptosis. |
2019-09-10 |
2023-08-13 |
Not clear |
| Lei Duan, Ricardo E Perez, Ling Chen, Lothar A Blatter, Carl G Mak. p53 promotes AKT and SP1-dependent metabolism through the pentose phosphate pathway that inhibits apoptosis in response to Nutlin-3a. Journal of molecular cell biology. vol 10. issue 4. 2019-09-10. PMID:29190376. |
the data indicate that p53 promotes akt and sp1-dependent activation of the ppp that protects cells from nutlin-3a-induced apoptosis. |
2019-09-10 |
2023-08-13 |
Not clear |
| James N Tsoporis, Anastasia Fazio, Ioannis K Rizos, Shehla Izhar, Gerald Proteau, Vasileos Salpeas, Angelos Rigopoulos, Eleftherios Sakadakis, Ioannis K Toumpoulis, Thomas G Parke. Increased right atrial appendage apoptosis is associated with differential regulation of candidate MicroRNAs 1 and 133A in patients who developed atrial fibrillation after cardiac surgery. Journal of molecular and cellular cardiology. vol 121. 2019-09-10. PMID:29885959. |
mechanistically, overexpression of mir-133a inhibited hypoxia-induced rat neonatal cardiomyocyte apoptosis and phosphorylated pro-survival akt, responses abolished by a mir-133a antisense inhibitor oligonucleotide or by pre-treatment with an akt inhibitor. |
2019-09-10 |
2023-08-13 |
rat |
| Jing Song, Yaqi Wang, Xiao Yuan, Qiuxia Ji, Cunhui Fan, Hongmei Zhao, Wenjing Hao, Dapeng Re. Stretching magnitude-dependent inactivation of AKT by ROS led to enhanced p53 mitochondrial translocation and myoblast apoptosis. Molecular biology of the cell. vol 30. issue 10. 2019-09-10. PMID:30865562. |
stretching magnitude-dependent inactivation of akt by ros led to enhanced p53 mitochondrial translocation and myoblast apoptosis. |
2019-09-10 |
2023-08-13 |
Not clear |
| Yan Zhang, Yuliang Jiang, Dongjie L. Diosmetin Suppresses Neuronal Apoptosis and Inflammation by Modulating the Phosphoinositide 3-Kinase (PI3K)/AKT/Nuclear Factor-κB (NF-κB) Signaling Pathway in a Rat Model of Pneumococcal Meningitis. Medical science monitor : international medical journal of experimental and clinical research. vol 25. 2019-09-10. PMID:30914630. |
in rat brain tissue, levels of inflammatory mediators were determined by enzyme-linked immunosorbent assay (elisa) and western blot for protein kinase b (akt), phosphoinositide 3-kinase (pi3k), myeloid differentiation primary response 88 (myd88), and nuclear factor-kappab (nf-kappab), and the tunel assay for apoptosis was performed. |
2019-09-10 |
2023-08-13 |
rat |
| Varun V Prabhu, Mala K Talekar, Amriti R Lulla, C Leah B Kline, Lanlan Zhou, Junior Hall, A Pieter J Van den Heuvel, David T Dicker, Jawad Babar, Stephan A Grupp, Mathew J Garnett, Ultan McDermott, Cyril H Benes, Jeffrey J Pu, David F Claxton, Nadia Khan, Wolfgang Oster, Joshua E Allen, Wafik S El-Deir. Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies. Cell cycle (Georgetown, Tex.). vol 17. issue 4. 2019-09-09. PMID:29157092. |
onc201 induced caspase-dependent apoptosis that involved activation of the integrated stress response (atf4/chop) pathway, inhibition of akt phosphorylation, foxo3a activation, downregulation of cyclin d1, iap and bcl-2 family members. |
2019-09-09 |
2023-08-13 |
Not clear |