| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Junning Yao, Zhan Li, Yeqing Fu, Ruxing Wu, Yixuan Wang, Chang Liu, Le Yang, Hanwang Zhan. Involvement of obesity-associated upregulation of chemerin/chemokine-like receptor 1 in oxidative stress and apoptosis in ovaries and granulosa cells. Biochemical and biophysical research communications. vol 510. issue 3. 2019-11-04. PMID:30722991. |
in vitro, mouse granulosa cells (mgcs) were cultured and treated with different concentrations of chemerin to investigate the effects of chemerin on viability, reactive oxygen species (ros), and apoptosis and on the phosphorylation of akt, amp-activated protein kinase α (ampkα), and nuclear factor-κb p65. |
2019-11-04 |
2023-08-13 |
mouse |
| Xing Kang, Hijuan Wang, Yanwei Li, Ying Xiao, Lili Zhao, Tingting Zhang, Shaohe Zhou, Xiaolun Zhou, Yi Li, Zhexing Shou, Chao Chen, Bin L. Alantolactone induces apoptosis through ROS-mediated AKT pathway and inhibition of PINK1-mediated mitophagy in human HepG2 cells. Artificial cells, nanomedicine, and biotechnology. vol 47. issue 1. 2019-11-04. PMID:31116036. |
alantolactone induces apoptosis through ros-mediated akt pathway and inhibition of pink1-mediated mitophagy in human hepg2 cells. |
2019-11-04 |
2023-08-13 |
human |
| Wenhu Zhan, Jinxin Che, Lei Xu, Yizhe Wu, Xiaobei Hu, Yubo Zhou, Gang Cheng, Yongzhou Hu, Xiaowu Dong, Jia L. Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors. European journal of medicinal chemistry. vol 180. 2019-11-04. PMID:31301565. |
a series of pyrazole-thiophene derivatives exhibiting good akt inhibitory activities were obtained on the basis of conformational restriction strategy, leading to the discovery of compound 1d and 1o which showed excellent in vitro antitumor effect against a variety of hematologic cancer cells and their potential of inducing apoptosis, blocking the cell cycles at s phase and significantly inhibiting the phosphorylation of downstream biomarkers of akt kinase of cancer cells. |
2019-11-04 |
2023-08-13 |
Not clear |
| Y Long, Y Zhang, S-S Cai, D-M Sun, Y-H L. Ulinastatin inhibits high glucose-induced cardiomyocyte apoptosis through activating Akt signaling. European review for medical and pharmacological sciences. vol 22. issue 14. 2019-10-29. PMID:30058707. |
ulinastatin inhibits high glucose-induced cardiomyocyte apoptosis through activating akt signaling. |
2019-10-29 |
2023-08-13 |
Not clear |
| Hong-Wei Zhang, Jin-Jiao Hu, Ruo-Qiu Fu, Xin Liu, Yan-Hao Zhang, Jing Li, Lei Liu, Yu-Nong Li, Qin Deng, Qing-Song Luo, Qin Ouyang, Ning Ga. Flavonoids inhibit cell proliferation and induce apoptosis and autophagy through downregulation of PI3Kγ mediated PI3K/AKT/mTOR/p70S6K/ULK signaling pathway in human breast cancer cells. Scientific reports. vol 8. issue 1. 2019-10-22. PMID:30050147. |
pretreatment with pi3kγ specific inhibitor as605240 potentiated flavonoids-mediated inactivation of akt, mtor, p70s6k, ulk, and apoptosis. |
2019-10-22 |
2023-08-13 |
human |
| Sunwoo Park, Fuller W Bazer, Whasun Lim, Gwonhwa Son. The O-methylated isoflavone, formononetin, inhibits human ovarian cancer cell proliferation by sub G0/G1 cell phase arrest through PI3K/AKT and ERK1/2 inactivation. Journal of cellular biochemistry. vol 119. issue 9. 2019-10-21. PMID:29761845. |
the formononetin-mediated regulation of cell proliferation and apoptosis involved decreased phosphorylation of erk1/2, p90rsk, akt, p70s6k, and s6 proteins, and increased phosphorylation of p38 protein in es2 and ov90 cells. |
2019-10-21 |
2023-08-13 |
human |
| Ding-Yan Lu, Jing Li, Jia Sun, Wei-Na Xue, Bin He, Yong-Jun Li, Yong-Lin Wang, Chang-Hu Lin, Ting Li. [Shenxiong Glucose Injection inhibits H_2O_2-induced apoptosis of H9c2 cells by activating PI3K/AKT pathway]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 44. issue 17. 2019-10-21. PMID:31602952. |
cell viability was detected by mts assay,morphological changes of apoptosis were observed by ao/eb fluorescence staining,apoptosis rate was detected by annexin/pi method,cell expression profile was detected by gene chip technology,the mrna of pik3 ca,bcl-2,bax,caspase-3 and gapdh were detected by qrt-pcr,the protein expression levels of pik3 ca,akt,p-akt,bcl-2,bax and caspase-3 were detected by western blot,and the contents of ldh and mda were detected by kit. |
2019-10-21 |
2023-08-13 |
Not clear |
| Yuan Tian, Lian-Lian Liu, Dong-Mei Guo, Yan Wang, Wen-Hui Zha, Yang Li, Fu-Ju W. TPX2 gene silencing inhibits cell proliferation and promotes apoptosis through negative regulation of AKT signaling pathway in ovarian cancer. Journal of cellular biochemistry. vol 119. issue 9. 2019-10-17. PMID:29904936. |
tpx2 gene silencing inhibits cell proliferation and promotes apoptosis through negative regulation of akt signaling pathway in ovarian cancer. |
2019-10-17 |
2023-08-13 |
mouse |
| Yuan Tian, Lian-Lian Liu, Dong-Mei Guo, Yan Wang, Wen-Hui Zha, Yang Li, Fu-Ju W. TPX2 gene silencing inhibits cell proliferation and promotes apoptosis through negative regulation of AKT signaling pathway in ovarian cancer. Journal of cellular biochemistry. vol 119. issue 9. 2019-10-17. PMID:29904936. |
taken together, tpx2 silencing negatively regulates the akt signaling pathway by which oc cell proliferation was inhibited yet cell apoptosis was accelerated, suggesting a potential therapeutic approach to oc. |
2019-10-17 |
2023-08-13 |
mouse |
| Maryam Farzaneh Behelgardi, Saber Zahri, Farhad Mashayekhi, Kamran Mansouri, S Mohsen Asghar. A peptide mimicking the binding sites of VEGF-A and VEGF-B inhibits VEGFR-1/-2 driven angiogenesis, tumor growth and metastasis. Scientific reports. vol 8. issue 1. 2019-10-15. PMID:30560942. |
administration of vgb4 led to the regression of 4t1 murine mct growth through decreased expression of p-vegfr1 and p-vegfr2 and abrogation of erk1/2 and akt activation followed by considerable decrease of tumor cell proliferation (ki67 expression) and angiogenesis (cd31 and cd34 expression), induction of apoptosis (increased p53 expression, tunel staining and decreased bcl2 expression), and suppression of metastasis (increased e-cadherin and decreased n-cadherin, nf-κb and mmp-9 expression). |
2019-10-15 |
2023-08-13 |
human |
| Sri HariKrishna Vellanki, Rodrigo G B Cruz, Hanne Jahns, Lance Hudson, Giovanni Sette, Adriana Eramo, Ann M Hopkin. Natural compound Tetrocarcin-A downregulates Junctional Adhesion Molecule-A in conjunction with HER2 and inhibitor of apoptosis proteins and inhibits tumor cell growth. Cancer letters. vol 440-441. 2019-10-11. PMID:30312728. |
tetrocarcin-a treatment or jam-a silencing reduced akt and erk phosphorylation, inhibited c-fos phosphorylation at threonine-232 (its transcriptional regulation site), inhibited nuclear localization of c-fos, and downregulated expression of the inhibitor of apoptosis proteins (iap). |
2019-10-11 |
2023-08-13 |
human |
| Reema Singh, Priyanka Chaudhary, Ranjana Ary. Role of IGF-1R in ameliorating apoptosis of GNE deficient cells. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29743626. |
igf-1 induced activation of igf-1r led to akt (protein kinase b) phosphorylation that may phosphorylate bad (bcl2 associated death promoter) and its dissociation from bcl2 to prevent apoptosis. |
2019-10-09 |
2023-08-13 |
Not clear |
| Reema Singh, Priyanka Chaudhary, Ranjana Ary. Role of IGF-1R in ameliorating apoptosis of GNE deficient cells. Scientific reports. vol 8. issue 1. 2019-10-09. PMID:29743626. |
a balance between the erk and akt pathways may determine the cell fate towards survival or apoptosis. |
2019-10-09 |
2023-08-13 |
Not clear |
| b' Mar\\xc3\\xada A Rodr\\xc3\\xadguez-Hern\\xc3\\xa1ndez, Ra\\xc3\\xbal Gonz\\xc3\\xa1lez, \\xc3\\x81ngel J de la Rosa, Paloma Gallego, Raquel Ord\\xc3\\xb3\\xc3\\xb1ez, Elena Navarro-Villar\\xc3\\xa1n, Laura Contreras, Mario Rodr\\xc3\\xadguez-Arribas, Javier Gonz\\xc3\\xa1lez-Gallego, Jos\\xc3\\xa9 M \\xc3\\x81lamo-Mart\\xc3\\xadnez, Lu\\xc3\\xads M Mar\\xc3\\xadn-G\\xc3\\xb3mez, Jos\\xc3\\xa9 A Del Campo, Jos\\xc3\\xa9 L Quiles, Jos\\xc3\\xa9 M Fuentes, Jes\\xc3\\xbas de la Cruz, Jos\\xc3\\xa9 L Mauriz, Francisco J Padillo, Jordi Muntan\\xc3\\xa. Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells. Journal of cellular physiology. vol 234. issue 1. 2019-10-04. PMID:30132846.' |
the current study evaluated cell signaling regulation of endoplasmic reticulum (er) stress, c-jun-n-terminal kinase (jnk), akt, and 5'amp-activated protein kinase (ampk) leading to autophagy and apoptosis induced by sorafenib. |
2019-10-04 |
2023-08-13 |
Not clear |
| Megan A Peppenelli, Michael J Miller, Aaron M Altman, Olesea Cojohari, Gary C Cha. Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes. Antiviral research. vol 158. 2019-10-03. PMID:30055197. |
furthermore, we found a unique interplay between hcmv-activated akt and the stress response transcription heat shock factor 1 (hsf1) that allowed for the synthesis of both cap- and internal ribosome entry site (ires)-containing antiapoptotic mrnas such as myeloid cell leukemia-1 (mcl-1) and x-linked inhibitor of apoptosis (xiap), respectively. |
2019-10-03 |
2023-08-13 |
human |
| Qijing Lei, Qin Pan, Na Li, Zhe Zhou, Juqing Zhang, Xin He, Sha Peng, Guangpeng Li, Kuldip Sidhu, Shulin Chen, Jinlian Hu. H19 regulates the proliferation of bovine male germline stem cells via IGF-1 signaling pathway. Journal of cellular physiology. vol 234. issue 1. 2019-10-02. PMID:30069947. |
results showed that igf-1 could activate the phosphorylation of akt and erk signaling pathways, and the igf-1 pathway played an important role in regulating the proliferation and apoptosis of bovine mgscs. |
2019-10-02 |
2023-08-13 |
mouse |
| Noreen Akhtar, Ishrat Jabee. Pharmacoinformatic Approaches to Design Novel Inhibitors of Protein Kinase B Pathways in Cancer. Current cancer drug targets. vol 18. issue 9. 2019-09-30. PMID:28669343. |
thus, inhibition of akt activation represents a promising concept to induce cell apoptosis in various cancers and evade chemotherapeutic resistance. |
2019-09-30 |
2023-08-13 |
human |
| Agapi Kataki, Ioannis Karagiannidis, Nikolaos Memos, Efthymios Koniaris, Pantelis Antonakis, Apostolos Papalois, George C Zografos, Manoussos M Konstadoulaki. Host's Endogenous Caveolin-1 Expression is Downregulated in the Lung During Sepsis to Promote Cytoprotection. Shock (Augusta, Ga.). vol 50. issue 2. 2019-09-30. PMID:28957875. |
alternations in 14-3-3b expression related to apoptosis were apparent and accompanied by increased akt phosphorylation activity late during sepsis progression.after pc administration, cell apoptosis was reduced (p = 0.004) and both the percentile and expression intensity of caveolin-1 positive cells were compromised (p = 0.009 and p = 0.027, respectively). |
2019-09-30 |
2023-08-13 |
Not clear |
| Long-Bin Jeng, Bharath Kumar Velmurugan, Ming-Cheng Chen, Hsi-Hsien Hsu, Tsung-Jung Ho, Cecilia-Hsuan Day, Yueh-Min Lin, V Vijaya Padma, Chuan-Chou Tu, Chih-Yang Huan. Fisetin mediated apoptotic cell death in parental and Oxaliplatin/irinotecan resistant colorectal cancer cells in vitro and in vivo. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29574877. |
western blot assays suggested that apoptosis was induced by fisetin administration, promoting caspase-8, and cytochrome-c expressions possibly by inhibiting aberrant activation of igf1r and akt proteins. |
2019-09-30 |
2023-08-13 |
mouse |
| Ning Ren, Ming Wan. microRNA-212-induced protection of the heart against myocardial infarction occurs via the interplay between AQP9 and PI3K/Akt signaling pathway. Experimental cell research. vol 370. issue 2. 2019-09-30. PMID:30017933. |
the expression of mir-212, aqp9, pi3k, akt, vegf, bax, and b cell lymphoma 2 (bcl-2), along with cell apoptosis were determined using reverse transcription quantitative polymerase chain reaction (rt-qpcr), western blot analysis and flow cytometry. |
2019-09-30 |
2023-08-13 |
rat |